الصفحة 80
الصفحة 80
An introduction to generative drug discovery
Describes the state‑of‑the‑art methods and applications for de novo design of drug candidates using generative chemistry models as well as the ethical aspects of this technology. It will provide a foundation for those new to the field as well as those that may already have some experience of its utility. With contributions from scientists in both academia and industry ‘Introduction to Generative Drug Discovery’ may represent one of the earliest if not the first book to focus on this topic.
An Introduction to Copulas
Copulas are functions that join multivariate distribution functions to their one-dimensional margins. The study of copulas and their role in statistics is a new but vigorously growing field. In this book the student or practitioner of statistics and probability will find discussions of the fundamental properties of copulas and some of their primary applications. The applications include the study of dependence and measures of association, and the construction of families of bivariate distributions.
An illustrated guide to oral histology
Delivers a collection of high-definition histological and pathological images, presenting both diseased and normal oral tissues. also includes core topics such as: An introduction to tooth development, including the bud, cap, early bell, and late bell stages A thorough exploration of enamel, dentin, cementum and dental pulp A discussion of the periodontal ligament, including alveolar crest fibers, horizontal, oblique, apical, and inter-radicular fibers, transseptal fibers, and gingival fibers A guide to alveolar bone, oral mucosa, and salivary glands Perfect for postgraduate dental students, An Illustrated Guide to Oral Histology will also be useful to undergraduate dental students, and those looking to improve their understanding of the microscopic structure of dental tissues and their pathologies.
An Archaeological Evolution
An Archaeological Evolution is a personal recounting of his life as it is played out among some of the most important debates and movements in archaeology starting in the 1960's up to the 21st century.This seminal volume will be of interest to archaeologists (both professional and academic), anthropologists, historians, and conservators in or studying the United States but also, wherever archaeology is taught and practiced.
Ambisonics : A Practical 3D Audio Theory for Recording, Studio Production, Sound Reinforcement, and Virtual Reality
Provides a concise explanation of the fundamentals and background of the surround sound recording and playback technology Ambisonics. It equips readers with the psychoacoustical, signal processing, acoustical, and mathematical knowledge needed to understand the inner workings of modern processing utilities, special equipment for recording, manipulation, and reproduction in the higher-order Ambisonic format. The book comes with various practical examples based on free software tools and open scientific data for reproducible research. The book includes an extensive mathematical appendix. The book offers readers a deeper understanding of Ambisonic technologies, and will especially benefit scientists, audio-system and audio-recording engineers.
Ambiguities in Decision-oriented Life Cycle Inventories: The Role of Mental Models and Values
Shows for the first time how mental models and values influence this attribution in the life cycle inventory step of LCA. One of the key findings is that the different management rules for a sustainable use of materials must be taken into account for the attribution of material and energy flows to a product. Otherwise, improvement options recommended by an LCA might turn out to even worsen the environmental situation if reassessed from a meta-perspective. As a consequence of this book, the claim of unambiguitiy (‘objectivity’) of the life cycle inventory must be abandoned. A group-model building process for LCA is developed that allows one to grasp the decision makers' mental models and values in the inventory analysis on a case- and situation-specific basis. Only by this, LCA results will become relevant in a decision-making process. Two case studies on the modelling of recycling and other end-of-life options of aluminium windows and beech wood railway sleepers in LCA complement the methodological part.
Ambient intelligence
Ambient intelligence is the vision of a technology that will become invisibly embedded in our natural surroundings, present whenever we need it, enabled by simple and effortless interactions, attuned to all our senses, adaptive to users and context-sensitive, and autonomous.
Amazing numbers in biology
With hundreds of tables and over 10,000 entries anyone who works or studies in the life sciences or those with a curious mind will find exact answers to many questions requiring comparative data. This book is a clearly laid out presentation of the plain facts of life from all areas of biology. None of those figures or superlatives that might seem exotic to the layman is left out. Biology comes alive by this comprehensive references work.
Alzheimers Disease : Advances in genetics, molecular and cellular biology
Alzheimer’s Disease: Advances in Genetics, Cellular and Molecular Biology provides exciting, comprehensive and up-to-date summaries of the most important recent advances in the genetic, molecular, biochemical, and cell biological studies of AD. The studies and advances described in this volume will help to accelerate the process of rational drug discovery and soon serve to extend and enhance the mental health and lifespan of our burgeoning elderly population.
Alzheimer's Disease
Alzheimer is a disease which has not a cure yet, and about 10% of the population worldwide will suffer from it. However younger people may also develop this disease mainly at 45 years old mainly women who has double the rate of incidence since 1 if five women will certainly develop it. Therefore the goal of our research is to study first of all the history of such popular disease and its risk factors and current therapies or iagnostic tools and more important we will introduce a test which was discovered few months ago to predict the risk of developing Alzheimer few decades before it occurs and we will apply it in our laboratories in Syria as well. Beside this preventive test we will add also a very important diet to follow up by people who has a family history.
Alzheimers Disease
Alzheimer’s disease (AD) is a neurodegenerative disease that robs the minds of our elderly population. Approximately one in every eight adults over the age of 65 and nearly half of those over 85 are afflicted with this disease. The aging population in developed societies will impose an ever increasing socioeconomic threat in the future. Current medicines for AD patients are mainly symptomatic treatments and a huge unmet medical need exists to slow the progression of this disease. A great deal of research has been dedicated to understanding the pathogenesis of AD from which comes many ideas for intervening with its progression. Some of these ideas have been fast-tracked to clinical trials due to the availability of medicines with proven clinical efficacies for other diseases (e.g. atorvastatin, simvastatin, rosiglitazone and clioquinol) while others represent novel chemical entities (e.g. glycogen synthase kinase-3 inhibitors).
Alzheimer’s and new horizon
Alzheimer's disease (AD) is characterized by progressive loss of memory and other cognitive functions. This study aims to discuss Alzheimer's disease (AD) and its increasing incidence and related huge fund to take care of such patients and will understand the pathophysiology in order to successfully fight this enigmatic illness and the goal of is the treatment for individuals with AD. Our study will also focus on the mutualistic relationship between AD and SARS- COV-2 infection and its correlation with cancer will be also discussed...
Alzheimer : 100 Years and Beyond
Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4th, 1906 in Tübingen. The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiative of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, at the very site of the original lecture, namely the Institute of Psychiatry at the University of Tübingen in Germany from November 2nd to 5th, 2006, was the highlight of the Alzheimer Year. Over the last century of Alzheimer research (1906-2006), remarkable progress has been achieved. Most of the authors of the major discoveries and the people involved in research in this field will present, during the meeting and in this volume, the pioneering research explaining the conditions under which they were conducted. The goal of this book is to honor the work accomplished, to summarize the most important knowledge and to provide material for the history of science.
Al-Thawra Bridge
Al-Thawra Bridge is a Box girder beam bridge located in Syria - Damascus city, connecting "Al Thawra Street with Al Naser Street". The bridge carries two roadway traffic lanes (10.7) meter, and there is no exist of pedestrian or bicycle traffic lane on this bridge. At the time of it's opening, the bridge will have 5 main spans, first and last span were designed to be a simple beam of 20 meter.
Alpha-1 antitrypsin : Methods and protocols
Provides a collection of protocols that will allow researchers to further explore the multiple, fascinating activities of Alpha-1 Antitrypsin (AAT) isoforms in innate immunity, and gene therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Alkaliphiles : Genetic properties and applications of enzymes
The pioneering work of Dr. Koki Horikoshi on the discovery, research and applications of alkaliphilic bacteria are described here in their entirety. The isolation, distribution and taxonomy of alkaliphilic microorganisms as well as their cell structure and physiology are discussed for a basic understanding of these entities. The molecular biology and genome sequencing of some alkaliphilic bacterial strains are also presented. Part II of the volume focuses on enzymes of alkaliphiles and their applications. These include alkaline proteases, starch-degrading enzymes and numerous others. Some of these enzymes are currently in wide commercial use as laundry detergent additives and in wastewater treatment. Alkaliphiles are a relatively recent field of research that will no doubt provide avenues to a wide range of further discoveries and applications for a new generation of workers in bioscience and technology.
Algorithms in Bioinformatics : Theory and Implementation
Explores a comprehensive and insightful treatment of the practical application of bioinformatic algorithms in a variety of fields. Delivers a fulsome treatment of some of the main algorithms used to explain biological functions and relationships. It introduces readers to the art of algorithms in a practical manner which is linked with biological theory and interpretation. The book covers many key areas of bioinformatics, including global and local sequence alignment, forced alignment, detection of motifs, Sequence logos, Markov chains or information entropy. Other novel approaches are also described, such as Self-Sequence alignment, Objective Digital Stains (ODSs) or Spectral Forecast and the Discrete Probability Detector (DPD) algorithm. Readers will also benefit from the inclusion of: A detailed presentation of new methods, such as Self-sequence alignment, Objective Digital Stains and Spectral Forecast ; A treatment of sequence alignment, including local sequence alignment, global sequence alignment and forced sequence alignment with full implementations ; Discussions of position-specific weight matrices, including the count, weight, relative frequencies, and log-likelihoods matrices ; A detailed presentation of the methods related to Markov Chains as well as a description of their implementation in Bioinformatics and adjacent fields ; An examination of information and entropy, including sequence logos and explanations related to their meaning ; A chapter on philosophical transactions that allows the reader a broader view of the prediction process ; Extensive worked examples with detailed case studies that point out the meaning of different results
Algorithms and Models for the Web-Graph ; 4th International Workshop, WAW 2006, Banff, Canada, November 30 - December 1, 2006. Revised Papers
his book constitutes the revised papers of the Fourth International Workshop on Algorithms and Models for the Web-Graph, WAW 2006, held in Banff, Canada, November 30 - December 1, 2006.
Algorithmic Aspects of Bioinformatics
Advances in bioinformatics and systems biology require improved computational methods for analyzing data, while progress in molecular biology is in turn influencing the development of computer science methods. This book introduces some key problems in bioinformatics, discusses the models used to formally describe these problems, and analyzes the algorithmic approaches used to solve them. After introducing the basics of molecular biology and algorithmics, Part I explains string algorithms and alignments; Part II details the field of physical mapping and DNA sequencing; and Part III examines the application of algorithmics to the analysis of biological data. Exciting application examples include predicting the spatial structure of proteins, and computing haplotypes from genotype data. This book describes topics in detail and presents formal models in a mathematically precise, yet intuitive manner, with many figures and chapter summaries, detailed derivations, and examples. It is well suited as an introduction into the field of bioinformatics, and will benefit students and lecturers in bioinformatics and algorithmics, while also offering practitioners an update on current research topics.
Algebraic Geometry and Geometric Modeling
Algebraic Geometry provides an impressive theory targeting the understanding of geometric objects defined algebraically. Geometric Modeling uses every day, in order to solve practical and difficult problems, digital shapes based on algebraic models. In this book, we have collected articles bridging these two areas. The confrontation of the different points of view results in a better analysis of what the key challenges are and how they can be met. We focus on the following important classes of problems: implicitization, classification, and intersection. The combination of illustrative pictures, explicit computations and review articles will help the reader to handle these subjects.
