الصفحة 1
الصفحة 1
White Biotechnology
The successful launch of polylactide marked white biotechnology’s break-through into the field of polymers and synthetics.Today crude oil is the most important energy source and the most widely used chemical raw material. Both primary industry and polymer chemistry currently depend to a great extent on oil. However, it is only a matter of time before the world’s oil reserves are depleted. Almost all studies presented to date agree that peak oil, i.e. the point in time when oil extraction reaches its highest level, will take place in the first half of the present century. The increasingly difficult development of new sources of oil have triggered initiatives worldwide to reduce national dependence on oil imports.
Therapeutic use of medicinal plants and their extracts ; Vol.2 : Phytochemistry and bioactive compounds
Starts with a general introduction to phytochemistry, followed by chapters on plant constituents, their origins and chemistry, but also discussing animal-, microorganism- and mineral-based drugs. Further chapters cover vitamins, food additives and excipients as well as xenobiotics and poisons. The book also explores the herbal approach to disease management and molecular pharmacognosy and introduces methods of qualitative and quantitative analysis of plant constituents. Phytochemicals are classified as primary (e.g. carbohydrates, lipids, amino acid derivations, etc.) or secondary (e.g. alkaloids, terpenes and terpenoids, phenolic compounds, glycosides, etc.) metabolites according to their metabolic route of origin, chemical structure and function. A wide variety of primary and secondary phytochemicals are present in medicinal plants, some of which are active phytomedicines and some of which are pharmaceutical excipients.
The Structure and Function of Plastids
Provides a comprehensive look at the biology of plastids, the multifunctional biosynthetic factories that are unique to plants and algae. The book is divided into five sections: (I): Plastid Origin and Development; (II): The Plastid Genome and Its Interaction with the Nuclear Genome; (III): Photosynthetic Metabolism in Plastids; (IV): Non-Photosynthetic Metabolism in Plastids; (V): Plastid Differentiation and Response to Environmental Factors. Each chapter includes an integrated view of plant biology from the standpoint of the plastid.
The Codes of Life : The Rules of Macroevolution
Building on a range of disciplines – from biology and anthropology to philosophy and linguistics – this book draws on the expertise of leading names in the study of organic, mental and cultural codes brought together by the emerging discipline of biosemiotics. The book’s 18 chapters present a range of experimental evidence which suggests that the genetic code was only the first in a long series of organic codes, and that it has been the appearance of new codes – organic, mental and cultural – that paved the way for the major transitions in the history of life.While the existence of many organic codes has been proposed since the 1980s, this volume represents the first multi-authored attempt to deal with the range of codes relevant to life, and to reveal the ubiquitous role of coding mechanisms in both organic and mental evolution. This creates the conditions for a synthesis of biology and linguistics that finally overcomes the old divide between nature and culture.
Selenium : Its Molecular Biology and Role in Human Health
Selenium is an essential trace element in the diet of humans and many other life forms. As discussed in this book, selenium plays an important role in preventing certain forms of cancer, heart disease and other cardiovascular and muscle disorders. Evidence points to numerous other health benefits including an indispensable function in development, male reproduction and the immune system. In addition, selenium serves as an antiviral agent and may delay the onset of AIDS in HIV positive patients and delay the aging process. This element occurs primarily in cellular proteins in the form of a novel amino acid selenocysteine. The emphasis of this book is on the current status of the molecular biology of selenium. The importance of this element in human health is also highlighted.
Reviews of Physiology Biochemistry and Pharmacolog
The eukaryotic translation machinery must recognize the site on a messenger RNA (mRNA) where decoding should begin and where it should end. The selection of the translation start site is generally given by the first AUG codon encoding the amino acid methionine. Dating initiation soluble translation initiation factors (eukaryotic translation initiation factors [eIFs] in eukaryotes and prokaryotic translation initiation factors [IFs] in prokaryotes) bind the mRNA, deliver the initiator Met-tRNA, and assemble to form a complete 80S ribosome from the 40S and 60S subunits. By progressing along the mRNA in the 5 -to-3 direction the ribosome decodes the information and translates it into the polypeptide chain. During this process, repeated delivery of amino-acyl tRNA (aa-tRNA) to the ribosome, peptide bond formation, movement of the mRNA, and the growing peptidyl-tRNA is mediated by both soluble elongation factors (eukaryotic translation elongation factors [eEFs] in euka- otes and prokaryotic translation elongation factors [EFs] in prokaryotes) and the activity of the ribosome. The ?nal step in the translation process occurs when one of the three t- mination codons occupies the ribosomal A-site. Translation comes to an end and soluble release factors (eukaryotic translation termination factors [eRFs] in eukaryotes and proka- otic translation termination factors [RFs] in prokaryotes) facilitate hydrolytical release of the polypeptide chain.
QSAR and Molecular Modeling Studies in Heterocyclic Drugs I
This series in heterocyclic chemistry is being introduced to collectively makeavailable critically and comprehensively reviewed literature scattered in vari-ous journals as papers and review articles. All sorts of heterocyclic compoundsoriginating from synthesis, natural products, marine products, insects, etc. willbe covered. Several heterocyclic compounds play a significant role in main-taining life. Blood constituent hemoglobin and purines as well as pyrimidines,the constituents of nucleic acid (DNA and RNA) are also heterocyclic com-pounds. Several amino acids, carbohydrates, vitamins, alkaloids, antibiotics,etc. are also heterocyclic compounds that are essential for life. Heterocycliccompounds are widely used in clinical practice as drugs, but all applications ofheterocyclic medicines can not be discussed in detail. In addition to such appli-cations, heterocyclic compounds also find several applications in the plasticsindustry, in photography as sensitizers and developers, and in dye industry asdyes, etc.
Protein 3D-structure prediction
Protein plays a major role in every cell it is responsible for every function in our body and every living being in their body. consisting of one or more long chains of amino acid residues. The 3D structure is responsible for the function of a protein, predicting the 3D structure it is a challenge for scientists and researchers by using AI systems and neural networks technics it's becoming a trend for reducing the time and cost, also helping scientists to understand how proteins act in real life a lot of universities around the world and institution they are competes to build a model and solution to help with predicting the proteins they invented CASP competition for this purpose it happens every two years, tomake the ability to predict protein’s 3D structure by sequences of amino acids this all happens by learning and calculating the distance between atoms and understanding the correlation between amino acids by using neural networks consists of bi directional LSTM to understand the sequence.
Prebiotic Chemistry : From Simple Amphiphiles to Protocell Models
Fve areas are covered in this special volume of Topics in Current Chemistry: The prebiotic chemistry of simple amphiphilic molecules and their selfassembly into compartmentalized structures, The prebiotic chemistry of nucleobases, nucleotides and oligonucleotides as essential elements of the hypothetical “RNA-world” and its relation to the proposed “pre-RNA-world(s), The prebiotic chemistry of amino acids and peptides; The possible prebiotic origin of homochirality; and , The possible formation of protocellular structures .
Peptide science : Chemical ligation, lead Generation, and therapeutic advances
Peptides are signaling molecules comprised of amino acids which play an important role in modulating certain physiological processes. They have a wide range of applications, particularly with respect to biological studies and therapeutical potentials. The explosive growth of peptide science in recent years and the variety of achievements in peptide drug discovery and related areas have made it an important area of study for new researchers and industry professionals. Overview of this burgeoning field and its major applications. Covering the chemistry, the pertinent technologies, and major existing therapies, it provides the tools required to integrate peptide research with virtually any area of research and development. Fully cognizant of the latest technological advances, it’s a must-own for anyone looking to understand a vital field of chemistry.
Oxygen Transport to Tissue XXIX
This volume about the 34th Annual Conference of the International Society on Oxygen Transport to Tissue (ISOTT) was held during August 12–17, 2006 in Louisville, Kentucky, USA. The emphasis of ISOTT-2006 was on ‘‘Expanding our Horizon. ’’ In terms of research topics, we added some newer ones – Translational Studies, Tissue Engineering, and Nanobiotechnology.
Organic Chemistry ; 9th ed.
Structure and Bonding / Polar Covalent Bonds; Acids and Bases / Organic Compounds: Alkanes and Their Stereochemistry / Organic Compounds: Cycloalkanes and Their Stereochemistry / Stereochemistry at Tetrahedral Centers / An Overview of Organic Reactions / Alkenes: Structure and Reactivity / Alkenes: Reactions and Synthesis / Alkynes: An Introduction to Organic Synthesis / Organohalides / Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations / Structure Determination: Mass Spectrometry and Infrared Spectroscopy / Structure Determination: Nuclear Magnetic Resonance Spectroscopy / Conjugated Compounds and Ultraviolet Spectroscopy / Benzene and Aromaticity / Chemistry of Benzene: Electrophilic Aromatic Substitution / Alcohols and Phenols / Ethers and Epoxides; Thiols and Sulfides / Aldehydes and Ketones: Nucleophilic Addition Reactions / Carboxylic Acids and Nitriles / Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions / Carbonyl Alpha-Substitution Reactions / Carbonyl Condensation Reactions / Amines and Heterocycles / Biomolecules: Carbohydrates / Biomolecules: Amino Acids, Peptides, and Proteins / Biomolecules: Lipids / Biomolecules: Nucleic Acids / The Organic Chemistry of Metabolic PathwaysOrbitals and Organic Chemistry: Pericyclic Reactions Synthetic / Polymers
Nutraceuticals in insomnia and sleep problems
Sleep is one of the most important and crucial physiological needs for maintaining a healthy life. However, in today’s day and age, insomnia and other sleep disorders, such as sleep apnea, are increasing rapidly. This new book details the nutraceuticals from foods that help to promote good health and optimum sleep. The authors discuss the importance of sleep, the role of diet in sleep, the role of specific vitamins and minerals, amino acids and opioids as nutraceuticals for sleep, newer technologies for use and delivery of nutraceuticals for treating insomnia, and more. The book not only explores nutraceuticals that promote optimum sleep but also details foods that cause insomnia, such as processed, chemical-rich, and refined foods. Chapters also cover commensal and symbiotic microbes, microbial metabolites, and bacteriocins and their impact on sleep. A chapter on the ethical issues related to addiction to nutraceuticals for sleep induction is also included.
Neurochemical Aspects of Excitotoxicity
Leading researchers offer cutting-edge information on glutamate metabolism in the brain, examining the role of glutamate transporters and the involvement of glutamate receptors in the pathogenesis of acute neural trauma and neurodegenerative diseases.
Nectaries and Nectar
This book is a modern and interdisciplinary text on nectar and nectaries, prompted by the expansion of knowledge, especially in the more ecological and now molecular fields, and the strong recent interest in pollination biology.
N-Acetylaspartate : A Unique Neuronal Molecule in the Central Nervous System
N-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of humans, yet its function remains elusive. This book reviews research from around the world in the study of NAA, and the roles it plays in neuronal development and functioning.
Mucins : Methods and protocols
Explores the latest advancements in mucin research. The chapters in this book are organized into 8 parts and cover a wide range of topics such as mucin extraction, isolation, physicochemical property analysis, and experimental methods. The chapters also discuss the origins of mucins in jellyfish, feces, saliva and salivary glands, bronchi, stomach, and cervical tract; organic synthesis of peptides glycosylated at specific sites; analysis of mucin gene expression and methylation-specific electrophoresis of genes; imaging of mucin networks by AFM; and experimental methods using supported molecular matrix electrophoresis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Molecular Gels : Materials with Self-Assembled Fibrillar Networks
Molecular gels and fibrillar networks – a comprehensive guide to experiment and theory Molecular Gels: Materials with Self-Assembled Fibrillar Networks provides a comprehensive treatise on gelators, especially low molecular-mass gelators (LMOGs), and the properties of their gels. The structures and modes of formation of the self-assembled fibrillar networks (SAFINs) that immobilize the liquid components of the gels are discussed experimentally and theoretically. The spectroscopic, rheological, and structural features of the different classes of LMOGs are also presented. Many examples of the application of the principal analytical techniques for investigation of molecular gels (including SANS, SAXS, WAXS, UV-vis absorption, fluorescence and CD spectroscopies, scanning electron, transmission electron and optical microscopies, and molecular modeling) are presented didactically and in-depth, as are several of the theories of the stages of aggregation of individual LMOG molecules leading to SAFINs. Several actual and potential applications of molecular gels in disparate fields (from silicate replication of nanostructures to art conservation) are described. Special emphasis is placed on perspectives for future developments.
Mitochondria : The Dynamic Organelle
This volume discusses the death pathways that are initiated by the mitochondria. Novel therapeutic interventions are proposed which interfere with the death cascades, thereby rescuing the cell from mitochondria-linked apoptosis and necrotic oncosis.
Microbial Sulfur Metabolism
In nature, sulfur occurs in many different oxidation states and is one of the most versatile elements in life. It is an integral part of many important cell constituents, such as the amino acids cysteine and methionine, and many sulfur compounds serve as the basis for energy-related processes in prokaryotes. In recent years, new methods have been applied to study the biochemistry and molecular biology of reactions of the global sulfur cycle, the microorganisms involved and their physiology, metabolism and ecology. These activities have uncovered fascinating new insights for the understanding of aerobic and anaerobic sulfur metabolism.
