الصفحة 6
الصفحة 6
Formulating poorly water soluble drugs
A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.
Food nanotechnology
Nanotechnology is increasingly being utilized within the food industry to create innovative products with new or improved properties. This book introduces the history of nanotechnology applications in the food industry. It then discusses the key physicochemical and structural characteristics of the different kinds of nanoparticles found in foods, as well as showing how these characteristics lead to their unique functional attributes. Applications of nanotechnology in the food and agricultural industries are then covered, including the creation of nanopesticides, nanofertilizers, nutrient delivery systems, functional ingredients, smart packaging materials, nanofilters, and sensors, as well as for the conversion of waste materials into value-added products. Finally, the potential toxicity of both organic and inorganic nanoparticles found in foods is critically assessed. The author is a Distinguished Professor of food science who uses physics, chemistry, and biology to improve the quality, safety, and healthiness of foods. He has published over a thousand scientific articles and numerous books in this area and is currently the most highly cited food scientist in the world. He has won numerous awards for his scientific achievements.
Fluid Transport in Nanoporous Materials : Proceedings of the NATO Advanced Study Institute, held in La Colle sur Loup, France, 16-28 June 2003
The most promising include molecular sieves which are being developed as inorganic or polymeric systems with 0. 3-30nm in pore dimensions. These nanoporous solids have a broad spectrum of applications in chemical and biochemical processes. The unique applications of molecular sieves are based on their sorption and transport selectivity. Yet, the transport processes in nanoporous systems are not understood well. At the same time, the theoretical capabilities have increased exponentially catalyzed by increases in computational capabilities. The interactions between a diffusing species and the host solid are being studied with increasing details and realism. Further, in situ experimental techniques have been developed which give an understanding of the interactions between diffusing species and nanoporous solids that was not available even a few years ago. The time was ripe to bring together these areas of common interest and study to understand what is known and what has yet to be determined concerning transport in nanoporous solids. Molecular sieves are playing an increasing role in a broad range of industrial petrochemical and biological processes. These include shape-selective separations and catalysis as well as sensors and drug delivery. Molecular sieves are made from inorganic as well as organic solids, e. g. , polymers. They can be employed in packed beds, as membranes and as barrier materials. Initially, the applications of molecular sieves were dominated by the use of zeolites.
Expert .NET Delivery Using NAnt and CruiseControl.NET
This book is a guide to the implementation of good processes in a .NET environment. Author Marc Holmes focuses on actual implementation, and details patterns and anti-patterns to watch out for. He also provides a practical and in-depth look at NAnt and CruiseControl.NET, and solutions to common problem scenarios.
Exosomes based drug delivery strategies for brain disorders
Provides a comprehensive overview of the role of exosomes in brain diseases, including stroke, multiple sclerosis, Parkinson's disease, Alzheimer's disease, epilepsy, and depression. It covers the basics of exosome biogenesis, composition, and synthesis, as well as the therapeutic potential of exosomes in brain disorders. The correlation between exosomes and neuroinflammation, the challenges of using exosomes as a novel carrier, and engineered exosomes to deliver therapeutic protein are covered well in this book. Use of radiolabelled exosomes as a diagnostic tool and the toxicity studies of exosomes with potential overcome approaches. It is an essential resource for researchers, clinicians, and healthcare professionals working in the field of exosome research, especially on its applications in brain disorders.
Ethnobotany : A phytochemical perspective
Explores the chemistry behind hundreds of plant medicines, dyes, fibers, flavors, poisons, insect repellants, and many other uses of botanicals. Bridging the gap between ethnobotany and chemistry, this book presents an introduction to botany, ethnobotany, and phytochemistry to clearly join these fields of study and highlight their importance in the discovery of botanical uses in modern industry and research. Part I. Ethnobotany, explores the history of plant exploration, current issues such as conservation and intellectual property rights, and a review of plant anatomy. An extensive section on plant taxonomy highlights particularly influential and economically important plants from across the plant kingdom. Part II. Phytochemistry, provides fundamentals of secondary metabolism, includes line drawings of biosynthetic pathways and chemical structures, and describes traditional and modern methods of plant extraction and analysis. The last section is devoted to the history of native plants and people and case studies on plants that changed the course of human history from five geographical regions: Africa, the Americas, Asia, Europe, and Ocean. Throughout the entire book, vivid color photographs bring science to life, capturing the essence of human botanical knowledge and the beauty of the plant kingdom.
Essentials of industrial pharmacy
Presents various pharmaceutical processes and equipment that are frequently used for production of pharmaceutical dosage forms, along with quality control tests of these dosage forms. Pictorial/graphical illustrations provide easier understanding of complex pharmaceutical concepts, manufacturing processes of pharmaceutical dosage forms. Since it is imperative for pharmacy students to have a clear understanding of the basic concepts used in development of drugs into suitable and stable dosage forms.
Essential pharmaceutics
Essential Pharmaceutics is suited to this modern teaching style, and is the first book of its kind to provide the resources and skills needed for successful implementation of an active learning pharmaceutics course.This text offers a format that is specifically suited for integration in an active learning, team-based classroom setting
Epigenome editing : Methods and protocols
This second volume details new and updated methods covering applications of epigenome editing. Chapters guide readers through general and topical reviews, DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Endodontic Irrigation : Chemical disinfection of the root canal system
Reviews the available information on bacterial disinfection in endodontics, with emphasis on the chemical treatment of root canals based on current understanding of the process of irrigation. It describes recent advances in knowledge of the chemistry associated with irrigants and delivery systems, which is of vital importance given that chemical intervention is now considered one of the most important measures in eliminating planktonic microbes and biofilms from the infected tooth.
Emerging drug delivery and biomedical engineering technologies : transforming therapy
Details the advances in drug discovery and delivery and the present need for emerging technologies. Throughout the text new micro and nanofabrication techniques are described, including methods such as electrohydrodynamic processes, additive manufacturing, and microfluidics, which have the potential to produce drug delivery systems that were not possible a few years ago. This book is of great use to both entry-level and experienced researchers in the field of emerging technologies for the manufacturing of drug delivery devices.
Emergency Radiology : Imaging and Intervention
There is an increasing trend towards the use of tries, hospital emergency departments have become a MDCT to evaluate traumatic injuries and non-traumatic major part of the healthcare safety net. In the last decade emergencies. The use of workstations for reporting and for economically-driven structural changes in health care further image reconstruction becomes standard practice. delivery have caused a dramatic increase in emergency On the occasion of the European Congress of Radiology department visits. In response to capacity and staffing (ECR) 2003 and 2004 a Categorical Course on “Emergency pressures, hospitals are developing and implementing a Radiology”has been organized to assess current devel- variety of strategies designed to improve patient flow and ments and concepts in this rapidly growing field. reduce overcrowding in the emergency department. Numerous radiologists,all outstanding and international- Several factors are considered critical for success, such as ly renowned experts in their field,have made superb c- having the right multidisciplinary teams in place and opti- tributions in an ECR syllabus.
Embedded systems design : The ARTIST roadmap for research and development
Embedded systems now include a very large proportion of the advanced products designed in the world, spanning transport (avionics, space, automotive, trains), electrical and electronic appliances (cameras, toys, televisions, home appliances, audio systems, and cellular phones), process control (energy production and distribution, factory automation and optimization), telecommunications (satellites, mobile phones and telecom networks), and security (e-commerce, smart cards), etc. The extensive and increasing use of embedded systems and their integration in everyday products marks a significant evolution in information science and technology. We expect that within a short timeframe embedded systems will be a part of nearly all equipment designed or manufactured in Europe, the USA, and Asia. There is now a strategic shift in emphasis for embedded systems designers: from simply achieving feasibility, to achieving optimality. Optimal design of embedded systems means targeting a given market segment at the lowest cost and delivery time possible. Optimality implies seamless integration with the physical and electronic environment while respecting real-world constraints such as hard deadlines, reliability, availability, robustness, power consumption, and cost. In our view, optimality can only be achieved through the emergence of embedded systems as a discipline in its own right.
Elements of Mathematics for Economics and Finance
Based on over 15 years’ experience in the design and delivery of successful first-year courses, this book equips undergraduates with the mathematical skills required for degree courses in economics, finance, management and business studies. The book starts with a summary of basic skills and takes its readers as far as constrained optimisation helping them to become confident and competent in the use of mathematical tools and techniques that can be applied to a range of problems in economics and finance
eHealth Solutions for Healthcare Disparities
eHealth Solutions for Health Care Disparities brings these currents together, challenging readers to use, promote, and develop new technology-based methods for closing these gaps. The book examines cyber-strategies with the greatest potential toward effective, equitable care, improved service delivery and better health outcomes for all.
Effective communication
Gives you the tools to improve your communication in a business environment. Discover how to improve your communication skills by learning to understand your audience, communicate strategically and discover which delivery approach is right for you. You'll also develop confidence, learn to listen effectively and give and receive feedback. In a slim, portable format, Essential Managers Effective Communication gives you a practical "how-to" approach with step-by-step instructions, tips, checklists & "ask yourself" features showing you how to overcome barriers to communication choose the right medium for your message, and make an impact
Effective and efficient organisations? : Government export promotion in Germany and the UK from an organisational economics perspective
Using organisational economics theory, the author develops a conceptual framework for analysing the effectiveness and efficiency of public services delivery. In applying the framework to case studies of export support organisations in Germany and the UK , the research establishes the causal links between organisational structures and outputs. The decisive variables are knowledge and incentives of the actors, and adaptability of the organisation.
Educational Decentralization : Asian Experiences and Conceptual Contributions
Decentralization and Education: Asian Experiences and Conceptual Contributions examines the specific ways in which decentralization policies have affected the structure and delivery of education in eleven Asian nations. Written by top scholars in the field, the case studies provide detailed and rich empirical evidence documenting the tensions as well as synchronisms between the ideas that form the basis of decentralization policy and the contexts into which they are introduced. The high quality of this collection essays and the careful attention to local contexts for implementation will make this book a must read for academics, policy planners, practitioners, and students of Asia.
E-cigarette : A safer choice or a potential killer?
Aims to define the term e-cigarettes, to explain in detail what e-cigarettes are, to explain how e-cigarettes work, to review the range of e-cigarettes that currently exist, to define the term vaping and to examine the impact of e-cigarette usage on human health. The study will add to the current body of knowledge by showing why e-cigarettes are a public health concern due to their impac on human health. In this study, it is revealed that chemical exposure through e-cigarette use can harm an individual's health
Drugs and a methodological compendium : From bench to bedside
Provides a meticulous view on methodological drug discovery and development insights from bench to bedside. Focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. Covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.
