الصفحة 6
الصفحة 6
Move : Architecture in Motion - Dynamic Components and Elements
Dynamic components and adaptive elements are becoming increasingly important in contemporary architecture, and not just because of their visual effect. If architects and engineers are engaging more and more with the issue of movement – whether in the form of sun-tracking solar cells, lowerable walls, or intelligently programmed elevators – it’s because they are busy exploring responses to three challenges: How can we control and reduce the energy requirement of buildings? How can we expand the range of possible uses? And how can we represent, illustrate, accommodate, and control dynamic movements in buildings?
Motor Control and Learning
Motor Control and Learning focuses on the effects of development, aging, and practice on the control of human voluntary movement. These issues have been at the center of attention of the motor control community, but no book until now has addressed all of these issues under one cover in the context of contemporary views on the control of human voluntary movement. This book emphasizes the links between progress in basic motor control research and applied areas such as motor disorders and motor rehabilitation.
Motion Planning in Medicine : Optimization and Simulation Algorithms for Image-Guided Procedures
The monograph written by Ron Alterovitz and Ken Goldberg combines ideas from robotics, physically-based modeling, and operations research to develop new motion planning and optimization algorithms for image-guided medical procedures. A challenge clinicians commonly face is compensating for errors caused by soft tissue deformations that occur when imaging devices or surgical tools physically contact soft tissue. A number of methods are presented which can be applied to a variety of medical procedures, from biopsies to anaesthesia injections to radiation cancer treatment. They can also be extended to address problems outside the context of medical robotics, including nonholonomic motion planning for mobile robots in field or manufacturing environments.
Morphological Models of Random Structures
This book covers methods of Mathematical Morphology to model and simulate random sets and functions (scalar and multivariate). The introduced models concern many physical situations in heterogeneous media, where a probabilistic approach is required, like fracture statistics of materials, scaling up of permeability in porous media, electron microscopy images (including multispectral images), rough surfaces, multi-component composites, biological tissues, textures for image coding and synthesis. The common feature of these random structures is their domain of definition in n dimensions, requiring more general models than standard Stochastic Processes.The main topics of the book cover an introduction to the theory of random sets, random space tessellations, Boolean random sets and functions, space-time random sets and functions (Dead Leaves, Sequential Alternate models, Reaction-Diffusion), prediction of effective properties of random media, and probabilistic fracture theories.
Moral reasoning at work : Rethinking ethics in organizations ; 2nd ed.
Moral Reasoning at Work offers a fresh perspective on how to live with them using ethics and moral psychology research. It argues that decision-makers must go beyond compliance and traditional approaches to ethics to prepare for moral dilemmas. The book has been updated with a range of examples from the author’s more recent research, to reflect current issues affecting organizations in the digital age. With two new chapters on artificial intelligence and social media, this new edition provides an up-to-date overview of ethical challenges in organizations.
Moral Psychology Today : Essays on Values, Rational Choice, and the Will
This book brings together in one volume some of the very latest developments in moral psychology that were presented at a major American conference in 2004. Moral psychology is a broad area at the intersection of moral philosophy and philosophy of mind and action. Essays in this collection deal with most of the central issues in moral psychology that are of interest to a large number of philosophers today, including important questions in normative ethical theory, meta-ethics, and applied ethics.
Moral Education : Beyond the Teaching of Right and Wrong
This volume is unique in providing a comprehensive discussion of moral education in the light of a range of ethical theories. In a balanced, thoughtful and penetrating account, all of these are shown to have a contribution to make to our moral understanding, and hence to moral education, even if none provides a definitive criterion of moral conduct. Though divine command is rejected as a source of moral justification, the possible contribution of some religious traditions to moral education is sympathetically considered. Fashionable relativism and recent moves towards inculcatory authoritarianism are both firmly rejected. The argument is philosophically rigorous throughout. Contemporary issues addressed include the links between personal morality and citizenship, including world citizenship, family values and sexual morality.
Moral Dilemmas in Real Life : Current Issues in Applied Ethics
The book begins with the general relation between the individual and society – instilling ethical tension, and even clashes, between the private and the public in our discourse. Going on, from general to specific, it gradually narrows the ethical playing field to touch on medical ethics, the family, and the practice of punishment. In all cases, the book addresses both consensual and conventional social institutions and distortions thereof.
Monetary and Wage Policies in the Euro Area
This book studies the interactions between monetary and wage policies in the euro area. It carefully discusses the process of policy competition and the structure of policy cooperation. As to policy competition, the focus is on competition between the European central bank, the American central bank, the German labour union, and the French labour union. As to policy cooperation, the focus is on the same institutions. These are higher-dimensional issues. The policy targets are price stability and full employment. The policy decisions are taken sequentially or simultaneously. Monetary and wage policies have spillover effects. Special features of this book are numerical simulations of policy competition and numerical solutions to policy cooperation.
Monetary and Fiscal Policies in the Euro Area
This book studies the interactions between monetary and fiscal poUcies in the euro area. It carefully discusses the process of policy competition and the structure of policy cooperation. As to policy competition, the focus is on competition between the European central bank, the American central bank, the German government, and the French government. As to policy cooperation, the focus is on the same institutions. These are higher-dimensional issues. The pohcy targets are price stability and full employment. The policy makers follow co- turkey or gradualist strategies. The policy decisions are taken sequentially or simultaneously. Monetary and fiscal policies have spillover effects. Special features of this book are numerical simulations of policy competition and numerical solutions to policy cooperation. The present book is part of a larger research project on European Monetary Union, see the references at the back of the book. Some parts of this project were presented at the World Congress of the International Economic Association. Other parts were presented at the International Conference on Macroeconomic Analysis, at the International Institute of Public Finance, at the Macro Study Group of the German Economic Association, at the Annual Meeting of the Austrian Economic Association, at the Gottingen Workshop on International Economics, at the Halle Workshop on Monetary Economics, at the Research Seminar on Macroeconomics in Freiburg, and at the Passau Workshop on International Economics.
Molecular Wires : From Design to Properties
In the emerging field of nanoscience the desire to construct objects which in the molecular scale can resemble and act as macroscopic devices is a constant trend. Amongst the simplest but also most attractive functional component molecular wires are surely the most investigated. The reason for such interest is quite obvious since wires, in today world, are used all around us and are the most indispensable unit to assemble any type of electronic devices.In this issue the synthesis and characterization of molecular wires based on organic or metal complexes components, their properties and some theoretical background will be illustrated.
Molecular Pathology of Gynecologic Cancer
This book focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. The volume begins with an explication of the editors’ hypothesis that cancer is mainly a disease of the cell cycle, based on the deregulation of the physiological process of cell reproduction. The following eleven chapters focus on specific issues in gynecologic cancers, including: a proposed model of ovarian serous carcinogenesis, molecular markers for ovarian epithelial cancer, an overview of the pathology of endometrial cancer, molecular genetic aspects of endometrial carcinoma and cervical cancer, a natural history of Human Papilloma Virus (HPV) as it relates to cervical cancer, and hereditary issues in gynecologic cancers. The concluding chapter proposes and outlines a holistic approach to the treatment of female cancer patients.
Molecular Parameters Indicating Adaptation to Mechanical Stress in Fibrous Connective Tissue
The present study pursues the hypothesis that local compressive force and the occurrence of cartilage-specific transformation processes within tendons and ligaments are directly correlated. In selected anatomical samples of human origin the distribution pattern of certain components of the extracellular matrix is assessed. Investigations are carried out at the extensor tendons of toes and fingers, at the transverse ligament of the atlas, at the transverse ligament of the acetabulum, and at the tendon of the superior oblique muscle and its trochlea. The molecular components of the extracellular matrix are detected with standardized immunohistochemical methods. The results show that certain molecules only occur due to compressive stress, others due to tensile stress. The molecular spectrum of the extracellular matrix allows qualifying conclusions to the mechanical situation of a given part of the tissue. The spatial expansion of the fibrocartilaginous adaptation zones in tendons and ligaments roughly corresponds with the zones subjected to compressive force; tensile stress alone does not result in a production of fibrocartilage.
Molecular Mechanisms of Parasite Invasion
All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.
Molecular Mechanisms of Cancer
Cancer may constitute the most extensively studied functions constitute a second line of defense that disease entity of our time. Nevertheless, our com- protects against transforming defects in oncogenes prehension of the cellular and molecular pathology or tumor-suppressor genes and are here considered of malignant transformation is incomplete.
Molecular Markers of Brain Tumor Cells : Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy
Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.
Molecular Genetic Pathology
Molecular Genetic Pathology presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology.
Molecular Biomethods Handbook
Recent advances in the biosciences have led to a range of powerful new technologies, particularly nucleic acid, protein and cell-based methodologies. The most recent insights have come to affect how scientists investigate and define cellular processes at the molecular level. Molecular Biomethods Handbook, 2nd Edition expands upon the techniques included in the first edition, providing theory, outlines of practical procedures, and applications for a range of techniques. Part A of the book describes nucleic acid methods, such as gene expression profiling, microarray analysis and quantitative PCR. In Part B, protein and cell-based methods are outlined, in subjects ranging from protein engineering to high throughput screening. Written by a well-established panel of research scientists, Molecular Biomethods Handbook, 2nd Edition provides an up-to-date collection of methods used regularly in the authors’ own research programs.
Molecular Biology of the Parathyroid
Caintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu M lar calcium levels, by acting on bone, kidney and intestine. The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex pression to its intracellular processing and the sequences in the gene control ling its transcription as well as those regulating mRNA processing, stability and translation are described.
Molecular Biology of Human Cancers: An Advanced Student's Textbook
Presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
