الصفحة 1
الصفحة 1
Neurology Study Guide : Oral Board Examination Review
The book is divided into two parts. Part 1 is devoted to practical tips on the exam’s structure, its etiquette and preparation. Particular emphasis is placed on reasons for failing the exam. Part 2 provides sample adult and pediatric vignettes, mirroring that part of the oral Board. Each vignette is presented in a format similar to the exam’s format. Each case provides a differential diagnosis, most likely diagnosis and treatment recommendations. Where relevant, potential pitfalls, do’s and don’ts, musts and shoulds and frequently asked questions, complement the case discussion.
Multimodal Concepts for Integration of Cytotoxic Drugs
The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on different forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies, derived from recent advances in molecular oncology. The second part of the book comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented. In addition, the topics of acute and late toxicity, supportive treatment and tolerance in elderly patients are reviewed.
Molecular Markers of Brain Tumor Cells : Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy
Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.
Minimally Invasive Neurosurgery and Neurotraumatology
Neurotraumatology patients present an enormous challenge to society. Neuros- gical management of brain and spinal cord injury has been a frustrating area, as s- gical methods, especially in moderate and severe injuries, have been limited to control of brain and spinal compression, control of intracranial pressure with its expected effect on cerebral blood flow, and structural repair of the supporting structures (skull, spine, brain and spinal cord coverings). Achieving the best outcome for the neu- traumatology patient, however, requires much more than that.
Hyperthermia In Cancer Treatment : A Primer
Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.
Evidence based practice in Neuro-oncology
This book provides evidence-based management in neuro-oncology covering all aspects such as pathology, radiology, surgery, radiation, and chemotherapy.The field of neuro-oncology is rapidly evolving and new evidence is coming out every day towards the optimal management of brain tumors. This necessitates a requirement of a complete guide that shall provide an evidence-based and personalized approach towards dealing with patients. This book also covers recent advances in personalized treatment formed through the relevant basis of anatomy, imaging, radiology, surgical, radiation and systemic treatment of brain and spinal tumors. In addition it also covers the , practical aspects of the planning of the Gamma knife and other radio surgical aspects.
Diffusion-Weighted MR Imaging of the Brain
Diffusion-weighted MR imaging is widely accepted as a means to identify stroke, thus enabling rapid and effective treatment. Over the past four years, these expert authors have presented over 30 exhibits and scientific reports on diffusion-weighted imaging at the RSNA and the American Society of Neuroradiology (ASNR), and more than 10 of these presentations have been recognized by specific awards. Diffusion-Weighted MR Imaging of the Brain’s chapters range from basic principles to interpretation of diffusion-weighted MR imaging and specific disease.
Diagnostic Criteria in Neurology
The criteria cover a wide spectrum of neurological conditions whose diagnosis does not depend solely on histopathology (e.g., brain tumors), including cerebrovascular diseases, dementias and behavioral disorders, demyelinating disorders, and disorders of consciousness and brain death.
Clinical Functional MRI : Presurgical Functional Neuroimaging
Functional magnetic resonance imaging (fMRI) has contributed significantly to progress in neuroscience by permitting noninvasive imaging of the "human brain at work" under physiological conditions. Within clinical neuroimaging, fMRI is opening up a new diagnostic field by measuring and visualizing brain function. However, fMRI is not yet a standard diagnostic imaging procedure. This textbook is devoted to preoperative fMRI in patients with brain tumors and epilepsies, which are the most well-established clinical applications. By localizing and lateralizing specific brain functions in individual patients, as well as epileptogenic zones, fMRI facilitates the selection of a safe treatment and the planning and performance of function-preserving neurosurgery.
Brain tumor pathology : Current diagnostic hotspots and pitfalls
Since Bailey and Cushing (1926), all brain tumor classifications have been called histogenetic. The nosographic position that the tumor types progressively acquired in the classification systems derived from the resemblance of tumor cells to those of the cytogenesis, modified whenever new information became available from different biological research fields and especially from molecular genetics. Classically, on the basis of the rough correspondence between the mature/immature aspect of tumor cells and the benign/malignant biological behavior of the tumors, the histological labels contained a prognostic significance. The supposed origin of the tumors was thus a factor for prognosis. Later on, with the concept of anaplasia (Cox, 1933; Kernohan et al., 1949) new criteria were introduced for establishing the malignancy grades of tumors. Immunohistochemistry and later molecular genetics further refined the prognostic diagnoses, substantially increasing the opportunities to recognize the cell origin of tumors, beside revealing the pathogenetic mechanisms. Prognoses became more accurate, as required by the greater and more targeted possibilities of therapy.
Brain Metastases
Brain metastases are the most dreaded complication of systemic cancer, affecting approximately 170,000 people a year, a far greater incidence than primary brain tumors. Advances in modern chemotherapy have led to an improved control of system cancers, often with agents that poorly penetrate the central nervous system, resulting in an increasing incidence of brain metastases. Traditional chemotherapy has had little impact on brain metastases. The main therapeutic option is radiation therapy, and in a small number of patients - surgery. However, refinements in all of these treatments offer some positive outcomes and an increased ability to stratify patients based on certain criteria.
3D Segmentation for medical images (OsteoVision) = التقطيع ثلاثي الأبعاد للصور الطبية
With the increasing integration of AI across various sectors, artificial intelligence (AI) is already playing a significant role in the healthcare industry, and its use is expected to grow further. AI systems used in image processing and computer vision algorithms have shown a significant ability to perform many operations such as segmentation, classification, and detection. This project presents the application of computer vision algorithms in the field of medical imaging for diagnostic, therapeutic, and interventional purposes. This thesis explores the use of several computer vision algorithms to address different pathologies, specifically brain tumors (glioma) (see Appendix A) and knee osteoarthritis (OA), as well as tracking the progression of knee osteoarthritis using the Kellgren and Lawrence (KL) grading system, a common method for classifying the severity of OA into five grades. To achieve the desired impact, the project employs various techniques, including 3D segmentation for brain tumors, 2D segmentation for knee joints, and multinomial classification for determining the severity of knee OA injuries. The primary aims of the project are to enhance diagnostic accuracy, assist in creating treatment plans, provide an assistive tool for healthcare providers to make more informed decisions, leverage AI's capabilities to detect abnormalities that might escape the human eye, and streamline workflow. To facilitate these goals, the project incorporates a user-friendly UI, a website, and a Flutter-based mobile application, enabling healthcare providers to efficiently integrate these tools into their practice and improve patient care.
