الصفحة 9
الصفحة 9
Human Drug Metabolism
The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact.
Human and Animal Relationships
Pathogenic fungi are widely distributed and can infect many organisms, particularly humans, but also other vertebrates and insects. Due to a growing number of fungal infections, there is an increasing need to understand the interaction of pathogenic fungi with their hosts. This second completely updated and revised edition of Volume VI of The Mycota consists of state of the art reviews written by experts in the field, covering three major areas of this rapidly developing field. In the first part the current understanding of pathogenic fungi and the physiological reactions relevant for the pathogen - host interaction are elucidated. The second part describes novel technologies for the identification of proteins, virulence factors and mechanisms central to the host - pathogen interaction. The third part deals with the characterization of the host response towards pathogenic fungi and addresses timely clinical aspects.
How does the Galaxy Work? : A Galactic Tertulia with Don Cox and Ron Reynolds
Presents a multi-disciplinary approach to the physical mechanisms which structure the shape, evolution and fate of the Galaxy. It contains 4 panel sessions (the recording transcripts of the galactic 'tertulias'), an introductory historical overview on the Galaxy research, 17 reviews, and the proceedings of more than 50 oral and poster contributions. This book is not a new edition of a previous volume but it is in some way related to the book "The Formation of the Milky Way" (1995; Cambridge University Press), which contains the proceedings of the first IAA-IAC-University of Pisa meeting, held in Granada ten years ago, on the formation of the Milky Way, (see Shore's introduction). Where many other books focus their attention on singular galactic components or specific driving forces, this title provides a wide overview on the gaseous and stellar components and on the physical mechanisms which maintain the dynamical equilibrium of such a complex system as the Galaxy. The book, intended for graduate students and researchers, provides a valuable overview on the different physical mechanisms which drive the galactic gas-stars feedback.
Hot cracking phenomena in welds II
This is the second in a series of compendiums devoted to weld hot cracking phenomena, where this subject has been further scrutinized, bringing to bare the most current thoughts on this complex and diverse subject. With 22 technical papers in total, this book is divided in such a way that specific classifications of hot cracks are examined in detail, including solidification, liquation, and ductility dip cracking. The first chapter looks at solidification cracking theory, applying the most modern approaches to modelling weld solidification. Also provided here is a comprehensive review of cracking models. This is followed by two chapters characterizing solidification cracking behaviour for specific alloy systems: ferrous plus nickel-based alloys and aluminium alloys, respectively. The fourth chapter considers liquation cracking in ferrous alloys, and the fifth examines ductility-dip cracking.
Hot cracking phenomena in welds
The first chapter provides an overview of the various hot cracking phenomena. Different mechanisms of solidification cracking proposed in the past decades are summarized and new insight is particularly given into the mechanism of ductility dip cracking. The effects of different alloying elements on the hot cracking resistance of various materials are shown in the second chapter and, as a special metallurgical effect, the initiation of stress corrosion cracking at hot cracks has been highlighted. The third chapter outlines how numerical analyses and other modelling techniques can be utilized to describe hot cracking phenomena and how such results might contribute to the explanation of the mechanisms. Various hot cracking test procedures are presented in the final chapter with a special emphasis on standardization. For the engineering and natural scientists in research and development the book provides both, new insight and a comprehensive overview of hot cracking phenomena in welds. The contributions additionally give numerous individual solutions and helpful advice for international welding engineers to avoid hot cracking in practice. Furthermore, it represents a very helpful tool for upper level metallurgical and mechanical engineering students.
Hormones and the brain
Peripheral hormones have a major impact on the brain: they are able to interfere with its development, to affect release of neurotransmitters and concentrations of receptors, to trigger growth factors involved in lesion repair. These multiple actions account for their capacity to modulate a number of physiological parameters, from reproductive functions to memory, behaviour and aging. Depending upon intensity and duration of exposure, they can be either neuroprotective or neurotoxic, for instance by affecting production of free radicals. This book, based on contributions of pioneer investigators in the field, outlines the ambiguous actions of gonadal steroids (estradiol, progesterone, testosterone, inhibin and activin) and of neurosteroids, related moieties produced in the brain itself. After summarizing their multiple mechanisms of action, which involve both direct effects on neuronal membranes and activation of genes coding for specific proteins in neurons or glial cells, the book outlines the role of hormones in pathogenic processes such as mental disturbances or neurodegenerative diseases.
Homing Endonucleases and Inteins
This book provides detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and inteins. These two unique protein superfamilies have generated considerable excitement for their fundamental, structural, and functional properties, their evolution as parasitic elements, and their widespread applications as gene targeting agents and as instruments for the generation of modified proteins and novel protein combinations.
Historic construction and conservation : Materials, Systems and Damage
Takes a modern approach to the meaning of a heritage structure and its conservation. The historical evolution of conservation is briefly addressed, considering prominent individuals and cases; along with the history of construction, focusing on materials and related structural elements, with insight on the sizing rules adopted by masons. This explains structural decisions made during the construction process and allows comparison of scientific theories from the 18th century to modern understanding of limit analysis. Damage and collapse mechanisms for masonry construction, as the most widespread structural form for historical buildings, is described. Excess permanent loading and settlement is differentiated from environmental and anthropogenic actions such as earthquake or incorrect intervention.
High Thermal Conductivity Materials
High thermal conductivity materials play an important role in addressing thermal management issues. This volume provides readers a basic understanding of the thermal conduction mechanisms in these materials and discusses how the thermal conductivity may be related to their crystal structures as well as microstructures developed as a result of their processing history. The techniques for accurate measurement of these properties on large as well as small scales have been reviewed. Detailed information on the thermal conductivity of diverse materials including aluminum nitride (AlN), silicon carbide (SiC), diamond, as well as carbon nanotubes has been presented. The emphasis is on developing basic understanding of the inter-relationships between thermal conductivity and processing such that the readers can conduct their own research in this exciting field of high thermal conductivity materials.
High dilution effects : Physical and biochemical basis
this volume provides evidence in support of effects from control clinical studies, and in vitro tests without any organisms (Chapter II). An overview of the methods for preparing drugs at ultra high dilution is also provided as well as the basic principles of homeopathy, (Chapter I). Chapter III provides physical basis of high dilutions as evidence from the NMR, IR, UV and fluorescence spectra of those drugs.Chapter IV focuses on the mechanism of action of potentized drugs in the living system, discussing the structure of the cell, the plasma membrane, the integral proteins on the membrane, the interaction between these proteins and high dilutions and the manifestations of the therapeutic effects of high dilutions.
Heterocyclic Antitumor Antibiotics
Heterocyclic Compounds Includes aspects such as synthesis, reaction mechanisms, structure complexity, properties, reactivity, stability, fundamental and theoretical studies, biology, biomedical studies, pharmacological aspects, applications in material sciences etc. Metabolism will be also included which will provide information useful in designing pharmacologically active agents. Pathways involving destruction of heterocyclic ring will also be dealt with so that synthesis of specifically functionalized non-heterocyclic molecules can be designed. Overall scope is to cover topics dealing with most of the areas of current trends in heterocyclic chemistry which will suit to a larger heterocyclic community.
Hebbian Learning and Negative Feedback Networks
This book is the outcome of a decade’s research into a speci?c architecture and associated learning mechanism for an arti?cial neural network: the - chitecture involves negative feedback and the learning mechanism is simple Hebbian learning. The research began with my own thesis at the University of Strathclyde, Scotland, under Professor Douglas McGregor which culminated with me being awarded a PhD in 1995 [52], the title of which was “Negative Feedback as an Organising Principle for Arti?cial Neural Networks”. Naturally enough, having established this theme, when I began to sup- vise PhD students of my own, we continued to develop this concept and this book owes much to the research and theses of these students at the Applied Computational Intelligence Research Unit in the University of Paisley . All of Chapters 3 to 8 deal with single stream arti?cial neural networks.
Hearing and Sound Communication in Amphibians
Hearing and Sound Communication in Amphibians is a compendium of the latest research on acoustic communication in these highly vocal vertebrates. The chapters are written by experts currently investigating the physiology and behavior of amphibians both in the laboratory and in the field. This integrated approach guides each chapter and provides a neuroethologically-driven and evolutionary basis for our understanding of acoustic communication and its underlying mechanisms. The intended audience ranges from senior undergraduates to physiologists, zoologists, evolutionary biologists and communication specialists.
Hearing : From Sensory Processing to Perception
Hearing – From Sensory Processing to Perception presents the papers of the latest International Symposium on Hearing. The 59 chapters treat topics such as: the physiological representation of temporal and spectral stimulus properties as a basis for the perception of modulation patterns, pitch and signal intensity; spatial hearing and the physiological mechanisms of binaural processing in mammals.
Handbook of psychodiagnostic testing : Analysis of personality in the psychological report
Since the debut of the original edition, the Handbook of Psychodiagnostic Testing has been an invaluable aid to students and professionals performing psychological assessments. The new Fourth Edition continues in that tradition, taking the reader from client referral to finished report, demonstrating how to synthesize details of personality and pathology into a document that is focused, coherent, and clinically meaningful. As with the previous editions, authors Kellerman and Burry offer a systematic framework for choosing the most relevant material from seemingly overwhelming amounts of test data. Separate chapters offer clear rationales for each component of the report (e.g., cognitive functioning, interpersonal behavior, control mechanisms), and how they relate to one another. Helpful summaries follow each chapter, and tables and charts provide salient facts and findings at a glance.
Handbook of neurochemistry and molecular neurobiology : Sensory neurochemistry
This volume of the Handbook of Neurochemistry and Molecular Biology focuses on molecular events involved in synapse formation, synaptic plasticity and ongoing neural activity. The volume explores axonal growth cones, synapse development, and mechanisms of LTP and LTD, and calcium dynamics.
Handbook of neurochemistry and molecular neurobiology : Development and Aging Changes in the Nervous System
In the animal nervous system, a very high metabolic turnover, fragile but steep ionic gradients, and morphological and structural constraints - dictated by the necessity for prompt neuronal transmission of electrical impulses and necessary plasticity - result in a highly fragile organ system. Here, we address a small sampling of major constituents of neural function at the cellular and molecular level that play important roles in development and aging, two endogenous processes that embody features of allostasis or the dynamic shifts in set points for specific homeostatic mechanisms associated with development and aging. These chapters stress the dynamic features of neuronal responses to internal (developmental) cues or the more harmful external events (injury and disease) in a modern perspective.
Handbook of Economic Sociology for the 21st Century : New Theoretical Approaches, Empirical Studies and Developments
This handbook provides an overview on major developments that occurred in the field of economic sociology after its rebirth since the 1980s in the US. It offers new insights on the uniqueness of European economic sociology compared to US economic sociology which emerged at the end of the 20th century. The handbook presents economic sociology as a developing field which started with certain foundations as new economic sociology, widening the perspective by introducing social factors thereby focusing more on general belief systems, social forms of coordination and the relationships between society and the economy. It offers an outstanding portrait of the research field helping to identify major foundations and trajectories as well as new research perspectives for a globalized economic sociology.
Handbook of Drug Monitoring Methods : Therapeutics and Drugs of Abuse
In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic.
Handbook of cardiac anatomy, physiology, and devices
Because of rapid growth in the medical device industry-which today enjoys revenues as large as those of the automobile industry-as well as in our understanding of cardiac disease processes, biomedical engineers must cope with a rising tide of highly complex information. In Handbook of Cardiac Anatomy, Physiology, and Devices, leading experts from the University of Minnesota's renowned Lillehei Heart Institute and scientists from Medtronic, Inc. have compiled a concise-yet detailed and comprehensive-reference source on the anatomic features, underlying physiologic mechanisms, and treatments for diseases of the heart. Here, active bioengineers working on cardiac devices will find the complete critical background they need to understand cardiac pacing, defibrillation, cardiac repair using stem cell therapy, robotics, less invasive cardiac surgery, biventricular pacing, cardiac bioenergetics, and more. Insightful chapters address animal models for cardiac research, cardiac mapping systems, heart valve disease, ventricular assist devices, and genomics-based tools and technology.
