الصفحة 63
الصفحة 63
Cancer du sein ; Compte rendu du cours supérieur francophone de cancérologie (Saint-Paul-de-V Vence, ence, 18–20 janvier 2007) = Breast cancer : Proceedings of the French-speaking oncology higher course (Saint-Paul-de-V Vence, ence, 18–20 January 2007)
Durant les deux premières journées, toutes les étapes importantes de la prise en charge des cancers du sein ont été déclinées. L’analyse du risque de voir survenir un cancer du sein a été explorée dans sa diversité suivie par les résultats du dépistage organisé et les problèmes du diagnostic. Les traitements locorégionaux ont précédé les traitements adjuvants sans oublier les patientes dont la tumeur présentait une hyperexpression de HER2. Une session a été consacrée aux cancers métastatiques et une autre aux personnes âgées. Comme à chaque cours, nous nous sommes penchés sur l’avenir en dissertant sur la classification moléculaire et sur le passé avec la très belle conférence du Pr David Khayat sur le bilan du Plan Cancer.
Cancer drug safety and public health policy : A changing landscape
Description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. Opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention – these fines are playing an important role in changing the landscape for pharmaceutical safety.
Campbell biology ; 11th ed.
Biology has always been important, although never as important as it is now. There has also never been a more exciting time to make biology you lifelong passion and career. the author team and those who bought this text to life worked to convey to you the challenges, the wonders and the foundations you will need as a practicing biologist specialising in the Southern Hemisphere and in Australia and New Zealand particularly
Calixarenes in the Nanoworld
Calixarenes have been widely exploited in all areas of supramolecular chemistry over the past three decades and many recent developments have concerned their applications in the production of chemical entities with the dimensions of nanometres, as in "nanochemistry".Calixarenes in the Nanoworld Relates calixarenes to nanochemistry – key information for industries engaged in the production of high-tech materials. Provides a timely review of both what is known and the exciting prospects provided by calixarenes, Contains several review articles which define the importance of calixarenes as reagents in nanochemistry.
Calculus of one variable
Aimed at first-year undergraduates in mathematics and the physical sciences, the only prerequisites are basic algebra, coordinate geometry and the beginnings of differentiation as covered in school. The transition from school to university mathematics is addressed by means of a systematic development of important classes of techniques, and through careful discussion of the basic definitions and some of the theorems of calculus, with proofs where appropriate, but stopping short of the rigour involved in Real Analysis.The influence of technology on the learning and teaching of mathematics is recognised through the use of the computer algebra and graphical package MAPLE to illustrate many of the ideas.
Calcium Signalling and Disease : Molecular Pathology of Calcium
This topic is a new entry in the area of cellular calcium signaling: yet, it now spans the entire area, with discoveries that cover both genetic and acquired pathologies, even offering glimpses in the direction of therapy.Cellular calcium homeostasis, and thus calcium signalling, is mainly regulated by membrane intrinsic proteins and calcium sensor proteins. Both classes may be involved in pathological processes that affect both human and animals, ranging from common and important diseases (e.g. migraine, diabetes, epilepsia, manic depression, infertility, various types of cancer, Alzheimer’s disease, muscular dystrophy) to rare genetic conditions (e.g., a number of genetic heart conditions, autoimmune retinopathies, night blindness, hereditary amyloid polyneuropathy, malignant hyperthermia, cerebellar ataxia, atherothrombotic disease).
Calcium in Human Health
Calcium performs diverse biological functions in the human body and is a micronutrient essential to human health and well-being. It serves as a second messenger for nearly every biological process, stabilizes many proteins, and in deficient amounts is associated with a large number diseases and disorders. In Calcium in Human Health, a panel of highly respected researchers and clinical practitioners comprehensively reviews the state of our knowledge concerning this ubiquitous micronutrient, not only demonstrating its importance to human health, but also defining its many complex roles.
Cable stayed bridges, Second ed.
The cable stayed bridge is an elegant, economical and efficient structure. Virtually unknown 40 years ago, these bridges have become increasingly important as their properties have been more fully understood. They have recently proved to be highly cost-effective for short to medium spans. The second edition of this extremely popular book has been updated and enhanced to cover the rapid technological progress in this field. Exceptionally well illustrated, the book examines all aspects of the design of cable stayed bridges.
By-catch Reduction in the Worlds Fisheries
This book comes after several decades of outstanding and successful research that has helped ameliorate some of the most important and controversial fisheries issues in the world – those associated with the unwanted wastage of fish from by-catch and discarding. The 8 chapters encompass contributions from 27 of the world’s leading experts in by-catch reduction. They take the reader through most aspects of the field at a variety of scales and viewpoints. They examine the methodologies used to develop by-catch reduction techniques and provide new avenues for assisting and broadening such work. Case studies are provided that encompass most of the world’s fishing techniques and regions.
Business Models and Corporate Reporting : Defining the Platform to Illustrate Value Creation
This book discusses the role of business models in corporate reporting. It illustrates the evolution of non-financial reporting, the importance of business model reporting, and the main conceptualisations of business models. It also offers a methodological contribution to the assessment of business model reporting. Finally, it discusses the main implication of business model reporting for different categories of subjects and some challenges related to this kind of disclosure
Business financial information secrets : How a business produces and utilizes critical financial information
Business Financial Information Secrets shows you how to produce, understand, and utilize financial information to the greatest effect for your business and the economy at large. This book guides you through the surprisingly clean and simple process of proper accounting and reporting, regardless of your organization’s size or structure. Cash flow and business capital management are covered extensively throughout the book as without a thorough understanding of these all-important concepts, you could be lacking critical information about the lifeline of your business.
Business ethics from the 19th century to today : An economist's view
Combines elements of economic and business history to study business ethics from the nineteenth century to today. It concentrates on American and British business history, delving into issues such as slavery, industrialization, firm behavior and monopolies, and Ponzi schemes. This book draws on the work of economists and historians to highlight the importance of changing technologies, religious beliefs, and cultural attitudes, showing that what is considered ethical differs across time and place.
Business and Professional Ethics
Learn why ethical behavior is so important and how to recognize potential pitfalls that involve much more than memorizing rules. You master the skills to develop a corporate culture of integrity that maintains stakeholder support and enables directors and auditors to complete their jobs. You also learn how to use ethical strategies to make decisions, as this edition examines the latest information on governance scandals, legal liability and professional accounting and auditing issues.
Buildings : Theory and Applications
This book treats Jacques Tits's beautiful theory of buildings, making that theory accessible to readers with minimal background. It includes all the material of the earlier book Buildings by the second-named author, published by Springer-Verlag in 1989, which gave an introduction to buildings from the classical (simplicial) point of view. This new book also includes two other approaches to buildings, which nicely complement the simplicial approach: On the one hand, buildings may be viewed as abstract sets of chambers with a Weyl-group-valued distance function; this point of view has become increasingly important in the theory and applications of buildings. On the other hand, buildings may be viewed as metric spaces. Beginners can still use parts of the new book as a friendly introduction to buildings, but the book also contains valuable material for the active researcher.
Building intuition : Insights from basic operations management models and principles
"‘This user-friendly book will help the reader to develop insights with respect to a number of models that are important in the study and practice of operations management’. … all the chapters are extremely well written and a pleasure to read. … This would be a good book to use as a text in any operations management course, and in particular for operations management courses which are part of a ‘liberal studies’ program. It would also be good book for managers … ." (R Bharath, Journal of the Operational Research society, Vol. 60 (7), 2009)
Building construction : From principle to detail ; Vol.1 : Fundamentals
Construction is the means by which designing architects and engineers transform a design idea into built reality. It is from this perspective that the subject of 'building construction design' is dealt with by the architect José Luis Moro in three comprehensive volumes. Each is dedicated to the methodological, physical and functional fundamentals, the conception of a constructional solution, and finally its implementation in the constructional detail. Not only do the three volumes provide extensive content; they also ensure the greatest possible clarity in the text and graphics, in order to make it easier for learners to access the material. Importantly, they focus not only on conveying technical and scientific information, but also on demonstrating the complex relationships and interactions between design, material and construction.
Building a Future with BRICs : The Next Decade for Offshoring
In 2003, Goldman Sachs published a startling report on the BRICs (Brazil, Russia, India, and China) region: These four countries would be larger than the G6 economics within 40 years, muscling their way to economic dominance over the coming decades, and powering past developed countries such as the United Kingdom, Germany, and Japan. This book focuses on the technology and technology-enabled services that underpin this social and economic revolution. The editor analyses the reasons why these four countries are in a unique position to lead a 21st century growth in international services. He then features 12 chapters written by the most important chief executives from the BRICs service economy. Indian technology leaders, such as Nandan Nilekani (Infosys), Shiv Nadar (HCL), and Rajendra Pawar (NIIT), feature alongside their peers from Brazil, Russia, and China outlining their views on the next decade for offshoring.
Buddhism and comparative constitutional law
The first comprehensive account of the entanglements of Buddhism and constitutional law,The authors also highlight the important ways in which Buddhist actors have (re)conceived Western liberal ideals such as constitutionalism, rule of law, and secularism.
Bridge Management 5 : Inspection, maintenance, assessment and repair ; Proceedings of the 5th International Conference on Bridge Management, organized by the University of Surrey, 11–13 April 2005
The last five years have seen the art of bridge management develop into a mature subject. Bridge owners and engineers recognise the importance of implementing fully operational bridge management strategies to ensure that all road and rail bridges remain functional for as long as possible.Bridge structures form a major part of the vast financial investment in infrastructure and consequently their careful management involving structural appraisal, repair and strengthening is of paramount importance.
Braid Groups
Braids and braid groups have been at the heart of mathematical development over the last two decades. Braids play an important role in diverse areas of mathematics and theoretical physics. The special beauty of the theory of braids stems from their attractive geometric nature and their close relations to other fundamental geometric objects, such as knots, links, mapping class groups of surfaces, and configuration spaces. In this presentation the authors thoroughly examine various aspects of the theory of braids, starting from basic definitions and then moving to more recent results. The advanced topics cover the Burau and the Lawrence--Krammer--Bigelow representations of the braid groups, the Alexander--Conway and Jones link polynomials, connections with the representation theory of the Iwahori--Hecke algebras, and the Garside structure and orderability of the braid groups.
