الصفحة 7
الصفحة 7
Ion channels as targets in drug discovery
Built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery. Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience
Invexity and Optimization
Invexity and Optimization presents results on invex function and their properties in smooth and nonsmooth cases, pseudolinearity and eta-pseudolinearity. Results on optimality and duality for a nonlinear scalar programming problem are presented, second and higher order duality results are given for a nonlinear scalar programming problem, and saddle point results are also presented. Invexity in multiobjective programming problems and Kuhn-Tucker optimality conditions are given for a multiobjecive programming problem, Wolfe and Mond-Weir type dual models are given for a multiobjective programming problem and usual duality results are presented in presence of invex functions. Continuous-time multiobjective problems are also discussed. Quadratic and fractional programming problems are given for invex functions. Symmetric duality results are also given for scalar and vector cases.
Invasive forest insects, introduced forest trees, and altered ecosystems : Ecological pest management in global forests of a changing world
Demand for timber and fibre continues to grow and is being met by increased reliance on plantation forestry. Many of the plantations that are being grown around the globe are non-native species that have characteristics of rapid growth and good commercial qualities. In some cases, the high rates of production are a result of the absence of native herbivore and diseases. This limited pest status is threatened as pest species move around the globe. At the same time there is concern about threats of these non-native plantation species on native communities and the impact of changing climates on forest productivity. This volume explores many of these issues for the first time.
Intrusion Detection Systems
Sٍheds new light on defense alert systems against computer and network intrusions. It also covers integrating intrusion alerts within security policy framework for intrusion response, related case studies and much more. This volume is presented in an easy-to-follow style while including a rigorous treatment of the issues, solutions, and technologies tied to the field.
Intrusion Detection and Correlation : Challenges and Solutions
Challenges and Solutions presents intrusion detection systems (IDSs) and addresses the problem of managing and correlating the alerts produced. This volume discusses the role of intrusion detection in the realm of network security with comparisons to traditional methods such as firewalls and cryptography. Challenges and Solutions analyzes the challenges in interpreting and combining (i.e., correlating) alerts produced by these systems. In addition, existing academic and commercial systems are classified; their advantage and shortcomings are presented, especially in the case of deployment in large, real-world sites. Challenges and Solutions is designed for a professional audience composed of researchers and practitioners in industry. This book is also suitable for graduate-level students in computer science.
Introductory Lectures on Fluctuations of Lévy Processes with Applications
Lévy processes are the natural continuous-time analogue of random walks and form a rich class of stochastic processes around which a robust mathematical theory exists. Their mathematical significance is justified by their application in many areas of classical and modern stochastic models including storage models, renewal processes, insurance risk models, optimal stopping problems, mathematical finance and continuous-state branching processes.The book aims to be mathematically rigorous while still providing an intuitive feel for underlying principles. The results and applications often focus on the case of Lévy processes with jumps in only one direction.
Introduction to Engineering Statistics and Six Sigma : Statistical Quality Control and Design of Experiments and Systems
Introduction to Engineering Statistics and Six Sigma contains precise descriptions of all of the many related methods and details case studies showing how they have been applied in engineering and business to achieve millions of dollars of savings. Specifically, the methods introduced include many kinds of design of experiments (DOE) and statistical process control (SPC) charting approaches, failure mode and effects analysis (FMEA), formal optimization, genetic algorithms, gauge reproducibility and repeatability (R&R), linear regression, neural nets, simulation, quality function deployment (QFD) and Taguchi methods. A major goal of the book is to help the reader to determine exactly which methods to apply in which situation and to predict how and when the methods might not be effective.
Introduction to Data Envelopment Analysis and Its Uses : With DEA-Solver Software and References
Recent years have seen a great variety of applications of DEA (Data Envelopment Analysis) for use in evaluating the performances of many different kinds of entities engaged in many different activities in many different contexts in many different countries. One reason is that DEA has opened up possibilities for use in cases which have been resistant to other approaches because of the complex (often unknown) nature of the relations between multiple inputs and multiple outputs involved in many of these activities (which are often reported in non-commeasurable units). It provide a systematic introduction to DEA and its uses as a multifaceted tool for evaluating problems in a variety of contexts.
Introduction to Classical Geometries
This book follows Felix Klein’s proposal of studying geometry by looking at the symmetries (or rigid motions) of the space in question. In this way the classical geometries are studied: Euclidean, affine, elliptic, projective and hyperbolic. For simplicity the focus is on the two-dimensional case, which is already rich enough, though some aspects of the 3- or n-dimensional geometries are included. Once plane geometry is well understood, it is much easier to go into higher dimensions.
Introduction to Applied Optimization
This text presents a multi-disciplined view of optimization, providing students and researchers with a thorough examination of algorithms, methods, and tools from diverse areas of optimization without introducing excessive theoretical detail. This second edition includes additional topics, including global optimization and a real-world case study using important concepts from each chapter.
Intraoperative complications in dental implants
Examines intraoperative complications associated with dental implant surgery, a critical and under-researched area in dental practice. The study focuses on identifying the most common intraoperative complications, their potential causes, and dental surgeons' strategies to manage these issues effectively. Through a comprehensive review of recent literature and a series of case studies, this research identifies specific risk factors and procedural challenges that lead to complications during the surgical phase of implant placement. Additionally, the thesis proposes a set of guidelines aimed at minimizing the occurrence of these complications.
Internet of things, artificial intelligence and blockchain technology
Explores the concepts and techniques of IoT, AI, and blockchain. Also discussed is the possibility of applying blockchain for providing security in various domains. The specific highlight of this book is focused on the application of integrated technologies in enhancing data models, better insights and discovery, intelligent predictions, smarter finance, smart retail, global verification, transparent governance, and innovative audit systems. Explains how blockchain can significantly increase data privacy and security while boosting accuracy and integrity in IoT generated data and AI processed information; Gives insight into blockchain’s numerous potential applications, starting with recent technologies that give users control over sharing and privacy; Shows readers how to employ blockchain in IoT and AI, helping them to understand what they can and cannot do with blockchain.
Internet of things from hype to reality : The road to digitization
Presents updated material on its core content: an end-to-end IoT architecture that is comprised of devices, network, compute, storage, platform, applications along with management and security components. As with the second edition, it is organized into six main parts: an IoT reference model; fog computing and the drivers; IoT management and applications; smart services in IoT; IoT standards; and case studies. This edition’s features include overhaul of the IoT Protocols (Chapter 5) to include an expanded treatment of low-power wide area networks including narrow band IoT (NB-IoT) protocol, updated IoT platforms and capabilities (Chapter 7) to include comparison of commercially available platforms (e.g. AWS IoT Platform, Google Cloud IoT Platform, Microsoft Azure IoT Platform, and PTC ThinkWorx), updated security (Chapter 8) to include approaches for securing IoT devices with examples of IoT devices used in security attacks and associated solutions including MUD and DICE, and finally new Appendix B to include six IoT project detailed for students.
Internationalisation of European ICT Activities : Dynamics of Information and Communications Technology
The internationalisation of information and communication technologies has accelerated since the 1990s in Europe and worldwide. Taking a close look at the empirical analysis of competitive trade positions, trends in foreign direct investment and the internationalisation of research and development in ICT brings many new insights about the expansion, innovation and adjustment in the EU’s most dynamic sector. Moreover, the analysis discusses case studies on key players in ICT and suggests major policy conclusions for a field considered fundamental in the context of the EU’s Lisbon Agenda. The theoretical and empirical analysis gives a new and differentiated picture of European ICT where the links between telecommunications dynamics, software innovation and digital services are crucial. Outsourcing, insourcing and offshoring are natural elements of a new digital international division of labour which require reforms in both the EU member countries and at the supranational level.
International Symposium on Fundamentals of Software Engineering ; International Symposium, FSEN 2007, Tehran, Iran, April 17-19, 2007, Proceedings
The present volume contains the post-proceedings of the second IPM Inter- tional Symposium on Fundamentals of Software Engineering (FSEN), Tehran, Iran, April 17–19, 2007. Thissymposium brought together researchers and practitioners working on di?erent aspects of formal methods in software engineering.
International Perspectives in Values-Based Mental Health Practice: Case Studies and Commentaries
This book offers essential information on values-based practice (VBP): the clinical skills involved, teamwork and person-centered care, links between values and evidence, and the importance of partnerships in shared decision-making. Different cultures have different values; for example, partnership in decision-making looks very different, from the highly individualized perspective of European and North American cultures to the collective and family-oriented perspectives common in South East Asia. In turn, African cultures offer yet another perspective, one that falls between these two extremes (called batho pele).
International Luxury Brand Strategy
Gives an overview of how a luxury brand is created through the understanding and application of economic rules and through firms adopting new management models across multiple business dimensions. It also explains the application of theories and models and illustrates specific issues through case studies drawn from international markets such as China and France. The Chinese cases provide unique opportunities and insights into how these new luxury brands were created and how they have benefited from the international market over time.
International leadership : Effecting success across borders in a boundaryless world
From both an academic’s and a practitioner’s perspective, the book focuses on international leaders and their potential to be or become enablers of international success, for and within their respective organizations. The contributions are assigned to three sections, corresponding to the three core challenges of international leadership: Leading international organizations, leading international teams, and (self)leadership with intercultural excellence. An additional section is dedicated to case studies, exhibiting these challenges in practice.
International human rights law : Cases, materials, commentary
Shows how human rights law is used as a tool to address contemporary issues such as counter-terrorism, global poverty and religious diversity. Materials are organised thematically, allowing readers to make comparisons and connections between different legal treaties and systems. Students can also easily assess how human rights are protected under domestic and international laws. The law is placed in context throughout, ensuring full understanding of why laws exist and how they work.
International Economic Policy Coordination
The book investigates the interplay of brand equity and technological assets at the corporate level. In a grounded theory approach it develops a model of how companies in technology intensive industries can improve the appropriation of the returns of their intangible technological assets with the help of brand equity and thus improve their competitiveness. The theoretical discussions are supported by two extensive case studies on Bayer Aspirin and Cisco Systems as well as an extensive econometric analysis. The developed model points out how the strategic relevance of immaterial technological assets and brand equity develop along the technology-life-cycle and indicates how companies can, by an integrated technology and brand equity management, appropriate the returns of their initial technological advantage in the long-run. The implications of the findings for business companies as well as researchers are clearly revealed.
