الصفحة 7
الصفحة 7
Mechanisms of Lymphocyte Activation and Immune Regulation X ; Innate Immunity
Mechanisms of Lymphocyte Activation and Immune Regulation X: Innate Immunity is the proceedings of the Xth International Conference on Mechanisms of Lymphocyte Activation and Immune Regulation: Innate Immunity, held February 6-8, 2004 in Newport Beach, California. It is the tenth volume of its kind to appear in the series Advances in Experimental Medicine and Biology. Topics include toll receptors, dendritic cells, NK cells, and complement receptors.
Mechanisms of Insulin Action
More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. In addition, between 17 and 40 million people have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities referred to variably as the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of these disorders, a central component of the pathophysiology is insulin resistance, i.e., reduced responsiveness to insulin in tissues such as muscle, fat and liver. Insulin resistance is also closely linked to other common health problems, including obesity, polycystic ovarian disease, hyperlipidemia, hypertension, and atherosclerosis. In this book, we will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists.
Mechanisms of Angiogenesis
Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.
Mechanics and Physics of Fracture : Multiscale Modeling of the Failure Behavior of Solids
Provides a comprehensive understanding of the macroscopic failure behavior of solids from the description of the microscopic failure processes and their coupling with the microstructure. Several fundamental questions were addressed: the relation between the microstructural features of materials and their fracture properties and crack trajectories; the role of damage mechanisms and non-linear deformations near the crack tip on the failure behavior of solids; and finally the role of dynamic inertial effects during fast fracture was more briefly evoked.
Meaning in Action : Constructions, Narratives, and Representations
are far from genetically ? xing what behavioral preferences they may possess. Instead, learning mechanisms offer a ? exible way of attaining locally important cultural knowledge within temporal windows of opportunity as has been convi- ingly shown by research in language and culture attainment. Similar mechanisms are likely to exist for other social capacities, such as mate preferences, for example. It is this role of our biological inheritance that social science must appreciate in order to furnish a more complete understanding of human behavior. Within the natural range of variation of capacities and armed with biologically conditioned learning mechanisms we live out lives of meaning – in which we hold some things to be real, rational, valuable or morally right, and others not. It is this world of meaning in which we ? nd love and hate, struggles for justice, power, and money, and the dramas that lend to life both its depth and passion.
Isomorphisms Between H¹ Spaces
Presents a thorough and self-contained presentation of H¹ and its known isomorphic invariants, such as the uniform approximation property, the dimension conjecture, and dichotomies for the complemented subspaces. The necessary background is developed from scratch. This includes a detailed discussion of the Haar system, together with the operators that can be built from it (averaging projections, rearrangement operators, paraproducts, Calderon-Zygmund singular integrals). Complete proofs are given for the classical martingale inequalities of C. Fefferman, Burkholder, and Khinchine-Kahane, and for large deviation inequalities. Complex interpolation, analytic families of operators, and the Calderon product of Banach lattices are treated in the context of H^p spaces. Througout the book, special attention is given to the combinatorial methods developed in the field, particularly J. Bourgain's proof of the dimension conjecture, L. Carleson's biorthogonal system in H¹, T. Figiel's integral representation, W.B. Johnson's factorization of operators, B. Maurey's isomorphism, and P. Jones' proof of the uniform approximation property. An entire chapter is devoted to the study of combinatorics of colored dyadic intervals."
Iron Nutrition in Plants and Rhizospheric Microorganisms
This book uses an interdisciplinary approach to provide a comprehensive review on the status of iron nutrition in plants. International scientists discuss research on acquisition of iron by strategy I and strategy II plants. These reviews summarize a variety of plant species and include both laboratory and field observations. Topics covered in this book include: plants as a source of iron for animals and humans, iron translocation in the plants, iron-stimulated activities that influence crop yield and fruit tree productivity, iron uptake by plants as influenced by microorganisms (i.e. free living soil microorganisms, symbiotic nitrogen-fixing and pathogenic bacteria), the role of plant hormones in iron transport, iron-metal competition in phytoremediation, root zone activities involving interactions between minerals and organic matter, the role of microbial siderophores in rhizospheric iron cycling, iron storage as phytoferritin, proteomic and metabolic studies associated with iron stress response, methods for studying iron metabolism including stable isotopes, and the correction of iron deficiency through the use of synthetic or natural chelates.
Introduction to Physics and Chemistry of Combustion : Explosion, Flame, Detonation
Most of the material covered in this book deals with the fundamentals of chemistry and physics of key processes and fundamental mechanisms for various combustion and combustion-related phenomena in gaseous combustible mixture. It provides the reader with basic knowledge of burning processes and mechanisms of reaction wave propagation
Introduction to Ion Beam Biotechnology
It presents treatment of modern ion beam biotechnology and with respect to applications of ion beam bombardment of living cellular material in the hybrid field of ion beam physics and biology.Key Topics include: – Ion beam formation – Ion implantation fundamentals – Interaction between energetic ions and biological organisms – Reaction processes of ion implanted biological small molecules – Damage and repair of ion-bombarded DNA – Cell damage due to ion bombardment – Biological effects of ion implantation – Fundamentals of ion-bombardment-induced genetic variation – Ion beam mutation breeding of crops – Ion beam mutation breeding of microbes – Ion beam induced gene transfer – Ion beam induced synthesis of organic molecules – Single-ion bombardment mutation of cells
Introduction to Epigenetics
This textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants.
Intrinsic Molecular Mobility and Toughness of Polymers II
The series Advances in Polymer Science presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and material science . the authors highlight the dual role of segmental jumps and displacements to improve toughness by energy dissipation and relaxation of critical stresses and to influence without exception all damage mechanisms. The dynamic response of a chain segment to thermo-mechanical excitation strongly depends on in-chain cooperative motions. By combining the powerful techniques of multi-dimensional Nuclear Magnetic Resonance and of dielectric and dynamic mechanical analysis Monnerie,
Intrinsic Molecular Mobility and Toughness of Polymers I
The series Advances in Polymer Science presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and material science . the authors highlight the dual role of segmental jumps and displacements to improve toughness by energy dissipation and relaxation of critical stresses and to influence without exception all damage mechanisms. The dynamic response of a chain segment to thermo-mechanical excitation strongly depends on in-chain cooperative motions. By combining the powerful techniques of multi-dimensional Nuclear Magnetic Resonance and of dielectric and dynamic mechanical analysis Monnerie,
Intracellular Mechanisms for Neuritogenesis
This book present in novel, distinct, but highly related aspects of the intracellular mechanisms required for the formation of a functional neurite, which include cytoskeletal organization, membrane traffic, and signal transduction.
Intestinal Microorganisms of Termites and Other Invertebrates
Soil microorganisms play a major role in the degradation and recycling of organic material. Microbes are involved in the food web and strongly contribute to soil fertility. In the past, attention was mainly directed towards free-living or particle-bound microorganisms, while the role of intestinal microbes of soil animals has been neglected. For the first time, "Intestinal Microorganisms of Termites and Other Invertebrates" focuses on the microbes in gut systems of soil animals. It starts with a profound overview of the biology of soil invertebrates. A major part deals with the gut microbiota of termites, the best investigated gut system of invertebrates. Termites are important soil processors in tropical and subtropical regions. Insight is given into the intestinal microbiota of further relevant primary litter decomposers, such as earthworms, springtails, millipeds, and woodlice. Novel techniques for studying intestinal microbes complete the volume.
Internet of things, artificial intelligence and blockchain technology
Explores the concepts and techniques of IoT, AI, and blockchain. Also discussed is the possibility of applying blockchain for providing security in various domains. The specific highlight of this book is focused on the application of integrated technologies in enhancing data models, better insights and discovery, intelligent predictions, smarter finance, smart retail, global verification, transparent governance, and innovative audit systems. Explains how blockchain can significantly increase data privacy and security while boosting accuracy and integrity in IoT generated data and AI processed information; Gives insight into blockchain’s numerous potential applications, starting with recent technologies that give users control over sharing and privacy; Shows readers how to employ blockchain in IoT and AI, helping them to understand what they can and cannot do with blockchain.
International reflections on the Netherlands didactics of mathematics : Visions on and experiences with realistic mathematics education
This book, inspired by the ICME 13 Thematic Afternoon on “European Didactic Traditions”, takes readers on a journey with mathematics education researchers, developers and educators in eighteen countries, who reflect on their experiences with Realistic Mathematics Education (RME), the domain-specific instruction theory for mathematics education developed in the Netherlands since the late 1960s. Authors from outside the Netherlands discuss what aspects of RME appeal to them, their criticisms of RME and their past and current RME-based projects.
Internal medicine for dental treatments: patients with medical diseases
Illustrates the precautions for dental treatment with patients with medical diseases and presents the correlation and relationship between oral symptoms and systemic diseases. It is organized into two parts; the first part is symptomatology presenting the description of some symptoms as general remarks. Then comes the part explaining the diseases, which describe the associations between each medical disease and the oral conditions. Chapters provide intraoral figures and in-depth information to help readers understand the symptoms, mechanisms, and responses, the comorbidities, and medications.
Internal friction in metallic materials : A handbook
This book is a unique collection of experimental data in the field of internal friction, anelastic relaxation, and damping properties of metallic materials. It reviews virtually all anelastic relaxation phenomena ever published, and also most of the internal friction effects based on other types of dissipation of mechanical (elastic) energy. Furthermore, the reader is also supplied with explanations of the basic physical mechanisms of internal friction, a summary of typical effects for different groups of metals, and more than 2000 references to original papers.
Intermittent fasting
The potential benefits of intermittent fasting are not limited to weight loss and weight management. Recent studies have shed light on its role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize energy metabolism and bolster cellular protection. By reprogramming metabolic and stress resistance pathways, intermittent fasting has the possible ability to increase longevity and reduce aging. Studies on animals have given promising result that show how intermittent fasting help prevent and treat diseases like diabetes, cancers, heart disease and neurodegeneration. Major mechanisms hypothesized to link fasting regimens with human health: circadian biology and the gastrointestinal microbiota.
Interior design masters
Contains 300 biographical entries of people who have significantly impacted design. They are the people, historical and contemporary, that students and practitioners should know. Coverage starts in the late-Renaissance, with a focus on the twentieth and twenty-first centuries. The book has five sections, with the entries alphabetical in each, so it can serve as a history text book and a reference guide. Theseventeeth- andeighteenth-century section covers figures from Thomas Chippendale to Horace Walpole. Thenineteenth-century section includes William Morris and Candace Wheeler. The earlytwentieth-century section presents modernisms design heroes, including Marcel Breuer, Eileen Gray, and Gilbert Rohde. The post-World War II designers range from Madeleine Castaing to Raymond Loewy. The final contemporary section includes Ron Arad and the Bouroullec brothers. These are the canonical figures who belong to any design history.
