الصفحة 8
الصفحة 8
Hormones and the brain
Peripheral hormones have a major impact on the brain: they are able to interfere with its development, to affect release of neurotransmitters and concentrations of receptors, to trigger growth factors involved in lesion repair. These multiple actions account for their capacity to modulate a number of physiological parameters, from reproductive functions to memory, behaviour and aging. Depending upon intensity and duration of exposure, they can be either neuroprotective or neurotoxic, for instance by affecting production of free radicals. This book, based on contributions of pioneer investigators in the field, outlines the ambiguous actions of gonadal steroids (estradiol, progesterone, testosterone, inhibin and activin) and of neurosteroids, related moieties produced in the brain itself. After summarizing their multiple mechanisms of action, which involve both direct effects on neuronal membranes and activation of genes coding for specific proteins in neurons or glial cells, the book outlines the role of hormones in pathogenic processes such as mental disturbances or neurodegenerative diseases.
Homing Endonucleases and Inteins
This book provides detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and inteins. These two unique protein superfamilies have generated considerable excitement for their fundamental, structural, and functional properties, their evolution as parasitic elements, and their widespread applications as gene targeting agents and as instruments for the generation of modified proteins and novel protein combinations.
Historic construction and conservation : Materials, Systems and Damage
Takes a modern approach to the meaning of a heritage structure and its conservation. The historical evolution of conservation is briefly addressed, considering prominent individuals and cases; along with the history of construction, focusing on materials and related structural elements, with insight on the sizing rules adopted by masons. This explains structural decisions made during the construction process and allows comparison of scientific theories from the 18th century to modern understanding of limit analysis. Damage and collapse mechanisms for masonry construction, as the most widespread structural form for historical buildings, is described. Excess permanent loading and settlement is differentiated from environmental and anthropogenic actions such as earthquake or incorrect intervention.
High Thermal Conductivity Materials
High thermal conductivity materials play an important role in addressing thermal management issues. This volume provides readers a basic understanding of the thermal conduction mechanisms in these materials and discusses how the thermal conductivity may be related to their crystal structures as well as microstructures developed as a result of their processing history. The techniques for accurate measurement of these properties on large as well as small scales have been reviewed. Detailed information on the thermal conductivity of diverse materials including aluminum nitride (AlN), silicon carbide (SiC), diamond, as well as carbon nanotubes has been presented. The emphasis is on developing basic understanding of the inter-relationships between thermal conductivity and processing such that the readers can conduct their own research in this exciting field of high thermal conductivity materials.
Heterocyclic Antitumor Antibiotics
Heterocyclic Compounds Includes aspects such as synthesis, reaction mechanisms, structure complexity, properties, reactivity, stability, fundamental and theoretical studies, biology, biomedical studies, pharmacological aspects, applications in material sciences etc. Metabolism will be also included which will provide information useful in designing pharmacologically active agents. Pathways involving destruction of heterocyclic ring will also be dealt with so that synthesis of specifically functionalized non-heterocyclic molecules can be designed. Overall scope is to cover topics dealing with most of the areas of current trends in heterocyclic chemistry which will suit to a larger heterocyclic community.
Hearing and Sound Communication in Amphibians
Hearing and Sound Communication in Amphibians is a compendium of the latest research on acoustic communication in these highly vocal vertebrates. The chapters are written by experts currently investigating the physiology and behavior of amphibians both in the laboratory and in the field. This integrated approach guides each chapter and provides a neuroethologically-driven and evolutionary basis for our understanding of acoustic communication and its underlying mechanisms. The intended audience ranges from senior undergraduates to physiologists, zoologists, evolutionary biologists and communication specialists.
Hearing : From Sensory Processing to Perception
Hearing – From Sensory Processing to Perception presents the papers of the latest International Symposium on Hearing. The 59 chapters treat topics such as: the physiological representation of temporal and spectral stimulus properties as a basis for the perception of modulation patterns, pitch and signal intensity; spatial hearing and the physiological mechanisms of binaural processing in mammals.
Handbook of psychodiagnostic testing : Analysis of personality in the psychological report
Since the debut of the original edition, the Handbook of Psychodiagnostic Testing has been an invaluable aid to students and professionals performing psychological assessments. The new Fourth Edition continues in that tradition, taking the reader from client referral to finished report, demonstrating how to synthesize details of personality and pathology into a document that is focused, coherent, and clinically meaningful. As with the previous editions, authors Kellerman and Burry offer a systematic framework for choosing the most relevant material from seemingly overwhelming amounts of test data. Separate chapters offer clear rationales for each component of the report (e.g., cognitive functioning, interpersonal behavior, control mechanisms), and how they relate to one another. Helpful summaries follow each chapter, and tables and charts provide salient facts and findings at a glance.
Handbook of neurochemistry and molecular neurobiology : Sensory neurochemistry
This volume of the Handbook of Neurochemistry and Molecular Biology focuses on molecular events involved in synapse formation, synaptic plasticity and ongoing neural activity. The volume explores axonal growth cones, synapse development, and mechanisms of LTP and LTD, and calcium dynamics.
Handbook of neurochemistry and molecular neurobiology : Development and Aging Changes in the Nervous System
In the animal nervous system, a very high metabolic turnover, fragile but steep ionic gradients, and morphological and structural constraints - dictated by the necessity for prompt neuronal transmission of electrical impulses and necessary plasticity - result in a highly fragile organ system. Here, we address a small sampling of major constituents of neural function at the cellular and molecular level that play important roles in development and aging, two endogenous processes that embody features of allostasis or the dynamic shifts in set points for specific homeostatic mechanisms associated with development and aging. These chapters stress the dynamic features of neuronal responses to internal (developmental) cues or the more harmful external events (injury and disease) in a modern perspective.
Handbook of Economic Sociology for the 21st Century : New Theoretical Approaches, Empirical Studies and Developments
This handbook provides an overview on major developments that occurred in the field of economic sociology after its rebirth since the 1980s in the US. It offers new insights on the uniqueness of European economic sociology compared to US economic sociology which emerged at the end of the 20th century. The handbook presents economic sociology as a developing field which started with certain foundations as new economic sociology, widening the perspective by introducing social factors thereby focusing more on general belief systems, social forms of coordination and the relationships between society and the economy. It offers an outstanding portrait of the research field helping to identify major foundations and trajectories as well as new research perspectives for a globalized economic sociology.
Handbook of Drug Monitoring Methods : Therapeutics and Drugs of Abuse
In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic.
Handbook of cardiac anatomy, physiology, and devices
Because of rapid growth in the medical device industry-which today enjoys revenues as large as those of the automobile industry-as well as in our understanding of cardiac disease processes, biomedical engineers must cope with a rising tide of highly complex information. In Handbook of Cardiac Anatomy, Physiology, and Devices, leading experts from the University of Minnesota's renowned Lillehei Heart Institute and scientists from Medtronic, Inc. have compiled a concise-yet detailed and comprehensive-reference source on the anatomic features, underlying physiologic mechanisms, and treatments for diseases of the heart. Here, active bioengineers working on cardiac devices will find the complete critical background they need to understand cardiac pacing, defibrillation, cardiac repair using stem cell therapy, robotics, less invasive cardiac surgery, biventricular pacing, cardiac bioenergetics, and more. Insightful chapters address animal models for cardiac research, cardiac mapping systems, heart valve disease, ventricular assist devices, and genomics-based tools and technology.
Gut orchestra : Micro-symphony turned onco-cacophony
The role of microbiota in colorectal cancer has been studied since alterations in its composition were observed. Ever since, there are more and more pieces of evidence that microbiota could be implicated in colorectal cancer progression. Thus, the components of the microbiota could be biomarkers for the diagnosis and prognosis of colorectal cancer. It is truly important to address how the microbiota interacts with the host and how the host shapes the microbiota, in order to understand the biological pathways and mechanisms involved in their relationship and the consequences of their interactions in colorectal cancer.
Guide to Biomolecular Simulations
Molecular dynamics simulations have become instrumental in replacing our view of proteins as relatively rigid structures with the realization that they were dynamic systems, whose internal motions play a functional role. Over the years, such simulations have become a central part of biophysics. Applications of molecular dynamics in biophysics range over many areas. They are used in the structure determination of macromolecules with x-ray and NMR data, the modelling of unknown structures from their sequence, the study of enzyme mechanisms, the estimation of ligand-binding free energies, the evaluation of the role of conformational change in protein function, and drug design for targets of known structures.
Group B Coxsackieviruses
This monograph reviews information published since 1997 on the group B coxsackieviruses (CVB), a large and important group of human enteroviruses. The CVB were discovered in the mid-20th century, during the search for other poliovirus types, and within a very few years of this discovery, the CVB had been implicated as causes of human myocarditis and pancreatitis. The study of the CVB is still inextricably linked with the fate of their well-known relatives, the polioviruses, for as poliovirus eradication proceeds around the world, the CVB emerge more prominently as the enteroviruses best suited for continuing studies in enteroviral molecular biology as well as understanding the mechanisms underlying enteroviral pathogenesis. This volume reviews and presents modern views on the spectrum of CVB biologies, from interaction of the virus with its receptor through replication, speciation, and induction of disease.
Grid economics and business models ; 5th International workshop, GECON 2008, Las Palmas de Gran Canaria, Spain, August 26, 2008. Proceedings
This volume constitutes the refereed proceedings of the 5th International Workshop on Grid Economics and Business Models, GECON 2008, held in Las Palmas de Gran Canaria, Spain, August 2008.The 10 full papers included in this volume were carefully selected from 27 submission. They aim at presenting current results and innovative research in the area of grid economics. The papers are organized in topical sections on grid business modeling, market mechanisms for the grid, grid markets, and grid architectures.The proceedings are rounded off by 9 project reports that give an overview of the current and ongoing research in grid economics.
Granular dynamic theory and its applications
Granular Dynamic Theory and Its Applications introduces both theory and applications in detail, including differential dynamical models of granular shearing, dynamical strength characteristics and the excited response of granules subject to vibration, granular liquefaction properties and the mechanisms under vibration, granular flow theory and vibration-aided flow, propagation laws of waves in granular media and their mechanism, fractal properties of granules, the vibrating ore-drawing technologies, and so on
Global Lessons from the AIDS Pandemic : Economic, Financial, Legal and Political Implications
This book examines the global HIV/AIDS pandemic from a multidisciplinary perspective, analyzing its economic impact, the reasons behind the political response to the pandemic, international laws relating to public health and patents and mechanisms for financing global and national responses. The authors paint a global picture of the HIV/AIDS pandemic one issue, one country and one region at a time and show why prevention, treatment and human rights protection must each form part of a comprehensive HIV/AIDS strategy. The book analyzes the successes and failures of national governments, international organizations and the private sector in fighting the HIV/AIDS pandemic and recommends changes to our international economic, financial, legal and political institutions. This book highlights the lessons the world has to learn from our experience with HIV/AIDS in order to improve the way we address global diseases.
Gettering Defects in Semiconductors
The authors address not only well-established gettering techniques but also describe contemporary trends in gettering technologies from an international perspective. The types and properties of structural defects in semiconductors, their generating and their transforming mechanisms during fabrication are described. The primary emphasis is placed on classifying and describing specific gettering techniques, their specificity arising from both their position in a general technological process and the regimes of their application. This book addresses both engineers and material scientists interested in semiconducting materials theory and also undergraduate and graduate students in solid–state microelectronics and nanoelectronics. A comprehensive list of references provides readers with direction for further reading.
