الصفحة 1
الصفحة 1
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Ontologies-Based Business Integration
E-business integration is a vision we have developed over a long period of time. As we have worked in business practice for many years prior to and in parallel with our academic research, we have always thought of such - tegration not only as an intellectual challenge but also as a real business tool. Consequently, when we started our project on Ontologies-based R- onciliation for Business Integration (ORBI) in 2004, not only pure science but also business objectives were at the center of our research. We were very happy to be able to form a project consortium that consisted not only of renowned researchers but also of experienced business practitioners from a range of companies. Each played a specific role – as user, provider or co-developer of the application components that are based on the me- ods we have developed. So may this book find its way not only to the desks of researchers and students, but also into the offices and minds of business practitioners worldwide who are dealing with the challenge of integrating their business processes, applications and information.
Online Investing on the Australian Sharemarket : How to Research, Trade and Invest in Shares and Securities Online
Offers step-by-step guidance on choosing an online broker, accessing and making best use of online share investing resources, planning trades, identifying profit-making opportunities, timing of and placing online orders, managing investment risks, and much more.
Online hate speech in the European Union : A discourse-analytic perspective
open access under a CC BY 4.0 license and reports on research carried out as part of the European Union co-funded C.O.N.T.A.C.T. project which targeted hate speech and hate crime across a number of EU member states. It showcases the bearing that discourse analytic research can have on our understanding of this phenomenon that is a growing global cause for concern.
Online Business Security Systems
On-Line Business Security Systems, a professional book, applies the concept of synchronization to security of global heterogeneous and hetero-standard systems by modeling the relationship of risk access spots (RAS) between advanced and developing economy's network platforms. The proposed model is more effective at securing the electronic security gap between these economies in real life applications.
On the Topology of Isolated Singularities in Analytic Spaces
The aim of this book is to give an overview of selected topics on the topology of real and complex isolated singularities, with emphasis on its relations to other branches of geometry and topology. The first chapters are mostly devoted to complex singularities and a myriad of results spread in a vast literature, which are presented here in a unified way, accessible to non-specialists. Among the topics are the fibration theorems of Milnor; the relation with 3-dimensional Lie groups; exotic spheres; spin structures and 3-manifold invariants; the geometry of quadrics and Arnold's theorem which states that the complex projective plane modulo conjugation is the 4-sphere. The second part of the book studies pioneer work about real analytic singularities which arise from the topological and geometric study of holomorphic vector fields and foliations. In the low dimensional case these turn out to be related to fibred links in the 3-sphere defined by meromorphic functions. This provides new methods for constructing manifolds equipped with a rich geometry.
On the move to meaningful internet systems 2007 : CoopIS, DOA, ODBASE, GADA, and IS ; OTM Confederated International Conferences, CoopIS, DOA, ODBASE, GADA, and IS 2007, Vilamoura, Portugal, November 25-30, 2007, Proceedings, Part II
This two-volume set LNCS 4803/4804 constitutes the refereed proceedings of the five confederated international conferences on Cooperative Information Systems (CoopIS 2007), Distributed Objects and Applications (DOA 2007), Ontologies, Databases and Applications of Semantics (ODBASE 2007), Grid computing, high performance and Distributed Applications (GADA 2007), and Information Security (IS 2007) held as OTM 2007 in Vilamoura, Portugal, in November 2007.
On the move to meaningful internet systems 2007 : CoopIS, DOA, ODBASE, GADA, and IS ; OTM Confederated International Conferences, CoopIS, DOA, ODBASE, GADA, and IS 2007, Vilamoura, Portugal, November 25-30, 2007, Proceedings, Part I
Constitutes the proceedings of the 5 confederated international conferences on Cooperative Information Systems, Distributed Objects and Applications, Ontologies, Databases and Applications of Semantics, Grid computing, high performance and Distributed Applications, and Information Security held as OTM 2007 in Vilamoura, Portugal, in November 2007.
On the Move to Meaningful Internet Systems : OTM 2008 ; OTM 2008 Confederated International Conferences, CoopIS, DOA, GADA, IS, and ODBASE 2008, Monterrey, Mexico, November 9-14, 2008, Proceedings, Part II
This two-volume set LNCS 5331/5332 constitutes the refereed proceedings of the five confederated international conferences on Cooperative Information Systems (CoopIS 2008), Distributed Objects and Applications (DOA 2008), Grid computing, high performAnce and Distributed Applications (GADA 2008), Information Security (IS 2008), and Ontologies, Databases and Applications of Semantics (ODBASE 2008), held as OTM 2008 in Monterrey, Mexico, in November 2008.
On the move to meaningful internet systems : OTM 2008 ; OTM 2008 Confederated International Conferences, CoopIS, DOA, GADA, IS, and ODBASE 2008, Monterrey, Mexico, November 9-14, 2008, Proceedings, Part I
This two-volume set LNCS 5331/5332 constitutes the refereed proceedings of the five confederated international conferences on Cooperative Information Systems (CoopIS 2008), Distributed Objects and Applications (DOA 2008), Grid computing, high performAnce and Distributed Applications (GADA 2008), Information Security (IS 2008), and Ontologies, Databases and Applications of Semantics (ODBASE 2008), held as OTM 2008 in Monterrey, Mexico, in November 2008.
OMDoc : An Open Markup Format for Mathematical Documents [version 1.2]
Computers arechanging the way wethink. Of course,nearly all desk-workers have access to computers and use them to email their colleagues, search the Web for information and prepare documents. But I’m not referring to that. I mean that people have begun to think about what they do in compu- tional terms and to exploit the power of computers to do things that would previously have been unimaginable. This observation is especially true of mathematicians.
Oil and Security : A World Beyond Petroleum
This book examines the economic impact of changes in the global demand and supply for fossil fuels both on the major producers in Middle Eastern countries around the Persian Gulf, other producers, as well as the world at large. The economic, social and political life of most countries is not only intimately linked to and influenced by the energy market but also affected by historical developments. Among other issues, it shows how the economic, social and political development of societies in Arabia, the peoples of the Arab Peninsula are influenced by their historic and cultural environment, and what the future may bring to this region when their principal economic assets, petroleum and gas, start to lose markets as alternative sources of fossil fuel, alternative, and renewable energy supply the bulk of global energy needs. It also describes how changing fossil fuel costs, access, security of supply, and environmental impacts may affect future economic, social, and political developments as well as technological advances and changes in priorities.
Office and SharePoint 2007 User’s Guide : Integrating SharePoint with Excel, Outlook, Access, and Word
Web sites. Collaboration. Document management. Paperless offices. We want it all in business today, but how do you achieve all of these goals? More importantly, if you work for one of the millions of small to medium–sized businesses, how do you find the time and build the expertise necessary to reach these goals? Even the most powerful tool will not allow you to succeed unless you can get the majority of your staff to use it efficiently and effectively. You need a guide that demonstrates a platform small to medium–sized businesses can use to reach these goals.
Obstructions in Security-Aware Business Processes : Analysis, Detection, and Handling
This book explores the dilemma-like stalemate between security and regulatory compliance in business processes on the one hand and business continuity and governance on the other. The growing number of regulations, e.g., on information security, data protection, or privacy, implemented in increasingly digitized businesses can have an obstructive effect on the automated execution of business processes. Such security-related obstructions can particularly occur when an access control-based implementation of regulations blocks the execution of business processes. By handling obstructions, security in business processes is supposed to be improved. For this, the book presents a framework that allows the comprehensive analysis, detection, and handling of obstructions in a security-sensitive way. Thereby, methods based on common organizational security policies, process models, and logs are proposed. The Petri net-based modeling and related semantic and language-based research, as well as the analysis of event data and machine learning methods finally lead to the development of algorithms and experiments that can detect and resolve obstructions and are reproducible with the provided software.
Object-oriented metrics in practice : Using software metrics to characterize, Evaluate, and Improve the design of object-oriented systems
The combination of theoretically sound results and practically tested procedures and solution paths makes this book an ideal companion for professional software architects, developers and quality engineers. The pattern-oriented description of disharmonies offers easy access to detecting shortcomings and applying solution strategies. "This well-written book is an important piece of work that takes the seemingly forgotten art of object-oriented metrics to the next level in terms of relevance and usefulness."
Nutraceuticals for the treatment and prevention of sexual disorders
Covers diverse aspects of sexual dysfunctions and the role of nutraceutical therapeutics, applying both traditional knoweldge and modern evidence-based research. The new book focuses on the use of nutraceuticals on sexual disorders, highlighting the working solutions as well as open problems and future challenges in the use of nutraceuticals in sexual disorder research. Disucssing state-of-the-art developments and trends in this field, the book covers the use of antioxidants in stress-induced male infertility, the role of nutraceuticals in prostate cancer, male sex hormone disturbances, and the impact of nutraceuticals on male accessory organs. The book also addresses the use of nutraceuticals on female sexual disorders and remedial measures in treating breast cancer, cervical complications, pregnancy health and disorders, menstrual disturbances, female sex hormones, female infertility, and prevention of vaginal infections. The book also covers the use of nutraceuticals to combat general sexual disorders such as urinogenital complications, geriatric sexual functions, traditional nutraceuticals use for sexual disorders, the use of nutritional spices for sexual disorders, and the role of nutraceuticals on transgendered individuals.
Numerical Solution of Partial Differential Equations on Parallel Computers
The scientific fields of Ma- ematics and Physics provide a powerful vehicle for such descriptions in terms of Partial Differential Equations (PDEs). Formulated as such equations, physical laws can become subject to computational and analytical studies. In the computational setting, the equations can be discreti ed for ef?cient solution on a computer, leading to valuable tools for simulation of natural and man-made processes. Numerical so- tion of PDE-based mathematical models has been an important research topic over centuries, and will remain so for centuries to come. In the context of computer-based simulations, the quality of the computed results is directly connected to the model’s complexity and the number of data points used for the computations. Therefore, computational scientists tend to ?ll even the largest and most powerful computers they can get access to, either by increasing the si e of the data sets, or by introducing new model terms that make the simulations more realistic, or a combination of both. Today, many important simulation problems can not be solved by one single computer, but calls for parallel computing.
Numerical analysis
Introduces readers to the theory and application of modern numerical approximation techniques. Providing an accessible treatment that only requires a calculus prerequisite, the authors explain how, why, and when approximation techniques can be expected to work-and why, in some situations, they fail. A wealth of examples and exercises develop readers' intuition, and demonstrate the subject's practical applications to important everyday problems in math, computing, engineering, and physical science disciplines.
Number Theory : An Introduction to Mathematics ; Part A
This book attempts to provide such an understanding of the nature and extent of mathematics. It is a modern introduction to the theory of numbers, emphasizing its connections with other branches of mathematics. This part A, which should be accessible to a first-year undergraduate, deals with elementary number theory.
Nuclear Law : The Global Debate
This open access book traces the journey of nuclear law: its origins, how it has developed, where it is now, and where it is headed. As a discipline, this highly specialized body of law makes it possible for us to benefit from the life-saving applications of nuclear science and technology, including diagnosing cancer as well as avoiding and mitigating the effects of climate change. This book seeks to give readers a glimpse into the future of nuclear law, science and technology. It intends to provoke thought and discussion about how we can maximize the benefits and minimize the risks inherent in nuclear science and technology. This compilation of essays presents a global view in discipline as well as in geography.
