الصفحة 5
الصفحة 5
Energy dissipation in molecular systems
Energy Dissipation in Molecular Systems analyzes experimental data on the redistribution and dissipation of energy injected into molecular systems by radiation or charged particles. These processes, competing with such practically important relaxation channels as chemical reaction or stimulated emission (laser action), are the primary focus in this monograph. Among other topics, the book treats vibrational redistribution and electronic relaxation in isolated molecules and the effects of inter-molecular interactions (collisions, complex formation, solvent effects) on the relaxation paths. Primary photo-chemical processes (such as isomerization, proton or hydrogen-atom transfer, electron transfer and ionization) are also treated as particular cases of vibrational or electronic relaxation. Only a basic knowledge of quantum mechanics and spectroscopy is assumed and calculations are kept to a strict minimum, making the book more accessible to students.
Emerging Therapies in Periodontics
This book equips dental care providers with a thorough understanding of the emerging therapies that promise to revolutionize the clinical management of periodontal diseases. This book introduces novel concepts and molecules that are currently being tested in preclinical and clinical models.
Elementary physics of complex plasmas
Complex plasmas are dusty plasmas in which the density and electric charges of the dust grains are sufficiently high to induce long-range grain-grain interactions, as well as strong absorption of charged-plasma components. Together with the sources replenishing the plasma such systems form a highly dissipative thermodynamically open system that exhibits many features of collective behaviour generally found in complex systems. Most notably among them are self-organized patterns such as plasma crystals, plasma clusters, dust stars and further spectacular new structures. Beyond their intrinsic scientific interest, the study of complex plasmas grows in importance in a great variety of fields, ranging from space-plasma sciences to applied fields such as plasma processing, thin-film deposition and even the production of computer chips by plasma etching, in which strongly interacting clouds of complex plasmas can cause major contamination of the final product.
Electron Scattering : From Atoms, Molecules, Nuclei and Bulk Matter
There is a unity to physics; it is a discipline which provides the most fundamental understanding of the dynamics of matter and energy. To understand anything about a physical system you have to interact with it and one of the best ways to learn something is to use electrons as probes. This book is the result of a meeting, which took place in Magdalene College Cambridge in December 2001. Atomic, nuclear, cluster, soHd state, chemical and even bio- physicists got together to consider scattering electrons to explore matter in all its forms. Theory and experiment were represented in about equal measure. It was meeting marked by the most lively of discussions and the free exchange of ideas. We all learnt a lot. The Editors are grateful to EPSRC through its Collaborative Computational Project program (CCP2), lOPP, the Division of Atomic, Molecular, Optical and Plasma Physics (DAMOPP) and the Atomic Molecular Interactions group (AMIG) of the Institute of Physics for financial support. The smooth running of the meeting was enormously facilitated by the efficiency and helpfulness of the staff of Magdalene College, for which we are extremely grateful.
Electron crystallography : Novel approaches for structure determination of nanosized materials
During the last decade we have been witness to several exciting achievements in electron crystallography. This includes structural and charge density studies on organic molecules complicated inorganic and metallic materials in the amorphous, nano-, meso- and quasi-crystalline state and also development of new software, tailor-made for the special needs of electron crystallography. This volume comprises the proceedings of the NATO Advanced Study Institute on Electron Crystallography: Novel Approaches for Structure Determination of Nanosized Materials, Erice, Italy, 10 - 24 June 2004
Drugs and a methodological compendium : From bench to bedside
Provides a meticulous view on methodological drug discovery and development insights from bench to bedside. Focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. Covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.
Drug repurposing and computational drug discovery strategies and advances
Defined as identifying new pharmacological indications from old, existing, failed, investigational, already marketed, or FDA-approved drugs and prodrugs, and applying these new uses in the treatment of diseases other than the drug’s original intended therapeutic use. The application of computational techniques in discovery research not only helps in the development of drugs from leads or existing drug molecules but can also be useful for the repurposing of existing drug candidates.
Drug disposition and pharmacokinetics : Principles and applications for medicine, toxicology and biotechnology
Delivers an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics.
Drug discovery with privileged building Blocks : Tactics in medicinal chemistry
Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book.
Drug discovery targeting drug-resistant bacteria
Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included.
Drug development and approval process
Drug discovery is the process of identifying and characterizing molecules with the potential to safely modulate disease, with a goal to bring medicines that can improve the lives of patients. It is a lengthy and resource intensive process, that requires close cooperation across multiple disciplines. Optimizing the process of drug discovery is of great interest to the pharmaceutical industry, as the efficient identification and selection of suitable drug candidates can have a dramatic impact on the cost and profitability of new medicines.
Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
DNA- and RNA-Based Computing Systems
DNA- and RNA-Based Computing Systems delivers an authoritative overview of DNA- and RNA-based biocomputing systems that touches on cutting-edge advancements in computer science, biotechnology, nanotechnology, and materials science.
Dense Molecular Gas around Protostars and in Galactic Nuclei : European Workshop on Astronomical Molecules 2004
The European Workshop on Astronomical Molecules was held at ‘The Conference Building’ in Zwolle, the Netherlands, on 18–20 February 2004. The idea behind the workshop was to bring together astronomers studying similar processes in different astrophysical environments; masers and dense molecular gas around young stars and galactic nuclei. There is considerable overlap in physical and chemical phenomena between these environments, with scales ranging from circumstellar to central regions of galaxies. This issue includes 12 reviews and 27 contributed papers presented in this Wo- shop, all of them were refereed by invited speakers or the editors. The quality of the papers is outstanding. The projects discussed here are often in an early stage and undoubtedly their progress has bene?ted greatly from the opportunity to discuss results with the experts in a wide range of areas. Similarly,
Defending Life : The Nature of Host-Parasite Relations
Defending Life discusses the relationship between hosts and parasites. A major contention of the book is that the immune system depends ontologically on the ecosystem in which it is embedded; it would not have the features it has if it was not related in one way or other to parasitic agents and to the host’s own cells and tissues. To sustain the argument, life is investigated at all layers – from molecules up through cells, organisms and ecosystems. Together with the inverse course, which goes from ecological contingencies down to gene-expression profiles, the approach facilitates an advanced understanding of immunocompetence as well as its converse, immunoincompetence. The emphasis on analytical abstractions, coherent patterns and generative mechanisms makes possible the distinction between genuine causality and coincidental associations, and thus increases the understanding of why we observe what we observe. The book contains detailed descriptions of the immune system and the microbial world as well as methodological and conceptual clarifications.
Computer-aided drug design
Computer-Aided Drug Design (CADD) is a comprehensive guide designed for both beginners and experienced users in CADD. Covers the fundamental principles and gradually delves into more advanced concepts and techniques, making it an invaluable resource to anyone interested in CADD. It begins by establishing a solid foundation, explaining the core concepts of CADD, the user interface and essential tools. It covers QSAR, molecular docking, homology modeling, virtual screening, pharmacophore modeling, ensuring that the reader can quickly become proficient in CADD. Provides in-depth insights into 3D modeling, rendering, and parametric design. The style of the book is simple, every topic begins from the very basics and explores advanced levels with clarity. Practical examples, step-by-step tutorials and hands-on exercises, are included for better understanding.
Comets and the Origin and Evolution of Life
Nine years after the publication of Comets and the Origin and Evolution of Life, one of the pioneering books in Astrobiology, this second edition revisits the role comets may have played in the origins and evolution of life. Recent analyses of Antarctic micrometeorites and ancient rocks in Australia and South Africa, the continuing progress in discovering complex organic macromolecules in comets, protostars and interstellar clouds, new insights into organic synthesis in comets, and numerical simulations of comet impacts on the Earth and other members of the solar system yield a spectacular wealth of new results.
Collagen : Primer in Structure, Processing and Assembly
This volume of Topics in Current Chemistry is an attempt to update and compile the biochemical, molecular knowledge of the still growing family of collagenous proteins. Its intention is to provide a comprehensive summary of all mechanisms known to be involved in synthesis, processing and deposition of collagen molecules, all of which are apparently shared by any known collagen type as part of a common biosynthetic route. From the intracellular initiation of protein translation to the extracellular deposition of mature molecules into the scaffold of the preformed tissue texture, collagen biosynthesis exhibits a profile of mechanisms absolutely unique when compared to other proteins
Marine Biotechnology II
This volume of Advances in Biochemical Engineering/Biotechnology illustrates several topics in line with the following broad objectives: thinking of marine biotechnology as the controlled production and use of marine organisms and molecules for useful purposes, firstly by exploring aspects of marine biodiversity and exploitation of biomass, then considering the identification, production and processing of marine products.
Marine Biotechnology I
Oceans, which occupy up to two thirds of the surface of our planet, were not really approached from scientific point of view until the second half of the 19th century and even the 20th with regard to microbial and unicellular life. Today, the importance of marine biodiversity has been fully recognized. It is, indeed, one of the aspects which, over the two past decades, have made a major contribution to our knowledge and vision of the living planetThis volume of Advances in Biochemical Engineering/Biotechnology illustrates several topics in line with the following broad objectives: thinking ofmarine biotechnology as the controlled production and use of marine organisms and molecules for useful purposes, firstly by exploring aspects of marine biodiversity and exploitation of biomass, then considering the identification, production and processing of marine products.
