الصفحة 6
الصفحة 6
Misbehaving Proteins : Protein (Mis)Folding, Aggregation, and Stability
Misfoldedaggregatedproteinoncewasconsideredasinterestingasyesterday’strash—a bothersome by-product of important and productive activities, to be disposed of and forgotten as quickly as possible. Yesterday’s trash has become today’s focus of cons- erable scienti?c interest for at least two reasons: (1) protein aggregates are at the core of a number of chronic degenerative diseases such as Alzheimer’s disease, and (2) - gregation poses signi?cant obstacles to the manufacture of safe, ef?cacious, and stable protein products. As interest in protein misfolding, aggregation, and stability has soared beyond the core group of traditional protein-folding scientists, and as substantial scienti?c progress in understanding and controlling protein misfolding has been achieved, the need to summarize the state of the art became manifest. Although there are many excellent texts and edited collections on protein structure and folding, these volumes tend to relegate protein misfolding and aggregation to a minor role. Review articles and books focused on the biological role of protein aggregates in diseases have been published recently.
Mining Equipment Reliability, Maintainability, and Safety
From its origins in the malachite mines of ancient Egypt, mining has grown to become a global industry which employs many hundreds of thousands of people. Today, the mining industry makes use of various types of complex and sophisticated equipment, for which reliability, maintainability and safety has become an important issue. Mining Equipment Reliability, Maintainability, and Safety is the first book to cover these three topics in a single volume.
Minimally Invasive Tumor Therapies
In the age of the World Wide Web, informed patients continue to surprise oncologists with detailed questions about popular tumor therapies. Although minimally invasive tumor therapies (MITT) have become daily clinical practice for palliative treatment of liver tumors, the acceptance of these palliative modalities still varies enormously. In addition, promising results have been published for in situ ablation of lung metastases, bone tumors, and renal cell carcinoma. This book gives an up-to-date overview of the popular techniques and clinical results of MITT, with a clarification of the actual indications including the size, tumor entities, and clinical benefits. Moreover, the book focuses on the prospectives and limitations of imaging methods - ultrasound, computed tomography, and magnetic resonance imaging - used for MITT.
Minimally invasive glaucoma surgery
This book covers all aspects of minimally invasive glaucoma surgery (MIGS) and provides detailed information on each MIGS device, including its mechanism of action; patient selection; implantation techniques; post-operative management; and a review of the existing literature. Step-by-step descriptions are provided for the surgical technique used in implanting each MIGS device, accompanied by clear photographs of each surgical stage. Other areas covered include intra-operative gonioscopy (with tips on optimising the view of the anterior chamber angle) and the management of the intra-operative and post-operative complications. Essential information on the anatomy and physiology of the different aqueous outflow pathways is also included.
Microwave Radiometry of Vegetation Canopies
Research into microwave radiation from the Earth’s surface in the presence of vegetation canopies, as well as the development of algorithms for retrieval of soil and vegetation parameters from microwave radiometric measurements, have been actively conducted for the last 30 years by scientific groups worldwide. The capability of the microwave radiometric method to determine soil moisture and vegetation biometric indices was revealed 25 years ago by the author and his colleagues. Soil moisture and vegetation covers play a key role in the hydrological cycle and in water and energy transfer on the border of land surface and atmosphere through evaporation and transpiration. Accomplishment of large international projects shows that microwave radiometry of soil and vegetation has become an instrument of practical application and operational use. A systematic account of questions concerning the microwave radiometry of the Earth’s surface in the presence of vegetation canopies is the main objective of the book.
Micro-Tomographic Atlas of the Mouse Skeleton
Micro-Tomographic Atlas of the Mouse Skeleton serves as an essential guide containing unique systematic description of all calcified components of the mouse. This detailed atlas fulfils an emerging need for high resolution anatomical details as mice become a standard laboratory animal in skeletal research and the use of m CT technology is rapidly increasing as a key analytical tool in the study of bone.
Microstructuring of Glasses
As microstructured glass becomes increasingly important for microsystems technology, the main application fields include micro-fluidic systems, micro-analysis systems, sensors, micro-actuators and implants. And, because glass has quite distinct properties from silicon, PMMA and metals, applications exist where only glass devices meet the requirements. The main advantages of glass derive from its amorphous nature, the precondition for its - theoretically - direction-independent geometric structurability. Microstructuring of Glasses deals with the amorphous state, various glass compositions and their properties, the interactions between glasses and the electromagnetic waves used to modify it.
Microsimulation Population Projections with SAS : A Reference Guide
This book for a researcher needs to perform microsimulation for population projections, building its own model with a common statistical software such as SAS might a good option, because this software is widely used among scholars and is taught in most social sciences departments. We define what is microsimulation: a modelling based on individual-level data rather than aggregated level data, in which transitions between the states are determined stochastically with a random experiment. We finally provide some examples of microsimulation models used by social scientists.
Microplastic in the Environment : Pattern and Process
This book examines global plastic pollution, an issue that has become a critical societal challenge with implications for environmental and public health. This volume provides a comprehensive, holistic analysis on the plastic cycle and its subsequent effects on biota, food security, and human exposure. Importantly, global environmental change and its associated, systems-level processes, including atmospheric deposition, ecosystem complexity, UV exposure, wind patterns, water stratification, ocean circulation, etc., are all important direct and indirect factors governing the fate, transport and biotic and abiotic processing of plastic particles across ecosystem types.
Micromanufacturing and Nanotechnology
Micromanufacturing and Nanotechnology is an emerging technological infrastructure and process that involves manufacturing of products and systems at the micro and nano scale levels. Development of micro and nano scale products and systems are underway due to the reason that they are faster, accurate and less expensive. Moreover, the basic functional units of such systems possesses remarkable mechanical, electronic and chemical properties compared to the macro-scale counterparts. Since this infrastructure has already become the prefered choice for the design and development of next generation products and systems it is now necessary to disseminate the conceptual and practical phenomenological know-how in a broader context. This book incorporates a selection of research and development papers. Its scope is the history and background, underlynig design methodology, application domains and recent developments.
Microbiome
Despite the increasing interest of healthy or fat as well sick people in selecting a suitable diet for them, as nutrition is becoming an interesting area recently, in contrast to that we have noticed that there is almost a rare or no interest in Microbiome field in our country by which we can be much more accurate in selecting a diet based on comparing a map of microbiomein healthy person with ill person individually to provide a patient with the right missing food to improve his immune system, or even for a child since birth, to build the best immune system as we compared the benefits of mother’s milk, and artificial one, therefore we will focus in our study on this new science for two reasons the first is to present it and secondly to integrate it in the practice by interested doctors.
Microbial Activity in the Rhizosphere
The rhizosphere is a very complex environment in which the effects of the plant on soil microorganisms and the effects of the microorganisms on the plant are interacting and are interdependent. Plant root exudates and breakdown products attract microbes and feed them and, in turn, the plants often benefit from the microbes. Interactions among microorganisms and plant roots are essential for nutritional requirements of the plant. Plant growth, development and productivity are largely dependent on the soil environment in the root region rhizosphere. The new techniques of studying the rhizosphere enables us to get a much better understanding of the dynamics of the rhizosphere population, such rhizosphere studies being of interest to agriculturists, soilbiologists, chemists, microbiologists and molecular biologists. The rhizosphere microbes in?uence the root environment in several ways. They may change the oxidation-reduction potential, influence the availability of moisture and nutrients, produce growth inhibiting or growth promoting substances in the form of exudates, provide competition and possibly induce many other effects. My corrhizal associations are beneficial in mineral uptake and in increasing root surface area for effective ion absorption. Antagonism, ompetition and synergism in soil and the rhizoplane (rhizosphere) are the most important microbial interactions to consider in the study of rhizosphere biology. With the growing information on the production of growth regulators, competitiveness of the microbes in the rhizosphere, microsymbionts, and other factors, their effect upon plant growth will become more evident. Experiments on the introduction of microbes or their products in the rhizosphere will help to improve our understandingofthebiologyoftherhizosphere.
Metallocenes in Regio- and Stereoselective Synthesis
Metallocene is a well known sandwich complex with two cyclopentadienyl ligands such as ferrocene. Recently, such metallocene compounds have been found to be very characteristic and they have become very important, not only in the area of organic synthesis, but also in polymerization in industry. Metal complexes with one cyclopentadienyl ligand have also become popular as half sandwich complexes. The number of researchers in the field of metallocenes has increased rapidly. However, the origin of the characteristic reactivity of metallocenes is not fully understood. In this volume, the chemistry of metal complexes with at least one cyclopentadienyl ligand is comprehensively covered by leading experts. Reactions discussed here are (i) natural product synthesis, (ii) catalytic asymmetric synthesis, (iii) cyclization reactions, (iv)catalytic reactions, (iv) polymerization reactions and (v) carbon-carbon bond cleavage reactions. The reader will have access to useful information about the current state of metallocene chemistry.
Metalliferous Sediments of the World Ocean : Fundamental Theory of Deep-Sea Hydrothermal Sedimentation
Dramatic advances in understanding global tectonics have been made in the last half century and the information and specific data acquired on the floor of the World Ocean by the scientific community probably has exc- ded that available in all previous time. With the benefit of new technology and advanced concepts in the earth sciences extensive exploration of the deep seabed became possible, and has been carried out in many parts of the world. Many features have been recognized and data recorded that are vital for understanding the fundamental processes that shape the earth=s surface and control the habitable environment. The data collected to date on the o- an floor and its physical environment greatly exceeds our understanding and appreciation of their fundamental importance in the earth sciences, and our ability to apply this knowledge effectively in improving our way of life.
Metal Matrix Composites
Metal matrix composites (MMCs) have become real engineering materials. MMCs have gone from "niche" materials to several high performance applications in aerospace, electronic packaging, automotive, and recreational products. This text focuses on the synergistic relationships among processing, microstructure, and properties of metal matrix composites. An introductory chapter is followed by a chapter each on reinforcements and common matrix materials. A chapter on the very important topic of processing of MMC is then presented. This is followed by a chapter on interfaces in MMCs, their characterization and techniques to obtain interfacial properties. Next there are chapters on monotonic mechanical and physical properties; followed by cyclic fatigue, creep, and wear resistance. We conclude with a chapter on applications of MMCs. The book is well-suited for upper level undergraduate students, graduate students, and as general source of reference on the subject for the professionals in the field.
Metal Catalyzed Cascade Reactions
Transition metal-catalyzed cascade reactions are an elegant approach to complex molecular scaffolds. Besides their esthetics and increase in structural complexity, they have also become mechanistic challenges for the combination of organometallic elementary steps. As a consequence, cascade reactions have revolutionized synthetic strategies and conceptual thinking. The authors highlight cyclization via carbopalladation and acylpalladation and Heck-pericyclic sequences. They discuss p-allyl palladium-based cascade reactions, Michael-type additions as an entry to transition-metal-promoted cyclizative transformations, and sequential or consecutive palladium-catalyzed processes, and show Pauson-Khand cascades, metal-catalyzed cyclizations of acyclic precursors, as well as cascade and sequential ruthenium-catalyzed transformations. Therefore, the reader finds overview of an exciting and highly dynamic field of a new and innovative methodological concept
Messung von Ressourceneffizienz mit der ESSENZ-Methode : Integrierte Methode zur ganzheitlichen Bewertung = Measuring resource efficiency with the ESSENCE method : Integrated method for holistic evaluation
Develops a reliable method for evaluating the use of resources. This is necessary because the strong economic growth of the last decades has led to an intensive use of natural resources. With their increasing use, there are also additional burdens on the environment and restrictions on the availability of resources. For these reasons, efficient use of resources is required as an important contribution to sustainable development.
Messenger RNA therapeutics
Focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine.
Meshfree Methods for Partial Differential Equations III
Meshfree methods for the numerical solution of partial differential equations are becoming more and more mainstream in many areas of applications. Their flexiblity and wide applicability are attracting engineers, scientists, and mathematicians to this very dynamic research area. This volume represents the state of the art in meshfree methods. It consists of articles which address the different meshfree techniques, their mathematical properties and their application in applied mathematics, physics and engineering.
Medicina fisica e riabilitativa nei disturbi di equilibrio = Physical and rehabilitative medicine in balance disorders
Balance disorders are very common in the population: particularly frequent over the age of 40, are the first motivation for a medical examination after the age of 65 and frequently tend to become chronic. Balance disorders are symptoms of system dysfunction vestibular, complex sensory-psycho-motor system, whose task is that to control the activity of the antigravity muscles to maintain the erect station, of the oculomotor ones to allow the stabilization of the visual field during movement, and the neurovegetative functions they have relationship with standing and movement. Whether the vestibular system provides the information necessary for the check-up of the erect position, the rachis realizes it through a "stability dynamic ", allowed by its structural characteristics proprioception the spine is also a fundamental sensor for controlling balance ; therefore the techniques of physical and rehabilitative medicine and of manual medicine represent a powerful tool for curing ailments equilibrium. This volume comes from the comparison between a physiatrist and an audiologist, who for 15 years have integrated their clinical experience and therefore proposes a new one inter-specialist approach to the diagnostic and therapeutic problems of patients with balance disorders.
