الصفحة 7
الصفحة 7
Genome integrity : Facets and perspectives
The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.
General Principles of Tumor Immunotherapy : Basic and Clinical Applications of Tumor Immunology
Brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated through both experimental clinical trials and review of current standard of care therapeutic agents. This information will be invaluable to both students of immunology and cancer research and practicing physicians who have patients with cancer. The book provides a comprehensive overview of the field, demonstrates how advances in basic immunology can and are being applied to cancer, and describes the current status of approved immunotherapy regimens.
Galactose Regulon of Yeast : From Genetics to Systems Biology
The galactose regulon of yeast is one of the best studied regulons. It is an ideal paradigm for demonstrating fundamental and evolving concepts in biology and is used in this book as a model system to explain various facets of conventional and modern biology. The book starts with a brief historical overview on yeast research, i.e. early observations in enzyme adaptation, classical genetics, formulating hypotheses based on genetic inference. This is followed by molecular genetics of the galactose regulon, isolation of genes and testing of the hypotheses. The power of mutational analysis in deciphering molecular mechanisms is conveyed. Further, contemporary topics such as genomics, evolution, single cell analysis of transcriptional switching, binary and graded responses, biological consequences of feed back regulation in genetic circuits, and stochasticity are addressed.
Future approaches for safe and effective pain management
Pain is defined as an unpleasant sensory and emotional experience that is associated with actual or potential tissue damage or described in terms of such damage. It is subjective and considered an important physiological mechanism by which humans prevent themselves from developing tissue injury. However, pain patients do not respond to treatment in the same way, which makes it challenging to issue a consistent treatment for all pain conditions. Excessive pain can markedly increase psychological health problems and decrease health‐related quality of life; therefore, pain should be managed appropriately by analgesics. Analgesics act in various ways on the peripheral and central pain pathways and are regarded as one of the most valuable but equally dangerous groups of medications. Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined. Pain severities as well as responses to analgesics, can also be very variable among sufferer.
Fungal Genomics
Presents an overview on mutualistic and pathogenic interactions between fungi and plants. This book offers reviews on fungal lifestyles, mechanisms of their interactions with their host plants, signal perception and transduction, and plant defense responses directed against attack by fungal pathogens. It is suitable for students in microbiology.
Fundamentals of Structural Dynamics : Theory and Computation
Emphasizes numerical methods, nonlinear response of structures, and the analysis of continuous systems (e.g., wave propagation). Fundamentals of Structural Dynamics: Theory and Computation builds the theory of structural dynamics from simple single-degree-of-freedom systems through complex nonlinear beams and frames in a consistent theoretical context supported by an extensive set of MATLAB codes that not only illustrate and support the principles, but provide powerful tools for exploration. The book is designed for students learning structural dynamics for the first time but also serves as a reference for professionals throughout their careers.
Fundamentals of airplane flight mechanics
Airplane flight mechanics is the application of Newton's laws to the study of airplane trajectories (performance), stability, and aerodynamic control. This text is limited to flight in a vertical plane and is divided into two parts. The first part, trajectory analysis, is concerned primarily with the derivation of analytical solutions of trajectory problems associated with the sizing of commercial jets, that is, take-off, climb, cruise, descent, and landing, including trajectory optimization. The second part, stability and control, is further classified as static or dynamic. On each iteration of airplane sizing, the center of gravity is placed so that the airplane is statically stable. Dynamic stability and control is included to study the response of an airplane to control and gust inputs, which is needed for the design of automatic flight control systems. Algorithms are presented for estimating lift, drag, pitching moment, and stability derivatives.
Functional Hemodynamic Monitoring
Hemodynamic monitoring is one of the major diagnostic tools available in the acute care setting to diagnose cardiovascular insufficiency and monitor changes over time in response to interventions. However, the rationale and efficacy of hemodynamic monitoring to affect outcome has come into question. We now have increasing evidence that outcome from critical illness can be improved by focused resuscitation based on existing hemodynamic monitoring, whereas non-specific aggressive resuscitation impairs survival. Thus, this book frames hemodynamic monitoring into a functional perspective wherein hemodynamic variables and physiology interact to derive performance and physiological reserve estimates that themselves drive treatment. This philosophy, as well as the limitations and applications of common and evolving hemodynamic measures and their focused use in the care of critically ill patients are discussed, relevant to one underlying truth: No monitoring device, no matter how simple or sophisticated, will improve patient-centered outcomes useless coupled to a treatment which, itself, improves outcome.
Fuchsian Reduction : Applications to Geometry, Cosmology, and Mathematical Physics
Fuchsian reduction is a method for representing solutions of nonlinear PDEs near singularities. The technique has multiple applications including soliton theory, Einstein's equations and cosmology, stellar models, laser collapse, conformal geometry and combustion. Developed in the 1990s for semilinear wave equations, Fuchsian reduction research has grown in response to those problems in pure and applied mathematics where numerical computations fail.
From Object to Experience : The New Culture of Architectural Design
Combines a history of ideas about architectural experience with the latest insights from the fields of neuroscience, cognitive science and evolutionary biology to make a powerful argument about the nature and future of architectural design. Today, the sciences have granted us the tools to help us understand better than ever before the precise ways in which the built environment can affect the building user's individual experience. Through an understanding of these tools, architects should be able to become better designers, prioritizing the experience of space - the emotional and aesthetic responses, and the sense of homeostatic well-being, of those who will occupy any designed environment. In From Object to Experience, Mallgrave goes further, arguing that it should also be possible to build an effective new cultural ethos for architectural practice. Drawing upon a range of humanistic and biological sources, and emphasizing the far-reaching implications of new neuroscientific discoveries and models, this book brings up-to-date insights and theoretical clarity to a position that was once considered revolutionary but is fast becoming accepted in architecture
From love to medicine : the applications of pheromones in health care
Explores the fascinating world of pheromones, chemical signals that trigger specific behavioral and physiological responses and social interactions in individuals of the same or different species, types, and importance of studying pheromones in a comprehensive manner. Firstly, it delves into the chemical nature of pheromones, including their structures, chemical properties, and the mechanism of action through the Jacobson's organ. Secondly, the project further investigates pheromones' role in communication, examining examples of pheromone-mediated communication and their effects on behavior...
From Innate Immunity to Immunological Memory
The ability to remember an antigenic encounter for several decades, even for a life time, is one of the fundamental properties of the immune system. This phenomenon known as "immunological memory", is the foundation upon which the concept if vaccination rests. Therefore, understanding the mechanisms by which immunological memory is regulated is of paramount importance. Recent advances in immunology, particularly in the field of innate immunity, suggest that the innate immune system plays fundamental roles in influencing immunological memory. Indeed, emerging evidence suggests that events that occur early, within hours if not minutes of pathogen or vaccine entry profoundly shape the quantity, quality and duration of immunological memory. The present volume assembles a collection of essays from leading experts that span the entire spectrum research from understanding the molecular mechanisms of innate immune recognition, to dendritic cell function, to the generation and maintenance of antigen-specific B and T-cell responses.
From disaster response to risk management : Australia's National Drought Policy
In 1992 Australia’s Commonwealth and State governments announced the introduction of a National Drought Policy adopting an innovative risk management approach, which received broad support from Australia’s major political parties and the policy community. This trail-blazing attempt and the experiences with the development and implementation of this policy over the past decade have intrigued the international scientific and policy communities. The present book comprises an academically focused collection of papers, which the Editors hope will provide others moving in a similar direction with the benefit of experience. The work highlights the successes and challenges of a move from disaster to risk management in responding to drought. As such it will be a valuable and useful addition to the international literature on drought preparedness and response.
From Assessing to Conserving Biodiversity : Conceptual and Practical Challenges
This book despite increasing communication, accelerating policy and management responses, and notwithstanding improving ecosystem assessment and endangered species knowledge, conserving biodiversity continues to be more a concern than an accomplished task. Why is it so? The overexploitation of natural resources by our species is a frequently recognised factor, while the short-term economic interests of governments and stakeholders typically clash with the burdens that implementing conservation actions imply. But this is not the whole story. This book develops a different perspective on the problem by exploring the conceptual challenges and practical defiance posed by conserving biodiversity, namely: on the one hand, the difficulties in defining what biodiversity is and characterizing that “thing” to which the word ‘biodiversity’ refers to; on the other hand, the reasons why assessing biodiversity and putting in place effective conservation actions is arduous.
Form-oriented analysis : A new methodology to model form-based applications
Form-based applications range from simple web shops to complex enterprise resource planning systems. Draheim and Weber adapt well-established basic modeling techniques in a novel way to achieve a modeling framework optimized for this broad application domain. They introduce new modeling artifacts, such as page diagrams and form storyboards, and separate dialogue patterns to allow for reuse. In their implementation they have developed new constructs such as typed server pages, and tools for forward and reverse engineering of presentation layers. The methodology is explained using an online bookshop as a running example in which the user can experience the modeling concepts in action. The combination of theoretical achievements and hands-on practical advice and tools makes this book a reference work for both researchers in the areas of software architectures and submit-response style user interfaces, and professionals designing and developing such applications. More information and additional material is also available online.
Foot-and-Mouth Disease Virus
The chapters in this volume provide an account of the present knowledge and understanding of Foot and Mouth disease virus pathogenesis and global epidemiology, the detailed structure of the virus itself and the properties of its RNA genome. Also considered are the immune response of the host and the state of the art in vaccine production, and the nature of virus evolution.
Food Price Volatility and Its Implications for Food Security and Policy
This book provides fresh insights into concepts, methods and new research findings on the causes of excessive food price volatility. It also discusses the implications for food security and policy responses to mitigate excessive volatility. The approaches applied by the contributors range from on-the-ground surveys, to panel econometrics and innovative high-frequency time series analysis as well as computational economics methods. It offers policy analysts and decision-makers guidance on dealing with extreme volatility.
Food allergens : methods and protocols
Provides a comprehensive collection of methods and protocols in food allergy and food allergens studies. The selected protocols explore the study of food allergens, from recombinant production, purification procedures, IgE and T cell epitopes characterization, to allergen structure description, cellular responses, and tolerance induction, through a variety of techniques and animal models.
FOBA : Buildings
The book also chronicles the FOB Homes systema FOBA subsidiary company established in 1999a uniquely creative response to the generic mass-produced pre-fabricated housing available in Japan. With five basic prototypes that can be easily adapted to any site or client, FOB Homes redefines the concept of standardized housing. Their simple, neutral white boxes counter the visual chaos of contemporary Japan and offer the elegance and experience of "architecture" to the general publica union of modernist aesthetics with the modernist ideology of democratic, affordable design.
Flood Warning, Forecasting and Emergency Response
This book provides a comprehensive account of flood warning, forecasting and emergency response processes, including techniques for predicting the development of flood events and for issuing appropriate warnings. Topics such as telemetry and information systems, flood warning economics, and river and coastal monitoring are also discussed. This book brings together many aspects of this interesting multidisciplinary topic and will serve as a valuable reference for researchers, policy makers and engineers.
