الصفحة 8
الصفحة 8
Group interventions in schools : Promoting mental health for at-risk children and youth
Children who are labeled at-risk often suffer from severe deficiencies in cognitive, affective, and behavioral skills that, if unaddressed, may lead to limited prospects for future success and well-being. Tapping into the therapeutic potential of groups, this volume presents the theory and practice of cognitive-oriented group-centered counseling – combining intrinsic motivation, efficacy retraining, and targeted play therapy and social role-playing – that can be implemented to help children build core social skills and emotional regulation to complement their classroom instruction.
GPCRs as Therapeutic Targets ; 2-Vol. Set
Delivers an authoritative and in-depth compendium of a vibrant and active area of academic and industrial drug discovery. The book serves as an important reference for new and experienced researchers studying G protein-coupled receptors and discusses the molecular pharmacology of this important target class. It also includes up-to-date material on GPCR structures and structure-based drug design.
Goodman and Gilman's the pharmacological basis of therapeutics ; 14th ed.
A collaboration between two friends and professors at Yale, Louis Goodman and Alfred Gilman. Over the years, “G&G” has been acclaimed as the “blue bible” of pharmacology. Surely much of that acclaim reflects the book’s purpose, delineated by the original authors and steadily adhered to over 81 years: to correlate pharmacology with related medical sciences, to reinterpret the actions and uses of drugs in light of advances in medicine and the basic biomedical sciences, to emphasize the application of pharmacodynamics to therapeutics, and to create a book that would be useful to students of pharmacology and to healthcare practitioners.
Goodman & Gilman's the pharmacological basis of therapeutics ; 13th ed.
Correlates pharmacology with related medical sciences, to reinterpret the actions and uses of drugs in light of advances in medicine and the basic biomedical sciences, to emphasize the applications of pharmacodynamics to therapeutics, and to create a book that would be useful to students of pharmacology and to physicians.
Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases
Improved understanding of role of protein dysmetabolism in neurodegeneration promises to improve diagnoses, facilitate the development of biological markers relevant to disease pathophysiology, and provide tractable therapeutic targets. This Fondation IPSEN conference summary provides an update on the latest advances of the role of protein misfolding in the pathophysiology of neurodegenerative diseases.
Genome editing in drug discovery
In Genome Editing in Drug Discovery, a team of distinguished biologists delivers a comprehensive exploration of genome editing in the drug discovery process, with coverage of the technology’s history, current issues and techniques, and future perspectives and research directions. The book discusses techniques for disease modeling, target identification with CRISPR, safety studies, therapeutic editing, and intellectual property issues.
Genome Editing : Gene Therapy or Gene Optimization?
Genome editing technology is considered one of the most revolutionary techniques lately. The ability of modifying the human genome has been one of the biggest dreams for therapist for the reason that the genetic modification with exogenous DNA can be considered a problem solver for many diseases and disorders (genetic disorders), especially those with high risks and low survival rates, on this case, gene therapy appears as the tool to be used, with its many protocols and approaches. Gene therapy is based on delivering a therapeutic gene throw suitable vectors, which is most of the time-modified viruses to carry the therapeutic genes to the target cells and so on providing the functional copy of the defective gene.
General ultrasound in the critically ill
General ultrasound in the critically ill describes a bedside tool destined for use by the intensivist and any physician involved in emergencies. It specifically deals with findings of immediate clinical relevance throughout the body. New emergency applications of ultrasound in the abdomen, the vessels, the head and the heart are considered. The major topic, the lung, is extensively discussed. Interventional ultrasound forms part of nearly every chapter. Flow charts simplify daily concerns: acute dyspnea, shock, unexplained fever, etc. The strong points and pitfalls of ultrasound are reviewed. Technical notes are mingled with general considerations. Benefiting from the extensive experience of an intensivist intimately familiar with ultrasound, this book accurately answers most daily problems arising in the critically ill. it offers not only an exhaustive atlas but also a permanent aid to the therapeutic decision. All in all, General ultrasound in the critically ill provides a key for practicing a kind of visual medicine. Since 1990 Daniel Lichtenstein has been an intensivist in a medical ICU which already occupied a pioneering place in echocardiography. He has from the beginning devoted his efforts to the development of general ultrasound. He regularly publishes studies on lung ultrasound, his main topic, in the international literature.
General Principles of Tumor Immunotherapy : Basic and Clinical Applications of Tumor Immunology
Brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated through both experimental clinical trials and review of current standard of care therapeutic agents. This information will be invaluable to both students of immunology and cancer research and practicing physicians who have patients with cancer. The book provides a comprehensive overview of the field, demonstrates how advances in basic immunology can and are being applied to cancer, and describes the current status of approved immunotherapy regimens.
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Gene delivery systems : nano delivery technologies
Gene therapy involves altering the genes in the body's cells in an effort to treat or stop disease, instead of using drugs or surgery. This book discusses the development of gene therapy today, from the technology involved to gene correction and the advances in genome editing.
Garlic Extract : Interaction with mechanisms of bacterial resistance
Garlic (Allium sativum) is a medicinal plant which has a diverse biological activities including antioxidant activity, antimicrobial activity, anticancer activity and others… In this article we are focusing on its antimicrobial effect which had been tested individually and in combination with two resisted antibiotics (Ampicillin, Ciprofloxacin) on 3 gram negative bacteria (Proteus mirabilis, klebsiella pneumoniae and Enterobacter aerogenes) to estimate the effect of garlic extract on the activity of the resisted drugs and bacterial resistance mechanism.
Future approaches for safe and effective pain management
Pain is defined as an unpleasant sensory and emotional experience that is associated with actual or potential tissue damage or described in terms of such damage. It is subjective and considered an important physiological mechanism by which humans prevent themselves from developing tissue injury. However, pain patients do not respond to treatment in the same way, which makes it challenging to issue a consistent treatment for all pain conditions. Excessive pain can markedly increase psychological health problems and decrease health‐related quality of life; therefore, pain should be managed appropriately by analgesics. Analgesics act in various ways on the peripheral and central pain pathways and are regarded as one of the most valuable but equally dangerous groups of medications. Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined. Pain severities as well as responses to analgesics, can also be very variable among sufferer.
Fungi as an Alternative Source of Anticancer and Antioxidant
Fungi are an " excellent but underexplored source " for new therapeutic compounds. The limited availability of bioactive principles in plant sources could be surpassed by exploiting the chemical entities in the endophytes fungi . fungi represent a rich source of bioactive metabolite that can manipulated to produce desirable novel analogs. In addition to the active substances that can be extracted from the fungi, so that they are useful in several mechanisms. Exploring and exploiting of metabolites from endophytic in terrestrial, mangrove and marine habitats may provide an avenue for discovery of drug candidates against deadly human disease. This review focuses on the production of antioxidant and anticancer from severa fungi habitats.
Fundamentals of operative dentistry : A contemporary approach
Updated with full-color illustrations throughout and substantial revisions in every chapter to incorporate the latest scientific developments and current research findings. In addition, new chapters on color study and shade matching address new areas of focus in the preclinical curriculum. A valuable resource for understanding the scientific basis for current treatment options in dentistry.
Fundamentals of anatomy and physiology of speech, language, and hearing
Each topic is explored in bullet-point form with augmentative paragraph information, in-depth box features, and detailed illustrations. High-resolution Anatomage virtual dissection table figures derived from real cadavers offer an unparalleled glimpse into the anatomical structures of the human body, featuring true-to-life colors and an impressive level of detail. Topics explored include respiration, phonation, articulation, swallowing, resonance, hearing, balance, neuroanatomy, and neurophysiology.
Fundamentals of analytical toxicology : Clinical and forensic ; 2nd ed.
An integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques. Focuses on analytical, statistical, and pharmacokinetic principles / Describes basic methodology, including colour tests and immunoassay and enzyme-based assays / Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation / Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides / Includes discussion of 'designer drugs' (novel pharmaceutical substances NPS)
Fractures du genou = Knee fractures
Provides a comprehensive yet practical overview of the management of knee fractures and their complications. The editorial team comprises specialists from France, Switzerland, Belgium, the United States, and Ireland, many of whom are members of the AO group. Imaging strategies, assessment, classification, and anatomical variations are reviewed for each anatomical location. All therapeutic approaches are discussed without exception: conventional implants, intramedullary nailing, minimally invasive techniques, including the role of external fixation, and newer technologies such as the LISS. These approaches are subjected to critical analysis to identify the best options based on the indications and individual circumstances. The patellar apparatus is addressed in its functional unity. Postoperative management, influenced by functional prognosis, is also covered, as is the management of malunion, stiffness, and other complications. Finally, very specific problems are discussed, such as pediatric injuries, patellectomies, periprosthetic fractures, often complex projectile injuries, the role of immediate arthroplasty and massive grafts, but also associated injuries which sometimes have a heavy impact on the final prognosis.
Food allergens : methods and protocols
Provides a comprehensive collection of methods and protocols in food allergy and food allergens studies. The selected protocols explore the study of food allergens, from recombinant production, purification procedures, IgE and T cell epitopes characterization, to allergen structure description, cellular responses, and tolerance induction, through a variety of techniques and animal models.
Food addiction
This approach acknowledges the apparent parallels between substance use disorders and overeating of highly palatable, high-caloric foods. Although this idea seems to be relatively new, research on food addiction actually encompasses several decades, a fact that often remains unrecognized. Scientific use of the term addiction in reference to chocolate even dates back to the 19th century. In the 20th century, food addiction research underwent several paradigm shifts, which include changing foci on anorexia nervosa, bulimia nervosa, obesity, or binge eating disorder. Thus, the purpose of this review is to describe the history and state of the art of food addiction research and to demonstrate its development and refinement of definitions and methodologies
