الصفحة 7
الصفحة 7
Life - As a Matter of Fat : The Emerging Science of Lipidomics
Lipids are as important for life as proteins, sugars, and genes. The present book gives a multi-disciplinary perspective on the physics of life and the particular role played by lipids and the lipid-bilayer component of cell membranes. The book is aimed at undergraduate students and young research workers within physics, chemistry, biochemistry, molecular biology, nutrition, as well as pharmaceutical and biomedical sciences. The emphasis is on the physical properties of lipid membranes seen as soft and molecularly structured interfaces. By combining and synthesizing insights obtained from a variety of recent studies, an attempt is made to clarify what membrane structure is and how it can be quantitatively described. Furthermore, it is shown how biological function mediated by membranes is controlled by lipid membrane structure and organization on length scales ranging from the size of the individual molecule, across molecular assemblies of proteins and lipid domains in the range of nanometers, to the size of whole cells. Applications of lipids in nano-technology and biomedicine are also described.
Le dépistage du cancer bronchique : De l'espoir à la réalité = Lung cancer screening : From hope to reality
An ambitious program has been launched in terms of research, diagnosis, prevention, and screening. Among cancers, the leading cause of cancer death is lung cancer. This disease, so closely linked to behavioral habits, both focuses and encapsulates the problem. Despite constant progress in treatment, the prognosis remains bleak, explaining the fatalistic impression left by the last decade. While significant efforts were being made in screening for other cancer sites, lung cancer remained in the shadows, with studies showing limited effectiveness in this approach. The advent of spiral CT scanning has revolutionized the field, giving rise to new hope alongside anti-smoking campaigns. Autofluorescence endoscopy, by enabling the diagnosis of pre-neoplastic lesions, completes an arsenal that finally allows us to envision an effective, combined strategy. This book brings together all the elements relating to screening and early diagnosis. The road from hope to reality is long, but we must acknowledge that, for the first time, we know it exists.
Late Effects of Cancer Treatment on Normal Tissues
Based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I conference held in 2006. It addresses a number of critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention.
La TC multidetettore nella diagnostica cardiovascolare : Opera multimediale di aggiornamento e formazione sulla cardio-TC = Multidetector CT in cardiovascular diagnostics : A multimedia training and refresher course on cardiac CT
Con il patrocinio della Società Italiana di Radiologia Medica e il supporto di GE Healthcare, Springer-Verlag Italia presenta un'opera multimediale di aggiornamento e formazione dedicata alla TC cardiovascolare. Curata da Rossella Fattori del Dipartimento Clinico di Scienze Radiologiche e Istocitopatologiche del Policlinico S. Orsola di Bologna e con il contributo dei più autorevoli esperti italiani, l'opera è articolata in 4 monografie che trattano in maniera completa gli ambiti applicativi della cardio-TC, un CD-ROM didattico e interattivo basato su casi clinici e un DVD che consentirà di apprendere preziose informazioni attraverso filmati di refertazione.
Kristian Birkeland : The First Space Scientist
PREFACEThisscientific biography of Kristian Birkeland (1867–1917) was written to bring the story ofa Norwegian national hero to the attention ofthe English-speaking world. Birkeland’sheroic stature was established not on a field of military battle,but in the bitter cold of the Artic wilderness ashe sought to answer basic questions abouthow the Sun controlled northern lights andmag-netic storms. He was also afather of Norsk Hydro one ofNorway’s largest industries. Birkel and died before reaching the age of 50.Because Birkel and never kept adiary, documented information about his family and private life is sparse. Before he died, Olaf Devik, the last of Birke-ffland’s close friends, gave along interview and graciously transferred his personal archive to A.E. Birkeland’s 82 scientific papers and three book-length publications map the progress of his investigations. addressed this book questions that had vexed European scientists for centuries. Why do the northern lights appear overhead when the Earth’s magnetic field is disturbed? How are magnetic storms connected to disturbances on the Sun? To answer these questions Birkeland interpreted his advance laboratory simulations and daring campaigns in the Arctic wilderness in the light of Maxwell’s newly discovered laws of electricity and magnetism. Birkeland’s ideas were dismissed for decades, only to be vindicated when satellites could fly above the Earth’s atmosphere.
Keto diet
It‘s a low-carb, high-fat eating plan. Most of what you eat is fat, whether that‘s unsaturated fats like nuts, seeds, and avocados, or saturated fats like butter and coconut oil. About 20%-30% of your diet is protein, either lean (like chicken breast) or fatty (like bacon). You‘re supposed to strictly limit carbs, even those that are typically considered healthy, such as beans, whole grains, milk, and many types of fruits and vegetables...
Jaundice
• Physiologic Anatomy Liver • HEMOGLOBIN FORMATION • Formation and Fate of Urobilinogen • Jaundice—Excess Bilirubin in the Extracellular Fluid • Hemolytic Jaundice Is Caused by Hemolysis of Red Blood Cells • Obstructive Jaundice Is Caused by Obstruction of Bile Ducts or Liver Disease • Diagnostic Differences Between Hemolytic and Obstructive Jaundice • Infant jaundice • Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate-glucuronosyltransferase gene • Acute bilirubin encephalopathy • Hepatitis (A + B + C) • Immune system abnormaly • Jaundice in the adult
Jacob Mincer : A Pioneer of Modern Labor Economics
This volume contains essays by or about Jacob Mincer who, along with Gary Becker, is a founding father of modern empirical labor economics. His methodology analyzes the economics of the working world, and his human capital model is a fundamental tool in empirical economics.
IUTAM Symposium on Mechanics and Reliability of Actuating Materials ; Proceedings of the IUTAM Symposium held in Beijing, China, 1-3 September, 2004
The general assembly of IUTAM approved in August, 2002 at Cambridge University, UK, a proposal to hold an IUTAM symposium to summarize the relevant research findings. The main themes of the symposium are: (i) the constitutive relations of actuating materials that couple mechanical, electrical, thermal and magnetic properties, as well as incorporate phase transformation and domain switch; (ii) the physical mechanisms of deformation, damage, and fatigue crack growth of actuating materials; (iii) the development of failure-resilient approaches that base on the macro-, meso-, and micro-mechanics analyses; (iv) the investigation of microstructural evolution, stability of phase transformation, and size effects of ferroelectric ceramics, shape memory alloys, actuating polymers, and bio-actuating materials.
IUTAM symposium on elastohydrodynamics and micro-elastohydrodynamics ; Proceedings of the IUTAM Symposium held in Cardiff, UK, 1-3 September 2004
This volume contains the proceedings of the IUTAM Symposium on Ela- ohydrodynamics and Microelastohydrodynamics held in Cardiff from 1st to 3rd September 2004. The symposium focused on theoretical, experimental and computational issues in elastohydrodynamic lubrication (EHL) both in relation to smooth surfaces and in situations where the?lm is of the same order or th- ner than the surface roughness (micro-EHL).
Comparative Perspectives on Work-Life Balance and Gender Equality : Fathers on Leave Alone
This book portrays men’s experiences of home alone leave and how it affects their lives and family gender roles in different policy contexts and explores how this unique parental leave design is implemented in these contrasting policy regimes. The book brings together three major theoretical strands: social policy, in particular the literature on comparative leave policy developments; family and gender studies, in particular the analysis of gendered divisions of work and care and recent shifts in parenting and work-family balance; critical studies of men and masculinities, with a specific focus on fathers and fathering in contemporary western societies and life-courses. Drawing on empirical data from in-depth interviews with fathers across eleven countries, the book shows that the experiences and social processes associated with fathers’ home alone leave involve a diversity of trends, revealing both innovations and absence of change, including pluralization as well as the constraining influence of policy, gender, and social context.
Climate change : Environment and history of the Near East
When the ?rst edition of this book was published in 2004, the following year 2005 has happened to have been the warmest year since 1880, when the ?rst reliable worldwide instrumental records came into existance. Claiming no li- age between the publication of our book and the temperature record, yet this record demonstrates the trend of increase in the global surface temperatures during thepast20years,reinforcedbyevidenceofriseofatmosphere’sand oceans’ temperatures, and increased melting of ice and snow in the arctic and antarctic regions as well as on mountain tops. All these observations are par- leled by the increase in the quantity of heat trapping gases in the atmosphere, causing most probably, the global greenhouse effect. In order to try and predict, what might be the impact of this effect on the on the natural and human environments of the Near East, (Figs. 1–1d) the authors adopted the saying that the past is the key for the future. The practical conclusion of this principle says that the acquiring knowledge of the impact of past climate changes on the nature and human societies, may allow conclusions with regard to future possible impact of climate changes. By correlating proxy data of all types, paleo-sea and lake levels, paleo-hydrology, pollen pro?les, environmental isotopes as well as archaeological and historical documents, the authors tried to collect as much as possible of this knowledge.
Choices in Palliative Care : Issues in Health Care Delivery
Keeping up with these statistics means improving on traditional concepts of palliative care to meet growing demands. Choices in Palliative Care brings together 31 leading experts to spotlight core issues in the field, identify ways PC can fill gaps in current care systems, and demonstrate state-of-the-art care that is both cost-effective and clinically appropriate. This far-sighted volume redefines palliative care as interdisciplinary and integrative, providing liaisons between patients, families, and doctors; minimizing loved ones’ care burdens; bridging acute and long-term care to respond to clients’ evolving needs; adaptable to non-fatal (and possibly curable) chronic illnesses.
Cerebral Hemorrhage
Cerebral hemorrhage is a common and often fatal subtype of stroke. while in the past it has received relatively little attention compared to ischemic stroke, there have been major advances in our understanding of this devastating form of stroke. The papers by world experts cover the field from molecular biology to clinical trials.
Cancer Neurology in Clinical Practice : Neurologic Complications of Cancer and Its Treatment
This book gives a comprehensive analysis of how cancer affects the nervous system, It encompasses the experience of senior physicians actively engaged in neuro-oncology centers throughout the world.
Cancer drug safety and public health policy : A changing landscape
Description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. Opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention – these fines are playing an important role in changing the landscape for pharmaceutical safety.
Bulk Metallic Glasses : An Overview
Bulk Metallic Glasses explores an emerging field of materials known as bulk metallic glasses. It summarizes the rapid development of these materials over the last decade and includes documentation on diverse applications of bulk metallic glasses; from structural applications to microcomponents. Some of the applications covered are pressure sensors, microgears for motors, magnetic cores for power supplies, and nano-dies for replacing next generation DVDs. The chapters cover current theories and recent research including an atomistic theory of local topological fluctuations, atomistic simulations, and unique microstructures of these amorphous materials. Other topics include glass formation, glass forming ability, and the underlying mechanisms and physical insights of these criteria. The mechanical deformation of bulk metallic glasses, fatigue, fracture, and corrosion behaviors of these materials are also reviewed.
Branded content : The fateful merging of media and marketing
This is a critical study of the changing relationship between media and marketing communications in the digital age. It examines the growth of content funded by brands, including brands’ own media, native advertising, and the integration of branded content across film, television, journalism and publishing, online, mobile, and social media.
Brain development in Drosophila melanogaster
The central nervous system (CNS) represents the organ with the highest structural and functional complexity. Accordingly, uncovering the mechanisms leading to cell diversity, patterning and connectivity in the CNS is one of the major challenges in developmental biology. The developing CNS of the fruitfly Drosophila melanogaster is an ideal model system to study these processes. Several principle questions regarding neurogenesis (like stem cell formation, cell fate specification, axonal pathfinding) have been addressed in Drosophila by focusing on the relatively simply structured truncal parts of the nervous system. This book provides an overview of some major facets of recent research on Drosophila brain development.
Biomarkers as targeted herbal drug discovery : A pharmacological approach to nanomedicines
Looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits. Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid. Reviews the literature on inflammatory biomarkers in the treatment of diseases Looks at the development of herbal drug discovery based on biomarkers Explores emerging concepts of nanomedicines for herbal drug delivery Takes an interdisciplinary approach, with application to disciplines related to medical, pharmaceutical, biotechnological, Ayurvedic, Unani and biomedical engineering fields
