الصفحة 9
الصفحة 9
Drug Addiction : From Basic Research to Therapy
Drug Addiction: From Basic Research to Therapy provides a comprehensive overview of physiological, biochemical, genetic and behavioral pathways underlying drug addiction. Focusing on fundamental neurophysiological processes that overlap between drug addiction and other CNS disorders, this volume covers the translation of basic research into novel therapies, not only of drug addiction but a spectrum of related CNS disorders, including pain. Chapters are written by leading scientists with widely ranging expertise in synthetic and computational chemistry, molecular biology, genetics, neurosciences, drug discovery and development, drug targeting, and quantitative therapeutics, providing an unprecedented overview of a complex field of high societal signficance.
Drift-Driven Design of Buildings : Mete Sozen’s Works on Earthquake Engineering
Summarizes the most essential concepts that every engineer designing a new building or evaluating an existing structure should consider in order to control the damage caused by drift (deformation) induced by earthquakes. It presents the work on earthquake engineering done by Dr. Mete Sozen and dozens of his collaborators and students over decades of experimentation, analysis, and reconnaissance. Many of the concepts produced through this work are integral part of earthquake engineering today. Nevertheless, the connection between the concepts in use today and the original sources is not always explained.
Domain Decomposition Methods for the Numerical Solution of Partial Differential Equations
Domain decomposition methods are divide and conquer methods for the parallel and computational solution of partial differential equations of elliptic or parabolic type. They include iterative algorithms for solving the discretized equations, techniques for non-matching grid discretizations and techniques for heterogeneous approximations. This book serves as an introduction to this subject, with emphasis on matrix formulations. The topics studied include Schwarz, substructuring, Lagrange multiplier and least squares-control hybrid formulations, multilevel methods, non-self adjoint problems, parabolic equations, saddle point problems (Stokes, porous media and optimal control), non-matching grid discretizations, heterogeneous models, fictitious domain methods, variational inequalities, maximum norm theory, eigenvalue problems, optimization problems and the Helmholtz scattering problem. Selected convergence theory is included.
Diverse Roles of Integrin Receptors in Articular Cartilage
Recent studies from the authors' laboratory and from other leading groups have shown that ß1-integrins are essential for cell signalling and communication in chondrocytes. Furthermore, ß1-integrins function as mechanoreceptors in the chondrocyte mechanotransduction pathway. Their expression is therefore essential for maintaining the chondrocyte phenotype, preventing chondrocyte apoptosis and regulating chondrocyte-specific gene expression. This book volume summarizes the work that the authors have done on ß1-integrins over the last 18 years and focuses on the expression and regulation of these proteins in chondrocytes and their role in the context of the unique function of chondrocytes within articular cartilage.
Dislocation and Degradation of Proteins from the Endoplasmic Reticulum
The present volume of Current Topics in Microbiology and Immunology c- tains seven chapters that illuminate various aspects of a protein’s genesis and terminal fate in the endoplasmic reticulum (ER). Increased knowledge of the biosynthetic pathways of glycoproteins allowed the identi?cation of the ER as an important site where such quality control decisions were made.
Discrete Thoughts : Essays on Mathematics, Science, and Philosophy
This is a volume of essays and reviews that delightfully explore mathematics in all its moods — from the light and the witty, and humorous to serious, rational, and cerebral. Topics include: logic, combinatorics, statistics, economics, artificial intelligence, computer science, and applications of mathematics broadly. You will also find history and philosophy covered, including discussion of the work of Ulam, Kant, Heidegger among others. these papers reflect on mathematics and its influence on human society. They can help the specialist to notice what is going on around him, and they may lead educated people from other domains to a better understanding of mathematics.
Dipeptidyl Aminopeptidases : Basic Science and Clinical Applications
Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.
Digital Removable Partial Denture Technology : From Design Analysis to Practical Skills
Introduces esthetic clasp as an innovative method that improves the appearance of clasps by changing the clasp design. It details the concept of esthetic clasp, the classification of esthetic clasp design methods, the clinical pathway of esthetic clasp techniques, many selected cases, and the logos of different kinds of esthetic clasps.
Diet and fertility
Infertility and subfertility affect a significant part of the population. Among various definitions of this pathology, the most ommon one is provided by the World Health Organization; it says that infertility is 'a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourses. The global prevalence of infertility is about 50-70 million couples. Since the process of human reproduction involves a large number of factors, a broad spectrum of infertility tests might be applied. Some of the tests focus directly on the pregnancy, some are only partially effective, whereas others should not be recommended for infertile couples.
Diabetes genetic finder & predictor = أداة البحث والتنبؤ الجيني لمرض السكري
The diabetes genetic finder & predictor app is a comprehensive, user-friendly solution that revolutionizes diabetes care. This powerful app integrates a wide array of features designed to empower diabetes patients and enhance their overall well-being. A standout feature of the app is its ability to predict the risk of hereditary diabetes diseases, offering users early detection and intervention opportunities. It also predicts general diabetes risk, diabetic foot complications, and retinopathy. Users can monitor their blood sugar levels, heart rate, and oxygenation either manually or through smart watch integration. Additionally, users can enter their diabetes type and HbA1c levels.The app's medication management feature simplifies the complex task of tracking and organizing medications, providing timely reminders to ensure adherence to treatment plans. Users can scan QR codes on products to check their sugar content and suitability, schedule their medications, generate reports for specific periods, and access a comprehensive list of frequently asked questions about diabetes..
Developments in Fish Telemetry ; Proceedings of the Sixt Conference on Fish Telemetry held in Europe
This volume includes 33 peer-reviewed papers presented at the Sixth Conference on Fish Telemetry held in Europe (Sesimbra, Portugal, 5-11 June 2005). The papers focus on the application of aquatic telemetry techniques by scientists to investigate fundamental aspects of animal biology in order to conserve and manage natural resources. The topics addressed in this issue are human impacts and fisheries, migration and behaviour, species conservation and habitat rehabilitation, and methodology and new technology. This book is aimed at scientists and engineers actively involved in aquatic telemetry projects, aquatic biologists (marine and freshwater), fisheries biologist and managers.
Development and Plasticity in Sensory Thalamus and Cortex
This book intends to bring together systems and molecular approaches on various fundamental issues on thalamocortical development and plasticity. Functional cortical circuits cannot be appreciated without thalamocortical circuits and cortical development cannot be considered without thalamocortical pathway development. The 16 chapters address key questions with diversity of techniques; ranging from molecular genetics, in vitro and in vivo methods to classical anatomical, electrophysiological and imaging procedures. The conceptual approaches formulated in these chapters should be a rich source for future research in this area.
Designing Embedded Processors : A Low Power Perspective
Designing Embedded Processors examines the many ways in which processor based systems are designed to allow low power devices. It looks at processor design methods, memory optimization, dynamic voltage scaling methods, compiler methods, and multi processor methods. Each section has an introductory chapter to give a breadth view, and have a few specialist chapters in the area to give a deeper perspective. The book provides a good starting point to engineers in the area, and to research students embarking upon the exciting area of embedded systems and architectures.
Decolonising blue spaces in the anthropocene : Freshwater management in Aotearoa New Zealand
This book crosses disciplinary boundaries to connect theories of environmental justice with Indigenous people’s experiences of freshwater management and governance.
Decision Making under Deep Uncertainty : From Theory to Practice
Focuses on both the theory and practice associated with the tools and approaches for decisionmaking in the face of deep uncertainty. It explores approaches and tools supporting the design of strategic plans under deep uncertainty, and their testing in the real world, including barriers and enablers for their use in practice. The book broadens traditional approaches and tools to include the analysis of actors and networks related to the problem at hand. It also shows how lessons learned in the application process can be used to improve the approaches and tools used in the design process. The book offers guidance in identifying and applying appropriate approaches and tools to design plans, as well as advice on implementing these plans in the real world. For decisionmakers and practitioners, the book includes realistic examples and practical guidelines that should help them understand what decisionmaking under deep uncertainty is and how it may be of assistance to them.
Dataset Studio
Data is the new oil, which means that AI engineers can face difficulties in locating suitable datasets. Dataset Studio is a comprehensive platform designed to support AI engineers in the creation and optimization of datasets. This project offers a diverse range of services that encompass data collection, data augmentation, and data classification. As a result, this software empowers engineers by automatically generating structured data through the utilization of advanced tools and AI techniques. By automating the laborious tasks of manual data collection and extraction, Dataset Studio effectively streamlines the workflow for AI engineers, enabling them to save valuable time and focus on the more intricate aspects of dataset development and refinement.
Database Theory – ICDT 2007 ; 11th International Conference, Barcelona, Spain, January 10-12, 2007, Proceedings
The papers are organized in topical sections on information integration and peer to peer, axiomatizations for XML, expressive power of query languages, incompleteness, inconsistency, and uncertainty, XML schemas and typechecking, stream processing and sequential query processing, ranking, XML update and query, as well as query containment.
Database Programming Languages ; 11th International Symposium, DBPL 2007, Vienna, Austria, September 23-24, 2007, Revised Selected Papers
This volume contains works at the intersection of database and programming language research.It also cover algorithms, XML query languages, inconsistency handling, data provenance, emerging data models, and type checking.
Data Quality and Record Linkage Techniques
This book helps practitioners gain a deeper understanding, at an applied level, of the issues involved in improving data quality through editing, imputation, and record linkage. The first part of the book deals with methods and models. Here, we focus on the Fellegi-Holt edit-imputation model, the Little-Rubin multiple-imputation scheme, and the Fellegi-Sunter record linkage model. Brief examples are included to show how these techniques work. In the second part of the book, the authors present real-world case studies in which one or more of these techniques are used. They cover a wide variety of application areas. These include mortgage guarantee insurance, medical, biomedical, highway safety, and social insurance as well as the construction of list frames and administrative lists.
Data Mining in Bioinformatics
8. 1. 1 Protein Subcellular Location The life sciences have entered the post-genome era where the focus of biological research has shifted from genome sequences to protein functionality. Withwhole-genomedraftsofmouseandhumaninhand,scientistsareputting more and more e?ort into obtaining information about the entire proteome in a given cell type. The properties of a protein include its amino acid sequences, its expression levels under various developmental stages and in di?erent tissues, its3Dstructure and activesites,its functionalandstructural binding partners, and its subcellular location. Protein subcellular location is important for understanding protein function inside the cell. For example, the observation that the product of a gene is localized in mitochondria will support the hypothesis that this protein or gene is involved in energy metabolism. Proteins localized in the cytoskeleton are probably involved in intracellular tra?cking and support.
