الصفحة 5
الصفحة 5
Gene Therapy of Autoimmune Disease
Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Gene delivery systems development and applications
Covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases.
Gas Transport in Porous Media
This book presents a compilation of state-of-the art studies on gas and vapor transport processes in porous and fractured media. A broad set of models and processes is presented, including advection/diffusion, the Dusty Gas Model, enhanced vapor diffusion, phase change, coupled processes, solid/vapor sorption, and vapor-pressure lowering. Numerous applications are also presented that illustrate these processes and models in current problems facing the scientific community.
Fundamentals of pattern recognition and machine learning
Fundamentals of Pattern Recognition and Machine Learning is designed for a one or two-semester introductory course in Pattern Recognition or Machine Learning at the graduate or advanced undergraduate level. The book combines theory and practice and is suitable to the classroom and self-study.
Fundamentals of image data mining : Analysis, features, classification and retrieval
Presents a comprehensive review of the essentials of image data mining, and the latest cutting-edge techniques used in the field. The coverage spans all aspects of image analysis and understanding, offering deep insights into areas of feature extraction, machine learning, and image retrieval. The theoretical coverage is supported by practical mathematical models and algorithms, utilizing data from real-world examples and experiments. Topics and features: Describes essential tools for image mining, covering Fourier transforms, Gabor filters, and contemporary wavelet transforms / Develops many new exercises (most with MATLAB code and instructions) / Includes review summaries at the end of each chapter / Analyses state-of-the-art models, algorithms, and procedures for image mining / Integrates new sections on pre-processing, discrete cosine transform, and statistical inference and testing / Demonstrates how features like color, texture, and shape can be mined or extracted for image representation / Applies powerful classification approaches: Bayesian classification, support vector machines, neural / networks, and decision trees / Implements imaging techniques for indexing, ranking, and presentation, as well as database visualization
From Vectors to Tensors
It is true that there exist many books dedicated to linear algebra and some what fewer to multilinear algebra, written in several languages, and perhaps one can think that no more books are needed. However, it is also true that in algebra many new results are continuously appearing, different points of view can be used to see the mathematical objects and their associated structures, and different orientations can be selected to present the material, and all of them deserve publication. he book assumes a certain knowledge of linear algebra, and is intended as a textbook for graduate and postgraduate students and also as a consultation book. It is addressed to mathematicians, physicists, engineers, and applied scientists with a practical orientation who are looking for powerful tensor tools to solve their problems.
From Assessing to Conserving Biodiversity : Conceptual and Practical Challenges
This book despite increasing communication, accelerating policy and management responses, and notwithstanding improving ecosystem assessment and endangered species knowledge, conserving biodiversity continues to be more a concern than an accomplished task. Why is it so? The overexploitation of natural resources by our species is a frequently recognised factor, while the short-term economic interests of governments and stakeholders typically clash with the burdens that implementing conservation actions imply. But this is not the whole story. This book develops a different perspective on the problem by exploring the conceptual challenges and practical defiance posed by conserving biodiversity, namely: on the one hand, the difficulties in defining what biodiversity is and characterizing that “thing” to which the word ‘biodiversity’ refers to; on the other hand, the reasons why assessing biodiversity and putting in place effective conservation actions is arduous.
Free-Convective Heat Transfer : With Many Photographs of Flows and Heat Exchange
Free Convective Heat Transfer is a thorough survey of various kinds of free-convective flows and heat transfer. Reference data are accompanied by a large number of photographs originating from different optical visualization methods illustrating the different types of flow. The formulas derived from numerical and analytical investigations are valuable tools for engineering calculations. They are written in their most compact and general form in order to allow for an extensive range of different variants of boundary and initial conditions, which, in turn, leads to a wide applicability to different flow types. Some specific engineering problems are solved in the book as exemplary applications of these formulas.
Free Convection Film Flows and Heat Transfer
This book presents recent developments in systematic studies of hydrodynamics and heat and mass transfer in laminar free convection, accelerating film boiling and condensation of Newtonian fluids, as well as accelerating film flow of non-Newtonian power-law fluids (FFNF). A novel system of analysis models is provided with a developed velocity component method, instead of traditional Falkner-Skan type transformation, and a system of models for treatment of variable thermophysical properties is presented with an innovative temperature parameter method that makes it easier to similarly treat related governing differential equations for consideration of fluid variable thermophysical properties. A pseudo-similarity method is applied for dealing with thermal boundary layer of FFNF, furthermore, with an induced local Prandtl number, which greatly simplifies the heat-transfer analysis and numerical calculation.
Frames and Bases : An Introductory Course
During the last several years, frames have become increasingly popular; they have appeared in a large number of applications, and several concrete constructions of frames of various types have been presented. Most of these constructions were based on quite direct methods rather than the classical sufficient conditions for obtaining a frame. Consequently, there is a need for an updated book on frames, which moves the focus from the classical approach to a more constructive one.
Foundation Mathematics for Computer Science : A Visual Approach
In this second edition of Foundation Mathematics for Computer Science, John Vince has reviewed and edited the original book and written new chapters on combinatorics, probability, modular arithmetic and complex numbers. These subjects complement the existing chapters on number systems, algebra, logic, trigonometry, coordinate systems, determinants, vectors, matrices, geometric matrix transforms, differential and integral calculus. During this journey, the author touches upon more esoteric topics such as quaternions, octonions, Grassmann algebra, Barrycentric coordinates, transfinite sets and prime numbers.
Foundation Form Creation with Adobe LiveCycle Designer ES
Form creation is key to information processing and forms workflow is a key concept within Adobe LiveCycle Enterprise Suite. Adobe LiveCycle Forms ES is a stand-alone product that also comes bundled with Adobe LiveCycle Enterprise Suite. This is the first and only book about this new product specifically created for the design, creation, and processing of dynamically interactive forms. Foundation Form Creation with Adobe LiveCycle Designer ES is written for users of all abilities, with introductory material for beginners and advanced techniques for more experienced users. It discusses both the best-practices of designing forms that work and the specifics of implementing them efficiently for data collection—the full life cycle of working with forms.
Foundation Flex for Developers : Data-Driven Applications with PHP, ASP.NET, ColdFusion, and LCDS
Flex is a very powerful and versatile technology for creating web application front-ends. But what every good web application needs is a robust data source, be it XML, or a database. Flex is very adaptable in terms of connecting to data sources, and that is the main focus of this book. In Foundation Flex for Developers, author Sas Jacobs assumes that you've got the basics of Flex down already, and explores in detail how to create professional data-centric Flex 2 and Flex 3 applications. In the first half of the book, she starts off with a brief exploration of Flex and ActionScript 3.0, before looking at application essentials in detail—creating custom components, user and web browser interactions, binding, formatting, and validating data, debugging, and more. In the second half of the book, the focus is on connecting Flex to data sources, and covers XML, LiveCycle Data Services, PHP, ASP.NET, and ColdFusion in detail, via a series of step-by-step case studies.
Foot and ankle in rheumatoid arthritis
This book broaches the theme of the most recent medicinal treatments, that of orthoses, made-to-measure shoes (the prescription of which practitioners and the rheumatologists often hand over to the orthopaedic surgeons), and finally that of local injections. These elements constitute the main treatment of the rheumatoid foot. Taking care of the ill subject does not necessarily stop there and a surgeon may need to operate on the forefoot, which is more common, or on the mid-foot or the ankle.
Foliations and Geometric Structures
Offers basic material on distributions and foliations. This book introduces and builds the tools needed for studying the geometry of foliated manifolds. Its main theme is to investigate the interrelations between foliations of a manifold on the one hand, and the many geometric structures that the manifold may admit on the other hand.
Flowing Matter
This book presents an introduction to selected research topics in the broad field of flowing matter, including the dynamics of fluids with a complex internal structure -from nematic fluids to soft glasses- as well as active matter and turbulent phenomena. Flowing matter is a subject at the crossroads between physics, mathematics, chemistry, engineering, biology and earth sciences, and relies on a multidisciplinary approach to describe the emergence of the macroscopic behaviours in a system from the coordinated dynamics of its microscopic constituents. Depending on the microscopic interactions, an assembly of molecules or of mesoscopic particles can flow like a simple Newtonian fluid, deform elastically like a solid or behave in a complex manner. When the internal constituents are active, as for biological entities, one generally observes complex large-scale collective motions. Phenomenology is further complicated by the invariable tendency of fluids to display chaos at the large scales or when stirred strongly enough. This volume presents several research topics that address these phenomena encompassing the traditional micro-, meso-, and macro-scales descriptions, and contributes to our understanding of the fundamentals of flowing matter.
Finite Elements III : First-Order and Time-Dependent PDEs
Volume III is divided into 28 chapters. The first eight chapters focus on the symmetric positive systems of first-order PDEs called Friedrichs' systems. This part of the book presents a comprehensive and unified treatment of various stabilization techniques from the existing literature. It discusses applications to advection and advection-diffusion equations and various PDEs written in mixed form such as Darcy and Stokes flows and Maxwell's equations. The remainder of Volume III addresses time-dependent problems: parabolic equations (such as the heat equation), evolution equations without coercivity (Stokes flows, Friedrichs' systems), and nonlinear hyperbolic equations (scalar conservation equations, hyperbolic systems). It offers a fresh perspective on the analysis of well-known time-stepping methods. The last five chapters discuss the approximation of hyperbolic equations with finite elements. Here again a new perspective is proposed.
Field Theory ; 2nd ed.
This book presents the basic theory of fields, starting more or less from the beginning. It is suitable for a graduate course in field theory, or independent study.There are new exercises, a new chapter on Galois theory from an historical perspective, and additional topics sprinkled throughout the text, including a proof of the Fundamental Theorem of Algebra, a discussion of casus irreducibilis, Berlekamp's algorithm for factoring polynomials over Zp and natural and accessory irrationalities.
Field Models in Electricity and Magnetism
Covering the development of field computation in the past forty years, Field Models in Electricity and Magnetism intends to be a concise, comprehensive and up-to-date introduction to field models in electricity and magnetism, ranging from basic theory to numerical applications. The approach assumed throughout the whole book is to solve field problems directly from partial differential equations in terms of vector quantities. Theoretical issues are illustrated by practical examples. In particular, a single example is solved by different methods so that, by comparison of results, limitations and advantages of the various methods are made clear.
