الصفحة 6
الصفحة 6
Extreme Man-Made and Natural Hazards in Dynamics of Structures
The present threat of the terrorist attacks or accidental explosions, the climate change which brings strong stormy winds or yet the destructive earthquake motion that occurs in previously inactive regions or brings about tsunamis, are a few examples of the kind of applications we seek to address in this work.
Ethnobotany and ethnopharmacology of medicinal and aromatic plants : steps towards drug discovery
Medicinal and aromatic plants are beneficial to human health. Plant-derived molecules possess biological activities that can be used to prevent many infectious diseases and metabolic disorders. Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants summarizes techniques and methods used to study the biological activities of plant-derived extracts and compounds to study ethnobotanical and ethnopharmacological features of medicinal and aromatic plants.
Epilepsy
Epilepsy has remained a significant social concern and financial burden globally. It is the most common neurological disease of the brain. Around 1% of the people worldwide have epilepsy and this disease affects people of all ages, Although the different types of epilepsy vary greatly, medication appropriate can control seizures in about 70% of patients, Medications are mainstays in controlling epileptic seizures, Partial seizures, which are the most common seizure type in adults, can be effectively controlled by virtually all the standard and newer antiepileptic drugs (AEDs). For the generalized epilepsies, valproate remains the drug of choice.
Epigenome editing : Methods and protocols
This second volume details new and updated methods covering applications of epigenome editing. Chapters guide readers through general and topical reviews, DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Epigenetics in oncology
Covers the most recent advances in RNA/histone/DNA epigenetics in Oncology. RNA/histone/DNA epigenetics have been shown to play pivotal roles in cancer initiation, progression, maintenance and drug response/resistance, tumor microenvironment, cancer stem cell self-renewal, cancer metabolism, and tumor immune evasion. In particular, research in RNA cancer epigenetics has made impressive progress in the last few years. Individual chapters in Part I (focusing on RNA epigenetics) are devoted to RNA modifications in Cancer Metabolism and Microenvironment, Cancer Stem Cell Biology, Immune Surveillance, Solid Tumors and Tumor Immunity, and Hematopoietic Malignancies, as well as to RNA editing in Cancer. Chapters in Part II and III of the book focus on histone epigenetics and DNA epigenetics, respectively.
Epigenetics and chromatin
This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility.
Encyclopedia of Molecular Pharmacology
It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Encyclopedia of Genetics, Genomics, Proteomics and Informatics
It includes about 56% more words than the 1,392-page 2nd edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. Cross-references among entries are expanded. The statements are supported by references; more than 14,000 journal papers and more than 3,000 books are listed. The book includes ~1,800 current databases and web servers. Retractions and corrigenda are pointed out.It covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, patents, etc. Similar integrated information is not available in textbooks or on the Internet. The journal reviews called it the best, high-quality resource for researchers, instructors and students of basic and applied biology, as well as for physicians and lawyers or even for interested laymen because of the clarity of presentation.
Emergent Computation : Emphasizing Bioinformatics
Emergent Computation is concerned with recent applications of Mathematical Linguistics or Automata Theory. This subject has a primary focus upon ""Bioinformatics"" (the Genome and arising interest in the Proteome), but the closing chapter also examines applications in Biology, Medicine, Anthropology, etc. The book is composed of an organized examination of DNA, RNA, and the assembly of amino acids into proteins. Rather than examine these areas from a purely mathematical viewpoint (that excludes much of the biochemical reality), the author uses scientific papers written mostly by biochemists based upon their laboratory observations. Thus while DNA may exist in its double stranded form, triple stranded forms are not excluded. Similarly, while bases exist in Watson-Crick complements, mismatched bases and abasic pairs are not excluded, nor are Hoogsteen bonds. Just as there are four bases naturally found in DNA, the existence of additional bases is not ignored, nor amino acids in addition to the usual complement of 20. Can there be more than ""64"" possible codons? RNA is examined from the point of view of Nussinov plots.
Egocentric video summarization
Video summarization is defined as the generation of a summary of extensive video content that comes from all kinds of videos including egocentric videos by detecting and presenting the material to potential users which is most informative and contains interesting information. Video summarization has many practical applications and Egocentric video summarization approaches have been proposed to solve various problems in the healthcare industry. This work focuses on Alzheimer. Patients suffering from Alzheimer’s face difficulties in remembering what happened during their day, the identity of persons and medicine they took.
Effect of antioxidants in plant extracts and free radicals on blood sample
Antioxidants are substances that inhibit and regulate the formation of free radicals, and prevent or slow down the damage to cells caused by free radicals. There is a balance between antioxidants and free radicals throughout the body, and free radicals become dangerous when the balance is disturbed Free radicals play a key role in many physiological decisions in cells. Since free radicals are toxic to cellular components, it is known that they cause DNA damage, contribute to DNA instability and mutation and thus favor carcinogenesis.Low levels of free radicals and steady state levels of antioxidant enzymes are responsible for the fine tuning of redox status inside cells. A change in redox state is a way to modify the physiological status of the cell.Many healthful foods contain antioxidants. If a person consumes some or all of these foods regularly, they may increase their antioxidant levels, potentially helping them prevent the damage that doctors associate with oxidative stress.
Ecology of Harmful Algae
Harmful algal blooms are one of the consequences of the human impact on aquatic ecosystems, particularly the process of eutrophication. They can cause a variety of deleterious effects, including the poisoning of fish and shellfish, habitat disruptions for many organisms, water discolouration, beach fouling, and even toxic effects for humans. This volume is a comprehensive synthesis of the latest research achievements concerning harmful algae (HA) ecology. International experts provide an in-depth analysis of HA topics including: global distribution, ecology of major HA groups, ecology and physiology of HA, HA and the food web, studying and mitigating HA, the human impact on HA and HA impact on human activity. This volume is an invaluable source of information for researchers in HA ecology as well as for advanced students, lecturers, and environmental managers.
Echinodermata
Members of the phylum Echinodermata are among the most familiar marine invertebrates. Forms such as the sea star have become virtually a symbol of sea life. Used in ancient oriental medicine as a source of bioactive compounds, sea cucumbers, sea stars and sea urchins are now used for the extraction and purification of cytotoxic, haemolytic, antiviral, antifungal, antifouling, antimicrobial and even anti-tumoural activities.
Drug Targets in Kinetoplastid Parasites
The book contains 12 chapters contributed by eminent scientists working in this field. The articles deal mainly with two aspects: visual identification of targets and identification of therapeutic agents.Several targets like kDNA replication machinery, purine salvage pathway, purine and pyrimidine biosynthetic pathway, histone deacetylase, DNA topoisomerases, membrane transporter proteins, glycoproteins and glycolipids are discussed in this book. Since current treatments for kinetoplastid parasitic diseases are far from ideal, there is an urgent and genuine need to develop newer compounds as antiparasitic drug candidates. Therefore evelopment of some lead compounds against these parasites as well as drug resistance are also included in this book. Moreover the vast amount of information generated after publication of the "Trytrip" genome sequence now makes possible several new approaches for target identification and discovery of therapeutic agents. This book is an outcome of the contributions of many scientists working in this important area.
DNA vaccines : Methods and protocols
Details practical procedures on the latest DNA vaccine technology. Chapters guide readers through methods and protocols on DNA vaccine design, the adjuvant influence, production and purification methodologies, delivery systems, and approaches of the influence of DNA vaccines in the immunological response performance and in the cancer immunotherapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
DNA Repair and Human Disease
DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.
DNA nanotechnology for cell research : from bioanalysis to biomedicine
Bringing together multidisciplinary aspects of chemical, material, and biological engineering, DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine presents an overview of DNA nanotechnology with emphasis on a variety of different applications in cell research and engineering, covering a unique collection of DNA nanotechnology for fundamental research and engineering of living cells, mostly in cellulo and in vivo, for the first time. Broad coverage of this book ranges from pioneering concepts of DNA nanotechnology to cutting-edge reports regarding the use of DNA nanotechnology for fundamental cell science and related biomedical engineering applications in sensing, bioimaging, cell manipulation, gene therapy, and drug delivery.
DNA Methylation, Epigenetics and Metastasis
Provides an outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. This book describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour
DNA Methylation and Cancer Therapy
DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.
DNA Methylation : Development, Genetic Disease and Cancer
It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.
