الصفحة 5
الصفحة 5
Ryanodine Receptors : Structure, function and dysfunction in clinical disease
In recent years, the ryanodine receptor has emerged as a new and very promising target for the treatment of several cardiovascular disorders, including cardiac arrhythmias and heart failure. This volume is the most current publication devoted to the major intracellular calcium-release channel, the ryanodine receptor. "In this series of brief but informative chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology."
RNA Technologies in Cardiovascular Medicine and Research
Cardiovascular disease is the number one cause of death worldwide. In 2005 17.5 million people, representing 30% of all global deaths, died of cardiovascular disease. For this reason every effort needs to be made to improve the early diagnosis and treatment procedures for combating this disease. This book - edited by Professors Erdmann and Barciszewski, both internationally recognised experts in the field of RNA molecular biology, and Professor Poller, an internationally respected expert in cardiology - will offer more than an introduction to these fields. More importantly, it will also lead the reader to the newest developments in RNA methods and technologies and show how they are currently employed for the diagnosis and treatment of cardiovascular disease. This book is also a must for all those interested in knowing more about the molecular medicine of tomorrow and how it will be revolutionised by its newest approach - RNA technologies.
Retinal Vascular Disease
Vascular diseases of the retina are a major cause of blindness among all age groups. Edited and written by internationally well-known experts, this state-of-the-art comprehensive overview of basic and clinical science will enhance the understanding of retinal vascular disease and help in the evaluation of current and future treatment approaches for the clinician.
Regenerative Medicine: Emerging Techniques to Translation Approaches
Focuses on the recent innovations and therapeutic potentials of regenerative medicine and discusses the applications of stem cells, biomaterials, and tissue engineering in regenerative medicine. The book covers essential aspects of regenerative medicine. It also reviews the applications of biosensing technologies in regenerative medicine. It focuses on the regenerative medicine approaches for diseases of the central nervous system. It also provides the therapeutic potential of regenerative medicine to improve soft tissue and wound healing, cardiovascular, neural, bone, and orofacial regeneration.
Regenerative Dentistry
Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment.
Reconstructive Neurosurgery
International experts present in this volume advances in reconstructive neurosurgery focusing on the fields of neurotrauma and neurodegenerative disorders. The highlights include building an international strategy for risk reduction, documentating an multidisciplinary approach towards restoration of function in paraplegic spinal cord-injured patients, describing a new approach for statistical analysis in traumatic brain injury trials, describing blood flow changes in diffuse brain injury, discussing rehabilitation programs in Germany following acute brain injury, describing research data form Taiwan on neurotrauma, showing the neuropsychiatric effects from deep brain stimuation fro ovement disorders, difining the role played by imanging for deep brain stimulation targeting in mental illness, using radiosurgery in decompresssion in the treatment of trigeminal neuralgia, describing the development of radiosurgery from brain to the spine, listing new transgenic animal models of Parkinson's disease, discussing gene therapy for neuropathic pain and Parkinson's disease, and finally, discussing constrained-induced movement therapy fro stroke patients, and endovascular therapy for cerebrovenous disorders.
Recent Advances in Thrombosis and Hemostasis
Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms for various intrinsic and extrinsic stimuli in viable tissues. In this volume, our intention has been to present the latest relevant information in molecular biology and genetics as well as the clinical implications of a better understanding of pathophysiology, novel diagnostic methodologies, and therapeutic applications for new methods of prevention in thrombosis/hemostasis and related disorders, including atherosclerosis.
Rational phytotherapy : A reference guide for physicians and pharmacists
A practice-oriented introduction to phytotherapy. Methodically classified by organic systems and fields of application, it offers a quick insight into dosage, form of application and effects of the most important herbal remedies. Only those herbal remedies that are of pharmacological and clinical efficiency have been considered. The authors are highly experienced in the field of postgraduate medical education, and, with this work, present an indispensable reference book for the medical practice. All practitioners and pharmacists interested in treatment with herbal remedies should have this book at their disposal.
Rapid ECG Interpretation
The ECG is the oldest cardiologic test, but even 100 years after its inception, it continues as the most commonly used cardiologic test. Despite the advent of expensive and sophisticated alternatives, the ECG remains the most reliable tool for the conÞrmation of acute myocardial infarction (MI). The ECG -- not the CK-MB, troponins, echocardiogram, or SPECT or PET scan -- dictates the timely administration of lifesaving PCI or thrombolytic therapy. There is no test to rival the ECG in the diagnosis of arrhythmias, which is a common and bothersome clinical cardiologic problem. In this new third edition, Rapid ECG Interpretation presents a systematic step-by-step approach that provides protocols consistent with changes in cardiology practice over the past decade.
Raising of Microvascular Flaps : A Systematic Approach
Raising of Microvascular Flaps provides all those dealing with microsurgical tissue transfer, i.e. plastic surgeons, ENT surgeons, trauma surgeons, and oral and maxillofacial surgeons with all they need to know in their daily practice. The systematic approach of this operative manual is based on photographs of perfect quality showing cadaver preparations alongside with explanatory colour drawings to even enhance the understanding of the anatomy through 3D perspectives and by also showing structures that are hidden in preparation. A clear didactic structure and perfect artwork supply the surgeon with invaluable guidelines for his daily work. Focusing on comprehensive, precise and teaching information, this text atlas is highly instructive.
Radiotherapy for Non-Malignant Disorders
This volume discusses the general background, radiobiology, radiophysics and clinical applications of radiation therapy in the treatment of non-malignant diseases. Within 39 chapters, it documents the rationale and indications for the use of state-of-the-art radiotherapy for various non-malignant disorders of the CNS, head and neck, eye, skin and soft tissues, bone and joints, and the vascular system. In so doing, it draws attention to and elucidates the scope for application of radiotherapy beyond the treatment of malignancies. Both the risks and the benefits of such treatment are fully considered, the former ranging from minor clinical problems to life-threatening diseases. With the assistance of many tables and colored figures, the extensive data from clinical studies are presented in a well-structured and informative way. Each chapter concludes with a list of key points, allowing the reader to quickly comprehend the main facts.
Radiologie interventionnelle des artères rénales = Interventional radiology of renal arteries
This book, published on the occasion of the joint meeting of the French Cardiac and Vascular Imaging Society (SFICV) and the Genitourinary Imaging Society (SIGU), is devoted to interventional radiology of renal arteries. This meeting was placed under the sponsorship of Francis Joffre, because for many he is the initiator and the "spiritual father" of cardiovascular and interventional radiology in France. In the first part of this book, you will find a well-deserved tribute to Professor Francis Joffre. The second part presents current points in interventional radiology, the third publishes the recommendations of the SFICV while the fourth part offers clinical cases.
Proteases in Gastrointestinal Tissues
This, the fifth volume in the Proteases in Biology and Disease series, is devoted to Proteases in Gastrointestinal Tissues. Of course, proteases play an important role in the digestion and utilization of ingested proteins, but besides that they elicit a wide range of physiological and pathological effects. Proteases have been recognized as essential regulators, acting both locally and systemically, of normal development, growth and functioning. Dysregulation of protease expression and/or enzymatic activity is often associated with the onset or progression of disease and, thus, proteases represent interesting targets for the pharmacological therapy of e. g. cancer, chronic inflammation, graft rejection, fibrosis, diabetes, vascular disease, and viral or bacterial infections.
Problems of High Altitude Medicine and Biology
The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle.
Principles of Molecular Cardiology
The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases, and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system. Authoritative and up-to-date, Principles of Molecular Cardiology offers cardiovascular scientists and fellows not only a quick yet insightful tour from bench to bedside of the molecular mechanisms underlying cardiovascular disease, but also an introduction to the just-now emerging therapies based on our enriched understanding of the heart's molecular biology and genetics.
Primary Care in Obstetrics and Gynecology : A Handbook for Clinicians
Subjects covered the latest in women’s health, and updated and new material has been added on elderly patients; cardiovascular hypertension; genomic and applied molecular biology; and nutrition, obesity, and eating disorders. New case studies complement the quality information that makes this handbook a must-have reference for obstetricians, gynecologists, and all medical professionals who cater to the unique healthcare needs of women.
Primary angioplasty : A practical guide
Offers a concise and practical review of key aspects of the treatment of ST-segment elevation myocardial infarction (STEMI) in the era of primary percutaneous coronary intervention (PPCI). In the context of STEMI, PPCI is the preferred mode of emergency revascularization. Access to PPCI is rapidly increasing and is now routinely practiced in both general and specialist hospitals and there has been a recent emphasis on developing STEMI networks to enhance and expedite the referral pathway. This coupled with concurrent developments to enhance the safety and efficacy of the PPCI procedure has heralded an era where STEMI interventions are increasingly considered an important subspecialty within interventional cardiology.
Preventive Cardiology : Insights Into the Prevention and Treatment of Cardiovascular Disease
Preventive Cardiology: Insights Into the Prevention and Treatment of Cardiovascular Disease, Second Edition provides an overview of the exciting opportunities to prevent the progression, and in some instances to regress the process, of coronary atherosclerosis and incorporate these strategies into the daily practice of clinical medicine. This valuable new edition provides clinical cardiologists, internists, primary care providers, and allied health care professionals with the tools and understanding necessary for their practice in preventive cardiology.
Prevention and treatment of atherosclerosis : Improving state-of-the-art management and search for novel targets
Reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets.
Practical Methods in Cardiovascular Research
The emphasis of the book is placed firmly on practical aspects of cardiovascular research. Divided into three sections, the book presents techniques for in vivo, in vitro and molecular level experimentation techniques. Within each chapter, general aspects of cardiovascular research are well presented in addition to detailed descriptions of methods, protocols and practical examples. Written by leading scientists in their field, chapters cover classical methods such as the Langendorff heart or working heart models as well as numerous new techniques and methods. Readers will benefit from the troubleshooting guide in each chapter, and the extensive reference lists for advanced reading.
