الصفحة 6
الصفحة 6
Gene delivery systems development and applications
Covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases.
Gene delivery systems : nano delivery technologies
Gene therapy involves altering the genes in the body's cells in an effort to treat or stop disease, instead of using drugs or surgery. This book discusses the development of gene therapy today, from the technology involved to gene correction and the advances in genome editing.
Future-Oriented Technology Analysis : Strategic Intelligence for an Innovative Economy
The application of foresight to address the challenges of uncertainty and rapid change has grown dramatically in the past decade. In that period, the techniques have been greatly refined and the scope has been broadened to encompass future-oriented technology analysis (FTA) and more recently, the concept and practice of strategic intelligence. FTA addresses directly the longer-term future through the active and continuous development of visions, and pathways to realise these visions. It is increasingly seen as a valuable management and policy tool complementing, and extending further into the future, classical strategy, planning, and decision-making approaches.
Future approaches for safe and effective pain management
Pain is defined as an unpleasant sensory and emotional experience that is associated with actual or potential tissue damage or described in terms of such damage. It is subjective and considered an important physiological mechanism by which humans prevent themselves from developing tissue injury. However, pain patients do not respond to treatment in the same way, which makes it challenging to issue a consistent treatment for all pain conditions. Excessive pain can markedly increase psychological health problems and decrease health‐related quality of life; therefore, pain should be managed appropriately by analgesics. Analgesics act in various ways on the peripheral and central pain pathways and are regarded as one of the most valuable but equally dangerous groups of medications. Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined. Pain severities as well as responses to analgesics, can also be very variable among sufferer.
Functional and operatorial statistics
An increasing number of statistical problems and methods involve infinite-dimensional aspects. This is due to the progress of technologies which allow us to store more and more information while modern instruments are able to collect data much more effectively due to their increasingly sophisticated design. This evolution directly concerns statisticians, who have to propose new methodologies while taking into account such high-dimensional data (e.g. continuous processes, functional data, etc.). The numerous applications (micro-arrays, paleo-ecological data, radar waveforms, spectrometric curves, speech recognition, continuous time series, 3-D images, etc.) in various fields (biology, econometrics, environmetrics, the food industry, medical sciences, paper industry, etc.) make researching this statistical topic very worthwhile. This book gathers important contributions on the functional and operatorial statistics fields
Freshwater Microplastics : Emerging Environmental Contaminants?
Focuses on microscopic plastic debris, also referred to as microplastics, which have been detected in aquatic environments around the globe and have accordingly raised serious concerns. The book explores whether microplastics represent emerging contaminants in freshwater systems, an area that remains underrepresented to date.Given the complexity of the issue, the book covers the current state-of-research on microplastics in rivers and lakes, including analytical aspects, environmental concentrations and sources, modelling approaches, interactions with biota, and ecological implications. To provide a broader perspective, the book also discusses lessons learned from nanomaterials and the implications of plastic debris for regulation, politics, economy, and society. In a research field that is rapidly evolving, it offers a solid overview for environmental chemists, engineers, and toxicologists, as well as water managers and policy-makers.
Freshwater Governance for the 21st Century
The objective of this book is to broadly illustrate the key aspects of water governance, mapping the spectrum of decision-making from techno-centric and eco-centric approaches, to hybrid concepts and people-centric approaches. Topics covered include the challenges for water-governance models, the polycentric model, the integration challenge, water in the decision-making hierarchy, and the rise of water-sensitive design, while also taking into account interdependencies between stakeholders, as well as the issue of scale.
Freshwater Animal Diversity Assessment
The Freshwater Animal Diversity Assessment gives a state of the art assessment of the diversity and distribution of Metazoa in the continental waters of the world. The project deals with all major animal groups plus the macrophytes, and encompasses the complete array of terrestrial aquatic ecosystems. It is the most comprehensive study of species- and genus-level diversity and chorology of the global freshwater fauna to date, and is the first to present comparable data on the different faunal groups concerned. The project draws from the collected expertise of numerous world-renowned taxonomic experts that have bundled efforts to produce this outstanding volume. The result is invaluable to all scientists, managers and conservationists interested in non-marine aquatic animals.
Foundations of Sport-Related Brain Injuries
A major take-home point from this book should be the assumption that symptom resolution does not necessarily mean injury resolution. As can be seen by research focusing on global metabolic cascades and neural activity of the brain, long-standing dysfunctional pathways continue to exist for extended periods of time even after a minor concussion. Until we completely understand the consequences of short-term perturbations and long-term residual brain dysfunctions, concussions must be treated with respect and given a higher priority for continued research activity.
Foundations of genetic algorithms ; 8th International Workshop, FOGA 2005, Aizu-Wakamatsu City, Japan, January 5-9, 2005, Revised Selected Papers
The8thWorkshopontheFoundationsofGeneticAlgorithms,FOGA-8,washeld at the University of Aizu in Aizu-Wakamatsu City, Japan, January 5–9, 2005. This series of workshops was initiated in 1990 to encourage further research on the theoretical aspects of genetic algorithms, and the workshops have been held biennially ever since. The papers presented at these workshops are revised, edited and published as volumes during the year following each workshop. This series of (now eight) volumes provides an outstanding source of reference for the theoretical work in this ?eld. At the same time this series of volumes provides a clear picture of how the theoretical research has grown and matured along with the ?eld to encompass many evolutionary computation paradigms including evolution strategies (ES), evolutionary programming (EP), and genetic programming (GP), as well as the continuing growthininteractionswith other ?elds suchas mathematics,physics, and biology.
Formal Methods for Computational Systems Biology ; 8th International School on Formal Methods for the Design of Computer, Communication, and Software Systems, SFM 2008 Bertinoro, Italy, June 2-7, 2008 Advanced Lectures
This volume presents the set of papers accompanying the lectures of the eighth International School on Formal Methods for the Design of Computer, Com- nication, and Software Systems (SFM). This series of schools addresses the use of formal methods in computer science asaprominent approach to theri gorousdesign of computer, communication, and software systems. The main aim of the SFM series is to ofer a good spectrum of current research in foundations as well as applications of formal methods, which can be of help for graduate students and young researchers who intend to approach the feld.
Force Sensors for Microelectronic Packaging Applications
This monograph is intended for wire bonding and flip-chip packaging professionals and for scientists and engineers working in the field of mechanical microsensors. New measurement technologies are introduced that allow in situ and real-time examination of physical processes during the packaging process or during subsequent reliability tests. The measurement system presented here enables measurements at formerly inaccessible packaging interconnects. For the first time it becomes possible to describe the wire bonding process window in terms of the physical forces at the contact zone instead of the applied machine settings. This is significant for a deeper understanding of these packaging processes. Applications of the sensor in the field of wire bonding and flip-chip characterization are illustrated. The reader will gain much insight into the important field of interconnection technology in semiconductor packaging.
Fixed orthodontic appliances : A practical guide
This guide to fixed appliance-based orthodontics is designed to serve as a comprehensive ‘how to’ manual. It will offer detailed support on the use of fixed orthodontic appliances with practical orthodontic treatments, while providing a valuable refresher and reference for more experienced clinicians.
Finite Mixture and Markov Switching Models
The prominence of finite mixture modelling is greater than ever. Many important statistical topics like clustering data, outlier treatment, or dealing with unobserved heterogeneity involve finite mixture models in some way or other. The area of potential applications goes beyond simple data analysis and extends to regression analysis and to non-linear time series analysis using Markov switching models.It is the first time that the Bayesian perspective of finite mixture modelling is systematically presented in book form. It is argued that the Bayesian approach provides much insight in this context and is easily implemented in practice. Although the main focus is on Bayesian inference, the author reviews several frequentist techniques, especially selecting the number of components of a finite mixture model, and discusses some of their shortcomings compared to the Bayesian approach. The aim of this book is to impart the finite mixture and Markov switching approach to statistical modelling to a wide-ranging community. This includes not only statisticians, but also biologists, economists, engineers, financial agents, market researcher, medical researchers or any other frequent user of statistical models. This book should help newcomers to the field to understand how finite mixture and Markov switching models are formulated, what structures they imply on the data, what they could be used for, and how they are estimated.
Finite element analysis and design of steel and steel–concrete composite bridges
The book’s eight chapters begin with an overview of the various forms of modern steel and steel-concrete composite bridges, current design codes (American, British, and Eurocodes), nonlinear material behavior of the bridge components, and applied loads and stability of steel and steel-concrete composite bridges. This is followed by self-contained chapters concerning design examples of steel and steel-concrete composite bridge components as well as finite element modeling of the bridges and their components. The final chapter focuses on finite element analysis and the design of composite highway bridges with profiled steel sheeting.
Finding the limits of the limes : Modelling demography, economy and transport on the edge of the Roman Empire
This book demonstrates the application of simulation modelling and network analysis techniques. The book shows the added value of state-of-the-art computer modelling techniques and bridges computational and conventional approaches. Topics that will be of particular interest to archaeologists are the question of (forced) surplus production, the demographic and economic effects of the Roman occupation on the local population, and the structuring of transport networks and settlement patterns. For modellers, issues of sensitivity analysis and validation of modelling results are specifically addressed. This book will appeal to students and researchers working in the computational humanities and social sciences, in particular, archaeology and ancient history.
Financial management for technology start-ups : How to power growth, track performance and drive innovation
Develops the financial intelligence you need to communicate effectively with investors, implement business strategies and pinpoint emerging pathways for profit / Outlines how to analyze your performance and undertake risk-return assessments to tactically grow your start-up / Offers proven methods for tracking your start-up's progress to ensure that growth is maintained and continuous / Analysis of financial statements directly from start-ups, new case studies on companies that have scaled up, focus on new digital technologies and market opportunities for start-ups, information on new players and potential future tech start-ups
Femtosecond laser pulses : Principles and experiments
This is the second edition of this advanced textbook written for scientists who require further training in femtosecond science. Four years after pub- cation of the ?rst edition, femtosecond science has overcome new challenges and new application ?elds have become mature. It is necessary to take into account these new developments. Two main topics merged during this period that support important scienti?c activities: attosecond pulses are now gen- ated in the X-UV spectral domain, and coherent control of chemical events is now possible by tailoring the shape of femtosecond pulses. To update this advanced textbook, it was necessary to introduce these ?elds; two new ch- ters are in this second edition: “Coherent Control in Atoms, Molecules, and Solids”(Chap.11)and“AttosecondPulses”(Chap.12)withwell-documented references. Some changes, addenda, and new references are introduced in the ?rst edition’s ten original chapters to take into account new developments and updatethisadvancedtextbookwhichistheresultofascienti?cadventurethat started in 1991. At that time, the French Ministry of Education decided that, in view of the growing importance of ultrashort laser pulses for the national scienti?c community, a Femtosecond Centre should be created in France and devoted to the further education of scientists who use femtosecond pulses as a research tool and who are not specialists in lasers or even in optics.
Fatty acids
Fatty acid metabolism, including the de novo synthesis, uptake, oxidation, and derivation of fatty acids, plays several important roles at cellular and organ levels. Recent studies have identified characteristic changes in fatty acid metabolism in idiopathic pulmonary fibrosis (IPF) lungs, which implicates its dysregulation in the pathogenesis of this disorder. Here, we review the evidence for how fatty acid metabolism contributes to the development of pulmonary fibrosis, focusing on the profibrotic processes associated with specific types of lung cells, including epithelial cells, macrophages, and fibroblasts. We also summarize the potential therapeutics that target this metabolic pathway in treating IPF.
Fashion forge
"Fashion forge" revolutionizes clothing shopping with a cutting-edge mobile application. This AI-powered platform empowers users to describe their dream garment and visualize it instantly, bridging the gap between imagination and reality for fashion-forward users and designers. A recommendation system tailors clothing suggestions based on user preferences, while stores leverage a dedicated social platform for effective marketing. "Fashion Forge" fosters a connected fashion community, empowering users, designers, and stores alike.
