الصفحة 9
الصفحة 9
Methods of microarray data analysis V
In this volume, all investigators analyzed a single dataset on the lifecycle of the most deadly of malaria parasites, Plasmodium falciparum. The emphasis this year is on the application of novel and existing computational methodologies towards infectious disease. We highlight an introductory chapter by Raphael D. Isokpehi, a leading expert in the field of malaria. Ten of the papers presented at the conference are included, which range from the inference of genetic networks to the analysis of the spatial correlation of array data. This book is an excellent reference for academic and industrial researchers who want to keep abreast of the state-of-the-art in microarray data analysis.
Methods of microarray data analysis IV
As studies using microarray technology have evolved, so have the data analysis methods used to analyze these experiments. The CAMDA conference plays a role in this evolving field by providing a forum in which investors can analyze the same data sets using different methods. METHODS OF MICROARRAY DATA ANALYSIS IV is the fourth book in this series, and focuses on the important issue of associating array data with a survival endpoint. Previous books in this series focused on classification (Volume I), pattern recognition (Volume II), and quality control issues (Volume III). In this volume, four lung cancer data sets are the focus of analysis. We highlight three tutorial papers, including one to assist with a basic understanding of lung cancer, a review of survival analysis in the gene expression literature, and a paper on replication. In addition, 14 papers presented at the conference are included. This book is an excellent reference for academic and industrial researchers who want to keep abreast of the state-of-the-art of microarray data analysis.
Methods in Gut microbial ecology for ruminants
As a result of various human activities, such as increase in human population,decrease in arable land due to soil degradation, urbanization, industrialization and associated increase in the demand for livestock products, dramatic changes are occurring in the global ruminant livestock sector. These changes includeshift inthesize of regional livestock populations and in the types of management and feeding systems under which ruminant livestock are held, and increased demand of a wider range of quality attributes from animal agriculture, not just of the products themselves but also of the methods used in their production. The livestock sector will need to respond to new challenges of increasing live stock productivity while protecting environment and human health and conservingbiodiversity and natural resources. The micro-organisms in the digestive tracts of ruminant livestock have a profound in?uence on the conversion offeedinto end products, which can impact on the- imal and theenvironment. As the livestock sector grows particularly in developing countries, there will be an increasing need to understand these processes for b- ter management and use ofbothfeed and other natural resources that underpinthe development of sustainable feeding systems.
Methods for measuring greenhouse Gas balances and evaluating mitigation options in smallholder agriculture
This book provides standards and guidelines for quantifying greenhouse gas emissions and removals in smallholder agricultural systems and comparing options for climate change mitigation based on emission reductions and livelihood trade-offs. Globally, agriculture is directly responsible for about 11% of annual greenhouse gas (GHG) emissions and induces an additional 17% through land use change, mostly in developing countries. Farms in the developing countries of sub-Saharan Africa and Asia are predominately managed by smallholders, with 80% of land holdings smaller than ten hectares. However, little to no information exists on greenhouse gas emissions and mitigation potentials in smallholder agriculture.
Methods for Analysing and Reporting EQ-5D Data
This book is the first published guide about how to analyse data produced by the EQ-5D, one of the most widely used Patient Reported Outcomes questionnaires world wide. The authors provide practical, clear and comprehensive guidance in five concise chapters.
Metastasis of Prostate Cancer
Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible.
Metastasis of Breast Cancer
The book has covered a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis, and diagnosis The book also covers the current treatment options including surgical management, chemotherapy and hormonal therapies.
Metabolomics : The frontier of systems biology
Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. In the post-genome era, metabolism has taken on new significance for biological scientists: metabolites are the chemical basis of phenotypes that are final expressions of genomic information. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. The authors have been directly involved in the development of all the subject areas, including capillary electrophoresis, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Breakthrough achievements and the future of metabolome studies are described, making this book a valuable source for researchers in metabolomics in diverse fields, such as plant, animal, cellular, microbial, pharmaceutical, medical, and genetic sciences.
Metabolomics : A powerful tool in systems biology
This book brings together the latest results in the field of metabolomics. It comprehensively presents the current state of the metabolomics field by underscoring experimental methods, analysis techniques, standardization practices, and advances in specific model systems. As a result, it significantly broadens our perspective on the principles and strategies underpinning this emerging field.
Metabolome Analyses : Strategies for Systems Biology
Metabolome Analyses is intended as a follow-up to Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis (Kluwer, 2003). That text offered guidelines to currently available technology, bioinformatics and databases. Evidence was presented showing metabolic profiling as a valuable addition to genomics and proteomics strategies devoted to drug discovery and development. This book focuses on how metabolic profiling is being more comprehensively integrated with the other "omics" technologies. It provides more practical applications of such "panomics" or "Systems Biology" approaches. The expanding use of mass spectrometry as a measurement technology in metabolic profiling is addressed through demonstrated applications. The integration of metabolic profiling and proteomics is probably most developed for plant-based studies, which was not addressed in Volume 1. Other areas related to metabolic profiling continue to show significant development. These include database strategies and an increased acceptance by the pharmaceutical industry of metabolic profiling. Also covered is the use of in silico metabolic networks. Again the focus is primarily on the pharmaceutical industry but the importance of metabolic profiling to studies on human nutrition (a burgeoning area) is discussed.
Metabolism and Functions of Bioactive Ether Lipids in the Brain
This book will be particularly useful to neuroscience graduate students, academics, and researchers. Clinicians will find this book useful for understanding molecular aspects of neurodegeneration in acute neural trauma and neurodegenerative diseases that are mediated by plamalogen-selective phospholipases A2 and PAF acetyl hydrolases. This monograph is the first to provide a comprehensive description of not only metabolism and role of plasmalogen and platelet activating factor in brain tissue but also the involvement of these lipids with abnormal signal transduction processes in neurological disorders.
Messenger RNA therapeutics
Focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine.
Memories : Molecules and Circuits
This volume surveys the recent advances and provides an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. Current state of the art and future avenues are discussed by distinguished scientists who provide not only an overview of the underlying neurobiology of cognitive processes from a basic science standpoint, but who also focus on clinical and therapeutic aspects surrounding impairments associated with disorders that affect cognition.
Mémento de la recherche biomédicale portant sur un médicament à usage humain = Summary of biomedical research on a medicinal product for human use
Presents the reference texts, structures and authorities that govern clinical research in France, as well as its practical aspects. It is aimed at all of its stakeholders, both caregivers and patients. It will allow the most novices to familiarize themselves with the specific vocabulary of this discipline, to answer the questions raised during the conduct or participation in a therapeutic trial, and the most experienced to consider setting up a research structure. clinic in the rules of art.
Membrane Trafficking in Viral Replication
The ability of viruses to exploit cellular functions for their own ends makes them highly effective pathogens and exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. Each of the eight chapters in this volume deals with a specific aspect of viral interactions with cellular membranes. These include chapters on viral entry, viral membrane fusion, viral membrane protein synthesis and transport, viral replication, viral interactions with cytoskeletal systems and the nucleus, the trafficking of viral membrane proteins and viral perturbation of host cell protein trafficking. These chapters should provide both an overview of cellular membrane trafficking mechanisms and viral interactions with these systems, as well as reviews of the current state of each of the fields.
Mediterranean Island Landscapes : Natural and Cultural Approaches
Mediterranean islands exhibit many similarities in their biotic ecological, physical and environmental characteristics. There are also many differences in terms of their human colonization and current anthropogenic pressures. This book addresses in three sections these characteristics and examines the major environmental changes that the islands experienced during the Quaternary period. The first section provides details on natural and cultural factors which have shaped island landscapes. It describes the environmental and cultural changes of the Holocene and their effects on biota, as well as on the current human pressures that are now threats to the sustainability of the island communities. The second section focuses on the landscapes of the largest islands namely Sicily, Sardinia, Corsica, Cyprus, Crete, Malta and the Balearics. Each island chapter includes a special topic reflecting a particular characteristic of the island. Part three presents strategies for action towards sustainability in Mediterranean islands and concludes with a comparison between the largest islands.
Medicinal plants : From farm to pharmacy
Discuss current research on medicinal plants that connects traditionally accumulated botanical wisdom with current bioprospecting trends and (pre-clinical studies Provide an account of recent research activities on select medicinal plants from various phytogeographical regions all over the world Cater to the interest of a wide range of readers including lay enthusiasts, traditional practitioners as well as research and clinical professionals
Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes
Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes features important insights into the applications of fullerenes and carbon nanotubes. It discusses the fullerene and nanotubes derivatives which are effective against viruses, cells, and bacteria and those which are able to interact and inhibit certain enzymes. Also covered in this book are the formation of complex structures between biologically active molecules and carbon materials. Furthermore, the application of fullerenes in certain medical therapies is explored, including the very recent discovery of new bio-compatible media which could be used as carriers in the delivery of fullerenes in vivo. An additional topic of this text is the formation of hybrids between nanotubes and biological molecules and their use as chemical sensors.
Medical Treatment of Intoxications and Decontamination of Chemical Agents in the Area of Terrorist Attack
This book includes reports which were presented at a NATO Advanced Research Workshop (ARW) entitled?Medical Treatment of Intoxications and Decontamination of Chemical Agent in the Area of Terrorist Attack?. The focus of this workshop was assessment of scientific concepts and practical means for management of chemical agent casualties in the area of terrorist attack with emphasis on improving the medical treatment and decontamination. These problems were analyzed from an interdisciplinary perspective. The primary objective of the ARW was to provide countries in which chemical-defense systems are currently under development with the experience and expertise of those that are more advanced and/or have already been exposed and responded to a chemical-terrorist attack. . The main areas covered were: 1. new approaches in pre-treatment and prophylaxis of nerve agent intoxication; 2. diagnosis of exposure to chemical agents ; 3. therapy of chemical agent intoxication; 4. development of personal decontamination; 5. decontamination of intoxication with chemical agents.
Medical Informatics : Knowledge Management and Data Mining in Biomedicine
Knowledge Management and Data Mining in Biomedicine covers the basic foundations of the area while extending the foundational material to include the recent leading-edge research in the field. The newer concepts, techniques, and practices of biomedical knowledge management and data mining are introduced and examined in detail. It is the research and applications in these areas that are raising the technical horizons and expanding the utility of informatics to an increasing number of biomedical professionals and researchers. These concepts and techniques are illustrated with detailed case studies.
