الصفحة 5
الصفحة 5
Emotion Regulation : Conceptual and Clinical Issues
Emotions: basic products of human functioning, intimately involved in physical health, they have been alternately embraced and ignored by generations of researchers and practitioners. Emotion Regulation offers a much-needed corrective to the conventional clinical wisdom, updating the knowledge base on emotions—specifically their expression and inhibition—as they affect stress, health, and well-being. An international team of researchers from a variety of fields sort out conflicting affect/health theories, and provide the latest findings on inter- and intrapersonal functions of emotions while acknowledging the role of individual variables. The book covers conceptual, developmental, and clinical issues and balances core topics with emerging areas of interest
Embedded computer systems : Architectures, modeling, and simulation ; Vol. 3553 ; 5th International Workshop, SAMOS 2005, Samos, Greece, July 18-20, Proceedings
The SAMOS workshop is an international gathering of highly quali?ed researchers from academia and industry, sharing in a 3-day lively discussion on the quiet and - spiring northern mountainside of the Mediterranean island of Samos. As a tradition, the workshop features workshop presentations in the morning, while after lunch all kinds of informal discussions and nut-cracking gatherings take place. The workshop is unique in the sense that not only solved research problems are presented and discussed but also (partly) unsolved problems and in-depth topical reviews can be unleashed in the sci- ti?c arena. Consequently, the workshop provides the participants with an environment where collaboration rather than competition is fostered. The earlier workshops, SAMOS I–IV (2001–2004), were composed only of invited presentations. Due to increasing expressions of interest in the workshop, the Program Committee of SAMOS V decided to open the workshop for all submissions. As a result the SAMOS workshop gained an immediate popularity; a total of 114 submitted papers were received for evaluation. The papers came from 24 countries and regions: Austria (1), Belgium (2), Brazil (5), Canada (4), China (12), Cyprus (2), Czech Republic (1), Finland (15), France (6), Germany (8), Greece (5), Hong Kong (2), India (2), Iran (1), Korea (24), The Netherlands (7), Pakistan (1), Poland (2), Spain (2), Sweden (2), T- wan (1), Turkey (2), UK (2), and USA (5). We are grateful to all of the authors who submitted papers to the workshop.
Early Development of the Human Pelvic Diaphragm
A sound and detailed knowledge of the anatomy of the pelvic floor is of the utmost importance to gynecologists, obstetricians, surgeons, and urologists, since they all share the same responsibility in treating patients with different pathological conditions caused by pelvic floor dysfunction. The most common clinical expressions of pelvic floor dysfunction are urinary incontinence, anal incontinence, and pelvic organ prolapse. Most often these clinical expressions are found in women, and they are briefly discussed below based on the outline presented in the Third International Consultation on Incontinence, a joint effort of the International Continence Society and the World Health Organization.
Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
DNA Methylation and Cancer Therapy
DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.
DNA Methylation : Development, Genetic Disease and Cancer
It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.
DNA Conformation and Transcription
the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
DNA Binders and Related Subjects
advances in technology and the application of new methods to outstanding problems have played a major part in the development of ideas about drug-nucleic acid recognition. The field has undergone an explosive diversification as wider and wider problems became accessible to study using the new ideas and techniques. This volume reflects that diversification by offering accounts of selected areas that illustrate recent advances in the study of ligand–nucleic acid binding over disparate areas of the subject. There are chapters dealing specifically with the invention and application of new methodology, and a particularly thoughtful essay on the interpretation of X-ray diffraction data which may not be as straightforward as is often imagined. Other chapters illustrate the diversity and complexity of drug-DNA binding from several perspectives, referring to particular groups of related compounds or the potential attractions of the less-preferred DNA major groove as a target for nucleotide sequence recognition by ligands.
Diverse Roles of Integrin Receptors in Articular Cartilage
Recent studies from the authors' laboratory and from other leading groups have shown that ß1-integrins are essential for cell signalling and communication in chondrocytes. Furthermore, ß1-integrins function as mechanoreceptors in the chondrocyte mechanotransduction pathway. Their expression is therefore essential for maintaining the chondrocyte phenotype, preventing chondrocyte apoptosis and regulating chondrocyte-specific gene expression. This book volume summarizes the work that the authors have done on ß1-integrins over the last 18 years and focuses on the expression and regulation of these proteins in chondrocytes and their role in the context of the unique function of chondrocytes within articular cartilage.
Dipeptidyl Aminopeptidases : Basic Science and Clinical Applications
Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.
Developments in language theory ; 8th International Conference, DLT 2004, Auckland, New Zealand, December 13-17, Proceedings
Basic Notions of Reaction Systems / A Kleene Theorem for a Class of Communicating Automata with Effective Algorithms / Algebraic and Topological Models for DNA Recombinant Processes / Contributed Papers : Regular Expressions for Two-Dimensional Languages Over One-Letter Alphabet / On Competence in CD Grammar Systems / The Dot-Depth and the Polynomial Hierarchy Correspond on the Delta Levels, and other
Defending Life : The Nature of Host-Parasite Relations
Defending Life discusses the relationship between hosts and parasites. A major contention of the book is that the immune system depends ontologically on the ecosystem in which it is embedded; it would not have the features it has if it was not related in one way or other to parasitic agents and to the host’s own cells and tissues. To sustain the argument, life is investigated at all layers – from molecules up through cells, organisms and ecosystems. Together with the inverse course, which goes from ecological contingencies down to gene-expression profiles, the approach facilitates an advanced understanding of immunocompetence as well as its converse, immunoincompetence. The emphasis on analytical abstractions, coherent patterns and generative mechanisms makes possible the distinction between genuine causality and coincidental associations, and thus increases the understanding of why we observe what we observe. The book contains detailed descriptions of the immune system and the microbial world as well as methodological and conceptual clarifications.
Deepfake
The technology used to create such digital content has quickly become accessible to the masses, such as “DEEPFAKE.” Deep fakes refer to manipulated videos, or other digital representations produced by sophisticated artificial intelligence, that yields to synthesize a sequence of face images and voices of characters corresponding to their identities, such as voice tone, facial expression, with a good lip synchronization. Therefore, this study is about developing real-time video generation software, which generates a target video from a single input image. Several methods and algorithms have been applied to detect, analyze personalize facial expression, voice and natural head poses to present a life-like image instead of a low quality one.
Deep Learning-Based Face Analytics
Provides an overview of different deep learning-based methods for face recognition and related problems. Specifically, the authors present methods based on autoencoders, restricted Boltzmann machines, and deep convolutional neural networks for face detection, localization, tracking, recognition, etc. The authors also discuss merits and drawbacks of available approaches and identifies promising avenues of research in this rapidly evolving field.
Data-Driven 3D Facial Animation
Data-Driven 3D Facial Animation: systematically describes the emerging data-driven techniques developed over the last ten years or so. Although data-driven 3D facial animation is used more and more in animation practice, to date there have been very few books that specifically address the techniques involved. Comprehensive in scope, the book covers not only traditional lip-sync (speech animation), but also expressive facial motion, facial gestures, facial modeling, editing and sketching, and facial animation transferring. It provides an up-to-date reference source for academic research and for professionals working in the facial animation field.
Data Mining in Bioinformatics
8. 1. 1 Protein Subcellular Location The life sciences have entered the post-genome era where the focus of biological research has shifted from genome sequences to protein functionality. Withwhole-genomedraftsofmouseandhumaninhand,scientistsareputting more and more e?ort into obtaining information about the entire proteome in a given cell type. The properties of a protein include its amino acid sequences, its expression levels under various developmental stages and in di?erent tissues, its3Dstructure and activesites,its functionalandstructural binding partners, and its subcellular location. Protein subcellular location is important for understanding protein function inside the cell. For example, the observation that the product of a gene is localized in mitochondria will support the hypothesis that this protein or gene is involved in energy metabolism. Proteins localized in the cytoskeleton are probably involved in intracellular tra?cking and support.
Cyclotomic Fields and Zeta Values
Cyclotomic fields have always occupied a central place in number theory, and the so called "main conjecture" on cyclotomic fields is arguably the deepest and most beautiful theorem known about them. It is also the simplest example of a vast array of subsequent, unproven "main conjectures'' in modern arithmetic geometry involving the arithmetic behaviour of motives over p-adic Lie extensions of number fields. These main conjectures are concerned with what one might loosely call the exact formulae of number theory which conjecturally link the special values of zeta and L-functions to purely arithmetic expressions.
Current Perspectives in microRNAs (miRNA)
In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.
Cultural heritage and human rights
The volume addresses a deeply political aspect of heritage preservation and management as it relates to human rights. Social and community advocates assert that heritage is necessary for the articulation and preservation of cultural identity. The display of heritage monuments and performance can be a strategy for asserting minority identity in the face of majority pressure – as well as a tool for resistance and the expression of difference.
Ctenophores : Methods and protocols
Explores emerging approaches and methods inspired by recent research using ctenophores or placozoans, facilitating the study of these enigmatic species and ancient animal lineages. Practical protocols are integrated with introductory chapters about general biology, summarizing the diversity, evolution, genomics, development, and neurobiology of these organisms. Special chapters outline strategies and applications for culturing, microscopy, physiology, electrical synapses, and bioluminescence, molecular and single-cell biology, transcription factors, as well as gene and protein expression analyses. The book also contains bioinformatics and computational chapters covering peptidomics and epigenomics. Written for the highly successful Methods in Molecular Biology series, chapters include detailed implementation advice that leads to dependable results in the laboratory.
