الصفحة 9
الصفحة 9
Les thérapies ciblées = Targeted therapies
We are at the start of the development of new therapeutic classes, directed against new molecular targets (EGFR, VEGF, IGFR, Rank, etc.) Several diseases such as kidney, colon or breast cancer, GIST, have a natural history now modified thanks to these therapies. This practical book takes stock of the current use of these molecules.
Les douleurs abdominales en questions : Rôle physiopathologique de la sensibilité viscérale = Abdominal pain in question : The pathophysiological role of visceral sensitivity
The gut-brain axis refers to the network of nerve pathways that connect the myenteric plexus, the veritable "gut brain," to the central nervous system. Nearly 80% of these neurons are sensory neurons, and the afferent pathways that transmit information from the digestive tract to the central nervous system play a crucial role in the physiological regulation of digestive functions, as well as in certain pathological conditions. A large majority of these sensations remain unconscious and give rise to reflex responses. Only those requiring a conscious response reach the level of awareness in a normal state (hunger, thirst, the urge to defecate). In pathological situations, the same is true for painful sensations of digestive origin. Functional bowel disorders are a frequent reason for consultation. Their pathophysiology is now based on a model integrating the various etiological factors around the brain-gut axis. These patients frequently present with visceral hypersensitivity, which manifests as an increased perception of digestive sensations, notably the onset of pain in response to stimuli that are not painful in normal subjects. Recognizing the role of visceral hypersensitivity has made it possible to explain the mechanism of action of medications used to treat functional bowel disorders and paves the way for the development of new molecules acting on digestive afferents. In this book, we will describe the anatomical and physiological basis for understanding the concept of visceral sensitivity and the role of digestive afferents in the pathophysiology of acute and chronic abdominal pain, particularly irritable bowel syndrome.
Learning network programming with Java
Learn to deliver superior server-to-server communication through the networking channels / Gain expertise of the networking features of your own applications to support various network architectures such as client/server and peer-to-peer Explore the issues that impact scalability, affect security, and allow applications to work in a heterogeneous environment
Le dépistage du cancer colorectal : État des lieux et perspectives = Colorectal cancer screening: Current status and perspectives
Prevention and screening are two major challenges for Public Health to reduce cancer mortality in our country. Screening for colorectal cancer is therefore quite exemplary. The number one cancer in both sexes in France, its incidence continues to increase due to the aging of the population. Its mortality remains high, in the order of fifty percent, despite the major therapeutic advances made in recent years. Preceded by a precancerous lesion - the adenomatous polyp, which can be removed by colonoscopy - colorectal cancer is also curable at the early stage. Finally, it can be the subject of a screening strategy, the impact of which has been demonstrated today on the reduction in mortality, when it is detected before any symptom by a simple test for blood in the stool followed by , in case of positivity, by a total colonoscopy. This book takes stock of the scientific rationale and the state of play of organized colorectal cancer screening in France. It is also an opportunity to discuss emerging techniques and strategies that can help improve the results of this screening if they prove their superiority over the current strategy. Intended primarily for doctors, this book is also intended for healthcare professionals and all those who, concerned about their health, have a proactive attitude in terms of screening and preventing this cancer.
Lamto : Structure, Functioning, and Dynamics of a Savanna Ecosystem
Known as "a dream place for scientists," the Lamto savannas, located on the edge of the Cote d'Ivoire rain forests, are one of the only savannas in the world where ongoing ecological research has endured for more than forty years. Drawing from and synthesizing this abundance of research, the book examines the structure, functioning, and dynamics of the Lamto humid savanna. Beginning with the history of the Lamto ecology station and an overview of the major environmental conditions of the site, this exacting work specifically examines the integrative view of energy and nutrient fluxes relative to the dynamics of the savanna's vegetation.
Knowledge Solutions : Tools, Methods, and Approaches to Drive Organizational Performance
Covers topics in knowledge management and competence in strategy development, management techniques, collaboration mechanisms, knowledge sharing and learning, as well as knowledge capture and storage. Presented in accessible “chunks,” it includes more than 120 topics that are essential to high-performance organizations. The extensive use of quotes by respected experts juxtaposed with relevant research to counterpoint or lend weight to key concepts; “cheat sheets” that simplify access and reference to individual articles; as well as the grouping of many of these topics under recurrent themes make this book unique. In addition, it provides scalable tried-and-tested tools, method and approaches for improved organizational effectiveness.
Knowledge graphs and big data processing
This book is part of the LAMBDA Project (Learning, Applying, Multiplying Big Data Analytics), funded by the European Union, GA No. 809965. Data Analytics involves applying algorithmic processes to derive insights.
Kinetics of Water-Rock Interaction
Systems at the surface of the Earth are continually responding to energy inputs derived from solar radiation or from the radiogenic heat in the interior. These energy inputs drive plate movements and erosion, exposing metastable mineral phases at the Earth’s surface. In addition, these energy fluxes are harvested and transformed by living organisms. As long as these processes persist, chemical disequilibrium at the Earth’s surface will be perpetuated. Chemical disequilibrium is also driven by human activities related to production of food, extraction of water and energy resources, and burial of wastes. To understand how the surface of the Earth will change over time, we must understand the rates at which reactions occur and the chemical feedbacks that relate these reactions across extreme temporal and spatial scales. This book addresses fundamental and applied questions concerning the rates of water-rock interactions driven by tectonic, climatic, and anthropogenic forcings.
Journal on Data Semantics VI
Data warehousing and semantic data mining • Spatial, temporal, multimedia and multimodal semantics • Semantics in data visualization • Semantic services for mobile users • Supporting tools • Applications of semantic-driven approaches These topics are to be understood as speci?cally related to semantic issues. Contributions submitted to the journal and dealing with semantics of data will be considered even if they are not within the topics in the list. While the physical appearanceof the journal issues looks like the books from the well-known Springer LNCS series, the mode of operation is that of a jo- nal. Contributions can be freely submitted by authors and are reviewed by the Editorial Board. Contributions may also be invited, and nevertheless carefully reviewed, as in the case for issues that contain extended versions of best papers from major conferences addressing data semantics issues. Special issues, foc- ing on a speci?c topic, are coordinated by guest editors once the proposal for a special issue is accepted by the Editorial Board.
ITI treatment guide ; Vol.1 : Implant therapy in the esthetic zone : Single-tooth replacements
Focuses on implant therapy for single-tooth replacement in the esthetic zone. It guides readers through the entire treatment process, beginning with assessment of the patient's individual esthetic risk profile and proceeding through ideal three-dimensional implant placement and proven prosthetic management options. Various procedures are illustrated through patient case studies. Detailed illustrations serve to clarify any potential ambiguities, and potential complications are explored to avert the most common problems.
Computational and Information Science ; 1st International Symposium, CIS 2004, Shanghai, China, December 16-18, 2004, Proceedings
this book present the proceedings of The 2004 International Symposium on Computational and Information Sciences (CIS 2004) aimed at bringing researchers in the area of computational and - formation sciences together to exchange new ideas and to explore new ground. The goal of the conference was to push the application of modern computing technologies to science, engineering, and information technologies to a new level of sophistication and understanding.
CompTIA Network+ guide to networks ; 9th ed.
It thoroughly prepares you for success on CompTIA's Network+ N10-007 certification exam with fully mapped coverage of all objectives, including protocols, topologies, hardware, network design, security and troubleshooting. Virtualization-based projects give you experience working with a wide variety of hardware, software, operating systems and device interactions, while "On the Job" stories, Applying Concepts activities, and Hands-On and Capstone Projects let you explore concepts in more depth. MindTap Networking offers additional practice and certification prep.
Comprehensive esthetic dentistry
Allows a clinician to shape dental treatment and elevate patient smiles. Based on scientific research, clinical evidence, and the practical experience of the authors, this book is a practical approach to esthetic dentistry.
Complex Inorganic Solids : Structural, Stability, and Magnetic Properties of Alloys
One the key aspects of this volume is to cut across the traditional taxonomy of disciplines in the study of alloys. Hence there has been a deliberate attempt to integrate the different approaches taken towards alloys as a class of materials in different fields, ranging from geology to metallurgical engineering. The emphasis of this book is to highlight commonalities between different fields with respect to how alloys are studied. The topics in this book fall into several themes, which suggest a number of different classification schemes. We have chosen a scheme that classifies the papers in the volume into the categories Microstructural Considerations, Ordering, Kinetics and Diffusion, Magnetic Considerations and Elastic Considerations. The book has juxtaposed apparently disparate approaches to similar physical processes, in the hope of revealing a more dynamic character of the processes under consideration. This monograph will invigorate new kinds of discussion and reveal challenges and new avenues to the description and prediction of properties of materials in the solid state and the conditions that produce them
Community and Identity in Contemporary Technosciences
This book provides new thinking on scientific identity formation. It thoroughly interrogates the concepts of community and identity, including both historical and contemporaneous analyses of several scientific fields.
Clinical Cases in Periodontics ; 2nd ed.
Clinical Cases in Periodontics offers: A thorough introduction to periodontic examination and diagnosis, including documentation, plaque, and non-plaque induced gingivitis A comprehensive exploration of non-surgical periodontal therapy, including local anatomic factors contributing to periodontal disease and local drug delivery Practical discussions of resective periodontal therapy, including gingivectomy and flap osseous surgery In-depth examinations of regenerative therapy, including the treatment of furcation and guided bone regeneration The latest advances in inter-disciplinary care, encompassing orthodontics, prosthodontics, and implant dentistry
Clinical cases in periodontics ; 1st ed.
Describes the core principles of periodontics and demonstrates their practical, every-day application through a range of representative cases building from the simple to the complex and from the common to the rare. This unique approach supports the new trend in case-based and problem-based learning, thoroughly covering topics ranging from infant oral health to complex pulp therapy.
Clinical cases in implant dentistry
Presents 49 actual clinical cases, accompanied by academic commentary, that question and educate the reader about essential topics in implant dentistry, encompassing diagnosis, surgical site preparation and placement, restoration, and maintenance of dental implants. Unique case-based format supports problem-based learning Promotes independent learning through self-assessment and critical thinking Highly illustrated with full-color clinical cases Covers all essential topics within implant dentistry
Clinical aspects of dental materials : Theory, practice, and cases
The book’s three-part structure addresses types of dental materials in the 22 chapters of Part I, includes laboratory and clinical applications (essentially a built-in lab manual) in Part II, and presents 11 case studies in Part III that serve as an overall review and help students strengthen their critical thinking skills when providing patient care.
Claude-Nicolas Ledoux : Architecture and uopia in the era of the French revolution
Claude-Nicolas Ledoux (1736-1806) is today regarded as chief representative of French revolutionary architecture. With his extraordinary inventiveness he projected the architectural ideals of his era. Ledoux's influential buildings and projects are presented and interpreted both aesthetically and historically in this book. His best-known projects - the Royal Saltwords of Arc-et-Senans, the tollgates of Paris, the ideal city of Chaux - reveal the architect's allegiance to the principles of antiquity and Renaissance but also illustrate the evolution of his own utopian language. With the French Revolution, Ledoux ceased building as his contemporaries perceived him as a royal architect. He focused on the development of his architectural theory and redefined the vision of the modern architect
