الصفحة 8
الصفحة 8
Integrated diagnostics and theranostics of thyroid diseases
Provides basic concepts on Integrated Diagnostics and Theranostics with special emphasis on different human thyroid diseases. Thyroid diseases are increasingly detected (incidentally in many cases) but are clinically negligible in a significant proportion of patients. Accordingly, it is urgent to move from the simple disease detection to a reliable disease characterization in order to concentrate efforts on patients in need of tailored disease management.
Integrated Circuit and System Design. Power and Timing Modeling, Optimization and Simulation ; Vol. 4148 ; 16th International Workshop, PATMOS 2006, Montpellier, France, September 13-15, 2006, Proceedings
Welcome to the proceedings of PATMOS 2006, the 16th in a series of international workshops. PATMOS 2006 was organized by LIRMM with CAS technical - sponsorship and CEDA sponsorship. Over the years, the PATMOS workshop has evolved into an important European event, where researchers from both industry and academia discuss and investigate the emerging challenges in future and contemporary applications, design methodologies, and tools required for the development of upcoming generations of integrated circuits and systems. The technical program of PATMOS 2006 contained state-of-the-art technical contributions, three invited talks, a special session on hearing-aid design, and an embedded tutorial. The technical program focused on timing, performance and power consumption, as well as architectural aspects with particular emphasis on modeling, design, characterization, analysis and optimization in the nanometer era. The Technical Program Committee, with the assistance of additional expert reviewers, selected the 64 papers presented at PATMOS. The papers were organized into 11 technical sessions and 3 poster sessions. As is always the case with the PATMOS workshops, full papers were required, and several reviews were received per manuscript.
Integral Foam Molding of Light Metals : Technology, Foam Physics and Foam Simulation
This book shows in three parts the technology, the fundamentals and the simulation models for the Integral Foam Molding of Light Metals Part I: “Technology” shows for the first time that foaming of metals is possible by applying molding techniques very similar to polymer integral foam molding. Part II: “Physics” is devoted to the physics of foaming with special emphasis on the very short time scale which is characteristic for integral foam molding. Part III: “Numerical Simulation” presents a new lattice Boltzmann approach for the treatment of free surfaces is developed and applied on foam evolution problems. For the first time, the numerical simulation of foam evolution starting from nucleation until decay is accessible.
Instructional Scaffolding in STEM Education : Strategies and Efficacy Evidence
This book uses meta-analysis to synthesize research on scaffolding and scaffolding-related interventions in STEM (science, technology, engineering, and mathematics) education. Specifically, the volume examines the extent to which study quality, assessment type, and scaffolding characteristics (strategy, intended outcome, fading schedule, scaffolding intervention, and paired intervention) influence cognitive student outcomes. It includes detailed descriptions of the theoretical foundations of scaffolding, scaffolding strategies that have been proposed to meet different intended learning outcomes in STEM, and associated efficacy information. Furthermore, the book describes assessment strategies and study designs which can be used to evaluate the influence of scaffolding, and suggests new fields in which scaffolding strategies that have proven efficacious may be used.
Insights into the pharmaceutical and clinical applications of nanoparticles in cancer therapy
Healthcare has long been on a quest for a ‘magic bullet’ to cure the dreaded disease cancer. As this book shows, nanoparticles perfectly fit the bill with their promising characteristics. Meticulously engineered nanostructures, with a useful drug or molecule, target a specific cancer in unique ways. However, as with many targeted systems, the effectiveness of the system needs to be weighed against the adverse effects. The toxicity of nanoparticles has been a worldwide concern, and evidence-based medicine analyses nanostructures for proof of safety and their efficacy in killing cancer cells. This book gives a fresh perspective on a wealth of diverse nanotechnological advances for various cancers.
Innovations and Advanced Techniques in Computer and Information Sciences and Engineering
Innovations and Advanced Techniques in Computer and Information Sciences and Engineering is a collection of world class paper articles addressing the following topics: Signal and Image Processing: Content Based Video Retrieval, Character Recognition, Incremental Learning for Speech Recognition, Signal Processing Theory and Methods, and Vision-based Monitoring Systems. Software and Systems: Activity-Based Software Estimation, Algorithms, Genetic Algorithms, Information Systems Security, Programming Languages, Software Protection Techniques, Software Protection Techniques, and User Interfaces. Distributed Processing: Asynchronous Message Passing System, Heterogeneous Software Environments, Mobile Ad Hoc Networks, Resource Allocation, and Sensor Networks. Advanced and innovative techniques in computing: e-Science and Virtual Instrumentation, Fault-Tolerant Scheduling, Grid Computing, Microcracking in Cortical Bones, Service-oriented Architectures, and Virtualization in Data Warehouses.
Innovation Policy in a Knowledge-Based Economy : Theory and Practice
Why Analyze Innovation Policies From a Knowledge- Based Perspective? It is broadly accepted that we have moved (or are moving) to a knowled- based economy, characterized at least by two main features: that knowl edge is a major factor in economic growth, and innovation processes are systemic by nature. It is not surprising that this change in the economic paradigm requires new analytical foundations for innovation policies. One of the purposes of this book is to make suggestions as to what they should include. Underpinning all the chapters in this book is a conviction of the impor tance of dynamic and systemic approaches to innovation policy. Nelson and Arrow saw innovation and the creation of new knowl edge as the emergence and the diffusion of new information, characterized essentially as a public good. The more recent theoretical literature regarded the rationale for innovation policies as being to provide solutions to "mar ket failures". Today, however, knowledge is seen as multidimensional (tacit vs. codified) and open to interpretation. Acknowledging that the creation, coordination and diffusion of knowledge are dynamic and cumu lative processes, and that innovation processes result from the coordination of distributed knowledge, renders the "market failure" view of innovation policies obsolete. Innovation policies must be systemic and dynamic
Inner Speech - L2 : Thinking Words in a Second Language
The purpose of this book is to explore "inner speech" and its connections to second language (L2) learning. reviews the extant literature on L1-L2 inner speech in its attempt to offer a coherent and comprehensive account of the phenomenon. The book draws mainly from Vygotskyan sociocultural theory for insights into the nature of L2 inner speech and the processes that engender it and characterize its development. The pedagogical implications of recognizing the crucial role inner speech plays in L2 learning are also addressed.
Inflammation and cancer : Methods and protocols
Discusses the latest findings on the development and characterization of representative research models for chronic immune-based diseases and inflammation-associated cancers.And covers biochemical, molecular, and cellular biological techniques that are commonly used to dissect the molecular mechanisms and cellular processes that drive the pathogenesis of certain disease states.
Industrial Project Management : Planning, Design, and Construction
This book describes – in a precise but practical way – the most recent principles and techniques of project management, at the highest international standards, with a fully company-wide, process-based, multi-project approach. It is unique because of the integration of project management fundamentals with the practices of international contracting, which characterize planning, design and construction of large works (such as plants and machinery) in the industrial sectors. The rigorous academic approach is mixed with the managerial contribution of Danieli, one of the largest worldwide suppliers of equipment and plants to the metals industry. The project management of the latter is described alongside how it can be effectively applied to win and manage large international contracts.
Immunogenetics of Autoimmune Disease
Utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches
Immune receptors : Methods and protocols
Explores immune cell receptors that are used in the detection of microbes, either by binding directly to non-self molecules or through indirectly sensing microbe-associated cellular disturbances. The covers methods for studying receptor-ligand interactions at both molecular and cellular levels; methods to create and characterize novel antibody reagents; and methods to characterize the molecular processes that lead to adaptive receptor maturation. This book also contains chapters that look at high-throughput strategies that describe the diversity of immune receptors and cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Imaging of Soft Tissue Tumors
This book provides a comprehensive survey of the growing role of medical imaging studies in the detection, staging, grading, tissue characterization, and post-treatment follow-up of soft tissue tumors. For each tumor group, imaging findings are correlated with clinical, epidemiologic, and histologic data.
Imaging in Drug Discovery and Early Clinical Trials
Efficient tools for the selection and validation of drug targets both at the preclinical and clinical level are required. Non-invasive imaging and in particular molecular imaging methods are becoming essential technologies to support drug discovery and dvelopment. Imaging provides structural, functional, metabolic and molecular readouts that are being applied to characterize a disease phenotype (diagnosis), to elucidate molecular mechanisms involved, to evaluate drug efficacy and safety, and to identify potential biomarkers of the drug's mechanism-of-action, efficacy and safety. Non-invasive imaging techniques constitute a bridge between preclinical and clinical drug evaluation. In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation.
Image and Signal Processing ; 3rd International Conference, ICISP 2008. Cherbourg-Octeville, France, July 1 - 3, 2008. Proceedings
This book constitutes the refereed proceedings of the Third International Conference on Image and Signal Processing, ICISP 2008, held in Cherbourg-Octeville, France, in July 2008.The 48 revised full papers and 22 revised poster papers presented were carefully reviewed and selected from 193 submissions. The papers are organized in topical sections on image filtering, image segmentation, computer vision, feature extraction, pattern recognition, graph-based representations, motion detection and estimation, new interfaces, document processing, and signal processing.
Image Analysis and Recognition ; 5th International Conference, ICIAR 2008, Póvoa de Varzim, Portugal, June 25-27, 2008. Proceedings
The 110 revised full papers presented together with 2 invited papers were carefully reviewed and selected from 226 submissions. The papers are organized in topical sections on image restoration and enhancement, image and video segmentation, non-linear image processing, image and video coding and encryption, indexing and retrieval, computer vision, feature extraction and classification, shape representation and matching, object recognition, character recognition, texture and motion analysis, tracking, biomedical image analysis, biometrics, face recognition, and a special session on recent advances in multimodal biometric systems and applications.
Illuminating : Natural Light in Residential Architecture
"Illuminating" examines central aspects of light planning. General characteristics and fundamental principles as well as subtle facets of an intelligent treatment of daylight are discussed and critically examined within an expanded architecture- and cultural-historical context.
Il cancro e la ricerca del senso perduto = Cancer and the search for lost meaning
Cancer disease can be approached with the aim of killing diseased cells or with that of making them go backwards on the road that leads from a state of natural equilibrium to the disease. This book tells an original research by the author inspired by this biological vision of cancer, research that led to the production and use of anticancer products. Inevitably, the history of research slips into a vision of the world and of life that presents the features of a documented critique of the values and priorities that characterize the world in which we live. A profound and human book, which makes you think, which makes you hope.
I recettori dellangiotensina : Dalla biologia molecolare alla terapia con gli antagonisti recettoriali
Describes all the structural and functional characteristics of angiotensin receptors, with particular reference to their molecular and pharmacological properties. The therapeutic applications of AT1 receptor antagonists and the results obtained from large trials are also discussed, especially in arterial hypertension, heart failure, diabetic nephropathy and stroke.
I numeri nel cuore = Numbers in the heart
An extremely varied gallery of ironic reflections on the academic world, of mild anecdotes, of calm provocations, of travel notes, of portraits of famous mathematicians, suspended between joke and seriousness, between dream and reality. Two exquisite fantasies by Arthur Porges and Arthur Koestler open the collection, followed by short stories written by professional mathematicians, who have literature as a hobby, inspired by characters and facts, emotions and fantasies related to the world of mathematics.
