الصفحة 71
الصفحة 71
Antiangiogenic Agents in Cancer Therapy
Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of angiogenesis in cancer. Leaders in the field present chapters on such topics as the environmental influences and the genetic and physiologic abnormalities that mediate angiogenesis and its role in the progression of malignant disease, working models of tumor angiogenesis, and the role of angiogenesis inhibition in the therapy of malignant disease in humans. Comprehensive and cutting-edge, Antiangiogenic Agents in Cancer Therapy, Second Edition is an ideal, valuable guide to the most recent advances in the field, and a collection that will be useful for many years to come.
Another side of drugs
Drug interactions remain an important consequence of pharmacologic intervention. It is clear that the pharmacologic response of a drug can be markedly influenced by concurrent administration of another therapeutic agent or food. These interactions may result in a decreased therapeutic effect or in an increase in the amount and extent of untoward reactions. Despite the well-described and real clinical consequences of certain drug interactions, this aspect of patient care often continues to be overlooked.
Ane's Encyclopedic Dictionary of General & Applied Entomology
Keeping the requirements of teachers and researchers in mind, this encyclopedic dictionary presents the terminology in entomology and pest management in the most authentic and comprehensive way. It also includes terms related to the close relatives of insects, such as mites and ticks and some other organisms which are pests of crops.
ANEMONA : A Mulit-agent Methodology for Holonic Manufacturing Systems
ANEMONA is a multi-agent system (MAS) methodology for holonic manufacturing system (HMS) analysis and design, based on HMS requirements. The development process of ANEMONA provides clear and HMS-specific modeling guidelines for HMS designers, and complete development phases for the HMS life cycle.
Ancient Philosophy of the Self
This volume explores the various ways in which selfhood was approached and conceptualised in antiquity. They also describe how the ancient philosophers understood human agents as capable of causing changes and being affected in and by the world. The themes of persistence, identity, self-examination and self-improvement recur in many of these essays. The articles of the collection combine systematic and historical approaches to ancient sources that range from Socrates to Plotinus and Augustine.
Ancient monuments and modern identities : A critical history of archaeology in 19th and 20th century Greece
Sets out to examine the role of archaeology in the creation of ethnic, national and social identities in 19th and 20th century Greece. The essays included in this volume examine the development of interpretative and methodological principles guiding the recovery, protection and interpretation of material remains and their presentation to the public. The role of archaeology is examined alongside prevailing perceptions of the past, and is thereby situated in its political and ideological context. The book is organized chronologically and follows the changing attitudes to the past during the formation, expansion and consolidation of the Modern Greek State. The aim of this volume is to examine the premises of the archaeological discipline, and to apply reflection and critique to contemporary archaeological theory and practice.
Analytical scientists in pharmaceutical product development : Task management and practical knowledge
Explains task management concepts and outlines practical knowledge to help pharmaceutical analytical scientists become productive and enhance their career. •Presents broad topics such as product development process, regulatory requirement, task and project management, innovation mindset, molecular recognition, separation science, degradation chemistry, and statistics. •Provokes thinking through figures, tables, and case studies to help understand how the various functions integrate and how analytical development can work efficiently and effectively by applying science and creativity in their work. •Discusses how to efficiently develop a fit-for-purpose HPLC method without screening dozens of columns, gradients, or mobile phase combinations each time, since the extra effort may not provide enough of a benefit to justify the cost and time in a fast-paced product development environment.
Analytical Methods for Problems of Molecular Transport
"This book is designed to serve a dual function. It is intended that it be capable of serving as a teaching instrument, either in a classroom environment or independently, for the study of basic analytical methods and mathematical techniques that may be used in the Kinetic Theory of Gases and is primarily suitable for use in graduate level physics and engineering courses on the subject. This book should also be useful as a reference for scientists and engineers working in the fields of Rarefied Gas Dynamics and Aerosol Mechanics. In addition, the material in this book may be of interest to individuals working in such areas as Physical Chemistry, Chemical Engineering, or any other applied discipline in which gas-surface interactions should play a significant role."-
Analytical approaches for reinforced concrete
Applies deductive reasoning, logic and mathematics to RC. Laying out, deductively, the principles of RC, it encourages researchers to re-imagine and innovate using a solid conceptual framework. Sections consider the reasoning behind key theories, as well as problems that remain unsolved.
Analytic Number Theory : Lectures given at the C.I.M.E. Summer School held in Cetraro, Italy, July 11-18, 2002
The four contributions collected in this volume deal with several advanced results in analytic number theory. Friedlander’s paper contains some recent achievements of sieve theory leading to asymptotic formulae for the number of primes represented by suitable polynomials. Heath-Brown's lecture notes mainly deal with counting integer solutions to Diophantine equations, using among other tools several results from algebraic geometry and from the geometry of numbers. Iwaniec’s paper gives a broad picture of the theory of Siegel’s zeros and of exceptional characters of L-functions, and gives a new proof of Linnik’s theorem on the least prime in an arithmetic progression. Kaczorowski’s article presents an up-to-date survey of the axiomatic theory of L-functions introduced by Selberg, with a detailed exposition of several recent results.
Analysis of variance for random models, Vol. 2 : Unbalanced data : Theory, methods, applications, and data analysis
Analysis of variance (ANOVA) models have become widely used tools and play a fundamental role in much of the application of statistics today. In particular, ANOVA models involving random effects have found widespread application to experimental design in a variety of fields requiring measurements of variance, including agriculture, biology, animal breeding, applied genetics, econometrics, quality control, medicine, engineering, and social sciences. This two-volume work is a comprehensive presentation of different methods and techniques for point estimation, interval estimation, and tests of hypotheses for linear models involving random effects. Both Bayesian and repeated sampling procedures are considered. Volume I examines models with balanced data (orthogonal models); Volume II studies models with unbalanced data (nonorthogonal models).
Analysis of Toeplitz Operators
Since the late 1980s, Toeplitz operators and matrices have remained a feld of extensive research and the development during the last nearly twenty years is impressive. One encounters Toeplitz matrices in plenty of applications on the one hand, and Toeplitz operators con?rmed their role as the basic elementary building blocks of more complicated operators on the other. Several monographs on Toeplitz and Hankel operators were written d- ing the last decade. These include Peller’s grandiose book on Hankel ope- tors and their applications and Nikolski’s beautiful easy reading on operators, functions, and systems, with emphasis on topics connected with the names of Hardy, Hankel, and Toeplitz.
Analysis and Algorithms for Service Parts Supply Chains
Services requiring parts has become a $1.5 trillion business annually worldwide, creating a tremendous incentive to manage the logistics of these parts efficiently by making planning and operational decisions in a rational and rigorous manner. This book provides a broad overview of modeling approaches and solution methodologies for addressing service parts inventory problems found in high-powered technology and aerospace applications. The focus in this work is on the management of high cost, low demand rate service parts found in multi-echelon settings. This unique book, with its breadth of topics and mathematical treatment, begins by first demonstrating the optimality of an order-up-to policy [or (s-1,s)] in certain environments. This policy is used in the real world and studied throughout the text. The fundamental mathematical building blocks for modeling and solving applications of stochastic process and optimization techniques to service parts management problems are summarized extensively. A wide range of exact and approximate mathematical models of multi-echelon systems is developed and used in practice to estimate future inventory investment and part repair requirements.
Analisi di Rasch e questionari di misura : Applicazioni in medicina e scienze sociali = Rasch analysis and measurement questionnaires: Applications in medicine and social sciences
Evaluation questionnaires are the most used tools nowadays in the field of medicine and the human sciences to evaluate variables such as disability, altruism or pain. However, clinicians are often unfamiliar with these tools. What do they really measure? How are the results to be interpreted? This book tries to answer these questions.
Anaesthesia, pain, intensive care and emergency medicine A.P.I.C.E. ; Proceedings of the 21st Postgraduate Course in Critical Medicine: Venice-Mestre, Italy - November 10-13, 2006
Developing sectors in the Intensive Care field – and in Critical Care Medicine in general – require specific levels of competence having a same common denominator: an in-depth knowledge of human pathophysiology. Although this volume presents plenty of topics in constant evolution, as witnessed by the collection of chapters compiled by several researchers, this edition includes, in particular, fields in which decision-making at the patient’s bedside prevails over theoretical argumentation. In other words, the first and foremost message this edition wants to provide is for the reader to focus his/her attention on evidence-based medicine.
An Undergraduate Primer in Algebraic Geometry
This book consists of two parts. The first is devoted to an introduction to basic concepts in algebraic geometry: affine and projective varieties, some of their main attributes and examples. The second part is devoted to the theory of curves: local properties, affine and projective plane curves, resolution of singularities, linear equivalence of divisors and linear series, Riemann–Roch and Riemann–Hurwitz Theorems.The approach in this book is purely algebraic. The main tool is commutative algebra, from which the needed results are recalled, in most cases with proofs. The prerequisites consist of the knowledge of basics in affine and projective geometry, basic algebraic concepts regarding rings, modules, fields, linear algebra, basic notions in the theory of categories, and some elementary point–set topology.
An Invitation to Abstract Mathematics
this book begins with a playful exploration of the building blocks of mathematics, such as definitions, axioms, and proofs. A study of the fundamental concepts of logic, sets, and functions follows, before focus turns to methods of proof. Having covered the core of a transition course, the author goes on to present a selection of advanced topics that offer opportunities for extension or further study. Throughout, appendices touch on historical perspectives, current trends, and open questions, showing mathematics as a vibrant and dynamic human enterprise.This second edition has been reorganized to better reflect the layout and curriculum of standard transition courses. It also features recent developments and improved appendices. An Invitation to Abstract Mathematics is ideal for those seeking a challenging and engaging transition to advanced mathematics, and will appeal to both undergraduates majoring in mathematics, as well as non-math majors interested in exploring higher-level concepts.
An Introduction to Optical Wireless Mobile Communications
Discusses existing conventional radio frequency (RF)-based wireless access technology and presents the challenges that can impact the requirements of the future wave of new wireless services in the context of artificial intelligence (AI) driven autonomous systems and machine-type communications. The relationship between visible light communications (VLC) and light fidelity (LiFi), is explored, and the major advantages of VLC and LiFi such as security and data density, and discuss existing research challenges are also introduced. Channel modeling techniques are provided for mobile multiuser scenarios, and will introduce key building blocks to achieve LiFi cellular networks achieving orders of magnitude improvements of area spectral efficiency compared to state-of-the-art. Challenges that arise from moving from a static point-to-point visible light link to a LiFi network that is capable of serving hundreds of mobile and fixed nodes are discussed. An overview of recent standardization activities and the commercialization challenges of this disruptive technology is also provided.
An Introduction to Number Theory
An Introduction to Number Theory provides an introduction to the main streams of number theory. Starting with the unique factorization property of the integers, the theme of factorization is revisited several times throughout the book to illustrate how the ideas handed down from Euclid continue to reverberate through the subject. In particular, the book shows how the Fundamental Theorem of Arithmetic, handed down from antiquity, informs much of the teaching of modern number theory. The result is that number theory will be understood, not as a collection of tricks and isolated results, but as a coherent and interconnected theory. A number of different approaches to number theory are presented, and the different streams in the book are brought together in a chapter that describes the class number formula for quadratic fields and the famous conjectures of Birch and Swinnerton-Dyer. The final chapter introduces some of the main ideas behind modern computational number theory and its applications in cryptography.
An Introduction to Network Programming with Java
This book provides an overview of Java … . Each chapter is supplemented with practical programming exercises.The combination of code templates with good supporting discussions allows a competent Java programmer to rapidly expand his or her skill base to include network programming.
