الصفحة 9
الصفحة 9
Human Challenge Studies in Endemic Settings : Ethical and Regulatory Issues
This book provides an extensive review of ethical and regulatory issues related to human infection challenge studies, with a particular focus on the expansion of this type of research into endemic settings and/or low- and middle-income countries (LMICs). Human challenge studies (HCS) involve the intentional infection of research participants, and this type of research is rapidly increasing in frequency worldwide
Hugo and Russell's pharmaceutical microbiology
Microbiology is one of the essential pharmaceutical sciences upon which the study and practice of pharmacy is built. It has a bearing on all aspects of the manufacture of medicines and sterile products, from their design and development to their delivery as quality products. Few interventions are more central to modern medicine than the treatment of infection, where antibiosis, vaccination and hygienic practices have essential roles to play. The COVID-19 pandemic, the appearance of new pathogens and the rise of antibiotic resistance have demonstrated most completely the need for pharmaceutical practitioners, researchers and industrial scientists to be fully conversant with this field. The 9th edition of Hugo and Russell’s Pharmaceutical Microbiology has been updated to meet this need. Having long served as the sole comprehensive textbook covering this subject, it has now been adapted to a critical new period in the advancement of medical and pharmaceutical research and development. Its experienced editors have incorporated contributions from subject experts and created a text which will serve the next generation of pharmacy students, pharmaceutical industry scientists and researchers.
How to Improve the Results of Peripheral Nerve Surgery
All over the world research is going on to improve the outcome of the treatment of peripheral nerve lesions. Questions over questions arise. Is the autologeous nerve grafting still the golden standard in bridging defects? Have alternative techniques to overcome defects reached a level to replace autografting? To which length are they effective? What is the role of allografting? Are there still indications for vascularized nerve grafts? What can be expected from end to side coaptation? Does it exist at all? Under what conditions useful recoveries can be achieved? Are there new developments in physical medicine and physiotherapy? Can the quality of recovery be influenced by surgery on muscles to provide a better equilibrium of forces? To what extent cerebral plasticity may be exploited to improve functional results? The contributions in this book give answers to all of these questions.
Hot Topics in Infection and Immunity in Children IV
Hot Topics in Infection and Immunity in Children IV contains chapters based on lectures given by speakers at the “Infection and Immunity in Children” course, held in June 2006 at Keble College, Oxford. It was the fourth annual course of this name and this is the fourth book in the series as well. Together the courses and books have become important components of the training available to paediatricians with an interest in this specialty and have become increasingly popular each year. This book covers topics in infectious diseases in children and is intended for Pediatric Infectious Disease trainees, trainers, and all those who manage children with infections.
Hot Topics in Infection and Immunity in Children III
This book is based on the course “Infection and Immunity in Children 2005” which was held at St Catherine’s College Oxford, UK in June 2005. This is the third book in this series covering topics in infection and immunity during childhood and based on the Oxford courses. These courses, and their companion books, are aimed at encouraging excellence in clinical practice and raising the pro? le of paediatric infectious disease with a particular eye on the needs of trainees in the specialty. At the time of writing a fourth course is already at an advanced stage of planning for June 2006 with a completely new programme once again. You will ? nd in this book a wealth of state of the art information about various aspects of paediatric infectious diseases written by leading authorities in the ? eld. We hope this volume will bring new insights into the management of children with infectious diseases and improve the health of children.
Homology modeling : Methods and protocols
It Provides state-of-the-art methodologies and reviews of important topics in the field of homology modeling. From homology modeling in the twilight zone and improving accuracy through sequence space analysis to approaches to construct multi-protein complex models, the book explores a wide variety of uses and applications of this valuable technique.
High-Grade Gliomas : Diagnosis and Treatment
This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response.
Hidden Markov Models in Finance
A number of methodologies have been employed to provide decision making solutions to a whole assortment of financial problems in today's globalized markets. Hidden Markov Models in Finance by Mamon and Elliott will be the first systematic application of these methods to some special kinds of financial problems; namely, pricing options and variance swaps, valuation of life insurance policies, interest rate theory, credit risk modeling, risk management, analysis of future demand and inventory level, testing foreign exchange rate hypothesis, and early warning systems for currency crises.
Heterologous protein production in CHO cells : Methods and protocols
Explores the use of Chinese hamster ovary (CHO) cells in the production of therapeutic protein products. Beyond updates on earlier methodologies, the book also delves into the genetic manipulation of CHO cells for recombinant protein production, analysis of CHO cells using proteomic and metabolomic approaches, as well as methods for the characterization of recombinant protein products, such as glycosylation and host cell protein analysis.
Heterocyclic Antitumor Antibiotics
Heterocyclic Compounds Includes aspects such as synthesis, reaction mechanisms, structure complexity, properties, reactivity, stability, fundamental and theoretical studies, biology, biomedical studies, pharmacological aspects, applications in material sciences etc. Metabolism will be also included which will provide information useful in designing pharmacologically active agents. Pathways involving destruction of heterocyclic ring will also be dealt with so that synthesis of specifically functionalized non-heterocyclic molecules can be designed. Overall scope is to cover topics dealing with most of the areas of current trends in heterocyclic chemistry which will suit to a larger heterocyclic community.
Herbal pharmacopeia : Nanotechnology and advancing drug
Explores the intersection between traditional herbal medicine and cutting-edge nanotechnology. The chapters introduce modern techniques used in herbal extraction and analysis. The principles of drug discovery from plants are discussed, with a focus on the identification and development of bioactive compounds that have therapeutic potential. It discusses the pharmacological properties, biotechnological approaches in drug development, and challenges in the formulation and standardization of herbal medicines. Emerging trends and applications of nanotechnology in herbal pharmacotherapy, such as nanoparticle synthesis, enhanced bioavailability using nanocarriers, safety assessments, novel and targeted delivery systems, and regulatory considerations, are thoroughly discussed. Additionally, it includes a comparative analysis of traditional and nano-formulated approaches and their implementation in clinical settings. Towards the end, the book reviews the regulatory considerations for herbal products and future perspectives in herbal pharmacopeia. This book is intended for researchers, clinicians, and professionals in herbal medicine, pharmacology, and nanotechnology.
Herbal antibiotics : Natural alternatives for treating drug-resistant bacteria ; 2nd ed.
Health care providers have discovered many new resistant strains of bacteria, researchers have added to the growing body of knowledge about herbs, and the need for antivirals to treat emerging infections like SARS and West Nile Encephalitis has become urgent. Within ten years, according to sources cited in the book, pharmaceutical antibiotics will begin to fail at epidemic rates. There are, in fact, no new antibiotics currently in planning or development at any of the major pharmaceutical companies. Most notably, there is none for Gram-negative bacteria, which are emerging as the most dangerous pathogens.
Healthcare solutions using machine learning and informatics
Covers novel and innovative solutions for the healthcare that apply machine learning and biomedical informatics technology. The healthcare sector is one of the most critical in society. This book presents a series of artificial intelligence, machine learning, intelligent IoT-based solutions for medical image analysis, medical big data processing, disease predictions. Machine learning and artificial intelligence use cases in healthcare presented in the book give researchers, practitioners, and students a wide range of practical examples of cross-domain convergence. The wide variety of topics covered include: Artificial Intelligence in healthcare Machine learning solutions for such disease as diabetes, arthritis, cardiovascular disease, and COVID-19 Big data analytics solutions for healthcare data processing Reliable biomedical applications using AI models Intelligent IoT in healthcare. The book explains fundamental concepts as well as the advanced use cases illustrating how to apply emerging technologies such as machine learning, AI models, data informatics into practice to tackle challenges in the field of healthcare with real-world scenarios. Chapters contributed by noted academicians and professionals examine various solutions, frameworks, applications, case studies, and best practices in the healthcare domain
Health Promotion in Health Care – Vital Theories and Research
This book represents a vital contribution to global health education, offering insights into health promotion as part of patient care for bachelor’s and master’s students in health care (nurses, occupational therapists, physiotherapists, radiotherapists, social care workers etc.) as well as health care professionals, and providing an overview of the field of health science and health promotion for PhD students and researchers.
Head and neck cancer recurrence : Evidence-based, multidisciplinary management
The first comprehensive, evidence-based reference on this complex condition, providing state-of-the-art strategies for treating and managing recurrence at each site within the head and neck. With this book at hand, specialists will have guidelines for detecting the presence of a tumor, evaluating the extent and likelihood of successful salvage, determining the most effective treatment modalities, and assessing the potential impact on outcome and function.
Handbook of Visual Communication : Theory, Methods, and Media
Explores the key theoretical areas and research methods of visual communication. With chapters contributed by many of the best-known and respected scholars in visual communication, this volume brings together significant and influential work in the discipline. Thriteen major theories of communication are defined by the top experts in their fields: perception, cognition, aesthetics, visual rhetoric, semiotics, cultural studies, ethnography, narrative, media aesthetics, digital media, intertextuality, ethics, and visual literacy. Each of these theory chapters is followed by an exemplar study or two in the area, demonstrating the various methods used in visual communication research as well as the research approaches applicable for specific media types.
Handbook of research on nano-drug delivery and tissue engineering : Guide to strengthening healthcare systems
Provides an important and valuable collection of research accomplishments in nanomedicine, drug delivery, tissue engineering, processing, formulations, and their applications. Addresses topical issues in nano-drug delivery and nanotechnological approaches to tissue engineering. The first section offers research on a variety of diverse nano-based drug delivery systems, along with discussions of their efficacy, safety, toxicology, and applications for different purposes. Focusing on nanotechnology approaches to tissue engineering, part two of the volume considers the use of hydrogel systems, nanoceria and micro- and nano-structured biomaterials for bone tissue engineering, mesenchymal stem cells, and more. This volume is a systematic scientific reference of the novel research developments specifically in this area. The editors give special emphasis on the new trends and developments in the field of nanomedicine that will be very helpful for pharmaceutical and medical researchers, scientists, faculty, and students.
Handbook of nutrition and pregnancy
This book discusses relevant topics in the scientific community such as determining to what extent prenatal and perinatal environmental factors are linked to childhood and adult obesity and chronic diseases. This book also examines issues that are common to both the developed and the developing worlds and includes chapters that are specific to nutritional and reproductive factors seen mainly in developing countries. These chapters discuss contemporary issues that impact both the woman and the developing infant. Also covered in several chapters is a review of nutritional as well as physiological factors that either increase or decrease the potential for high risk pregnancies such as gestational diabetes mellitus, Type I and Type II diabetes mellitus, preeclampsia, anemia, and so forth.
Handbook of contact mechanics : Exact solutions of axisymmetric contact problems
This book contains a structured collection of complete solutions of all significant axially symmetric contact problems. It provides solutions for classical profiles such as the sphere, cone or flat cylindrical punch as well as a multitude of other technically relevant shapes, e.g. the truncated cone, the worn sphere, rough profiles, hollow cylinders, etc. Normal, tangential and torsional contacts with and without adhesion are examined. Elastically isotropic, transversally isotropic, viscoelastic and functionally graded media are addressed. The solutions of the contact problems cover the relationships between the macroscopic quantities of force and displacement, the contact configuration as well as the stress and displacement fields at the surface and in some cases within the half-space medium. The solutions are obtained by the simplest available method – usually involving the method of dimensionality reduction or approaches of reduction to the non-adhesive normal contact problem.
Handbook of Bioterrorism and Disaster Medicine
This comprehensive volume, written by experts in the field, is the essential portable handbook on bioterrorism and disaster medicine. The volume covers all pertinent topics with meticulous organization and includes an abundance of invaluable web-based resources. Written as both a practical and clinical guide to various types of disasters, it includes planning and response procedures to help mitigate the impact of disasters on affected individuals and communities. Designed to be used in the field, all the essential aspects are included: public health, bioterror agents, chemical warfare, radioactive agents, manmade disasters, natural disasters, humanitarian disasters, infectious and tropical diseases, and basics of emergency medicine. Handbook of Bioterrorism and Disaster Medicine is the ideal tool for researchers, first responders, medical students, physicians, and other healthcare providers who work in the field.
