Antibiotic pharmacokinetic : Pharmacodynamic considerations in the critically Ill
Provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.
Anthropologies of Global Maternal and Reproductive Health : From Policy Spaces to Sites of Practice
This open access edited book brings together new research on the mechanisms by which maternal and reproductive health policies are formed and implemented in diverse locales around the world, from global policy spaces to sites of practice. The authors – both internationally respected anthropologists and new voices – demonstrate the value of ethnography and the utility of reproduction as a lens through which to generate rich insights into professionals’ and lay people’s intimate encounters with policy.
Analysis, Control and Optimization of Complex Dynamic Systems
Analysis, Control and Optimization of Complex Dynamic Systems gathers in a single volume a spectrum of complex dynamic systems related papers written by experts in their fields, and strongly representative of current research trends. Complex systems present important challenges, in great part due to their sheer size which makes it difficult to grasp their dynamic behavior, optimize their operations, or study their reliability. Yet, we live in a world where, due to increasing inter-dependencies and networking of systems, complexity has become the norm. With this in mind, the volume comprises two parts. The first part is dedicated to a spectrum of complex problems of decision and control encountered in the area of production and inventory systems. The second part is dedicated to large scale or multi-agent system problems occurring in other areas of engineering such as telecommunication and electric power networks, as well as more generic context.
Analysis of Toeplitz Operators
Since the late 1980s, Toeplitz operators and matrices have remained a feld of extensive research and the development during the last nearly twenty years is impressive. One encounters Toeplitz matrices in plenty of applications on the one hand, and Toeplitz operators con?rmed their role as the basic elementary building blocks of more complicated operators on the other. Several monographs on Toeplitz and Hankel operators were written d- ing the last decade. These include Peller’s grandiose book on Hankel ope- tors and their applications and Nikolski’s beautiful easy reading on operators, functions, and systems, with emphasis on topics connected with the names of Hardy, Hankel, and Toeplitz.
An Atlas of Radioscopic Catheter Placement for the Electrophysiologist
Atlas of Radioscopic Catheter Placement for the Electrophysiologist is unique because it is the first book that provides a teaching tool for fellows in training, allied health professionals and accomplished electrophysiologists on relevant X-ray views commonly encountered in different electrophysiology procedures, and how these views correlate with cardiac anatomy.
Agile software construction
Agile software is a means of putting the software first while at the same time reacting to these user requirements in a flexible and agile way.Agile Software Construction covers the emerging methods and approaches (including extreme programming, feature-driven development and adaptive software development), that are loosely described as "Agile" and shows how to apply them effectively to software development projects. It shows how to plan, organise and develop systems using agile techniques, and highlights some of the problems that may be encountered.
Advances in pharmacokinetics and pharmacodynamics
Provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
A Course in Credibility Theory and its Applications
It covers the subject of Credibility Theory extensively and includes most aspects of this topic from the simplest case to the most general dynamic model. The first four chapters contain plenty of material The book therefore treats explicitly the tasks which the actuary encounters in his daily work such as estimation of loss ratios, claim frequencies and claim sizes. The models are worked out in detail (including the estimation of structural parameters) so that they can immediately be applied in practice. Most exercises are based on real insurance data and real situations from practice and many of them have the characteristics of a case study. The extension to practical problems arising from the general area of finance is often quite straightforward. This book deserves a place on the bookshelf of every actuary and mathematician who works, teaches or does research in the area of insurance and finance.for a first course on Credibility.
A Course in Calculus and Real Analysis
Provides a self-contained and rigorous introduction to calculus of functions of one variable. The presentation and sequencing of topics emphasizes the structural development of calculus. At the same time, due importance is given to computational techniques and applications. The authors have strived to make a distinction between the intrinsic definition of a geometric notion and its analytic characterization. It highlight the fact that calculus provides a firm foundation to several concepts and results that are generally encountered in high school and accepted on faith. For example, one can find here a proof of the classical result that the ratio of the circumference of a circle to its diameter is the same for all circles. Also, this book helps get a clear understanding of the concept of an angle and the definitions of the logarithmic, exponential and trigonometric functions together with a proof of the fact that these are not algebraic functions. A number of topics that may have been inadequately covered in calculus courses and glossed over in real analysis courses are treated here in considerable detail. As such, this book provides a unified exposition of calculus and real analysis.
501 Math Word Problems
Contains only word problems - the kinds you encounter at school and on high stakes tests. Gaining familiarity with this specific question type is a proven technique for increasing test scores. The Skill Builder in Focus method provides the targeted practice on these questions necessary to attain higher scores. Questions are divided into six chapters: algebra, geometry, fractions, percents, decimals, and miscellaneous math. Within each chapter, questions move from easy to advanced, giving test-takers the opportunity to gain confidence in each math area. Each chapter contains questions, answers, and detailed explanations to reinforce learning and understanding. Diagrams and useful terminology help clarify math rules for effective studying and retention.









