الصفحة 6
الصفحة 6
Metal Catalyzed Cascade Reactions
Transition metal-catalyzed cascade reactions are an elegant approach to complex molecular scaffolds. Besides their esthetics and increase in structural complexity, they have also become mechanistic challenges for the combination of organometallic elementary steps. As a consequence, cascade reactions have revolutionized synthetic strategies and conceptual thinking. The authors highlight cyclization via carbopalladation and acylpalladation and Heck-pericyclic sequences. They discuss p-allyl palladium-based cascade reactions, Michael-type additions as an entry to transition-metal-promoted cyclizative transformations, and sequential or consecutive palladium-catalyzed processes, and show Pauson-Khand cascades, metal-catalyzed cyclizations of acyclic precursors, as well as cascade and sequential ruthenium-catalyzed transformations. Therefore, the reader finds overview of an exciting and highly dynamic field of a new and innovative methodological concept
Messenger RNA therapeutics
Focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine.
Menopause
As people live longer, women are spending most of their lives in menopause, affected by a variety of estrogen-related conditions such as osteoporosis, cognitive and cardiovascular decline, increased risk of breast cancer and other symptoms that decrease the overall quality of life. Unfortunately, hormonal therapy was found to be less effective in decreasing the severity of some of these conditions than previously thought and may actually increase the risk of cancer. The aim of this research was to put a spotlight on natural treatments for menopause like changing life style and herbal medicines.
Men’s care center
"سين" مركزٌ للعافية والاسترخاء، مصمم بمزيج فريد من العناصر الطبيعية والهندسة المعمارية الحديثة ليمنح الزوار تجربة حسية متكاملة. يدمج المشروع المساحات الخضراء الداخلية والإضاءة الهادئة وخطوط التصميم المعاصرة لخلق بيئة فاخرة وهادئة. تشمل المساحات الرئيسية الحديقة الداخلية، والحمام التركي التقليدي، وغرف كبار الشخصيات، ومنطقة الاستقبال - جميعها مُرتبة بعناية لتعزيز الهدوء والتوازن. يركز التصميم على التفاصيل المعمارية والوظيفية، موفرًا للضيوف ملاذًا من ضغوط الحياة اليومية. خضعت التصاميم الداخلية والخارجية لدراسة دقيقة لضمان تجربة راقية وشاملة. “Sén” is a wellness and re laxation center designed with a unique blend of natural elements and modern architecture to provide visitors with a complete sensor experience. The project integrates indoor greenery, calming lighting, and con temporary design lines to create a luxurious and peaceful environment. Key spaces include the indoor garden, traditional hammam, VI P rooms, and reception area — all carefully arranged to promote tranquility and balance. The design focuses on architectural and functional details, offering guests a retreat from the stresses of everyday life. Both interior and exterior designs were carefully studied to ensure a refined and holistic experience.
MEGAFLOW - Numerical Flow Simulation for Aircraft Design ; Results of the second phase of the German CFD initiative MEGAFLOW, presented during its closing symposium at DLR, Braunschweig, Germany, December 10 and 11, 2002
This volume contains results of the German CFD initiative MEGAFLOW which combines many of the CFD development activities from DLR, universities and aircraft industry. It highlights recent improvements and enhancements of the MEGAFLOW software system.
Medical laboratory technology procedure : manual for routine diagnostic tests ; Vol.3
Salient features Predominantly tailored to the requirements of laboratories with limited facilities in developing countries, this manual: Introduces methods and procedures for producing reliable laboratory findings Describes all tests in a step-by-step manner with guidelines to avoid errors and hazards Explains care and use of laboratory equipment and preparation of reagents Details Zika and Chikungunya virus infections Highlights the clinical significance of laboratory findings Provides illustrations for easy comprehension The fourth edition features a number of important additions containing the latest topics relevant to the subject
Medical imaging systems : An introductory guide
Gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.
Medical image synthesis : Methods and clinical applications
Image synthesis across and within medical imaging modalities is an active area of research with broad applications in radiology and radiation oncology. This book covers the principles and methods of medical image synthesis, along with state-of-the-art research. First, various traditional non-learning-based, traditional machine-learning-based, and recent deep-learning-based medical image synthesis methods are reviewed. Second, specific applications of different inter- and intra-modality image synthesis tasks and of synthetic image-aided segmentation and registration are introduced and summarized, listing and highlighting the proposed methods, study designs, and reported performances with the related clinical applications of representative studies. Third, the clinical usages of medical image synthesis, such as treatment planning and image-guided adaptive radiotherapy, are discussed. Last, the limitations and current challenges of various medical synthesis applications are explored, along with future trends and potential solutions to solve these difficulties.
Medical Decisions, Estrogen and Aging
This book is unique in that it integrates core findings from within the Decision Sciences and Evidence Based Medicine in light of the research that has been done on HT. Medical Decisions, Estrogen and Aging integrates the various components that go into medical decision making in the context of understanding the dilemmas that surround HT. Therefore this book is intended for both specialists and generalists in the field, and it is ideally suited for use by graduate and medical students, medical health care professionals, behavioral scientists, medical ethicists, gerontologists, historians of science, and endocrinologists.
Medical Applications of Colloids
This volume collects chapters dealing with significant topics in colloids and surfaces relevant to medical applications. The book will be of interest to scientists and practitioners in areas as diverse as medical diagnostics, drug formulations, X-ray photoelectron spectroscopy of biomaterials, and particle transport in human airways.
Mechanisms of Lymphocyte Activation and Immune Regulation XI ; B Cell Biology
These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
Mechanics of Biological Tissue
The mechanics of biological tissues is a multidisciplinary and rapidly expanding area of research. This book highlights some important research directions that combine mechanical sciences with exciting new developments in biology. This collection of papers should be of interest to theoretical, computational and experimental researchers and doctoral students in the area of biomechanics and in related areas of engineering, biology and medicine.
Mathematics teacher education in the Andean region and Paraguay : A comparative analysis of issues and challenges
This Open Access book is an excellent synthesis of the initial and continuing preparation for Mathematics Teaching in Bolivia, Ecuador, Paraguay and Peru, from which comparative analyses can be made that show similarities and differences, and highlight various perspectives. This book brings to the international Educational Community an important collection of experiences and ideas in the Mathematics Education of four Latin-American countries in the developing Andean region and Paraguay. The dissemination of these results can promote the search for international collaborative actions in a wider scale.
Mathematics and Technology
Mathematics and Technology presents technological applications of mathematics making use of elegant mathematical concepts. The selected subjects consist of: public key cryptography, error correcting codes, the global positioning system (GPS) and cartography, image compression using fractals and the JPEG format, digital recording, robot movement, DNA computing, Google's PageRank algorithm, savings and loans, gamma ray surgery and random number generators. The authors highlight how mathematical modeling, together with the power of mathematical tools, have been crucial for innovation in technology. The exposition is clear, straightforward, motivated by excellent examples, and user-friendly. Numerous exercises at the end of every chapter reinforce the material. An engaging quality is the various historical notes accompanying the mathematical development.
Mathematical Problems in Image Processing : Partial Differential Equations and the Calculus of Variations
The goals of this book are to present a variety of image analysis applications, the precise mathematics involved and how to discretize them. Thus, this book is intended for two audiences. The first is the mathematical community by showing the contribution of mathematics to this domain. It is also the occasion to highlight some unsolved theoretical questions. The second is the computer vision community by presenting a clear, self-contained and global overview of the mathematics involved in image processing problems. This work will serve as a useful source of reference and inspiration for fellow researchers in Applied Mathematics and Computer Vision, as well as being a basis for advanced courses within these fields.
Mathematical Problems from Applied Logic II : Logics for the XXIst Century
Mathematical Problems from Applied Logic II presents chapters from selected, world renowned, logicians. Important topics of logic are discussed from the point of view of their further development in light of requirements arising from their successful application in areas such as Computer Science and AI language. Fields covered include: logic of provability, applications of computability theory to biology, psychology, physics, chemistry, economics, and other basic sciences; computability theory and computable models; logic and space-time geometry; hybrid systems; logic and region-based theory of space.
Mathematical Problems from Applied Logic I : Logics for the XXIst Century
Mathematical Problems from Applied Logic I presents chapters from selected, world renowned, logicians. Important topics of logic are discussed from the point of view of their further development in light of requirements arising from their successful application in areas such as Computer Science and AI language. An overview of the current state as well as open problems and perspectives are clarified in such fields as non-standard inferences in description logics, logic of provability, logical dynamics and computability theory. The book contains interesting contributions concerning the role of logic today, including some unexpected aspects of contemporary logic and the application of logic. This should be of interest to logicians and mathematicians in general.
IP Networking over Next-Generation Satellite Systems ; International Workshop, Budapest, July 2007
Highlights the very latest research output of several EU satellite-related projects and addresses many unresolved issues in next-generation satellite systems, such as efficient deployment of IPv6 over satellites, working with WLAN and WiMax, QoS provisioning over multi-segment networks (including satellite networks), multicast networks and security.
Investment Management and Mismanagement : History, Findings, and Analysis
These issues include performance, anomalies, market timing, suitability, and churning, among others. The construct of mismanagement is presented in light of the impact of various costs on investment returns.
Inventive communication and computational technologies ; Proceedings of ICICCT 2020
This book gathers selected papers presented at the 4th International Conference on Inventive Communication and Computational Technologies (ICICCT 2020), held on 28–29 May 2020 at Gnanamani College of Technology, Tamil Nadu, India. The respective contributions highlight recent research efforts and advances in a new paradigm called ISMAC (IoT in Social, Mobile, Analytics and Cloud contexts). The topics covered include the Internet of Things, Social Networks, Mobile Communications, Big Data Analytics, Bio-inspired Computing and Cloud Computing. Given its scope, the book is chiefly intended for academics and practitioners working to resolve practical issues in this area.
