الصفحة 7
الصفحة 7
Cell-Cell Channels
The biological sciences are dominated by the idea that cells are the functionally autonomous, physically separated, discrete units of life. This concept was propounded in the 19th century by discoveries of the cellular structuring of both plants and animals. Moreover, the ap parent autonomy of unicellular eukaryotes, as well as the cellular basis of the mammalian brain (an organ whose anatomy for a long while defied attempts to validate the idea of the cellular nature of its neurons), seemed to provide the final conclusive evidence for the completeness of *cell theory', a theory which has persisted in an almost dogmatic form up to the present day. However, it is very obvious that there are numerous observations which indicate that it is not the cells which serve as the basic units of biological life but that this property falls to some other, subcellular assemblage. To deal with this intricate problem concerning the fundamental unit of living matter, we proposed the so-called Cell Body concept which, in fact, devel ops an exceedingly original idea proposed by Julius Sachs at the end of the 19th century. In the case of eukaryotic cells, DNA-enriched nuclei are intimately associated with a microtubular cytoskeleton. In this configuration—as a Cell Body—these two items comprise the fundamental functional and struc tural unit of eukaryotic living matter. The Cell Body seems to be inherent to all cells in all organisms.
Cell Adhesion and Cytoskeletal Molecules in Metastasis
In this volume, the expression of specific adhesion molecules within human cancer tissues are highlighted. The expression signatures from published DNA microarray and immunohistochemistry studies are detailed. The concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses is detailed in this volume; both features are essential for the survival of an invading tumor cell. Defining the minimal adhesion receptors preserved on cancer cells during tumor progression will define the metastatic adhesion signature. Understanding the metastatic adhesion signature will reveal vulnerabilities that could be exploited for the prevention and/or eradication of the invading cancer cell.
Cathodic Arcs : From Fractal Spots to Energetic Condensation
Cathodic Arcs: From Fractal Spots to Energetic Condensation is the first book in over a decade dedicated to the physics and technology of cathodic arcs. It includes a detailed account of arc history, a textbook-like introduction to cathode phenomena, and some basic physics of expanding plasmas; it deals with the infamous macroparticle issue and describes a host of practical plasma filter solutions. In contrast to previous books on cathodic arcs, the focus is on the relation of arc plasmas and their properties to surface modification and thin film deposition. The book contains sections on basic plasma physics and thin film materials science. It also deals with practical issues of coatings such as stress control and the often-underrated issue of the coating’s color. By stressing the fractal nature of cathode spots, the theme of fluctuations can be found throughout the book: fluctuations affect all plasma properties and thereby have consequences for plasma-based surface modifications and film growth.
Biology and mechanics of blood flows ; Part I : Biology
Biology and Mechanics of Blood Flows presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. Part I of this two-volume sequence, Biology, addresses the nanoscopic and microscopic scales. The nanoscale corresponds to the scale of biochemical reaction cascades involved in cell adaptation to mechanical stresses among other stimuli. The microscale is the scale of stress-induced tissue remodeling associated with acute or chronic loadings. The cardiovascular system, like any physiological system, has a complicated three-dimensional structure and composition. Its time dependent behavior is regulated, and this complex system has many components.
Bioceramic Materials in Clinical Endodontics
This book focuses on hydraulic calcium silicate-based materials available in clinical dentistry, used as pulp capping materials, root canal sealers, root-end fillers, or root repair materials and which offer improved properties and easier clinical application compared with the original mineral trioxide aggregate. The book introduces the current classification of bioceramic materials and explains their characterization and their physicochemical and biological properties.
Big Data in Energy Economics
Combines energy economics and big data modeling analysis in energy conversion and management and comprehensively introduces the relevant theories, key technologies, and application examples of the smart energy economy. With the help of time series big data modeling results, energy economy managers develop reasonable and feasible pricing mechanisms of electricity price and improve the absorption capacity of the power grid. In addition, they also carry out scientific power equipment scheduling and cost–benefit analysis according to the results of data mining, so as to avoid the loss caused by accidental damage of equipment. Energy users adjust their power consumption behavior through the modeling results provided and achieve the effect of energy saving and emission reduction while reasonably reducing the electricity expenditure.
Autonomy oriented computing : From problem solving to complex systems modeling
Autonomy Oriented Computing explores the important theoretical and practical issues in AOC, by analyzing methodologies and presenting experimental case studies. The book serves as a comprehensive reference source for researchers, scientists, engineers, and professionals in all fields concerned with this promising new development in computer science. It can also be used as a main or supplementary text in graduate and undergraduate programs across a broad range of computer-related disciplines, including Robotics and Automation, Amorphous Computing, Image Processing and Computer Vision, Programming Paradigms, Computational Biology, and many others. The first part of the book, Fundamentals, describes the basic concepts and characteristics of an AOC system, and then it enumerates the critical design and engineering issues faced in AOC system development. The second part of the book, AOC in Depth, provides a detailed analysis of methodologies and case studies to evaluate the use of AOC in problem solving and complex system modeling. The final chapter reviews the essential features of the AOC paradigm and outlines a number of possibilities for future research and development.
Autonomous intelligent systems : Agents and data mining ; International workshop, AIS-ADM 2005
This book constitutes the refereed proceedings of the International Workshop on Autonomous Intelligent Systems: Agents and Data Mining, AIS-ADM 2005, held in St. Petersburg, Russia in June 2005. The 17 revised full papers presented together with 5 invited papers and the abstract of an invited talk were carefully reviewed and selected from 29 submissions. The papers are organized in topical sections on agent-based data mining issues, ontologies and Web mining, and applications and case studies.
Atlas of confocal laser scanning in-vivo microscopy in ophthalmology : principles and applications in diagnostic and therapeutic
Confocal microscopy with laser scanning technology yields in-vivo images of ocular and ocular adnexal surfaces that are so brilliant that they rival histology in terms of quality.This unique atlas and textbook demonstrates normal in-vivo anatomy of the cornea, limbus and conjunctiva, quantifies various cellular structures using cell-density calculations and establishes correlations between novel optical sections of various diseases of the ocular surface and clinical findings.
Asymmetric organo-metal catalysis : Concepts, principles, and applications
In Asymmetric Organo-Metal Catalysis: Concepts, Principles, and Applications, accomplished chemist Liu-Zhu Gong delivers a comprehensive discussion of how to design efficient organo/metal combined catalyst systems, new cooperatively catalyzed asymmetric reactions, relay catalytic cascades, and multicomponent reactions. The distinguished author covers critical topics, like the combined catalysis of chiral phase transfer catalysts, enamine, iminium, nucleophilic Lewis base, or Bronsted acids with metal complexes, while also covering the cooperative catalysis of photocatalysts and organocatalysts.
Assessing Recent Soil Erosion Rates through the Use of Beryllium-7 (Be-7)
This book is the first comprehensive guideline for the beryllium-7 (Be-7) technique that can be applied to evaluate short-term patterns and budgets of soil redistribution in agricultural landscapes. While covering the fundamental and basic concepts of the approach, this book distinguishes itself from other publications by offering step-by-step instructions on how to use this isotopic technique effectively. It covers experimental design considerations and clear instruction is given on data processing. As accurate laboratory measurement is crucial to ensure successful use of Be-7 to investigate soil erosion, a full chapter is devoted to its specific determination by gamma spectrometry.
Asias debt capital markets : Prospects and strategies for development
The book has three parts. Part I describes the characteristics and historical origins of these markets. Part II examines the contemporary bond markets and shows how they contribute to general welfare, describes the relationship between the banking sector and capital markets, and assesses prospects for reform in Asia's governmental and corporate debt markets. Part III explains the micro-level impediments and obstacles that must be the first targets of any reform efforts, provides an appraisal of attempts at regional cooperation to stimulate structural reform, and lastly contributes proposals to accelerate the growth and reach of bond markets throughout Asia.
Artificial intelligence hardware design : Challenges and solutions
Learn foundational and advanced topics in Neural Processing Unit design with real-world examples from leading voices in the field. A thorough introduction to neural networks and neural network development history, as well as Convolutional Neural Network (CNN) models Explorations of various parallel architectures, including the Intel CPU, Nvidia GPU, Google TPU, and Microsoft NPU, emphasizing hardware and software integration for performance improvement Discussions of streaming graph for massive parallel computation with the Blaize GSP and Graphcore IPU An examination of how to optimize convolution with UCLA Deep Convolutional Neural Network accelerator filter decomposition
Applied Physiology in Intensive Care Medicine
A series of short papers published in Intensive Care Medicine since 2002 under the heading Physiologic Notes attempts to capture the essence of the physiologic perspectives that underpin both our understanding of disease and response to therapy. Tis present volume combines the complete list of these Physiologic Notes up until July 2006 with the ass o ciated review articles over the same in terval that also address edthese central issues.
Antiviral drug discovery and development
Summarizes antiviral drug design and discovery approaches Provides the latest update in the field of antiviral therapeutics Includes antiviral research of coronaviruses
Angiogenesis : An integrative approach from science to medicine
It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor.
Analysis, design and construction of foundations
Outlines methods for analysis and design the construction of shallow and deep foundations with particular reference to case studies in Hong Kong and China, as well as a discussion of methods used in other countries. It introduces the main approaches used by geotechnical and structural engineers, and the precautions required for planning and designing foundation structures. Some computational methods and computer programs are reviewed to provide tools for performing more realistic analysis of foundation systems.
An Introduction to Meshfree Methods and Their Programming
This book aims to present meshfree methods in a friendly and straightforward manner, so that beginners can very easily understand, comprehend, program, implement, apply and extend these methods. It provides first the fundamentals of numerical analysis that are particularly important to meshfree methods. Typical meshfree methods, such as EFG, RPIM, MLPG, LRPIM, MWS and collocation methods are then introduced systematically detailing the formulation, numerical implementation and programming. Many well-tested computer source codes developed by the authors are attached with useful descriptions. The application of the codes can be readily performed using the examples with input and output files given in table form. These codes consist of most of the basic meshfree techniques, and can be easily extended to other variations of more complex procedures of meshfree methods. Readers can easily practice with the codes provided to effective learn and comprehend the basics of meshfree methods.
An Introduction to Infinite-Dimensional Analysis
In this revised and extended version of his course notes from a 1-year course at Scuola Normale Superiore, Pisa, the author provides an introduction – for an audience knowing basic functional analysis and measure theory but not necessarily probability theory – to analysis in a separable Hilbert space of infinite dimension.Starting from the definition of Gaussian measures in Hilbert spaces, concepts such as the Cameron-Martin formula, Brownian motion and Wiener integral are introduced in a simple way. These concepts are then used to illustrate some basic stochastic dynamical systems (including dissipative nonlinearities) and Markov semi-groups, paying special attention to their long-time behavior: ergodicity, invariant measure. Here fundamental results like the theorems of Prokhorov, Von Neumann, Krylov-Bogoliubov and Khas'minski are proved. The last chapter is devoted to gradient systems and their asymptotic behavior.
Ageing and the Glass Transition
Understanding cooperative phenomena far from equilibrium is one of fascinating challenges of present-day many-body physics. Glassy behaviour and the physical ageing process of such materials are paradigmatic examples. The present volume, primarily intended as introduction and reference for postgraduate students and nonspecialist researchers from related fields, collects six extensive lectures addressing selected experimental and theoretical issues in the field of glassy systems.
