الصفحة 9
الصفحة 9
Multi-Scale Approaches in Drug Discovery : From Empirical Knowledge to In silico Experiments and Back
Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents.
Multirate Statistical Signal Processing
This book introduces a statistical theory for extracting information from signals that have di?erent sampling rates. This new theory generalizes the conventional (deterministic) theory of multirate systems beyond many of its constraints.Furthermore,itallowsfortheformulationofseveralnewproblems such as spectrum estimation, time-delay estimation and sensor fusion in the realm of multirate signal processing. I have arrived at the theory presented here by integrating concepts from diverse areas such as information theory, inverse problems and theory of - equalities. The process of merging a variety of concepts of di?erent origin results in both merits and shortcomings. The former include the fresh and - di?erentiated view of an amateur, providing scope of application. The latter include a lack of in-depth experience in each of the original ?elds. Granted, this may lead to gaps in continuity, however it goes without saying that a complete theory can seldom be achieved by one person and in a short time.
Multiple Criteria Decision Analysis :State of the Art Surveys
The handbook presents the most up-to-date discussions on well-established methodologies and theories in the field, while systematically surveying emerging fields in MCDA such as conjoint measurement, fuzzy preferences, fuzzy integrals, rough sets, etc. MULTIPLE CRITERIA DECISION ANALYSIS is a valuable reference volume (more than 2000 references) for the field of decision analysis. It provides graduate students, researchers, and practitioners with a sweeping survey of MCDA theory, methodologies, and applications. It is a handbook that is particularly suitable for use in seminars in Decision Analysis, Decision Support, and Decision Theory.
Multiobjective Problem Solving from Nature : From Concepts to Applications
he book focuses on how MOEAs and related techniques can be used to solve problems, particularly in the disciplines of science and engineering. Contributions by leading researchers show how the concepts of multiobjective optimization can be used to reformulate and resolve problems in broad areas such as constrained optimization, coevolution, classification, inverse modelling and design. The book is distinguished from other texts on MOEAs in that it is not primarily about the algorithms, nor specific applications, but about the concepts and processes involved in solving problems using a multiobjective approach. Each chapter contributes to the central, deep concepts and themes of the book: evaluating the utility of the multiobjective approach; discussing alternative problem formulations; showing how problem formulation affects the search process; and examining solution selection and decision making.
Multimodality in architecture : Collaboration, technology and education
Examines multimodality in architecture and its impacts on collaborative, technical and educational processes or systems. Multimodality is becoming increasingly critical in contemporary architectural practice and education. Creative design teams face new challenges when they embrace new modes of communication, technology, and knowledge development processes. From diverse online modes of communication to shared digital environments, generative AI and advanced hardware solutions, new modes of information creation, sharing, and application are changing the ways architects and designers work. The book presents new research which empowers international researchers and designers to work more effectively in a diverse range of digital environments. Whether the readers are architects, teachers, students, or scholars, this book provides critical insights and practical tools for understanding and optimising processes in architecture and design.
Multimodal Texts in Disciplinary Education : A Comprehensive Framework
This book provides an introduction to multimodality and the role of multimodal texts in today’s education. Presenting a comprehensive framework for analysing and working with multimodal texts in disciplinary education, it serves as a tool for researchers and teachers alike. The second part of the book focuses on sample analyses of a variety of educational texts for different age groups and from different disciplines, including games and online resources. The authors also comment on the specific challenges of each text, and how teachers can discuss such texts with their students to enhance both their understanding of the content and their multimodal literacy.
Multimedia Database Retrieval : A Human-Centered Approach
Multimedia Database Retrieval: A Human-Centered Approach presents the latest development in user-centered methods and the state-of-the-art in visual media retrieval. It includes discussion on perceptually inspired non-linear paradigm in user-controlled interactive retrieval (UCIR) systems. It also features a coherent approach which focuses on specific topics within content/concept-based retrievals via audio-visual information modeling of multimedia. Highlights include: * Exploring an adaptive machine that can learn from its environment * Optimizing the learning system by incorporating self-organizing adaptation into the retrieval process * Demonstrating state-of-the-art applications within small, medium, and large databases
Multilevel Block Factorization Preconditioners : Matrix-based Analysis and Algorithms for Solving Finite Element Equations
This monograph is the first to provide a comprehensive, self-contained and rigorous presentation of some of the most powerful preconditioning methods for solving finite element equations in a common block-matrix factorization framework. Topics covered include the classical incomplete block-factorization preconditioners and the most efficient methods such as the multigrid, algebraic multigrid, and domain decomposition. Additionally, the author discusses preconditioning of saddle-point, nonsymmetric and indefinite problems, as well as preconditioning of certain nonlinear and quadratic constrained minimization problems that typically arise in contact mechanics. The book presents analytical as well as algorithmic aspects.
Multifunctional Barriers for Flexible Structure : Textile, Leather and Paper
The intent of this book is to give a complete overview of the present state of the art of flexible barrier materials such as textile, paper and leather, including methods for barrier evaluation. It will be of interest to readers in industries, consumers, and members of the scientific community. The scope of the field is clearly delineated here for the first time, and it deals with a number of specific topics such as barrier to fire, antibacterial properties, resistance to waves (electrostatic, electromagnetic, acoustics), anti-odor, etc. combined with characterization techniques as well as material nanotechnology.
Multidisciplinary Scheduling : Theory and Applications ; 1st International Conference, MISTA '03 Nottingham, UK, 13-15 August 2003. Selected Papers
MULTIDISCIPLINARY SCHEDULING: Theory and Applications is a volume of nineteen reviewed papers that were selected from the sixty-seven papers presented during the First Multidisciplinary International Conference of Scheduling: Theory and Applications (MISTA). This is the initial volume of MISTA—the primary forum on interdisciplinary research on scheduling. Each paper in the volume has been rigorously reviewed and carefully copyedited to ensure the volume's readability. The book contains leading edge papers on the fundamentals of scheduling, multi-criteria objective scheduling, personnel scheduling, scheduling in space, scheduling the Internet, machine scheduling, bin packing, educational timetabling, sports scheduling, transport scheduling, aircraft scheduling, and heuristic and meta-heuristic scheduling
Multidisciplinary Economics : The Birth of a New Economics Faculty in the Netherlands
Multidisciplinary economics deliberately uses the insights and approaches of other disciplines and examines what consequences their contributions have for existing economic methods, theories and solutions to economic problems. Multidisciplinary economists should be at home in their own discipline and meet the high international standards of economic teaching and research that the discipline has developed. At the same time they should be able to recognise the limits of economics and be willing to open up new horizons by following new, discipline-transcending paths on which new insights into the analysis and solutions of economic problems can be found in collaboration with representatives of other disciplines. As a result of this search, economic methods and theories may have to be adjusted in such a way that they take insights from other disciplines into account. They may even have to be replaced by methods and theories that have been developed by other disciplines.
Multidimensional Screening
The book brings into a focus all necessary mathematical knowledge necessary to understand the economics of multidimensional results screening and applies them straightaway to economic models. The first part of this book contains a review of vector calculus, the theory of partial differential equations, and the theory of generalized convexity. These techniques are extensively used in multidimensional screening models. Part II is devoted to the economics of sceening models. It starts with a detailed discussion of economics and mathematics of unidimensional screening problems and three approaches to their solution: direct, dual, and Hamiltonian. It uses the Hamiltonian approach to unify all known results, which were previously obtained using different arguments. Then the major difficulties with direct and dual approach in the multidimensional context are discussed and the Hamiltonian approach is used to provide the most complete characterization of the solution known in the literature.
Multicriteria Scheduling : Theory, Models and Algorithms
Scheduling and multicriteria optimisation theory have been subject, separately, to numerous studies. Since the last twenty years, multicriteria scheduling problems have been subject to a growing interest. However, a gap between multicriteria scheduling approaches and multicriteria optimisation field exits. This book is an attempt to collect the elementary of multicriteria optimisation theory and the basic models and algorithms of multicriteria scheduling. It is composed of numerous illustrations, algorithms and examples which may help the reader in understanding the presented concepts. This book covers general concepts such as Pareto optimality, complexity theory, and general method for multicriteria optimisation, as well as dedicated scheduling problems and algorithms: just-in-time scheduling, flexibility and robustness, single machine problems, parallel machine problems, shop problems, etc.
Multicriteria Optimization
Decision makers in many areas, from industry to engineering and the social sector, face an increasing need to consider multiple, conflicting objectives in their decision processes. In many cases these real world decision problems can be formulated as multicriteria mathematical optimization models. The solution of such models requires appropriate techniques to compute so called efficient, or Pareto optimal, or compromise solutions that - unlike traditional mathematical programming methods - take the contradictory nature of the criteria into account. This book provides the necessary mathematical foundation of multicriteria optimization to solve nonlinear, linear and combinatorial problems with multiple criteria. Motivational examples illustrate the use of multicriteria optimization in practice. Numerous illustrations and exercises as well as an extensive bibliography are provided.
Multibody Mechanics and Visualization
Multibody Mechanics and Visualization is designed to appeal to computer-savvy students who will acquire significant skills in mathematical and physical modelling of mechanical systems in the process of producing attractive computer simulations and animations.
Multibody Dynamics : Computational Methods and Applications
Multibody Dynamics is an area of Computational Mechanics which blends together various disciplines such as structural dynamics, multi-physics - chanics, computational mathematics, control theory and computer science, in order to deliver methods and tools for the virtual prototyping of complex mechanical systems. Multibody dynamics plays today a central role in the modeling, analysis, simulation and optimization of mechanical systems in a variety of ?elds and for a wide range of industrial applications.
Multiagent Engineering : Theory and Applications in Enterprises
1 Multiagent Engineering: A New Software Construction Paradigm Multiagent systems have a long academic tradition. They have their roots in distributed problem solving in Artificial Intelligence (AI) from where they emerged in the mid-eighties as a distinctive discipline. Research in multiagent systems owes much to the work of Rosenschein on rationality and autonomy of intelligent agents, the European MAAMAW workshop series
MRI in Clinical Practice
The book covers the basic Physics behind MRI, quality assurance, up-to-date safety guidelines and a useful gallery of image artefacts. Part of the book focuses on the specific areas of the body in which MRI is currently exploited, describing how MRI is performed in practice. In each of these sections, a common theme is followed with illustrations of MR images acquired with clinically relevant settings and typical imaging protocols are also explicitly stated. Additional information is provided which includes a subjective view of the strengths and weaknesses of MRI in comparison to other imaging modalities. As well as covering routine clinical techniques, the latest advanced methods (e.g. spectroscopy, fMRI, diffusion, high field MRI) are discussed and placed into the context of clinical application.
Mountain Ecosystems : Studies in Treeline Ecology
This volume focuses on interaction between vegetation, relief, climate, soil and fauna in the treeline ecotone, and the effects of climate change and land use in North America and Europe.
Morse Theoretic Methods in Nonlinear Analysis and in Symplectic Topology
It covered an ample spectrum of subjects which are re ected in the present volume: Morse theory and related techniques in in nite dim- sional spaces, Floer theory and its recent extensions and generalizations, Morse and Floer theory in relation to string topology, generating functions, structure of the group of Hamiltonian difieomorphisms and related dynamical problems, applications to robotics and many others. We thank all our main speakers for their stimulating lectures and all p- ticipants for creating a friendly atmosphere
