الصفحة 5
الصفحة 5
Bioinformatics drug discovery
Quantitative tools are becoming increasingly important in order to understand complex cascade of signal transduction events, pathways or biochemical reactions. The book showcases how computational techniques and algorithms are applied to biological data analysis, interpretation, and modelling. It covers applications in drug design and discovery, immune systems, phylogenetic analysis and protein structures.
Biochemistry of Atherosclerosis
Advances in Biochemistry in Heath and Disease presents state-of-the-art discussions in cutting-edge biochemical research, offering exciting developments that impact healthcare and disease research. Volumes in the series focus on cross-disciplinary biomedical research and examine various topics in biochemistry, cell biology, molecular biology, and biomedicine. Biochemistry of Atherosclerosis examines atherosclerosis in great detail, focusing on the risk of atherosclerosis, and the biochemical pathways involved. It provides a breadth of knowledge as well as new insights into a variety of topics relating to atherosclerosis from leading scientists around the world who are at the forefront of atherosclerosis research. Biochemistry of Atherosclerosis is essential reading for biomedical and clinical researchers.
Axon growth and guidance
The complexarchitectureofneuronal networks togetherwith the extraordinary associated functions make the nervous system a fascinating biological structure. The considerable work performed to explore this cellular machinery is nowadays successfulbecause the mysteryofnervous system developmentisbeing unravelled. As described in their outstanding review published 10 years ago in Science.' Marc Tessier-Lavigne and Corey Goodman-the pioneers of the molecular era of axon guidance-summarized the assembly of nervous system connections as a subtle game of attraction and repulsion of neuronal growth cones. The cellular ballet ensuring the formation of billions of synapses, which ultimately gives rise to the highest cognitive functions, is primarily orchestrated by a step-by-step mechanism of growth driven by multiple molecular cues. While our general concept of axon guidance remains identical, a profound evolution ofour knowledge ofthe molecular identityofthe guidance cues together with their interactions and signalling pathways occurred over the past ten years.
Arum palaestenium in cancer therapies
Cancer is a very complicated sequence of disease conditions progressing gradually with a generalized loss of growth control.1–3 There were only a few options of cancer treatment for patients for many decades which include surgery, radiation therapy, and chemotherapy as single treatments or in combination.4,5 But recently, many pathways involved in cancer therapy progression and how they can be targeted has improved dramatically, with combinatorial strategies, involving multiple targeted therapies or “traditional” chemotherapeutics, such as the taxanes and platinum compounds, being found to have a synergistic effect.6 New approaches, such as drugs, biological molecules, and immune-mediated therapies, are being used for treatment.
Apoptotic pathways as targets for novel therapies in cancer and other diseases
The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients.
Apoptosis, Senescence, and Cancer
Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers.this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment.
Angiogenesis and Direct Myocardial Revascularization
In Angiogenesis and Direct Myocardial Revascularization, an interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis.
Amino acid biosynthesis : Pathways, regulation and metabolic engineering
Amino Acids Biosynthesis presents the current knowledge of fundamental as well as applied microbiology of amino acids. Topics discussed are the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The characterization of the control mechanisms of amino acid biosynthesis has revealed insights into principles of genetic and biochemical regulation, such as transcriptional regulators and a new class of regulatory elements, the riboswitch. The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives.
Alternative Splicing and Disease
Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.
Aging and Senescence
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. Although recent developments in molecular biology are far from understanding the biological basis of aging, research suggests that targeting the aging process itself could ameliorate many age-related pathologies.
Acute Myelogenous Leukemia
The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation.
Achieving the Paris Climate Agreement goals ; Part 2 : Science-based target setting for the finance industry — Net-Zero Sectoral 1.5˚C pathways for real economy sectors
Provides an in-depth analysis of industry sectors globally, and its purpose is to present emission reduction targets in 5-year steps (2025 to 2050) for the main twelve finance sectors per the Global Industry Classification System. This scientific analysis aims to support the United Nations Principles for Responsible Investment initiative to give sustainability guidance for the global finance industry. The industry sector pathways presented here are based on the latest global and regional 100% renewable energy and non-energy greenhouse gas Representative Concentration Pathways in order to keep climate change significantly under +1.5 C and thereby achieve the Paris Climate Agreement goals. The heart of this book is three chapters presenting the results of industry scenario modelling. These chapters cover twelve industry and service sectors as well as transportation and buildings. The specific energy demand and specific emissions are presented based on the emission accounting concept of “Scope 1, Scope 2 and Scope 3” emission pathways. This methodology has been developed to measure the climate and sustainability index for companies, and this research project expands the methodology to apply it to entire industry sectors ...
Achieving the Paris climate agreement goals : Global and regional 100% renewable energy scenarios with non-energy GHG Pathways for +1.5°C and +2°C
Presents detailed pathways to achieve 100% renewable energy by 2050, globally and across ten geographical regions. Based on state-of-the-art scenario modelling, it provides the vital missing link between renewable energy targets and the measures needed to achieve them. Bringing together the latest research in climate science, renewable energy technology, employment and resource impacts, the book breaks new ground by covering all the elements essential to achieving the ambitious climate mitigation targets set out in the Paris Climate Agreement. For example, sectoral implementation pathways, with special emphasis on differences between developed and developing countries and regional conditions, provide tools to implement the scenarios globally and domestically. Non-energy greenhouse gas mitigation scenarios define a sustainable pathway for land-use change and the agricultural sector. Furthermore, results of the impact of the scenarios on employment and mineral and resource requirements provide vital insight on economic and resource management implications.
A guide for delineation of lymph nodal clinical target volume in radiation therapy
This book will facilitate the understanding of cross-sectional anatomy details and assist radiation oncologists in the difficult task of a detailed delineation of lymph node targets in multiple anatomical locations.
