الصفحة 1
الصفحة 1
Ondansetron Patches
The objective of this study was to develop the matrix of transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH), in which ondansetron is the first serotonin subtype 3 receptor antagonist indicated for the treatment and/or prophylaxis of postoperative, chemotherapy or radiotherapy induced emesis. It has been proven efficient and safe to treat such symptoms, by using in vitro drug release study and evaluate the effect of eucalyptus oil and different percentage of carbopol 940. The result of drug release decreased by increasing the percentage of carbopol 940 which achieved the purpose of the study by prolonging the release of the ondansetron . The patch provides a means to reduce the side effects associated with its oral therapy, avoidence of the first-pass metabolism and minimize inconsistency in absorption across GIT. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin.
Numerical Techniques for Chemical and Biological Engineers Using MATLAB® : A Simple Bifurcation Approach
This book addresses the bifurcation characteristics of chemical and biological processes as the general case and treats systems with a unique steady state as special cases. It uses a system approach which is the most efficient for knowledge organization and transfer. The book develops mathematical models for many commercial processes utilizing the mass-, momentum-, and heat-balance equations coupled to the rates of the processes that take place within the boundaries of the system. The models are solved numerically through MATLAB codes with emphasis on the design and optimization of the chemical and biological industrial equipment and plants.
Neutron and X-ray Spectroscopy
Neutron and X-Ray Spectroscopy delivers an up-to-date account of the principles and practice of inelastic and spectroscopic methods available at neutron and synchrotron sources, including recent developments. The chapters are based on a course of lectures and practicals (the HERCULES course) delivered to young scientists who require these methods in their professional careers. Each chapter, written by a leading specialist in the field, introduces the basic concepts of the technique and provides an overview of recent work. This volume, which focuses on spectroscopic techniques in synchrotron radiation and inelastic neutron scattering, will be a primary source of information for physicists, chemists and materials scientists who wish to acquire a basic understanding of these techniques and to discover the possibilities offered by them. Emphasizing the complementarity of the neutron and X-ray methods, this tutorial will also be invaluable to scientists already working in neighboring fields who seek to extend their knowledge.
Nanotechnology for Oral Drug Delivery : From Concept to Applications
Discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance.
Multiphase Flow Dynamics 3 : Turbulence, Gas Absorption and Release, Diesel Fuel Properties
Volume 3 is devoted to selected Chapters of the multiphase fluid dynamics that are important for practical applications. The state of the art of the turbulence modeling in multiphase flows is presented. As introduction, some basics of the single-phase boundary layer theory including some important scales and flow oscillation characteristics in pipes and rod bundles are presented. Then the scales characterizing the dispersed flow systems are presented. The description of the turbulence is provided at different level of complexity: simple algebraic models for eddy viscosity, algebraic models based on the Boussinesq hypothesis, modification of the boundary layer share due to modification of the bulk turbulence, modification of the boundary layer share due to nucleate boiling. Then the role of the following forces on the matematical description of turbulent flows is discussed: the lift force, the lubrication force in the wall boundary layer, and the dispersion force.
Molecular Gels : Materials with Self-Assembled Fibrillar Networks
Molecular gels and fibrillar networks – a comprehensive guide to experiment and theory Molecular Gels: Materials with Self-Assembled Fibrillar Networks provides a comprehensive treatise on gelators, especially low molecular-mass gelators (LMOGs), and the properties of their gels. The structures and modes of formation of the self-assembled fibrillar networks (SAFINs) that immobilize the liquid components of the gels are discussed experimentally and theoretically. The spectroscopic, rheological, and structural features of the different classes of LMOGs are also presented. Many examples of the application of the principal analytical techniques for investigation of molecular gels (including SANS, SAXS, WAXS, UV-vis absorption, fluorescence and CD spectroscopies, scanning electron, transmission electron and optical microscopies, and molecular modeling) are presented didactically and in-depth, as are several of the theories of the stages of aggregation of individual LMOG molecules leading to SAFINs. Several actual and potential applications of molecular gels in disparate fields (from silicate replication of nanostructures to art conservation) are described. Special emphasis is placed on perspectives for future developments.
Modern Optical Spectroscopy : With Exercises and Examples from Biophysics and Biochemistry
This textbook offers clear explanations of the theory of optical spectroscopic phenomena and shows how these ideas are used in modern molecular and cellular biophysics and biochemistry. The topics covered include electronic and vibrational absorption, fluorescence, resonance energy transfer, exciton interactions, circular dichroism, coherence and dephasing, ultrafast pump-probe and photon-echo spectroscopy, single-molecule and fluorescence-correlation spectroscopy, Raman scattering, and multiphoton absorption.
Modern Developments in X-Ray and Neutron Optics
This volume describes modern developments in reflective, refractive and diffractive optics for short wavelength radiation as well as recent theoretical approaches to modelling and ray-tracing the X-ray and neutron optical systems. It is based on the joint research activities of specialists in X-ray and neutron optics from 11 countries, working together under the framework of the European Programme for Cooperation in Science and Technology (COST, Action P7) in the period 2002--2006. The chapters are written by leading specialists from European laboratories, universities and large facilities. In addition to new ideas and concepts, the contents provide a large amount of practical information about recently implemented devices and methods.
Modeling of Soft Matter
Soft matter plays a role in a wide variety of important processes and application. For example, gel swelling and dynamics are an essential part of many biological and individual processes, such as motility mechanisms in bacteria and the transport and absorption of drugs. Ferroelectrics, liquid crystals, and elastomers are being used to design ever faster switching devices. Experimental studies, such as scattering, optical and electron microscopy, have provided a great deal of detailed information on structures. But the integration of mathematical modeling and analysis with experimental approaches promises to greatly increase our understanding of structure-property relationships and constitutive equations. The workshop on Modeling of Soft Matter has taken such an integrated approach.
Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics : Homogeneous and Heterogeneous Approaches
The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
Minimally Invasive Bariatric Surgery
This book covers the full spectrum of laparoscopic weight loss surgery and the pathophysiology of obesity. The chapter authors, all currently operating experts in the field, cover the essentials of establishing a bariatric surgery program, including equipment needs, guidelines for training, and patient selection. The operative chapters discuss in full detail the surgical techniques and outcomes, including laparoscopic VGB, laparoscopic adjustable gastric banding, laparoscopic Roux-en-Y, and laparoscopic malabsorption procedures. The text also tackles post-operative issues, such as complications, reoperation, plastic surgery after weight loss, nutritional issues, and pregnancy following obesity surgery.
Mid-infrared Semiconductor Optoelectronics
Mid-infrared Semiconductor Optoelectronics is an overview of the current status and technological development in this rapidly emerging area. It is composed of four parts. First, the basic physics and some of the main problems facing the design engineer (together with a comparison of possible solutions) are laid out. Next, there is a consideration of the multifarious lasers used as sources for mid-infrared technology, including an inspection of current approaches to the lack of such a source in the 3–4 µm region. Part III reviews recent work in light-emitting diodes and detectors and also deals with negative luminescence. The final part of the book is concerned with applications and highlights, once more, the diversity and technological importance of the mid-infrared spectral region.
Mid-Infrared Coherent Sources and Applications
Coherent sources of mid-infrared (mid-IR) radiation are of great interest for a wide range of scienti?c and technological applications from spectroscopy and frequency metrology to information technology, industrial process control, pho- chemistry, photobiology and photomedicine. The mid-IR spectrum, which may be de?ned as wavelengths beyond ?2µm, covers important atmospheric windows, and numerous molecular gases, toxic agents, air, water, and soil pollutants, c- ponents of human breath, and several explosive agents have strong absorption ?ngerprints in this region. The development of practical coherent solid-state sources in the mid-IR can thus provide indispensable tools for a variety of - plications in environmental monitoring and pollution control, detection of water and soil contaminants, food quality control, agriculture and life sciences, and n- invasive disease diagnosis and therapy through breath analysis.
Microscale Heat Transfer - Fundamentals and Applications ; Proceedings of the NATO Advanced Study Institute on Microscale Heat Transfer - Fundamentals and Applications in Biological and Microelectromechanical Systems, Cesme-Izmir, Turkey, 18-30 July, 2004
This volume contains an archival record of the NATO Advanced Institute on Microscale Heat Transfer – Fundamental and Applications in Biological and Microelectromechanical Systems held in Çesme – Izmir, Turkey, July 18–30, 2004.
Microbial Activity in the Rhizosphere
The rhizosphere is a very complex environment in which the effects of the plant on soil microorganisms and the effects of the microorganisms on the plant are interacting and are interdependent. Plant root exudates and breakdown products attract microbes and feed them and, in turn, the plants often benefit from the microbes. Interactions among microorganisms and plant roots are essential for nutritional requirements of the plant. Plant growth, development and productivity are largely dependent on the soil environment in the root region rhizosphere. The new techniques of studying the rhizosphere enables us to get a much better understanding of the dynamics of the rhizosphere population, such rhizosphere studies being of interest to agriculturists, soilbiologists, chemists, microbiologists and molecular biologists. The rhizosphere microbes in?uence the root environment in several ways. They may change the oxidation-reduction potential, influence the availability of moisture and nutrients, produce growth inhibiting or growth promoting substances in the form of exudates, provide competition and possibly induce many other effects. My corrhizal associations are beneficial in mineral uptake and in increasing root surface area for effective ion absorption. Antagonism, ompetition and synergism in soil and the rhizoplane (rhizosphere) are the most important microbial interactions to consider in the study of rhizosphere biology. With the growing information on the production of growth regulators, competitiveness of the microbes in the rhizosphere, microsymbionts, and other factors, their effect upon plant growth will become more evident. Experiments on the introduction of microbes or their products in the rhizosphere will help to improve our understandingofthebiologyoftherhizosphere.
In situ NMR Methods in Catalysis
In Situ NMR Methods in Catalysis is part of the Springer series Topics in Current Chemistry. The book contains five chapters and a helpful author and subject index. Chapter by chapter, the individual contributions are well written and structured . The book presents an excellent resource for the reader who is interested in a delivery of topics related to homogenous catalysis, some of which can be investigated by NMR.This will be a must-have work for scientists and practitioners in any field related to modern chemical research. It will also be highly useful for many workers in industry who are required to keep up-to-date with the latest news in chemistry and applied chemistry. So much is covered here in critical review, from the present position of developing research to future trends.
High-Speed Photodiodes in Standard CMOS Technology
High-speed Photodiodes in Standard CMOS Technology describes high-speed photodiodes in standard CMOS technology which allow monolithic integration of optical receivers for short-haul communication. For short haul communication the cost aspect is important , and therefore it is desirable that the optical receiver can be integrated in the same CMOS technology as the rest of the system. If this is possible then ultimately a singe-chip system including optical inputs becomes feasible, eliminating EMC and crosstalk problems, while data rate can be extremely high.
High Power Diode Lasers : Technology and Applications
In a very comprehensive way this book covers all aspects of high power diode laser technology for materials processing. Basics as well as new application oriented results obtained in a government funded national German research project are described in detail.
Handbook of X-Ray Data
This sourcebook an X-ray data reference for scientists and engineers working in the field of energy or wavelength dispersive X-ray spectrometry and related fields of basic and applied research, technology, or process and quality controlling. The most important data connected with the emission of characteristic X-ray lines are tabulated for all elements up to Z = 95 (Americium).
Elementary physics of complex plasmas
Complex plasmas are dusty plasmas in which the density and electric charges of the dust grains are sufficiently high to induce long-range grain-grain interactions, as well as strong absorption of charged-plasma components. Together with the sources replenishing the plasma such systems form a highly dissipative thermodynamically open system that exhibits many features of collective behaviour generally found in complex systems. Most notably among them are self-organized patterns such as plasma crystals, plasma clusters, dust stars and further spectacular new structures. Beyond their intrinsic scientific interest, the study of complex plasmas grows in importance in a great variety of fields, ranging from space-plasma sciences to applied fields such as plasma processing, thin-film deposition and even the production of computer chips by plasma etching, in which strongly interacting clouds of complex plasmas can cause major contamination of the final product.
