الصفحة 5
الصفحة 5
March's Advanced Organic Chemistry : Reactions, Mechanisms, and Structure
The opening chapters of March's Advanced Organic Chemistry deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Further coverage concerns general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation. The relationship between structure and reactivity is also covered.
Light-Associated Reactions of Synthetic Polymers
This book presents a range of reactions and materials with some of the most exciting current and future applications. It includes a brief introduction to photochemistry; in-depth discussion of photosensitizers, photoinititiators, and the processes of light curing and crosslinking; listing of light responsive polymers and their uses; and a discussion of polymeric materials for use in non-linear optics.
Kinetics of Water-Rock Interaction
Systems at the surface of the Earth are continually responding to energy inputs derived from solar radiation or from the radiogenic heat in the interior. These energy inputs drive plate movements and erosion, exposing metastable mineral phases at the Earth’s surface. In addition, these energy fluxes are harvested and transformed by living organisms. As long as these processes persist, chemical disequilibrium at the Earth’s surface will be perpetuated. Chemical disequilibrium is also driven by human activities related to production of food, extraction of water and energy resources, and burial of wastes. To understand how the surface of the Earth will change over time, we must understand the rates at which reactions occur and the chemical feedbacks that relate these reactions across extreme temporal and spatial scales. This book addresses fundamental and applied questions concerning the rates of water-rock interactions driven by tectonic, climatic, and anthropogenic forcings.
Kinetics of Catalytic Reactions--Solutions Manual
This textbook contains all the information needed for graduate students or industrial researchers to design kinetic experiments involving heterogeneous catalysts, to characterize these catalysts, to acquire valid rate data, to verify the absence of mass (and heat) transfer limitations, to propose reaction models, to derive rate expressions based on these models and, finally, to assess the consistency of these rate equations.The most recent technique to calculate heats of adsorption and activation barriers on metal surfaces, the BOC-MP approach, is discussed in detail. Methods to measure metal surface areas and crystallite sizes using x-ray diffraction, transmission electron microscopy and various chemisorption techniques are discussed. Different experimental techniques to determine the influence of mass transfer limitations, especially within the pores of a catalyst, are reviewed in detail, with a particular emphasis on liquid-phase reactions.
Kinetics of Catalytic Reactions
This textbook contains all the information needed for graduate students or industrial researchers to design kinetic experiments involving heterogeneous catalysts, to characterize these catalysts, to acquire valid rate data, to verify the absence of mass (and heat) transfer limitations, to propose reaction models, to derive rate expressions based on these models and, finally, to assess the consistency of these rate equations.Many illustrations of these and other topics are provided along with numerous problems and a Solutions Manual for instructors. This book will be applicable to any graduate course in chemical engineering, chemistry or materials science that involves kinetics of catalytic reactions, including those catalyzed by enzymes.
Jaundice
Jaundice in an adult patient can be caused by a wide variety of benign or life-threatening disorders. Organizing the differential diagnosis by prehepatic, intrahepatic, and posthepatic causes may help make the work-up more manageable. Prehepatic causes of jaundice include haemolysis and hematoma resorption, which lead to elevated levels of unconjugated (indirect) bilirubin. Intrahepatic disorders can lead to unconjugated or conjugated hyperbilirubinemia. The conjugated (direct) bilirubin level is often elevated by alcohol, infectious hepatitis, drug reactions, and autoimmune disorders. Posthepatic disorders also can cause conjugated hyperbilirubinemia. Gallstone formation is the most common and benign posthepatic process that causes jaundice; however, the differential diagnosis also includes serious conditions such as biliary tract infection, pancreatitis, and malignancies.
Click chemistry
In chemical synthesis, click chemistry is a class of simple atomic economy reactions commonly used to join two selected molecular entities. Click chemistry is not one specific reaction, but describes a method for generating products that follow examples in nature, which also generates substances by joining small modular units. In many applications, click interactions that join a biomolecule and a reporter molecule. Click chemistry is not limited to biological conditions: the concept of a 'click' reaction has been used in protein chemistry, pharmacokinetics, and many biomimetic applications. However, they have been made remarkably useful in the discovery, localization and qualification of biomolecules.
Chemistry for pharmacy students : General, organic and natural product chemistry ; 2nd ed.
Opens with an overview of the general aspects of chemistry and their importance to modern life, with emphasis on medicinal applications. The text then moves on to discuss the concepts of atomic structure and bonding and the fundamentals of stereochemistry and their significance to pharmacy in relation to drug action and toxicity. Various aspects of organic functional groups, organic reactions, heterocyclic chemistry, nucleic acids and their pharmaceutical importance are then covered in subsequent chapters, with the final chapter dealing with drug discovery and development, and natural product chemistry. Provides a student-friendly introduction to the main areas of chemistry required by pharmacy degree courses. Written at a level suitable for non-chemistry students in pharmacy, but also relevant to those in life sciences, food science, and the health sciences Includes learning objectives at the beginning of each chapter Focuses on the physical properties and actions of drug molecules
Chemical Kinetics and Reaction Dynamics
Chemical Kinetics and Reaction Dynamics brings together the major facts and theories relating to the rates with which chemical reactions occur from both the macroscopic and microscopic point of view. This book helps the reader achieve a thorough understanding of the principles of chemical kinetics and includes: *Detailed stereochemical discussions of reaction steps / *Classical theory based calculations of state-to-state rate constants / *A collection of matters on kinetics of various special reactions such as micellar catalysis, phase transfer catalysis, inhibition processes, oscillatory reactions, solid-state reactions, and polymerization reactions at a single source. / The growth of the chemical industry greatly depends on the application of chemical kinetics, catalysts and catalytic processes.
Chalcogenocarboxylic acid derivatives
Chalcogenocarboxylic acid derivatives are a large class of compounds including more than one chalcogenocarboxyl group in which one or two oxygen atoms of the carboxyl group are replaced with sulfur, selenium or tellurium atoms. The chemistry of metal chalcogenocarboxylates has not been explored extensively as that of carboxylates and dithiocarbamates. This volume presents a comprehensive overview of the syntheses and their limitations, structures and reactions of chalcogenocarboxylic acid derivatives, by emphasizing the developments in organic and inorganic chalcogen chemistry over the last 5 to 20 years.
Catalytic role of amino acids in organic reactions
Asymmetric organometallic and organocatalytic processes have attracted great interest. Asymmetric synthesis using both natural and unnatural amino acids has been tremendously important from synthetic as well as industrial viewpoints, and numerous new methodologies have been developed in the last decades. Herein we provide an overview of old and very recent (since 1900 till now) advances and applications in the area of heterogeneous catalysis, homogeneous catalysis, electrocatalysis, photocatalysis, organocatalysis, thermal catalysis using amino acids [proline, glycine, alanine, valine, serine, threonine, cysteine, methionine, asparagine, glutamine, lysine, arginine, histidine, aspartate, glutamate, phenylalanine, and tryptophan], (supported or unsupported), an amino acid containing materials or amino acids derivatives as an essential component of catalysts, this book highlights the most important and recent developments to immobilize or support amino acids on various support materials. This book is suitable as supplementary reading for courses targeting the design, synthesis, and application of chiral catalysts, asymmetric catalysis, and sustainable production.
Catalytic Carbonylation Reactions
Carbonylation reactions are of major importance in both organic and industrial chemistry. Due to the availability, price and reactivity pattern, carbon monoxide is becoming a more and more important building block for fine and bulk chemicals. The major reaction types of carbon monoxide are comprehensively discussed by leading experts from academia and industry. The authors highlight important carbonylation reactions such as hydroformylation, alkoxy-carbonylations, co/olefin-copolymerization, Pauson-Khand reactions and others. They illustrate applications in organic synthesis and give industrial examples.
Cancer drug safety and public health policy : A changing landscape
Description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. Opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention – these fines are playing an important role in changing the landscape for pharmaceutical safety.
Biological mechanisms of tooth movement ; 3rd ed.
Cover subjects such as: The development of biological concepts in orthodontics, including the cellular and molecular biology behind orthodontic tooth movement Mechanics meets biology, including the effects of mechanical loading on hard and soft tissues and cells, and biological reactions to temporary anchorage devices Inflammation and orthodontics, including markers for tissue remodeling in the gingival crevicular fluid and saliva Personalized diagnosis and treatment based on genomic criteria, including the genetic influences on orthodontic tooth movement Rapid orthodontics, including methods to accelerate or decelerate orthodontic tooth movement Perfect for residents and PhD students of orthodontic and periodontal programs, Biological Mechanisms of Tooth Movement is also useful to academics, clinicians, bone biologists, and researchers with an interest in the mechanics and biology of tooth movement.
Bioinformatics drug discovery
Quantitative tools are becoming increasingly important in order to understand complex cascade of signal transduction events, pathways or biochemical reactions. The book showcases how computational techniques and algorithms are applied to biological data analysis, interpretation, and modelling. It covers applications in drug design and discovery, immune systems, phylogenetic analysis and protein structures.
Biochemistry
Biochemistry and the organization of cells -- Water : the solvent for biochemical reactions -- Amino acids and peptides -- The three-dimensional structure of proteins -- Protein purification and characterization techniques -- The behavior of proteins : enzymes -- The behavior of proteins : enzymes, mechanisms, and control -- Lipids and proteins are associated in biological membranes -- Nucleic acids : how structure conveys information -- Biosynthesis of nucleic acids : replication -- Transcription of the genetic code : the biosynthesis of RNA -- Protein synthesis : translation of the genetic message -- Nucleic acid biotechnology techniques -- Viruses, cancer, and immunology -- The importance of energy changes and electron transfer in metabolism -- Carbohydrates -- Glycolysis
Bioactive Heterocycles II
As part of the series Topics in Heterocyclic Chemistry, this volume titled Bio- tive Heterocycles II presents comprehensive and up-to-date reviews on selected topics regarding synthetic as well as naturally occurring bioactive heterocycles. The frst chapter, "High Pressure Synthesis of Heterocycles Related to Bio- tive Molecules" by Kiyoshi Matsumoto, presents a unique high-pressure s- thetic methodology in heterocyclic chemistry. Basic principles and fruitful examples for pericyclic reactions, such as Diels-Alder reactions, 1,3-dipolar reactions, and also for ionic reactions, such as S and addition reactions, are N discussed.
Bioactive Confirmation II
Specific binding of a ligand to a receptor is a key step in a variety of biol- ical processes, such as immune reactions, enzyme cascades, or intracellular transport processes. The ligand-receptor terminology implies that the rec- tor molecule is signi?cantly larger than the ligand, and the term "bioactive conformation" usually characterizes the conformation of a ligand when it is bound to a receptor. In a more general sense, bioactive conformation applies toanymoleculeinabiologicallyrelevantboundstateregardlessofsizecons- erations. Mostofthecontributions tothisbookaddressligandsthat aremuch smaller than their receptors. X-ray crystallography and high resolution NMR spectroscopy are the two main experimental techniques used to study bioactive conformations. The- fore, the twovolumes ofthisbookcover approachesthat use either ofthetwo techniques, or a combination thereof.
Barile's clinical toxicology : Principles and mechanisms ; 3rd ed.
Examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. Special emphasis is placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs. Includes the source, pharmacological and toxicological mechanism of action, detection and identification in body fluids, and treatment of exposure. An overview of protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology, are discussed. In addition, effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered
Atmospheric Aerosol Properties : Formation, Processes and Impacts
An increasing interest in studies of atmospheric aerosols in the context of their impact on the formation of climate, heterogeneous chemical reactions in the atmosphere affecting in particular the environmental quality, problems of visibility and human health is the cause of unusual scales of developments connected with studies of atmospheric aerosols. The necessity has arisen to analyze the latest results concerning, first of all, three aspects of the problems considered: 1. aerosol properties from data of complex field observational experiment; 2. processes of aerosol formation and interaction of aerosol with clouds, 3. aerosol as a climate-forming atmospheric component (including the problem of long-range transport). The monograph in hand is dedicated mainly to the problems of the impact of aerosol on climate processes in the atmosphere, from microphysical processes of formation and evolution of aerosol properties to the formation of macro-scale cloud sytems on aerosol particles.
