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More Joel on software : Further toughts on diverse and occasionally related matters that will prove of interest to software developers, designers, and managers, and to those who, whether by good fortune or III Luck, work with them in some capacity
Joel Spolsky started his weblog in March 2000 in order to offer his insights, based on years of experience, on how to improve the world of programming. This weblog has become infamous among the programming world, and is linked to more than 600 other web sites and translated into 30+ languages! Spolsky's extraordinary writing skills, technical knowledge, and caustic wit have made him a programming guru. With the success of Joel on Software, there has been a strong demand for additional gems and advice, and this book is the answer to those requests. Containing a collection of all–new articles from the original, More Joel on Software has even more of an edge than the original, and the tips for running a business or managing people have far broader application than the software industry.
Molecules in Superfluid Helium Nanodroplets : Spectroscopy, Structure, and Dynamics
This book covers recent advances in experiments using the ultra-cold, very weakly perturbing superfluid environment provided by helium nanodroplets for high resolution spectroscopic, structural and dynamic studies of molecules and synthetic clusters. The recent infra-red, UV-Vis studies of radicals, molecules, clusters, ions and biomolecules, as well as laser dynamical and laser orientational studies, are reviewed. The Coulomb explosion studies of the uniquely quantum structures of small helium clusters, X-ray imaging of large droplets and electron diffraction of embedded molecules are also described. Particular emphasis is given to the synthesis and detection of new species by mass spectrometry and deposition electron microscopy.
Molecular Pathology of Gynecologic Cancer
This book focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. The volume begins with an explication of the editors’ hypothesis that cancer is mainly a disease of the cell cycle, based on the deregulation of the physiological process of cell reproduction. The following eleven chapters focus on specific issues in gynecologic cancers, including: a proposed model of ovarian serous carcinogenesis, molecular markers for ovarian epithelial cancer, an overview of the pathology of endometrial cancer, molecular genetic aspects of endometrial carcinoma and cervical cancer, a natural history of Human Papilloma Virus (HPV) as it relates to cervical cancer, and hereditary issues in gynecologic cancers. The concluding chapter proposes and outlines a holistic approach to the treatment of female cancer patients.
Molecular Paradigms of Infectious Disease : A Bacterial Perspective
This comprehensive volume, written by leading authors in the field, provides a fundamental understanding of the complex cellular and molecular processes that are important for bacterial virulence and the infectious disease process. Written in a clear and engaging manner, the book highlights key techniques and methodologies that have driven recent discoveries in bacterial pathogenesis, major structures and mechanisms in bacteria that are important for the pathogenesis of these organisms, the regulation of these virulence determinants by global regulators, and bacterial biowarfare agents. Molecular Paradigms of Infectious Disease: A Bacterial Perspective is an ideal book for students, microbiologists, immunologists and scientists and researchers of bacterial pathogenesis.
Molecular Neurosurgery with Targeted Toxins
Focuses on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.
Molecular Imaging II
The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is beeing addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.
Molecular Imaging I
The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is being addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.
Molecular Imaging ; An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy
The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.
Molecular Imaging : Computer Reconstruction and Practice
This book reports the majority of lectures given during the NATO Advanced Study Institute ASI-982440, which was held at the European Scienti?c Institute of Archamps (ESI, Archamps – France) from November 9 to November 21, 2006. The ASI course was structured in two parts, the ?rst was dedicated to individual imaging techniques while the second is the object of this volume and focused on data modelling and processing and on image archiving and distribution. Courses devoted to nuclear medicine and digital imaging techniques are collected in a c- plementary volume of NATO Science Series entitled “Physics for Medical Imaging Applications”
Molecular genetics, structures, mechanisms, and functions : Principles of gene manipulation and genomics ; Vol.1
Provides an overview of the future of genetic engineering and delves into the role of biotechnology and its applications in genetic engineering. It discusses the tools of recombinant technology, which have brought about revolution in our understanding of various complex biological phenomena. Chapters cover mutagenesis, construction, and sequencing of DNA libraries along with applications of genetic engineering for improving health, preventing genetic diseases, enhancing food resources, managing environmental bioremediation, and more. Topics include genetic engineering tools for restriction enzymes and vectors, gene and cell division, mutation detection and screening in plants, population genetics, sexuality in bacteria, and more. Several chapters focus on the tools of recombinant technology, such as restriction enzymes, vectors, etc., that have paved the way for creating organisms of choice and opened new horizons in the field of medicine, agriculture, and industry for human welfare.
Molecular Basis of Thyroid Cancer
Molecular Basis of thyroid Cancer brings together top-flight experts from across the globe to consider present state of the art treatment and techniques and what the future holds. The product of this effort is invaluable to endocrinologists, particularly those with an interest in the thyroid, molecular oncologists, nuclear medicine physicians and those in biotechnology intent on devising innovative therapies for cancer. "Significant advances in our understanding of thyroid cancer have occurred over the previous decade. This text discusses the molecular alterations and pathologic manifestations seen in this disease. Distinguished investigators address both the basic biology and clinical issues pertinent to our understanding and management of patients with thyroid cancer."
Modern Sports Dentistry
A one-stop reference that will assist primary care community dentists, sports physicians, athletic trainers, and emergency room physicians in meeting the needs of athletes when managing facial and dental trauma and sports-related oral diseases. The opening chapters provide a complete review of sports-related dentoalveolar trauma, with coverage of emergent care, the role of endodontics, surgical issues, and restorative considerations. Prevention of dental trauma by means of mouthguards is then examined, with attention to materials and design, public policy concerning the use of mouthguards, and the role of mouthguards in relation to the ever more pressing issue of concussion in sport. Dental erosion in athletes, for example due to energy drinks, is discussed, as are the possible sequelae of use of spit tobacco, performance-enhancing drugs, and ergogenic aids. The new topic of the potential value of dental appliances in enhancing sports performance is also addressed.
Modern Developments in X-Ray and Neutron Optics
This volume describes modern developments in reflective, refractive and diffractive optics for short wavelength radiation as well as recent theoretical approaches to modelling and ray-tracing the X-ray and neutron optical systems. It is based on the joint research activities of specialists in X-ray and neutron optics from 11 countries, working together under the framework of the European Programme for Cooperation in Science and Technology (COST, Action P7) in the period 2002--2006. The chapters are written by leading specialists from European laboratories, universities and large facilities. In addition to new ideas and concepts, the contents provide a large amount of practical information about recently implemented devices and methods.
Modern Computational Intelligence Methods for the Interpretation of Medical Images
A detailed description of up-to-date methods used for computer processing and interpretation of medical images is given. The scope of the book include images acquisition, storing with compression, processing, analysis, recognition and also its automatic understanding In introduction general overview of the computer vision methods designed for medical images is presented. Next sources of medical images are presented with their general characteristics. Both traditional (like X-ray) and very modern (like PET) sources of medical images are presented. The main emphasis is placed on such properties of medical images given by particular medical imaging methods which are important form the point of view of its computer processing, analysis and recognition.
Modern Biogeochemistry : Environmental Risk Assessment
At present, quantitative ecological risk assessment is widely used in different contexts, however very often without an understanding of the natural mechanisms that drive the processes of environmental and human risk. Its application is often accompanied by high uncertainty about risk values. On the other hand, the sustainability of modern technoecosystems is known because of their natural biogeochemical cycling that has been transformed to various extents by anthropogenic studies. Accordingly our understanding of the principal mechanisms that drive the biogeochemical food webs allows us to present a quantitative ecological risk assessment and to propose technological solutions for management of various ERA enterprises. It also enables us to devise a powerful mechanism for ecological insurance, to assign responsibilities and protect rights while managing the control of damage from natural and anthropogenic accidents and catastrophes.
Modeling and Management of Fuzzy Semantic RDF Data
Presents the latest research findings in fuzzy RDF data modeling and management. Fuzziness widely exist in many data and knowledge intensive applications. With the increasing amount of metadata available, efficient and scalable management of massive semantic data with uncertainty is of crucial importance. This book goes to great depth concerning the fast-growing topic of technologies and approaches of modeling and managing fuzzy metadata with Resource Description Framework (RDF) format. Its major topics include representation of fuzzy RDF data, fuzzy RDF graph matching, query of fuzzy RDF data, and persistence of fuzzy RDF data in diverse databases. The objective of the book is to provide the state-of-the-art information to researchers, practitioners, and postgraduates students who work on the area of big data intelligence and at the same time serve as the uncertain data and knowledge engineering professional as a valuable real-world reference.
Mobile World : Past, Present and Future
Key reading for all those involved with the future of mobile communications, this book is a valuable resource, particularly for advanced undergraduate and postgraduate students on Mobile Technology courses, practitioners, and researchers working in mobile communications, CSCW and HCI. This volume is a sequel to Brown et al: Wireless World: Social and Interactional Aspects of the Mobile Age, also in the CSCW series. "This book presents a rich insight into how and why the mobile has become so important in today’s society. It explores the strong emotional attachment that people have to these devices, and argues that it is people and not the technology that developers must put at the heart of future mobile offerings. A valuable book for industry and academics alike."
Mobile Information Systems II ; IFIP Working Conference on Mobile Information Systems, MOBIS 2005, Leeds, UK, December 6-7, 2005
Contains the proceedings of the second IFIP TC8 Working Conference on Mobile Information Systems which was held in December 2005 in Leeds, UK and sponsored by the International Federation of Information Processing (IFIP). Mobile Information Systems II aims to: · Clarify differences and similarities between the development of mobile and more traditional information systems. · Investigate the organizational impact of mobile information systems. · Investigate the 'e to m shift' , for example in m-Commerce relative to e-Commerce. · Investigate mobile commerce applications combined with the advantages of mobile communications technologies, the drivers of which have been identified as ubiquity, accessibility, security, convenience, localization, instant connectivity, and personalization. · Evaluate existing and newly developed approaches for the analysis, design, implementation, and evolution of mobile information systems. · Investigate technical issues and the constraints they impose on mobile information systems functionalities and design.
Mobile health technologies for ambient assisted living and healthcare
The use of telemedicine and mobile devices is growing, and sensors might aid in creating creative solutions. Developing these solutions is crucial for monitoring senior citizens, lifestyles, and medical procedures. The development of assistive technology for various users to follow sports and other activities is strongly tied to this study area. Data protection is crucial, and the development of these solutions for medical uses should be verified. The security and privacy of the information may be tied to other recognized research projects for their acceptability. ICT research has considerably improved quality of life and has fully assimilated all citizens into society through medical rehabilitation and assistive technology. The technologies and research fields that influence medical informatics include databases, networking, graphical user interfaces, data mining, machine learning, intelligent decision support systems, and specialized programming languages.
Mobile Communications : Re-negotiation of the Social Sphere
Mobile Communications: Renegotiation of the Social Sphere surveys some of the broader issues associated with the adoption and use of mobile communication, and explores developing areas of inquiry. Mobile communications are looked at in the context of other types of mediated interaction (e-mail, instant messaging, Wi-Fi, landline telephone etc.), thus demonstrating the uniqueness of this form of communication and how it is influencing the renegotiation of the social sphere. A truly international set of contributors consider how mobile communication has impacted on society and reflect on how it is used (and sometimes resented) in various public and private spaces. They provide an in-depth analysis of specific areas which complement our understanding of the phenomena including: • The psychological dimensions of mobile communication (addiction, proclivity to be disturbed by others use of the mobile phone), • The linguistics of mobile communication, and • The understanding of mobile communication’s commercialisation. This book will be a valuable addition to any researcher’s or professional’s reading material in the area of interaction of technology and society, providing the reader with a broad insight and specific knowledge of how mobile communication is reformulating the social sphere.
