الصفحة 8
الصفحة 8
Immunoinformatics
Immunoinformatics is an emerging subdiscipline of bioinformatics. It utilizes mathematics, information science, computer engineering, genomics, proteomics and immunological methods to bridge immunology and informatics. Similar to bioionformatics which became a driving force in genome research, immunoinformatics enables data-driven research strategies and systems approaches that aim at understanding the networks regulating the immune system. Considering the breath of topic, Immunoinformatics was composed to provide a cross-section of research ranging from data integration, epitope predictions to systems level applications. In ten chapters experts in the field introduce and discuss research strategies for immunologists and bioinformaticians who wish to endeavour existing and new approaches to gain insight into the workings of the immune system.
Immunogenetics: Methods and Protocols
Explores techniques for working in the field of immunogenetics, i.e. fundamental and translational research into the adaptive immune receptor repertoire. Many chapters are dedicated to lab protocols, bioinformatics, and immunoinformatics analysis of high-resolution immunome analysis, exemplified by numerous applications. Additionally, the newest technological variations on these protocols are discussed, including non-amplicon, single-cell, and cell-free strategies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Immunogenetics of Autoimmune Disease
Utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches
Immune Mechanisms in Inflammatory Bowel Disease
Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.
Il Parlagioco : Uno strumento per comunicare attraverso il gioco = he Parlagioco: A tool for communicating through play
Il Parlagioco nasce da un'esperienza riabilitativa con un bambino autistico, il cui linguaggio aveva bisogno di regole comunicative. Per questo è stato creato un gioco di carte per realizzare uno scambio interattivo attraverso il desiderio di comunicare giocando. Il Parlagioco è servito anche a ridurre l'iperselettività tipica dell'autismo, orientando l'attenzione del bambino verso gli elementi esaustivi, ignorando i dettagli insignificanti allo scopo di cogliere i nessi di un insieme necessari a una comprensione globale. Da questa esperienza il Parlagioco è stato ulteriormente sviluppato per promuovere la pragmatica della comunicazione e le regole del linguaggio in ambito clinico. La sua applicazione nei disturbi specifici del linguaggio permette di ampliare il lessico, la comprensione di nuovi vocaboli e la produzione di richieste. Quando il disturbo del linguaggio è invece associato a ritardo mentale nelle malattie genetiche o neurologiche, esso consente delle facilitazioni nel proporre compiti specifici di riabilitazione linguistica. La presentazione grafica allettante e la proposta ludica fannno si' che esso sia facilmente applicabile anche in ambito scolastico e familiare.
Il cancro e la ricerca del senso perduto = Cancer and the search for lost meaning
Cancer disease can be approached with the aim of killing diseased cells or with that of making them go backwards on the road that leads from a state of natural equilibrium to the disease. This book tells an original research by the author inspired by this biological vision of cancer, research that led to the production and use of anticancer products. Inevitably, the history of research slips into a vision of the world and of life that presents the features of a documented critique of the values and priorities that characterize the world in which we live. A profound and human book, which makes you think, which makes you hope.
I recettori dellangiotensina : Dalla biologia molecolare alla terapia con gli antagonisti recettoriali
Describes all the structural and functional characteristics of angiotensin receptors, with particular reference to their molecular and pharmacological properties. The therapeutic applications of AT1 receptor antagonists and the results obtained from large trials are also discussed, especially in arterial hypertension, heart failure, diabetic nephropathy and stroke.
I disturbi della consapevolezza nelle malattie neuropsichiatriche = Disturbances of awareness in neuropsychiatric diseases
Aims to outline the set of current international knowledge on disease awareness in various neuropsychiatric conditions (hemiplegia resulting from brain damage, psychosis, dementia and mood disorders), with particular reference to anosognosia and 'insight. The comparison between different conceptualizations and the variety of clinical manifestations gives rise to a very complex picture that requires a multidimensional approach, especially as regards the diagnostic moment. To this end, the authors propose an integration of various contributions on the pathogenetic level, based on neuroanatomical evidence and supported by the most recent neuroimaging techniques. In addition, the use of a complex diagnostic battery is suggested, capable of analyzing the different aspects of the phenomenon, and distinguishing it from the psychological defensive mechanism of denial. Research in this field is also essential to promote rehabilitation and compliance with treatment, as well as the enrichment of knowledge on the processes underlying consciousness and awareness in the human being.
Hypoplastic Left Heart Syndrome
Hypoplastic Left Heart Syndrome draws together the experiences of the leading experts in the field. Through their work in all aspects of congenital cardiac care, they have become acknowledged as the world leaders in the diagnostic, medical and social needs of children born with hypoplasia of the left heart. More importantly, for the first time the book recognizes the crucial contributions made by the families of these children. Diagnostic possibilities, options for medical and surgical treatment and a history of their evolution are looked into and the book also gives an insight into the longer-term effects that treatment has on the child and its family. As well as including contributions from medical clinicians, nurses, and psychologists, for the first time a forum is provided for the parents, who have complemented the contributions from the medical and nursing experts to provide a holistic view of the lives and experiences of the children born with this condition. No other publication, currently available, offers such a comprehensive overview of the care required by a child with hypoplasia of the left heart. This book provides the ultimate reference for anyone treating children with this heart condition, particularly paediatric cardiac clinical and nursing teams, radiologists and radiographers, obstetric medical and nursing teams, psychologists, pathologists, geneticists and workers in social care.
Hybrid metaheuristics ; Vol. 4030 ; 3rd International Workshop, HM 2006, Gran Canaria, Spain, October 13-14, 2006, Proceedings
The selection of papers for HM 2006 consolidated some of the mainstream issues that have emerged from the past editions. Firstly, there are prominent examples of e?ective hybrid techniques whose design and implementation were motivated by challenging real-world applications. We believe this is particularly important for two reasons: on the one hand, researchers are conscious that the primary goal of developing algorithms is to solve relevant real-life problems; on the other hand, the path towarde?cient solving methods for practical problems is a source of new outstanding ideas and theories. A second important issue is that the research community on metaheur- tics has become increasingly interested in and open to techniques and methods known from arti?cial intelligence (AI) and operations research (OR). So far, the most representative examples of such integration have been the use of AI/OR techniques as subordinates of metaheuristic methods. As a historical and - ymological note, this is in perfect accordance with the original meaning of a metaheuristic as a “general strategy controlling a subordinate heuristic. ” The awareness of the need for a sound experimental methodology is a third keypoint.
Hybrid metaheuristics ; Vol. 3636 ; 2nd International Workshop, HM 2005, Barcelona, Spain, August 29-30, 2005. Proceedings
Constitutes the refereed proceedings of the Second International Workshop on Hybrid Metaheuristics, HM 2005, held in Barcelona, Spain, in August 2005. In this book, the papers addresses topics such as: low-level hybridization, high-level hybridization, portfolio techniques, expert systems, co-operative search, taxonomy, terminology, and more.
Hybrid metaheuristics ; 4th International Workshop,HM 2007, Dortmund, Germany, October 8-9, 2007, Proceedings
This book constitutes the refereed proceedings of the 4th International Workshop on Hybrid Metaheuristics, HM 2007, held in Dortmund, Germany. The 14 revised full papers discuss specific aspects of hybridization of metaheuristics, hybrid metaheuristics design, development and testing.
Hybrid Intelligent Systems for Pattern Recognition Using Soft Computing : An Evolutionary Approach for Neural Networks and Fuzzy Systems
This monograph describes new methods for intelligent pattern recognition using soft computing techniques including neural networks, fuzzy logic, and genetic algorithms. Hybrid intelligent systems that combine several soft computing techniques are needed due to the complexity of pattern recognition problems.
Hybrid Intelligent Systems : Analysis and Design
The objective of this edited volume is to offer a general view at the recent conceptual developments of Soft Computing (SC) regarded as a general methodology supporting the design of hybrid systems along with their diversified applications to modeling, simulation and control of non-linear dynamical systems. As of now, SC methodologies embrace neural networks, fuzzy logic, genetic algorithms and chaos theory. Each of these methodologies exhibits well delineated advantages and disadvantages. Interestingly, they have been found useful in solving a broad range of problems. However, many real-world complex problems require a prudent, carefully orchestrated integration of several of these methodologies to fully achieve the required efficiency, accuracy, and interpretability of the solutions. In this edited volume, an overview of SC methodologies, and their applications to modeling, simulation and control, will be given in an introductory paper by the Editors. Then, detailed methods for integrating the different SC methodologies in solving real-world problems will be given in the papers by the other authors in the book. The edited volume will cover a wide spectrum of applications including areas such as: robotic dynamic systems, non-linear plants, manufacturing systems, and time series prediction.
Hybrid Evolutionary Algorithms
Hybridization of evolutionary algorithms is getting popular due to their capabilities in handling several real world problems involving complexity, noisy environment, imprecision, uncertainty and vagueness. This edited volume is targeted to present the latest state-of-the-art methodologies in ’Hybrid Evolutionary Algorithms’. This book deals with the theoretical and methodological aspects, as well as various applications to many real world problems from science, technology, business or commerce. This volume comprises of 14 chapters including an introductory chapter giving the fundamental definitions and some important research challenges. Chapters were selected on the basis of fundamental ideas/concepts rather than the thoroughness of techniques deployed.
Human tooth and developmental dental defects : compositional and genetic implications
Focuses on the qualitative and quantitative properties of the sound enamel and dentin as well as the affected human tooth structures. It examines how genetics impact oral and dental health, the role of fluoride and trace elements in mineralization and the related clinical implications, and the impact of different approaches to diagnose and treat these developmental disorders.
Human Nucleotide Expansion Disorders
Human neurological and neuromuscular disorders caused by nucleotide expansion, first discovered in 1991, are the focus of growing interest of practicing physicians and of interested biomedical researchers. This volume represents a comprehensive and up-to-date description of many of the better-studied disorders. The expert authors discuss molecular, clinical and pathological aspects of the diseases as well as our current understanding of their underlying mechanisms. Of special interest are ideas and initial results of the different therapeutic strategies that can be employed to overcome some of the disorders. As a summary of the state-of-the-art research in this field, this book is of value to human geneticists, molecular biologists and biochemists as well as to practicing neurologists and pediatricians.
Human mitochondrial DNA and the evolution of homo sapiens
Mitochondrial DNA is one of the most explored genetic systems because of what it can tell us about the human past. This volume takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents the global picture of human mitochondrial DNA variation. It takes a critical look at the field, flagging the problems, as well as the successes, and always placing the mitochondrial phylogeny centre stage.
Human Longevity, Individual Life Duration, and the Growth of the Oldest-Old Population
Old-age survival has considerably improved in the second half of the twentieth century. In this book, these fundamental questions are explored by experts from such diverse fields as biology, medicine, epidemiology, demography, sociology, and mathematics: they report on recent cutting-edge studies about essential issues of human longevity such as evolution of lifespan of species, genetics of human longevity, reasons for the recent improvement in survival of the elderly, medical and behavioral causes of deaths among very old people, and social factors of long survival in old age.
Human genetics : concepts and applications
Human genetics is about variation more than about illnesses, and increasingly about the common rather than about the rare. Once an obscure science or an occasional explanation for an odd collection of symptoms, human genetics is now part of everyday conversation. This book shows students how and why that is true.
