الصفحة 5
الصفحة 5
Impact of drug-microbiome interactions on drug response
Explains the mechanisms of drug-microbiome interactions, as well as the role of multiomic approaches, including metagenomics, metabolomics, and 16S rRNA sequencing to assess drug response variability. Findings suggest that integrating microbiome profiling into precision medicine could enhance personalized drug therapy, minimize adverse effects and optimize treatment outcomes.
Immunology of fungal infections
Covers all aspects of the immunology of fungal infection. Beyond the basics, coverage includes recent developments in innate and adaptive immunological mechanisms involved in the host response to fungal infection.
Immunogenicity of Biopharmaceuticals
This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.
Immunogenetics of Autoimmune Disease
Utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches
Immunobiology of natural killer cell receptors
Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.
Immune receptors : Methods and protocols
Explores immune cell receptors that are used in the detection of microbes, either by binding directly to non-self molecules or through indirectly sensing microbe-associated cellular disturbances. The covers methods for studying receptor-ligand interactions at both molecular and cellular levels; methods to create and characterize novel antibody reagents; and methods to characterize the molecular processes that lead to adaptive receptor maturation. This book also contains chapters that look at high-throughput strategies that describe the diversity of immune receptors and cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Immobilisation of DNA on Chips II
DNA chips are gaining increasing importance in different fields ranging from medicine to analytical chemistry with applications in the latter in food safety and food quality issues as well as in environmental protection. In the medical field, DNA chips are frequently used in arrays for gene expression studies to identify diseased cells due to over- or under-expression of certain genes, to follow the response of drug treatments, or to grade cancers), for genotyping of individuals, for the detection of single nucleotide polymorphisms, point mutations, and short tandem reports, or moreover for genome and transcriptome analyses in the quasi post-genomic sequencing era. Furthermore, due to some unique properties of DNA molecules, self-assembled layers of DNA are promising candidates in the field of molecular electronics.the main focus of these two volumes is on the immobilization chemistry, considering the various aspects of the immobilization process itself, since different types of nucleic acids, support materials, surface activation chemistries and patterning tools are of key concern.
Imaging of the liver and Intra-hepatic biliary tract ; Vol.2 : Tumoral pathologies
This is the second of two volumes that together provide a comprehensive analysis of the embryology, normal anatomy, and pathology of the liver and intrahepatic biliary tract as seen on modern diagnostic imaging techniques. In this second volume, readers will find comprehensive description and illustration of the imaging appearances of tumoral pathologies, both in the “normal liver” and in the context of chronic liver disease and liver cirrhosis. In addition, the imaging findings in relation to different treatment approaches are presented, with extensive coverage of imaging of tumor response and post-treatment changes.
Imaging in Transplantation
This book covers all topics related to the imaging of organ transplantation. An introductory section addresses such issues as organ procurement, patient selection, immune responses, and ethical and economic considerations. The main part of the book then offers in-depth coverage of heart, renal, liver, lung, bone marrow and pancreatic and intestinal transplantation.
Image Analysis and Recognition ; Vol. 4142 ; 3rd International Conference, ICIAR 2006, Póvoa de Varzim, Portugal, September 18-20, 2006, Proceedings, Part II
ICIAR 2006, the International Conference on Image Analysis and Recognition, was the third ICIAR conference, and was held in P´ ovoa de Varzim, Portugal. ICIARisorganizedannually,andalternatesbetweenEuropeandNorthAmerica. ICIAR 2004 was held in Porto, Portugal and ICIAR 2005 in Toronto, Canada. The idea of o?ering these conferences came as a result of discussion between researchers in Portugal and Canada to encourage collaboration and exchange, mainlybetweenthesetwocountries,butalsowiththeopenparticipationofother countries, addressing recent advances in theory, methodology and applications. The response to the call for papers for ICIAR 2006 was higher than the two previous editions. From 389 full papers submitted, 163 were ?nally accepted (71 oral presentations, and 92 posters). The review process was carried out by the Program Committee members and other reviewers; all are experts in various image analysis and recognition areas. Each paper was reviewed by at least two reviewers, and also checked by the conference Co-chairs. The high quality of the papers in these proceedings is attributed ?rst to the authors, and second to the quality of the reviews provided by the experts.
Image Analysis and Recognition ; Vol. 4141 ; 3rd International Conference, ICIAR 2006, Póvoa de Varzim, Portugal, September 18-20, 2006, Proceedings, Part I
ICIAR 2006, the International Conference on Image Analysis and Recognition, was the third ICIAR conference, and was held in P´ ovoa de Varzim, Portugal. ICIARisorganizedannually,andalternatesbetweenEuropeandNorthAmerica. ICIAR 2004 was held in Porto, Portugal and ICIAR 2005 in Toronto, Canada. The idea of o?ering these conferences came as a result of discussion between researchers in Portugal and Canada to encourage collaboration and exchange, mainlybetweenthesetwocountries,butalsowiththeopenparticipationofother countries, addressing recent advances in theory, methodology and applications. The response to the call for papers for ICIAR 2006 was higher than the two previous editions. From 389 full papers submitted, 163 were ?nally accepted (71 oral presentations, and 92 posters). The review process was carried out by the Program Committee members and other reviewers; all are experts in various image analysis and recognition areas. Each paper was reviewed by at least two reviewers, and also checked by the conference Co-chairs. .
Image Analysis and Recognition ; Vol. 3656 ; 2ond International Conference, ICIAR 2005, Toronto, Canada, September 28-30, 2005, Proceedings
ICIAR 2005, the International Conference on Image Analysis and Recognition, was the second ICIAR conference, and was held in Toronto, Canada. ICIAR is organized annually, and alternates between Europe and North America. ICIAR 2004 was held in Porto, Portugal. The idea of o?ering these conferences came as a result of discussion between researchers in Portugal and Canada to encourage collaboration and exchange, mainly between these two countries, but also with the open participation of other countries, addressing recent advances in theory, methodology and applications. TheresponsetothecallforpapersforICIAR2005wasencouraging.From295 full papers submitted, 153 were ?nally accepted (80 oral presentations, and 73 posters). The review process was carried out by the Program Committee m- bers and other reviewers ; all are experts in various image analysis and recognition areas. Each paper was reviewed by at least two reviewers, and also checked by the conference co-chairs. The high quality of the papers in these proceedings is attributed ?rst to the authors,and second to the quality of the reviews provided by the experts. We would like to thank the authors for responding to our call, andwewholeheartedlythankthe reviewersfor theirexcellentwork,andfortheir timely response. It is this collective e?ort that resulted in the strong conference program and high-quality proceedings in your hands.
Ifo Survey Data in Business Cycle and Monetary Policy Analysis
The business surveys of the Ifo Institute (short for Information and Forschung) are internationally renowned. Every month close to 7,000 enterprises are questioned on their short-term planning and their appraisals of the actual and future business situation. The confidence indicator frequently referred to as the Ifo Business Climate Index is derived from the responses to this Ifo Business Survey. While the Index attracts a lot of attention by practitioners (especially financial market analysts), the use and empirical exploitation of this and other components of Ifo business surveys is – amongst academics – still relatively scarce. The present volume, based on a conference entitled "The Academic Use of Ifo Survey Data", gives examples of timely research questions which can be addressed by qualitative survey data like the monthly Ifo Business Survey. It shows that this type of real-time data can be very informative when it comes to forecasting real economic activity or exploring monetary policy transmission.
Hydrological and Biological Responses to Forest Practices : The Alsea Watershed Study
Through analyses of works generated by the study, Hydrological and Biological Responses to Forest Practices: The Alsea Watershed Study addresses the quantification of forest resource sustainability and bolsters the case for long-term monitoring at a time when managers and policy makers are searching for ways to restore the runs of salmon and steelhead to rivers and streams of the Pacific Northwest. Edited by John D. Stednick, a forest hydrologist responsible for the study’s reactivation, this book will be of interest to students in natural resources, land managers, policy makers, and researchers, particularly in water and fishery resources.
Human Cytomegalovirus
The golden age of cytomegalovirus research was ushered in during the late 1970s and early 1980s by a set of powerful new technologies that included restriction enzymes, DNA cloning, DNA sequencing, and open reading frame prediction. The genetic manipulation and propagation of novel CMV strains was accelerated with the app- cation of bacterial artificial chromosome technology. Today, we still struggle to understand the full spectrum of disease associated with human CMV. To the molecular biologist, CMV is a master of regulation in the eukaryotic cell where it either replicates or remains latent. To the immunologist, CMV is a master of immune evasion with tools to escape both the innate and acquired immune responses. The use of animal models with non-human CMVs has become significantly more sophisticated and tied to a more certain understanding of the interrelationships of non-human and human CMV genes.
Human and Animal Relationships
Pathogenic fungi are widely distributed and can infect many organisms, particularly humans, but also other vertebrates and insects. Due to a growing number of fungal infections, there is an increasing need to understand the interaction of pathogenic fungi with their hosts. This second completely updated and revised edition of Volume VI of The Mycota consists of state of the art reviews written by experts in the field, covering three major areas of this rapidly developing field. In the first part the current understanding of pathogenic fungi and the physiological reactions relevant for the pathogen - host interaction are elucidated. The second part describes novel technologies for the identification of proteins, virulence factors and mechanisms central to the host - pathogen interaction. The third part deals with the characterization of the host response towards pathogenic fungi and addresses timely clinical aspects.
How to Gain Gain : A Reference Book on Triodes in Audio Pre-Amps
The 17 chapters of How to Gain Gain give a detailed insight into a collection of the most common gain producing and constant current generating possibilities (28) of triodes for audio pre-amplifier purposes. These chapters also offer complete sets of formulae to calculate gain, frequency and phase responses of certain building blocks built-up with this type of vacuum valve (tube).
How Data Quality Affects our Understanding of the Earnings Distribution
This book demonstrates how data quality issues affect all surveys and proposes methods that can be utilised to deal with the observable components of survey error in a statistically sound manner. This book begins by profiling the post-Apartheid period in South Africa's history when the sampling frame and survey methodology for household surveys was undergoing periodic changes due to the changing geopolitical landscape in the country. This book profiles how different components of error had disproportionate magnitudes in different survey years, including coverage error, sampling error, nonresponse error, measurement error, processing error and adjustment error.
Hot Property : The Housing Market in Major Cities
This book discusses booming housing markets in cities around the globe, and the resulting challenges for policymakers and central banks. Cities are booming everywhere, leading to a growing demand for urban housing. In many cities this demand is out-pacing supply, which causes house prices to soar and increases the pressure on rental markets. These developments are posing major challenges for policymakers, central banks and other authorities responsible for ensuring financial stability, and economic well-being in general. This volume collects views from high-level policymakers and researchers, providing essential insights into these challenges, their impact on society, the economy and financial stability, and possible policy responses. The respective chapters address issues such as the popularity of cities, the question of a credit-fueled housing bubble, the role of housing supply frictions and potential policy solutions. Given its scope, the book offers a revealing read and valuable guide for everyone involved in practical policymaking for housing markets, mortgage credit and financial stability.
High-Grade Gliomas : Diagnosis and Treatment
This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response.
