الصفحة 59
الصفحة 59
Bisphosphonates in medical practice : Actions - side effects - indications - strategies
Clinical osteology is now an independent specialty which nevertheless encompasses all branches of medicine and effects each and every one of us: Bone is Every Body´s Business: This book has been designed as an up to date manual to deal with the currently recognized indications for bisphosphonates, to outline situations and conditions for prevention of skeletal disorders, and to provide practical guidelines for treatment. It is intended for doctors who seek precise information on bisphosphonates in medical practice to enable them to treat patients with disorders of bone or better still to avoid their occurrence .
Bipolar disorder
Mood" is defined as a ubiquitous and sustained feeling or emotion that dominates a person’s behavior and affects his perception. Mood disorders also known as affective disorders include unipolar and bipolar disorders. Manic-depressive disorder--more contemporarily identified as bipolar disorder (BD)--is a chronic and complex disorder of mood that is characterized by a combination of manic, hypomanic, and depressive episodes, with subsyndromal symptoms extant in between the mood episodes. It is one of the leading causes of worldwide disability and morbidity.
Biotechnologies for plant mutation breeding : Protocols
This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries. The collection of protocols equips users with the techniques they need in order to start a program on mutation breeding or functional genomics using both forward and reverse-genetic approaches. Methods are provided for seed and vegetatively propagated crops (e.g. banana, barley, cassava, jatropha, rice) and can be adapted for use in other species.
Biomimetic neural learning for intelligent robots : Intelligent systems, cognitive robotics, and neuroscience
This book presents research performed as part of the EU project on biomimeticmultimodal learning in a mirror neuron-based robot (MirrorBot) and contribu-tions presented at the International AI-Workshop on NeuroBotics. The over-all aim of the book is to present a broad spectrum of current research intobiomimetic neural learning for intelligent autonomous robots. In this book we show the development of newtechniques using cell assemblies, associative neural networks, and Hebbian-typelearning in order to associate vision, language and motor concepts. We havedeveloped biomimetic multimodal learning and language instruction in a robotto investigate the task of searching for objects. As well as the research performedin this area for the MirrorBot project, the second part of this book incorporatessignificant contributions from other research in the field of biomimetic robotics.This second part of the book concentrates on the progress made in neuroscienceinspired robotic learning approaches (in short: NeuroBotics). We hope that this book stimulates and encourages new research in this in-teresting and dynamic area.
BioMEMS and biomedical nanotechnology ; Vol. III : Therapeutic Micro/Nanotechnology
The human body is composed of structures organized in a hierarchical fashion: from biomolecules assembled into polymers, to multimeric assemblies such as cellular or-ganelles, to individual cells, to tissues, to organ systems working together in health and disease- each dominated by a characteristic length scale. Decades of science and engineer-ing are now converging to provide tools that enable the orderly manipulation of biological systems at previously inaccessible, though critically important, length scales (<100 mi-crons). Thus, the approaches described in this volume provide a snapshot of how micro-and nanotechnologies can enable the investigation, prevention, and treatment of human disease.The volume is divided into three parts. The first part, Cell-based therapeutics; cov- ers the merger of cells with micro- and anosystems for applications in regenerative medicine spanning the development of novel nanobiomaterials.
Biomarkers for alzheimer’s disease drug development
Helping to accelerate Alzheimer’s disease drug development. Addressing the latest advances in preclinical and clinical research, including new insights into the molecular mechanisms and emerging therapeutic strategies, the book continues by exploring digital biomarkers and advanced neuroimaging analysis which will transform how clinical trials in the Alzheimer’s disease field are performed.
Biomarkers as targeted herbal drug discovery : A pharmacological approach to nanomedicines
Looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits. Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid. Reviews the literature on inflammatory biomarkers in the treatment of diseases Looks at the development of herbal drug discovery based on biomarkers Explores emerging concepts of nanomedicines for herbal drug delivery Takes an interdisciplinary approach, with application to disciplines related to medical, pharmaceutical, biotechnological, Ayurvedic, Unani and biomedical engineering fields
Bioinformatics drug discovery
Quantitative tools are becoming increasingly important in order to understand complex cascade of signal transduction events, pathways or biochemical reactions. The book showcases how computational techniques and algorithms are applied to biological data analysis, interpretation, and modelling. It covers applications in drug design and discovery, immune systems, phylogenetic analysis and protein structures.
Biogeochemistry of Trace Elements in Arid Environments
Global warming has worsened the water resource crisis in many arid zones worldwide, from Africa to Asia, affecting millions of people and putting them at risk of hunger. Effective management of arid zone resources, including understanding the risks of toxic trace and heavy elements to humans, coupled with the need to produce more food to feed the world’s growing population, has thus become increasingly important. This very timely book, the only one of its kind on the market, fills the gap of our knowledge of trace elements in these regions. This book begins by introducing the nature and properties of arid zone soil, followed by an updated overview and comprehensive coverage of the major aspects of the trace elements and heavy metals of most concern in the world’s arid and semi-arid soils. These aspects include: - content and distribution - solution chemistry - solid-phase chemistry - selective sequential dissolution techniques - transfer fluxes - bioavailability - pollution and remediation In order to illustrate the themes, a comprehensive and focused case study on transfer fluxes of trace elements in Israeli arid soils is presented. Finally it closes with the global perspectives on anthropogenic interferences in the natural trace elements’ distribution.
Biofuels and sustainability : Holistic perspectives for policy-making
This open access book presents a comprehensive analysis of biofuel use strategies from an interdisciplinary perspective using sustainability science. This interdisciplinary perspective (social science-natural science) means that the strategies and policy options proposed will have significant impacts on the economy and society alike. Biofuels are expected to contribute to reducing greenhouse gas emissions, revitalizing economies in agricultural communities and alleviating poverty. However, despite these anticipated benefits, international organizations such as the FAO, OECD and UN have published reports expressing concerns that biofuel promotion may lead to deforestation, water pollution and water shortages. The impacts of biofuel use are extensive, cross-sectoral and complex, and as such, comprehensive analyses are required in order to assess the extent to which biofuels can contribute to sustainable societies.
Bioethics across the globe : Rebirthing bioethics
This book addresses a variety of issues relating to bioethics, in order to initiate cross-cultural dialogue. Beginning with the history, it introduces various views on bioethics, based on specific experiences from Japan. It describes how Japan has been confronted with Western bioethics and the ethical issues new to this modern age, and how it has found its foothold as it decides where it stands on these issues. In the last chapter, the author proposes discarding the overarching term ‘Global Bioethics’ in favor of the new term, ‘Bioethics Across the Globe (BAG)’, which carries a more universal connotation.
Bioeconomy and Global Inequalities Socio-Ecological Perspectives on Biomass Sourcing and Production
This book explores bioeconomy and bioenergy policies across South America, Asia and Europe. It discusses how a transition away from a fossil and towards a bio-based economic order alters, reinforces and challenges socio-ecological inequalities. A series of conceptual discussions and case studies with a multidisciplinary background in the Social Science illuminate how the deployment of biomass sources from the agricultural and forestry sectors affect societal changes concerning knowledge production, land and labour relations, political participation and international trade
Big Data and Global Trade Law
Explores the relevance of global trade law for data, big data and cross-border data flows. Contributing authors from different disciplines including law, economics and political science analyze developments at the World Trade Organization and in preferential trade venues by asking what future-oriented models for data governance are available and viable in the area of trade law and policy. The collection paints the broad picture of the interaction between digital technologies and trade regulation as well as provides in-depth analyses of critical to the data-driven economy issues, such as privacy and AI, and different countries' perspectives.
Big Data : Conceptual Analysis and Applications
The book is devoted to the analysis of big data in order to extract from these data hidden patterns necessary for making decisions about the rational behavior of complex systems with the different nature that generate this data. To solve these problems, a group of new methods and tools is used, based on the self-organization of computational processes, the use of crisp and fuzzy cluster analysis methods, hybrid neural-fuzzy networks, and others. The book solves various practical problems. In particular, for the tasks of 3D image recognition and automatic speech recognition large-scale neural networks with applications for Deep Learning systems were used.
Beyond Media Borders ; Vol.2 : Intermedial Relations among Multimodal Media
This book promotes the idea that all media types are multimodal and that comparing media types, through an intermedial lens, necessarily involves analysing these multimodal traits.
Beyond Media Borders ; Vol.1 : Intermedial relations among multimodal media
This book promotes the idea that all media types are multimodal and that comparing media types, through an intermedial lens, necessarily involves analysing these multimodal traits.
Beyond Kyoto : A new global climate certificate system : Continuing Kyoto commitsments or a global ´Cap and Trade´ scheme for a sustainable climate policy?
This book shows how humankind can ‘prevent dangerous interference with the c- mate system’ without dangerous interference with the global economic system. In the two underlying studies on behalf of the Ministry of Environment and Transport of i the German federal state of Baden-Württemberg, the results have been elaborated through scientific evaluation of different climate protection systems and intensive developmental work on an efficient climate protection system. The results will be presented in nine chapters according to the following nine basic R&D steps: 1. Quantifying the ‘ultimate climate objective’ of the world community in order ‘to prevent dangerous interference with the climate system,’ thus achieving climate sustainability; 2. Development of a comprehensive standard system for evaluating the prospect of success for different climate protection systems; 3. Based on this scientific standard system, evaluation of the current Kyoto system and of the most important proposals for ‘incremental regime evolution’ of the Kyoto system. Unfortunately, it must be noted that these systems are incapable of achi- ing climate sustainability; 4. Evaluating three proposals for ‘structural regime change’ of the Kyoto system. Following this objective evaluation process and numeric comparison of the diff- ent proposals, 5. Description of the eight basic elements of GCCS and its in-depth ‘critical asse- ment;’ 6.
Best of five MCQs for the endocrinology and diabetes SCE
Including questions based on the latest National Institute for Health & Care Excellence (NICE), Joint British Diabetes Societies (JBDS) & Endocrine Society clinical practice guidelines. Includes 20 more questions on diabetes to reflect the increased weighing given to this subject in the SCE exam. New tables and algorithms have been added to provide specialty trainees useful information relevant to clinical practice
Benefit/Cost-Driven Software Development : With Benefit Points and Size Points
This book presents a set of basic techniques for estimating the benefit of IT development projects and portfolios. It also offers methods for monitoring how much of that estimated benefit is being achieved during projects. Readers can then use these benefit estimates together with cost estimates to create a benefit/cost index to help them decide which functionalities to send into construction and in what order. This allows them to focus on constructing the functionality that offers the best value for money at an early stage.
Benchmarking, Temporal Distribution, and Reconciliation Methods for Time Series
This book discusses the statistical methods most often applied for such adjustments, ranging from ad hoc procedures to regression-based models. The latter are emphasized, because of their clarity, ease of application, and superior results. Each topic is illustrated with many real case examples. In order to facilitate understanding of their properties and limitations of the methods discussed, a real data example, the Canada Total Retail Trade Series, is followed throughout the book.This book brings together the scattered literature on these topics and presents them using a consistent notation and a unifying view.
