الصفحة 6
الصفحة 6
Leveraging applications of formal methods, verification and validation : Applications ; 9th International Symposium on Leveraging Applications of Formal Methods, ISoLA 2020, Rhodes, Greece, October 20–30, 2020, Proceedings, Part III
The three-volume set LNCS 12476 - 12478 constitutes the refereed proceedings of the 9th International Symposium on Leveraging Applications of Formal Methods, ISoLA 2020, which was planned to take place during October 20–30, 2020, on Rhodes, Greece. The event itself was postponed to 2021 due to the COVID-19 pandemic. The papers presented were carefully reviewed and selected for inclusion in the proceedings. Each volume focusses on an individual topic with topical section headings within the volume: Part III, Applications: Reliable Smart Contracts: State-of-the-art, Applications, Challenges and Future Directions; Automated Verification of Embedded Control Software; Formal methods for DIStributed COmputing in future RAILway systems.
Large-Scale Knowledge Resources. Construction and Application ; 3rd International Conference on Large-Scale Knowledge Resources, LKR 2008, Tokyo, Japan, March 3-5, 2008. Proceedings
At the start of the 21st century,we are now well on the way to wards aknowled- intensive society, in which knowledge plays ever more important roles. Thus, research interest should inevitably shift from information to knowledge, with the problems of building, organizing, maintaining and utilizing knowledge - coming centralissues in a wide varietyof felds. The 21stCentury COE program “Framework for Systematization and Application of Large-scale Knowledge - sources (COE-LKR)” conducted by the Tokyo Institute of Technology is one of several early attempts worldwide to address these important issues. Inspired by this project, LKR2008 aimed at bringing together diverse contributions in cognitive science, computer science, education and linguistics to explore design, construction, extension, maintenance, validation and application of knowledge.
IUTAM Symposium on Fluid-Structure Interaction in Ocean Engineering ; Proceedings of the IUTAM Symposium held in Hamburg, Germany, July 23-26, 2007
This book collects contributions from leading scientists working on the following topics: Ocean waves, probabilistic models of sea waves, fluid-loading on structures including pipes, cables, drill-strings etc., behavior of floating systems, stability and capsizing of ships, coupled structural behavior, sloshing in tanks, CFD validation and verification.
Composites with micro- and nano-structure : Computational modeling and experiments
The book contains atomistic and continuum numerical methods and experimental validation for composite materials reinforced with particles or fibres, porous materials, homogenization and other important topics for research in this field.
Component-Based Software Development for Embedded Systems : An Overview of Current Research Trends
Embedded systems are ubiquitous. They appear in cell phones, microwave ovens, refrigerators, consumer electronics, cars, and jets. Some of these embedded s- tems are safety- or security-critical such as in medical equipment, nuclear plants, and X-by-wire control systems in naval, ground and aerospace transportation - hicles. With the continuing shift from hardware to software, embedded systems are increasingly dominated by embedded software. Embedded software is complex. Its engineering inherently involves a mul- disciplinary interplay with the physics of the embedding system or environment. Embedded software also comes in ever larger quantity and diversity. The next generation of premium automobiles will carry around one gigabyte of binary code. The proposed US DDX submarine is e?ectively a ?oating embedded so- ware system, comprising 30 billion lines of code written in over 100 programming languages. Embedded software is expensive. Cost estimates are quoted at around US$15– 30 per line (from commencement to shipping). In the defense realm, costs can range up to $100, while for highly critical applications, such as the Space Shuttle, the cost per line approximates $1,000. In view of the exponential increase in complexity, the projected costs of future embedded software are staggering.
Complex Effects in Large Eddy Simulations
This volume contains a collection of expert views on the state of the art in Large Eddy Simulation (LES) and its application to complex ?ows. Much of the material in this volume was inspired by contributions that were originally presented at the symposium on Complex E?ects in Large Eddy Simulation held in Lemesos (Limassol), Cyprus, between September 21st and 24th, 2005.
Comparison of digital anesthesia using articaine vs. lidocaine for mandibular infiltration in pediatric patients : Aged 4-5 vs. 6-8 years
Articaine and lidocaine exhibit equivalent efficacy for mandibular infiltration via computerized systems in children aged 4–8 years. While articaine may marginally improve injection comfort, both agents provide reliable anesthesia with minimal complications. Computerized delivery enhances patient experience, supporting its adoption to reduce dental anxiety.This investigation aims to : determine whether articaine's theoretical advantages translate to clinically significant improvements in young children, identify optimal anesthetic protocols for different pediatric age groups, validate the effectiveness of digital delivery systems in pediatric mandibular anesthesia and provide robust data to replace current adult-derived guidelines with pediatric-specific evidence.
Cleaning validation : Practical compliance approaches for pharmaceutical manufacturing
Timely coverage of cleaning validation for the pharmaceutical industry, a dynamic area in terms of health-based limits. Encourages pharmaceutical manufacturers, and particularly upper management, to meet the challenges of the science-based and riskbased approaches to cleaning validation. Draws on the author’s vast experience in the field of cleaning validation and hazardous materials. Discusses EMA vs. ISPE on Cleaning Limits and revised Risk-MaPP for highly hazardous products in shared facilities. A diverse list of topics from protocol limits for yeasts and molds to cleaning validation for homeopathic drug products.
Classifications and lists in oral and maxillofacial surgery
Contains a concise collection of the most important oral and maxillofacial surgery classifications and lists. Such classifications help to describe diseases in a comprehensible, measurable, validated and reproducible manner and are the first step towards a systematic approach for treating specific conditions. Elsewhere in this book, lists provide clinical guidance on key subspecialty topics. Using subdivisions such as trauma, head and neck cancer, and orthognathic surgery, this is a succinct and easy-to-use guide for the head and neck clinician.
Circular RNAs
Guide readers through circular RNA purification, in silico characterization, circRNA detection, sequence validation, quantification , techniques related to gain- and loss-of-function approaches, circular RNA synthesis, split ligation, engineering, nanoparticle packaging, RNA modifications on circular RNA biogenesis, RNA translation potential, and vaccines based on circular RNAs.
Chemogenomics : Methods and protocols
Presents both theoretical guidance and protocols on chemogenomics including chemogenomics library assembly, compound profiling, and phenotypic assays. The chapters in this book cover topics such as the assembly and use of Kinase Chemogenomics; data mining for chemogenomic compound candidates; protocols for protein family-focused assay systems to profile chemogenomic compounds; functional and target engagement assays in cellular settings for broad characterization; and a discussion on phenotypic assays where chemogenomic sets may be applied.
Cell-Cell Channels
The biological sciences are dominated by the idea that cells are the functionally autonomous, physically separated, discrete units of life. This concept was propounded in the 19th century by discoveries of the cellular structuring of both plants and animals. Moreover, the ap parent autonomy of unicellular eukaryotes, as well as the cellular basis of the mammalian brain (an organ whose anatomy for a long while defied attempts to validate the idea of the cellular nature of its neurons), seemed to provide the final conclusive evidence for the completeness of *cell theory', a theory which has persisted in an almost dogmatic form up to the present day. However, it is very obvious that there are numerous observations which indicate that it is not the cells which serve as the basic units of biological life but that this property falls to some other, subcellular assemblage. To deal with this intricate problem concerning the fundamental unit of living matter, we proposed the so-called Cell Body concept which, in fact, devel ops an exceedingly original idea proposed by Julius Sachs at the end of the 19th century. In the case of eukaryotic cells, DNA-enriched nuclei are intimately associated with a microtubular cytoskeleton. In this configuration—as a Cell Body—these two items comprise the fundamental functional and struc tural unit of eukaryotic living matter. The Cell Body seems to be inherent to all cells in all organisms.
Breast cancer research and treatment : innovative concepts
Focuses on innovative treatment options for breast cancer, including surgery, radiotherapy, systemic therapy and of course immunotherapy that is changing outcomes in some aggressive breast cancer histotypes. Subsequent chapters also address the ongoing emerging research in the screening, diagnostics, and management of all subtypes of breast cancers. All current landscapes and future perspectives in each molecular subtype: luminal, HER2-positive, and triple-negative breast cancers are discussed within the different chapters. Breast cancer is still the most common cancer and cause of cancer deaths among women worldwide. The improvement of breast cancer outcome appears to be strictly related to the validation of precise biomarkers that enable us to better select personalized approaches in breast cancer management. The closing chapters deal with the challenges of low income countries of conducting research in the era of precision medicine for cancer. The book is edited and authored by leading experts in this field and will be of interest for clinicians and scientists alike
Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries ; 7th International Workshop, BrainLes 2021, Held in Conjunction with MICCAI 2021, Virtual Event, September 27, 2021, Revised Selected Papers, Part I
The content of thebook covers the current state-of-the-art literature on federated learning applications for cancer research and Vclinical oncology analysis, as well as an overview of the deep learning approaches improving the current standard of care for brain lesions and current neuroimaging challenges. It is also focusing on the accepted BrainLes workshop submissions, is to provide an overview of new advances of medical image analysis in all the aforementioned brain pathologies. It brings together researchers from the medical image analysis domain, neurologists, and radiologists working on at least one of these diseases. The aim is to consider neuroimaging biomarkers used for one disease applied to the other diseases.
Biomedical Image Registration ; 3rd International Workshop, WBIR 2006, Utrecht, The Netherlands, July 9-11, 2006, Proceedings
This book constitutes the thoroughly refereed post-proceedings of the Third International Workshop on Biomedical Image Registration. The 20 revised full papers and 18 revised poster papers presented were carefully reviewed and selected for inclusion in the book. The papers cover all areas of biomedical image registration; methods of registration, biomedical applications, and validation of registration.
Biomarkers in drug discovery and development : A handbook of practice, application, and strategy
Discusses biomarker characterization and validation and applications throughout drug discovery and development. Explains where proper use of biomarkers can substantively impact drug development timelines and costs, enable selection of better compounds and reduce late stage attrition, and facilitate personalized medicine. Helps readers get a better understanding of biomarkers and how to use them, for example which are accepted by regulators and which still non-validated and exploratory. Updates developments in genomic sequencing, and application of large data sets into pre-clinical and clinical testing; and adds new material on data mining, economics, and decision making, personal genetic tools, and wearable monitoring. Includes case studies of biomarkers that have helped and hindered decision making
Bioinformatics tools for pharmaceutical drug product development
Presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. And include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall.
Beginning Information Cards and Cardspace : From novice to professional
If you work at all with Internet-facing solutions, you know that the lack of an identity metasystem is a critical vulnerability in the design. Various consortiums have worked to define a system of identity—a platform-agnostic way of communicating and validating claims of identity. If you work with identity solutions or structures, you will find Beginning Information Cards and CardSpace: From Novice to Professional essential to understanding and successfully implementing CardSpace solutions.
Beginning ASP.NET 2.0 in VB 2005 : From novice to professional
This book includes best practices and comprehensive discussions about key database and XML principles, which are essential for you to become effective with ASP.NET. The book also emphasizes the invaluable coding techniques of object orientation and code behind, which will enable you to build real-world websites immediately rather than just scraping by with simplified coding practices. By the time you've finished this book, you will have mastered the core techniques and possess the necessary knowledge to begin work as a professional ASP.NET developer.
Beginning ASP.NET 2.0 in C# 2005 : From novice to professional
This book provides thorough coverage of ASP.NET, guiding you from beginning to advanced techniques, such as querying databases from within a web page and performance-tuning your site. You'll find tips for best practices and comprehensive discussions of key database and XML principles. The book also emphasizes the invaluable coding techniques of object orientation and code-behind, which will enable you to build real-world websites instead of just scraping by with simplified coding practices. By the time you finish this book, you will have mastered the core techniques essential to professional ASP.NET developers.
