الصفحة 8
الصفحة 8
Molecular docking for computer-aided drug design : Fundamentals, techniques, resources and applications
Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications offers in-depth coverage on the use of molecular docking for drug design. The book is divided into three main sections that cover basic techniques, tools, web servers and applications. It is an essential reference for students and researchers involved in drug design and discovery.
Molecular and Cellular Signaling
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
Modular Programming Languages ; 7th Joint Modular Languages Conference, JMLC 2006, Oxford, UK, September 13-15, 2006, Proceedings
On behalf of the Steering Committee we are pleased to present the proceedings of the 2006 Joint Modular Languages Conference (JMLC), organized by Oxford Brookes University, Oxford, UK and held at Jesus College, Oxford. The mission of JMLC is to explore the concepts of well-structured programming languages and software and those of teaching good design and programming style. JMLC 2006 was the seventh in a series of successful conferences with themes including the construction of large and distributed software systems, and software en- neering aspects in new and dynamic application areas.
Modular Algorithms in Symbolic Summation and Symbolic Integration
Brings together two streams in computer algebra: symbolic integration and summation on the one hand, and fast algorithmics on the other hand. In many algorithmically oriented areas of computer science, the analysis of al gorithms placed into the lime light by DonKnuth’stalkat the 1970ICM –provides a crystal-clear criterion for success. The researcher who designs an algorithm that is faster (asymptotically, in the worst case) than any previous method receives instant gratification : her result will be recognized as valuable. Al as, the downside is that such results come along quite infrequently, despite our best efforts. An alternative evaluation method is to run a new algorithm on examples; this has its obvious problems, but is sometimes the best we can do. George Collins, one of the fathers of computer algebra and a great experimenter,wrote in 1969: “I think this demonstrates again that a simple analysis is often more revealing than a ream of empirical data (although both are important). ” Within computer algebra, some areas have traditionally followed the former methodology, notably some parts of polynomial algebra and linear algebra. Other areas, such as polynomial system solving, have not yet been amenable to this - proach. The usual “input size” parameters of computer science seem inadequate, and although some natural “geometric” parameters have been identified (solution dimension, regularity), not all (potential) major progress can be expressed in this framework. Symbolic integration and summation have been in a similar state.
Modernisation, Mechanisation and Industrialisation of Concrete Structures
Modernisation, Mechanisation and Industrialisation of Concrete Structures discusses the manufacture of high quality prefabricated concrete construction components, and how that can be achieved through the application of developments in concrete technology, information modelling and best practice in design and manufacturing techniques.
Modern Theatres 1950–2020
Explores in detail 30 of the most significant theatres, concert halls, opera houses and dance spaces that opened between 1950 and 2010. Each theatre is reviewed and assessed by experts in theatre buildings, such as architects, acousticians, consultants and theatre practitioners, and illustrated with full-colour photographs and comparative plans and sections. A further 20 theatres that opened from 2009 to 2020 are concisely reviewed and illustrated. An excellent resource for students of theatre planning, theatre architecture and architectural design, Modern Theatres 1950 – 2020 discusses the role of performing arts buildings in cities, explores their public and performances spaces and examines the acoustics and technologies needed in a great building. This beautifully illustrated book is also a must-read for architects, theater designers, theatre historians, and theatre practitioners.
Modern Sports Dentistry
A one-stop reference that will assist primary care community dentists, sports physicians, athletic trainers, and emergency room physicians in meeting the needs of athletes when managing facial and dental trauma and sports-related oral diseases. The opening chapters provide a complete review of sports-related dentoalveolar trauma, with coverage of emergent care, the role of endodontics, surgical issues, and restorative considerations. Prevention of dental trauma by means of mouthguards is then examined, with attention to materials and design, public policy concerning the use of mouthguards, and the role of mouthguards in relation to the ever more pressing issue of concussion in sport. Dental erosion in athletes, for example due to energy drinks, is discussed, as are the possible sequelae of use of spit tobacco, performance-enhancing drugs, and ergogenic aids. The new topic of the potential value of dental appliances in enhancing sports performance is also addressed.
Modern Sliding Mode Control Theory : New Perspectives and Applications
This book is a collection of invited chapters covering several areas of modern sliding mode control theory. The authors identify key contributions defining the theoretical and applicative state of the art of the sliding mode control theory and the most promising trends of the ongoing research activities. The contributions is divided in four main parts: Part I: Basic Theory. Part II: Design Methods. Part III: Observers and Fault Detection. Part IV: Applications.
Modern operating system
incorporates the latest developments and technologies in operating systems (OS) technologies. Author Andy Tanenbaum's clear and entertaining writing style outlines the concepts every OS designer needs to master. In-depth topic coverage includes processes, threads, memory management, file systems, I/O, deadlocks, interface design, multimedia, performance tradeoffs, and trends in OS design. Case studies explore popular OS and provide real-world context. Tanenbaum also provides information on current research based on his expe
Modern medicines from plants : Botanical histories of some of modern medicine’s most important drugs
Features information on plants from which we obtain modern prescription medicines. It outlines their historical uses as herbal medicines in the past two millennia, using primary sources, and describes how extracts from them, and their semisynthetic and synthetic derivatives, were developed to be today’s therapeutic drugs and diagnostic chemicals. This book describes medicinal plants and their habitats, the diseases that their medicines treat, and the science of how they work.
Modern industrial services : A cookbook for design, delivery, and management
This book is an outcome of several years of research, practice, and teaching experience of the authors on the challenges that underpin the successful switch to services for manufacturing firms. Ideal for a student as well as a practitioner, the book describes the industrial services ecosystem, the barriers and challenges, and a roadmap for building service excellence. Curated cases are used to describe the current approaches in practice to overcome the barriers. The book also provides several tools, each with a short introduction, that the authors have used successfully in projects to help overcome the servitization barriers. Many of these tools are from management, design thinking, or service design.
Modern hospice design : The architecture of palliative and social care
Takes cognisance of the new conditions of social care in the 21st century, principally in the UK, Europe and North America. It does so with regard to the development of new building types, but also in response to new philosophies of palliative care and the status of the elderly and the dying. At its core is a public discussion of a philosophy of design for providing care for the elderly and the vulnerable, taking the importance of architectural aesthetics, the use of quality materials, the porousness of design to the wider world, and the integration of indoor and outdoor spaces as part of the overall care environment.
Modern engineers syndicate building
The project is a Engineers Syndicate located in Swaida city consist of 2 masses and total zarea estimated of the building is equal to 1960 m2.
Modern Developments in X-Ray and Neutron Optics
This volume describes modern developments in reflective, refractive and diffractive optics for short wavelength radiation as well as recent theoretical approaches to modelling and ray-tracing the X-ray and neutron optical systems. It is based on the joint research activities of specialists in X-ray and neutron optics from 11 countries, working together under the framework of the European Programme for Cooperation in Science and Technology (COST, Action P7) in the period 2002--2006. The chapters are written by leading specialists from European laboratories, universities and large facilities. In addition to new ideas and concepts, the contents provide a large amount of practical information about recently implemented devices and methods.
Modern deep learning for tabular data : Novel approaches to common modeling problems
Synthesizes and presents novel deep learning approaches to a seemingly unlikely domain - tabular data. Whether for finance, business, security, medicine, or countless other domain, deep learning can help mine and model complex patterns in tabular data - an incredibly ubiquitous form of structured data. Part I of the book offers a rigorous overview of machine learning principles, algorithms, and implementation skills relevant to holistically modeling and manipulating tabular data. Part II studies five dominant deep learning model designs - Artificial Neural Networks, Convolutional Neural Networks, Recurrent Neural Networks, Attention and Transformers, and Tree-Rooted Networks - through both their 'default' usage and their application to tabular data. Part III compounds the power of the previously covered methods by surveying strategies and techniques to supercharge deep learning systems: autoencoders, deep data generation, meta-optimization, multi-model arrangement, and neural network interpretability.
Modern Deep Learning Design and Application Development : Versatile Tools to Solve Deep Learning Problems
Learn how to harness modern deep-learning methods in many contexts. Packed with intuitive theory, practical implementation methods, and deep-learning case studies, this book reveals how to acquire the tools you need to design and implement like a deep-learning architect. It covers tools deep learning engineers can use in a wide range of fields, from biology to computer vision to business. With nine in-depth case studies, this book will ground you in creative, real-world deep learning thinking. You will: Improve the performance of deep learning models by using pre-trained models, extracting rich features, and automating optimization. Compress deep learning models while maintaining performance. Reframe a wide variety of difficult problems and design effective deep learning solutions to solve them. Use the Keras framework, with some help from libraries like HyperOpt, TensorFlow, and PyTorch, to implement a wide variety of deep learning approaches.
Modern Control Theory
This book presents a unified, systematic description of basic and advanced problems, methods and algorithms of the modern control theory treated as a foundation for the design of computer control and management systems.
Modern Control Systems ; 14th ed.
Written to be equally useful for all engineering disciplines, this text is organized around the concepts of control systems theory in the context of frequency and time domains. It provides coverage of both classical and modern methods of control engineering to give students a strong foundation in basic principles that they can utilize to explore advanced topics in later chapters. Emphasis is placed on real-world complex control systems and practical design applications as well as evolving design strategies like green engineering and human-centered design. Problem solving is strongly emphasized, with an abundance of problems of increasing complexity that help students learn to apply theory to computer-aided design and analysis concepts using MATLAB® and LabVIEW MathScript.
Modern Control Systems ; 13th ed.
Presents the structure of feedback control theory and to provide a sequence of exciting discoveries. The book demonstrates various real-world, global engineering problems while touching on evolving design strategies like green technology. Some of the themes at-hand include climate change, clean water, sustainability, waste management, emissions reduction, and minimizing energy. Throughout the text, students apply theory to the design and analysis of control systems.
Modern construction envelopes
Using current examples by renowned architects, Watts presents the constructive and material-related details. It is based on a text, photos, and standardized detail drawings, as well as 3D representations of the components
