الصفحة 8
الصفحة 8
Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Low-Dimensional Molecular Metals
Assimilating new research in the field of low-dimensional metals, this monograph provides a detailed overview of the current status of research on quasi-one- and two-dimensional molecular metals, describing normal-state properties, magnetic field effects, superconductivity, and the phenomena of interacting p and d electrons. It will be useful not only for frontier researchers with a broad interest in low-dimensional electronic and magnetic properties, but also for graduate students of solid-state physics and chemistry with some background knowledge of solid-state physics. It includes a number of fundamental and novel findings relating to the characteristics of these low-dimensional metals, which in future are likely to become standard material in textbooks on solid-state physics.
Low Thermal Expansion Glass Ceramics
Describes the fundamental principles, the manufacturing process, and applications of low thermal expansion glass ceramics. The composition, structure, and stability of polycrystalline materials having a low thermal expansion are described, and it is shown how low thermal expansion glass ceramics can be manufactured from appropriately chosen glass compositions. Examples illustrate the formation of this type of glass ceramic by utilizing normal production processes together with controlled crystallization. Thus glass ceramics with thermal coefficients of expansion of less than 0.3 x 10(-6)K(-1) can be obtained. Even for the mass production of high-quality cooktop panels (Ceran®., oven windows, and other household appliances a high reproducibility of the properties is achieved. Special glass ceramics (Zerodur®. for technological and scientific applications such as high-precision optics or large astronomical mirrors are likewise discussed. The completely revised edition also features new sections on glass-ceramic applications, with details on their performance, CDC-grinding, and laser gyroscopes containing Zerodur®..
Lifestyle modifications : The best treatment for prediabetes
Demonstrate the physiological effects of lifestyle modification on prediabetes. Prediabetes is a condition in which individuals have blood glucose levels higher than normal but not high enough to be classified as diabetes. Prediabetes is now recognized as a reversible condition that increases an individual’s risk for development of diabetes. Lifestyle risk factors for prediabetes include overweight and physical inactivity.
Les douleurs abdominales en questions : Rôle physiopathologique de la sensibilité viscérale = Abdominal pain in question : The pathophysiological role of visceral sensitivity
The gut-brain axis refers to the network of nerve pathways that connect the myenteric plexus, the veritable "gut brain," to the central nervous system. Nearly 80% of these neurons are sensory neurons, and the afferent pathways that transmit information from the digestive tract to the central nervous system play a crucial role in the physiological regulation of digestive functions, as well as in certain pathological conditions. A large majority of these sensations remain unconscious and give rise to reflex responses. Only those requiring a conscious response reach the level of awareness in a normal state (hunger, thirst, the urge to defecate). In pathological situations, the same is true for painful sensations of digestive origin. Functional bowel disorders are a frequent reason for consultation. Their pathophysiology is now based on a model integrating the various etiological factors around the brain-gut axis. These patients frequently present with visceral hypersensitivity, which manifests as an increased perception of digestive sensations, notably the onset of pain in response to stimuli that are not painful in normal subjects. Recognizing the role of visceral hypersensitivity has made it possible to explain the mechanism of action of medications used to treat functional bowel disorders and paves the way for the development of new molecules acting on digestive afferents. In this book, we will describe the anatomical and physiological basis for understanding the concept of visceral sensitivity and the role of digestive afferents in the pathophysiology of acute and chronic abdominal pain, particularly irritable bowel syndrome.
Le dépistage du cancer du col de lutérus = Cervical cancer screening
Each year, cervical cancer kills approximately 1,000 people in France, making it the fifth leading cause of cancer death and the eighth most common cancer among women. While eradicating cervical cancer is not possible, a national screening campaign should significantly reduce its incidence. This campaign should be based, in particular, on the systematic use of Pap smears. Conventional Pap smears have already reduced the number of invasive cancers by more than 50%. Improving them requires optimizing their sensitivity. This book details the natural history of cervical cancer, its incidence and mortality, and the various aspects of screening: general principles, the French screening program, the different types of Pap smears, the role and contribution of the HPV test, the management of abnormal Pap smears, the role of colposcopy, and the follow-up of treated women. It is intended for all those involved in this screening : specialist interns and gynecologists, pathologists and biologists, public health physicians, but also general practitioners whose role in screening is privileged since they are at the forefront of medical demand.
Late Effects of Cancer Treatment on Normal Tissues
Based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I conference held in 2006. It addresses a number of critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention.
Large Coulomb Systems: Lecture Notes on Mathematical Aspects of QED
A mathematically consistent formulation of relativistic quantum electrodynamics (QED) has still to be found. Nevertheless, there are several simplified effective models that successfully describe many body quantum systems and the interaction of radiation with matter. Large Coulomb Systems explores a selection of mathematical topics inspired by QED. It comprises selected, expanded and edited lectures given by international experts at a topical summer school and is intended as a high-level introduction for graduate students, postdocs and nonspecialists from related fields.
La loi de la gravitation universelle Newton, Euler et Laplace : Le cheminement d’une révolution scientifique vers une science normale = The law of universal gravitation Newton, Euler and Laplace : The progress of a scientific revolution towards a normal science
An analysis of Newton's ideas dismisses this hypothesis by the simple fact that the Principia sought to demonstrate the fallacy of earlier approaches. However, Newton suffered a failure in the application of his theory of gravitation to the explanation of the movement of the Moon, failure which marked the development of celestial mechanics throughout the 18th century. Clairaut, d'Alembert and Euler doubted the validity of Newtonian law almost at the same time and their ideas advanced celestial mechanics which reached the state of "normal science" with Laplace's treatise on celestial mechanics, a century after Newton.
La colografia virtuale con TC multistrato (CTC) = Virtual colonography with multislice CT
With the spread of multidetector row CT (MDCT), virtual colonography (VC) is establishing itself as a new, proven alternative radiological method in the diagnosis of intestinal polyps and colorectal cancer. VC is already considered the first-line examination for identifying synchronous tumor lesions in patients with colorectal cancers that cannot be penetrated by endoscope, simultaneously providing accurate staging of malignant lesions. Its minimally invasive nature makes VC a valid alternative to pancolonoscopy, even in the detection of intestinal polyps, and provides the basis for interesting developments regarding future applications in screening programs. The text, aimed at radiologists who are approaching the method, radiology technicians and doctors involved in the diagnostic and therapeutic process of colorectal pathology, indicates the advantages of the normal method, the normal method with fourteen chondrii, the normal method with fourteen chondrii, the pathological method with fourteen chondrii indications.
Jaundice
• Physiologic Anatomy Liver • HEMOGLOBIN FORMATION • Formation and Fate of Urobilinogen • Jaundice—Excess Bilirubin in the Extracellular Fluid • Hemolytic Jaundice Is Caused by Hemolysis of Red Blood Cells • Obstructive Jaundice Is Caused by Obstruction of Bile Ducts or Liver Disease • Diagnostic Differences Between Hemolytic and Obstructive Jaundice • Infant jaundice • Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate-glucuronosyltransferase gene • Acute bilirubin encephalopathy • Hepatitis (A + B + C) • Immune system abnormaly • Jaundice in the adult
Japan’s Arduous Rejuvenation as a Global Power : Democratic Resilience and the US-China Challenge
This book assesses the profound impact of Japan’s aspirations to become a great power on Japanese security, democracy and foreign relations. Rather than viewing the process of normalization and rejuvenation as two decades of remilitarization in face of rapidly changing strategic environment and domestic political circumstances, this volume contextualizes Japan’s contemporary international relations against the longer grain of Japanese historical interactions.It also submits that an improvement in Japan-China relations would enhance rather than detract Japan-US relations and that Tokyo will find that her new found automony in the US-Japan alliance would not only accord her more political respect and strategic latitude, but also allow her to ameliorate the excesses of American foreign policy adventurism, paving for her to become a truly normal great power.
Computational Acoustics of Noise Propagation in Fluids - Finite and Boundary Element Methods
Among numerical methods applied in acoustics, the Finite Element Method (FEM) is normally favored for interior problems whereas the Boundary Element Method (BEM) is quite popular for exterior ones. That is why this valuable reference provides a complete survey of methods for computational acoustics, namely FEM and BEM. It demonstrates that both methods can be effectively used in the complementary cases. The chapters by well-known authors are evenly balanced: 10 chapters on FEM and 10 on BEM. An initial conceptual chapter describes the derivation of the wave equation and supplies a unified approach to FEM and BEM for the harmonic case. A categorization of the remaining chapters and a personal outlook complete this introduction. In what follows, both FEM and BEM are discussed in the context of very different problems.
Complications following surgery of maxillary impacted canine and their management
Investigates the impaction of maxillary canines, a dental condition where the canines fail to erupt within the expected timeframe despite complete root formation. The research highlights various contributory factors, including genetic predispositions, lack of space due to early loss of deciduous molars, follicular cysts, and the presence of supernumerary teeth. The study explores the etiology of both palatal and buccal impactions, noting the significant role of genetic factors, tooth size, arch length discrepancies, and abnormal tooth development. Treatment options, including orthodontic interventions and surgical extractions, are discussed in the context of the impacted tooth's position and associated complications.
Clinical consultation skills in medicine : A primer for MRCP PACES
Follows the revised format of the Practical Assessment Clinical Examination Skills (PACES) exam conducted by the Royal College of Physicians in the UK, where ‘clinical consultation skills’ will be tested twice in two separate stations. Thus, coming closest to what doctors do in real life: obtain a structured history, perform a focussed examination and explain the problem to the patient in lay terms. This book takes readers through a rational approach to 63 common presenting symptoms or laboratory abnormalities in medicine. It is aimed at improving the clinical consultation skills of young doctors and preparing them for the new format of MRCP PACES
Cleft and Craniofacial Orthodontics
Provides orthodontists, plastic and oral and maxillofacial surgeons, speech and language therapists, pediatric dentists, and prosthodontists with the information they need to evaluate and treat these conditions. Highlighting the multidisciplinary team approach, the book aids clinicians in developing a complete plan for their patients.
Classifying madness : A philosophical examination of the diagnostic and statistical manual of mental disorders
Classifying Madness examines the conceptual foundations of the D.S.M., the main classification of mental disorders used by psychiatrists world-wide. It will be of interest to both mental health professionals and to philosophers interested in classification in science. The D.S.M. has become extremely controversial, and the possibility that there may be philosophical difficulties with it has become a commonplace in the mental health literature. Classifying Madness offers mental health professionals an opportunity to explore suspicions that there might be conceptual problems with the D.S.M. For philosophers, this book aims to contribute to debates in the philosophy of science concerning natural kinds, the theory-ladenness of classification, and the effect of sociological factors in science. These issues are normally approached via a consideration of the natural sciences and, as will be seen, approaching them via a consideration of psychiatry helps shed new light on old problems.
Classification des Groupes Algébriques Semi-simples = The Classification of Semi-Simple Algebraic Groups
The third volume of the Collected Works of Claude Chevalley assembles his work on semi-simple algebraic groups contained, for the most part, in the notes of the famous "Sminaire Chevalley" held at the Ecole Normale Suprieure in Paris between 1956 and 1958 and written up by participants of the seminar namely, P. Cartier, A. Grothendieck, R. Lazard and J.L. Verdier. These texts have been entirely reset in TeX for this edition, and edited and annotated by Pierre Cartier. Almost 50 years after the original writing, these texts still constitute a choice reference from which to enter
Citation Analysis in Research Evaluation
This book is written for members of the scholarly research community, and for persons involved in research evaluation and research policy. More specifically, it is directed towards the following four main groups of readers: – All scientists and scholars who have been or will be subjected to a quantitative assessment of research performance using citation analysis. – Research policy makers and managers who wish to become conversant with the basic features of citation analysis, and about its potentialities and limitations. – Members of peer review committees and other evaluators, who consider the use of citation analysis as a tool in their assessments. – Practitioners and students in the field of quantitative science and technology studies, informetrics, and library and information science. Citation analysis involves the construction and application of a series of indicators of the ‘impact’, ‘influence’ or ‘quality’ of scholarly work, derived from citation data, i.e. data on references cited in footnotes or bibliographies of scholarly research publications. Such indicators are applied both in the study of scholarly communication and in the assessment of research performance. The term ‘scholarly’ comprises all domains of science and scholarship, including not only those fields that are normally denoted as science – the natural and life sciences, mathematical and technical sciences – but also social sciences and humanities.
Characteristics Finite Element Methods in Computational Fluid Dynamics
This book details a systematic characteristics-based finite element procedure to investigate incompressible, free-surface and compressible flows. The fluid dynamics equations are derived from basic thermo-mechanical principles and the multi-dimensional and infinite-directional upstream procedure is developed by combining a finite element discretization of a characteristics-bias system with an implicit Runge-Kutta time integration. For the computational solution of the Euler and Navier Stokes equations, the procedure relies on the mathematics and physics of multi-dimensional characteristics. As a result, the procedure crisply captures contact discontinuities, normal as well as oblique shocks, and generates essentially non-oscillatory solutions for incompressible, subsonic, transonic, supersonic, and hypersonic inviscid and viscous flows.
