الصفحة 7
الصفحة 7
Molecular Markers of Brain Tumor Cells : Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy
Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.
Molecular Marker Systems in Plant Breeding and Crop Improvement
Successful release of new and better crop varieties increasingly requires genomics and molecular biology. This volume presents basic information on plant molecular marker techniques from marker location up to gene cloning. The text includes a description of technical approaches in genome analysis such as comparison of marker systems, positional cloning, and array techniques in 19 crop plants. A special section focuses on converting this knowledge into general and specific breeding strategies, particularly in relation to biotic stress. Theory and practice of marker assisted selection for QTL, gene pyramiding and the future of MAS are summarized and discussed for maize, wheat, and soybean. Furthermore, approaches in silviculture on the examples of Fagus, Populus, Eucalyptus, Picea and Abies are presented. The volume ends with a comprehensive review of the patents relevant for using molecular markers and marker assisted selection.
Molecular Imaging II
The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is beeing addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.
Molecular Imaging I
The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is being addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.
Molecular Biology of the Parathyroid
Caintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu M lar calcium levels, by acting on bone, kidney and intestine. The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex pression to its intracellular processing and the sequences in the gene control ling its transcription as well as those regulating mRNA processing, stability and translation are described.
Molecular and Cellular Signaling
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
Modes of Esports Engagement in Overwatch
This book provides a comprehensive review of the rapidly developing esport phenomenon by examining one of its contemporary flagship titles, Overwatch (Blizzard Entertainment 2016), through three central themes and from a rich variety of research methods and perspectives. As a game with more than 40 million individual players, an annual international World Cup, and a franchised professional league with teams from Canada, China, Europe, South Korea, and the US, Overwatch provides a multifaceted perspective to the cultural, social, and economic topics associated with the development of esports, which has begun to attract attention from both commercial and academic audiences.
Modern Theatres 1950–2020
Explores in detail 30 of the most significant theatres, concert halls, opera houses and dance spaces that opened between 1950 and 2010. Each theatre is reviewed and assessed by experts in theatre buildings, such as architects, acousticians, consultants and theatre practitioners, and illustrated with full-colour photographs and comparative plans and sections. A further 20 theatres that opened from 2009 to 2020 are concisely reviewed and illustrated. An excellent resource for students of theatre planning, theatre architecture and architectural design, Modern Theatres 1950 – 2020 discusses the role of performing arts buildings in cities, explores their public and performances spaces and examines the acoustics and technologies needed in a great building. This beautifully illustrated book is also a must-read for architects, theater designers, theatre historians, and theatre practitioners.
Modern Sports Dentistry
A one-stop reference that will assist primary care community dentists, sports physicians, athletic trainers, and emergency room physicians in meeting the needs of athletes when managing facial and dental trauma and sports-related oral diseases. The opening chapters provide a complete review of sports-related dentoalveolar trauma, with coverage of emergent care, the role of endodontics, surgical issues, and restorative considerations. Prevention of dental trauma by means of mouthguards is then examined, with attention to materials and design, public policy concerning the use of mouthguards, and the role of mouthguards in relation to the ever more pressing issue of concussion in sport. Dental erosion in athletes, for example due to energy drinks, is discussed, as are the possible sequelae of use of spit tobacco, performance-enhancing drugs, and ergogenic aids. The new topic of the potential value of dental appliances in enhancing sports performance is also addressed.
Modern Aspects of Electrochemistry ; Vol. 41
The 41st volume in this series covers a range of topics that touch on issues of potential interest to those working in electrochemistry-related fields. … Overall, this text contains a diverse collection of topics that would be of varying degrees of interest to the broader electrochemistry community. More likely, the individual chapters would be most valued by specialists working in these areas."As the most recent volume of a successful series established 1954 and carefully continued this book provides a timely collection of four review papers covering widely distributed aspects of electrochemistry in representative contributions.
Modelling, Computation and Optimization in Information Systems and Management Sciences ; 2nd International Conference MCO 2008, Metz, France - Luxembourg, September 8-10, 2008. Proceedings
This book constitutes the refereed proceedings of the Second International Conference MCO 2008, Metz, France, September 2008.The 65 revised full papers presented were carefully reviewed and selected from 160 submissions. The papers are organized in topical sections on optimization and decision making; data mining theory, systems and applications; computer vision and image processing; computer communications and networks; optimization and search techniques for security, reliability, trust.
Modelling the dispersion of radionuclides in the marine environment : An introduction
This book is a practical guide to the subject of numerical modelling of radioactivity dispersion in the marine environment. Thus, the techniques and numerical procedures required are explained in detail, with the aim of enabling the reader to build a real mathematical model. The book covers basic concepts and techniques, such as solving the advection-diffusion equation in a simple 1D form, as well as the most recent developments (full 3D models for non-conservative radionuclides including chemical reactions and speciation). A chapter is dedicated to the basic hydrodynamic modelling that is always required to simulate the dispersion of tracers in the sea; Eulerian and Lagrangian modelling techniques are also described. A chapter describes sensitivity and uncertainty analysis, the final stage in modelling works. A review on some published radionuclide dispersion models is also included.
Modelling and Development of Intelligent Systems ; 6th International Conference, MDIS 2019, Sibiu, Romania, October 3–5, 2019, Revised Selected Papers
This volume constitutes the refereed proceedings of the 6th International Conference on Modelling and Development of Intelligent Systems, MDIS 2019, held in Sibiu, Romania, in October 2019. The 13 revised full papers presented in the volume were carefully reviewed and selected from 31 submissions. The papers are organized in topical sections on adaptive systems; conceptual modelling; data mining; intelligent systems for decision support; machine learning.
Modelling and Control of Dynamical Systems : Numerical Implementation in a Behavioral Framework
This book reviews known topics of the Behavioral Approach and offers new theoretic results with the advantage of including control algorithms implemented numerically in the computer. In addition, issues of numerical analysis are also included. The programs and algorithms are MATLAB based.
Modeling Uncertainty : An Examination of Stochastic Theory, Methods, and Applications
Modeling Uncertainty: An Examination of Stochastic Theory, Methods, and Applications, is a volume undertaken by the friends and colleagues of Sid Yakowitz in his honor. Fifty internationally known scholars have collectively contributed 30 papers on modeling uncertainty to this volume. Each of these papers was carefully reviewed and in the majority of cases the original submission was revised before being accepted for publication in the book. The papers cover a great variety of topics in probability, statistics, economics, stochastic optimization, control theory, regression analysis, simulation, stochastic programming, Markov decision process, application in the HIV context, and others. There are papers with a theoretical emphasis and others that focus on applications. A number of papers survey the work in a particular area and in a few papers the authors present their personal view of a topic. It is a book with a considerable number of expository articles, which are accessible to a nonexpert - a graduate student in mathematics, statistics, engineering, and economics departments, or just anyone with some mathematical background who is interested in a preliminary exposition of a particular topic. Many of the papers present the state of the art of a specific area or represent original contributions which advance the present state of knowledge. In sum.
Modeling of Creep for Structural Analysis
"Creep Modeling for Structural Analysis" develops methods to simulate and analyze the time-dependent changes of stress and strain states in engineering structures up to the critical stage of creep rupture. The principal subjects of creep mechanics are the formulation of constitutive equations for creep in structural materials under multi-axial stress states; the application of structural mechanics models of beams, plates, shells and three-dimensional solids and the utilization of procedures for the solution of non-linear initial-boundary value problems. The objective of this book is to review some of the classical and recently proposed approaches to the modeling of creep for structural analysis applications as well as to extend the collection of available solutions of creep problems by new, more sophisticated examples.
Modeling Decisions for Artificial Intelligence ; 5th International Conference, MDAI 2008 Sabadell, Spain, October 30-31, 2008. Proceedings
This book constitutes the refereed proceedings of the 5th International Conference on Modeling Decisions for Artificial Intelligence, MDAI 2008, held in Sabadell, Spain, in October 2008.The 19 revised full papers presented together with 2 invited lectures were thoroughly reviewed and selected from 43 submissions; they are devoted to theory and tools for modeling decisions, as well as applications that encompass decision making processes and information fusion techniques. The papers are organized in topical sections on aggregation operators, decision making, clustering and similarity, computational intelligence and optimization, as well as data privacy.
Modeling and Using Context ; 5th International and Interdisciplinary Conference, CONTEXT 2005, Paris, France, July 5-8, 2005, Proceedings
Context is of crucial importance for research and applications in many disciplines, as evidenced by many workshops, symposia, seminars, and conferences on specific aspects of context. The International and Interdisciplinary Conference on Modeling and Using Context (CONTEXT), the oldest conference series focusing on context, provides a unique interdisciplinary emphasis, bringing together participants from a wide range of disciplines, including artificial intelligence, cognitive science, computer science, linguistics, organizational science, philosophy, psychology, ubiquitous computing, and application areas such as medicine and law, to discuss and report on context-related research and projects. Previous CONTEXT conferences were held in Rio de Janeiro, Brazil (1997), Trento, Italy (1999, LNCS 1688), Dundee, UK (2001, LNCS 2116), and Palo Alto, USA (2003, LNCS 2680). CONTEXT 2005 was held in Paris, France during July 5–8, 2005. There was a strong response to the CONTEXT 2005 Call for Papers, with 120 submissions received. A careful review process assessed all submissions, with each paper first reviewed by the international Program Committee, and then reviewer discussions were initiated as needed to assure that the final decisions carefully considered all aspects of each paper. Reviews of submissions by the Program Chairs were supervised independently and anonymously, to assure fair consideration of all work. Out of the 120 submissions, 23 were selected as full papers for oral presentation, and 20 were selected as full papers for poster presentation. These outstanding papers are presented in this proceedings.
Modeling and computations in electromagnetics ; A volume dedicated to Jean-Claude Nédélec
Modeling and computations in electromagnetics is a quite novel and growing discipline, expanding as a result of the steadily increasing demand for designing electrical devices, modeling electromagnetic materials, and simulating electromagnetic fields in nanoscale structures. The aim of this volume is to bring together prominent worldwide experts to review state-of-the-art developments and future trends of modeling and computations in electromagnetics. This volume is devoted to merging the expertise of scientists working in this dynamic discipline, and to raising interest for challenging issues. The most significant advances in computational techniques have been made only in the last few years, and several challenging technological applications are presented in this volume.
Model-Driven Development of Reliable Automotive Services ; 2nd Automotive Software Workshop, ASWSD 2006, San Diego, CA, USA, March 15-17, 2006, Revised Selected Papers
This book constitutes the thoroughly refereed post-workshop proceedings of the Second Automotive Software Workshop, ASWSD 2006, held in San Diego, CA, USA in March 2006.The 11 revised full papers presented were carefully reviewed and selected from 18 lectures held at the workshop, that brought together experts from industry and academia, working on highly complex, distributed, reactive software systems related to the automotive domain. The papers are organized in topical sections on modeling techniques and infrastructures, model transformations, quality assurance, real-time control, as well as services and components.
