الصفحة 5
الصفحة 5
Inductive logic programming ; 15th International Conference, ILP 2005, Bonn, Germany, August 10-13, 2005, Proceedings
“Change is inevitable.” Embracing this quote we have tried to carefully exp- iment with the format of this conference, the 15th International Conference on Inductive Logic Programming, hopefully making it even better than it already was. But it will be up to you, the inquisitive reader of this book, to judge our success. The major changes comprised broadening the scope of the conference to include more diverse forms of non-propositional learning, to once again have tutorials on exciting new areas, and, for the ?rst time, to also have a discovery challenge as a platform for collaborative work. This year the conference was co-located with ICML 2005, the 22nd Inter- tional Conference on Machine Learning, and also in close proximity to IJCAI 2005, the 19th International Joint Conference on Arti?cial Intelligence. - location can be tricky, but we greatly bene?ted from the local support provided by Codrina Lauth, Michael May, and others. We were also able to invite all ILP and ICML participants to shared events including a poster session, an invited talk, and a tutorial about the exciting new area of “statistical relational lea- ing”. Two more invited talks were exclusively given to ILP participants and were presented as a kind of stock-taking—?ttingly so for the 15th event in a series—but also tried to provide a recipe for future endeavours.
In Vitro Drug Release Testing of Special Dosage Forms
Covers the in vitro release testing of: lipid based oral formulations; chewable oral drug products; injectables; drug eluting stents; inhalation products; transdermal formulations; topical formulations; vaginal and rectal delivery systems and ophthalmics. The book concludes with a look at regulatory aspects. Covers both oral and non-oral dosage forms Describes current regulatory conditions for in vitro drug release testing Features contributions from well respected global experts in dissolution testing
In Search of Dark Matter
The dark matter problem is one of the most fundamental and profoundly difficult to solve problems in the history of science. Not knowing what makes up most of the known universe goes to the heart of our understanding of the Universe and our place in it. In Search of Dark Matter is the story of the emergence of the dark matter problem, from the initial erroneous ‘discovery’ of dark matter by Jan Oort to contemporary explanations for the nature of dark matter and its role in the origin and evolution of the Universe. Written for the educated non-scientist and scientist alike, it spans a variety of scientific disciplines, from observational astronomy to particle physics. Concepts that the reader will encounter along the way are at the cutting edge of scientific research. However the themes are explained in such a way that no prior understanding of science beyond a high school education is necessary.
Imaging in Drug Discovery and Early Clinical Trials
Efficient tools for the selection and validation of drug targets both at the preclinical and clinical level are required. Non-invasive imaging and in particular molecular imaging methods are becoming essential technologies to support drug discovery and dvelopment. Imaging provides structural, functional, metabolic and molecular readouts that are being applied to characterize a disease phenotype (diagnosis), to elucidate molecular mechanisms involved, to evaluate drug efficacy and safety, and to identify potential biomarkers of the drug's mechanism-of-action, efficacy and safety. Non-invasive imaging techniques constitute a bridge between preclinical and clinical drug evaluation. In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation.
ICCS 2007 ; Proceedings of the 15th International Workshops on Conceptual Structures
The 15th International Conference on Conceptual Structures (ICCS 2007) is the latest in a series of annual conferences that have been held in Europe, Australia, and North America since 1993. Some of the world's best minds in information technology, arts, humanities and social science converged to explore novel ways that information and communications technology (ICT) can augment human intelligence.
Ibuprofen : Discovery, development and therapeutics
Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered.
Hybrid metaheuristics ; 5th International Workshop, HM 2008, Málaga, Spain, October 8-9, 2008. Proceedings
This book constitutes the refereed proceedings of the 5th International Workshop on Hybrid Metaheuristics, HM 2008, held in Malaga, Spain, in October 2008.The 14 revised full papers presented were carefully reviewed and selected from 33 submissions. The papers discuss specific aspects of combinations of metaheuristics and other solving techniques for tackling particular relevant constrained optimization problems, such as fiber optic networks, time tabling and freight train scheduling problems.
Hybrid Artificial Intelligent Systems ; 15th International Conference, HAIS 2020, Gijón, Spain, November 11-13, 2020, Proceedings
This book constitutes the refereed proceedings of the 15th International Conference on Hybrid Artificial Intelligent Systems, HAIS 2020, held in Gijón, Spain, in November 2020. The 65 regular papers presented in this book were carefully reviewed and selected from 106 submissions. The papers are grouped into these topics: advanced data processing and visualization techniques; bio-inspired models and optimization; learning algorithms; data mining, knowledge discovery and big data; and hybrid artificial intelligence applications.
Hubble : 15 Years of Discovery
This book forms part of the European Space Agency’s 15th anniversary celebration activities for the 1990 launch of the NASA/ESA Hubble Space Telescope. As an observatory in space, Hubble is one of the most successful scientific projects of all time, both in terms of scientific output and its immediate public appeal.Hubble creates an enormous impact by exploiting a unique scientific niche where no other instruments can compete. It consistently delivers super-sharp images and clean, uncontaminated spectra over the entire near-infrared and ultraviolet regions of the electromagnetic spectrum. This has opened up new scientific territory and resulted in many paradigm-breaking discoveries.
Hox Gene Expression
The study of Hox genes is crucial not only in exploring the enigma of homeosis but also in understanding normal development at the fundamental molecular level. "Hox Gene Expression" starts with the amazing discovery of the homeobox twenty-three years ago and follows the exciting path thereafter of a series of breakthroughs in Genetics, Development and Evolution. It deals with homeotic genes- their evolution, structure, normal and abnormal function. Researchers and graduate students in Biology and Medicine will benefit from this integrated overview of Hox gene activities.
High-Velocity Clouds
On the occasion of the retirement of Ulrich Schwarz, a symposium was held in Groningen in May of 1996, celebrating his contributions to the study of the int- stellar medium, including his work on the high-velocity clouds. The coming together of many specialists in the latter ?eld prompted the idea of compiling a book c- taining their contributions, and summarizing the status of our understanding of the high-velocity cloud phenomenon. This seemed especially worthwhile at the time, since many exciting developments were taking place. After the discovery of some H i clouds with high velocities, about 40 years ago, the subject had been dominated by 21-cm observations of H i emission. Starting in the mid-1980s much progress was being made because of the availability of new instruments, such as large ground-based optical telescopes and UV observatories in space. The connections between the work on high-velocity clouds and other studies of the properties of the (hot) interstellar medium also became clearer.
High performance computing for drug discovery and biomedicine
Explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. Collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. And delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects.
Heterogeneous Objects Modelling and Applications : Collection of Papers on Foundations and Practice
Heterogeneous object modelling is a new and quickly developing research area. This book is one of the first attempts to systematically cover the most relevant themes and problems of this new and challenging subject area. It is a collection of invited papers and papers co-authored by the editors. Each chapter presents either new research results or a survey on the following topics:Formal models and abstractions of heterogeneous objects including geometric, topological, discrete and continuous models, operations forming special algebras and conversions between different model types.
Herbal pharmacopeia : Nanotechnology and advancing drug
Explores the intersection between traditional herbal medicine and cutting-edge nanotechnology. The chapters introduce modern techniques used in herbal extraction and analysis. The principles of drug discovery from plants are discussed, with a focus on the identification and development of bioactive compounds that have therapeutic potential. It discusses the pharmacological properties, biotechnological approaches in drug development, and challenges in the formulation and standardization of herbal medicines. Emerging trends and applications of nanotechnology in herbal pharmacotherapy, such as nanoparticle synthesis, enhanced bioavailability using nanocarriers, safety assessments, novel and targeted delivery systems, and regulatory considerations, are thoroughly discussed. Additionally, it includes a comparative analysis of traditional and nano-formulated approaches and their implementation in clinical settings. Towards the end, the book reviews the regulatory considerations for herbal products and future perspectives in herbal pharmacopeia. This book is intended for researchers, clinicians, and professionals in herbal medicine, pharmacology, and nanotechnology.
Herbal medicine in India : Indigenous knowledge, practice, innovation and its value
Covers Indian herbal medicines, health products, pharmaceuticals, nutraceuticals, and cosmetics. Highlights the status quo and future prospects of traditional medicine in India / Provides information on drug discovery, ethnobotany, isolation of phytochemicals, importance of herbal nutraceuticals, etc. / Covers innovation, validation and IPR issues related to Indian traditional medicine
Hepatitis Delta Virus ; Vol. 307
Since its discovery nearly 30 years ago, hepatitis delta virus (HDV) has continued to surprise and fascinate. At 1,680 nucleotides the HDV genome is the smallest known to infect man. It is unique among animal viruses, the closest known relatives being plant viroids. To compensate for its limited protein coding capacity, HDV relies heavily on host functions and on structural features of its circular RNA genome. HDV infection depends on hepatitis B virus as a helper, and increases the severity of liver disease caused by HBV alone. There is currently neither an effective HDV vaccine nor a generally accepted useful therapy for HDV infection. This volume encompasses recent developments in HDV research, from molecular virology to genetics to experimental investigation of new therapeutic and vaccine candidates.
Health Information Science ; 9th International Conference, HIS 2020, Amsterdam, The Netherlands, October 20–23, 2020, Proceedings
This book constitutes the proceedings of the 9th International Conference on Health Information Science, HIS 2020, which took place in Amsterdam, The Netherlands, during October 20-23, 2020. The 11 full papers and 6 short papers presented in this volume were carefully reviewed and selected from 62 submissions. They were organized in topical sections named: mental health; medical record processing; medical information systems; medical diagnosis with machine learning; and health behavior and medication.
Hardware and software : Verification and testing ; 1st International Haifa Verification Conference, Haifa, Israel, November 13-16, 2005, Revised Selected Papers
The First Haifa Verification Conference was held at the IBM Haifa Research Lab and at the Haifa University in Israel from November 13 to16, 2005. The conference incorporated three different workshops that took place separately in previous years. The IBM Verification Workshop is now its sixth year, the IBM Software Testing Workshop is now in its fourth year, and the PADTAD Workshop on testing and debugging multi-threaded and parallel software was held for the third time. The Verification Conference was a three-day, single-track conference followed by a one-day tutorial on the testing and review of multi-threaded code. The conference presented a unique combination of fields that brought together the hardware and software testing communities. Merging the different communities under a single roof gave the conference a distinctive flavor and provided the participants with added benefits. While the applications in these separate fields are different, the techniques used are often very similar. By offering lectures in these disparate but related disciplines, the conference engendered an environment of collaboration and discovery.
Hans Christian Ørsted and the Romantic Legacy in Science : Ideas, Disciplines, Practices
This volume owes its origin to the perception of a puzzling paradox. Hans Christian Ørsted, the great Danish scientist and philosopher, was one of the founders of modern physics through his experimental discovery in 1820 of the interaction of electricity and magnetism—a key step and model for the further unification of the forces of nature. Followers such as Maxwell and Einstein were, and today searchers worldwide are, enchanted by the hope for a completion of that grand program. In addition to Ørsted’s discovery of electromagnetism, his work in science included other fields, chiefly high-pressure physics and acoustics.
Handbook of Radiopharmaceuticals : Methodology and Applications ; 2nd ed.
A comprehensive review of the field, presenting up-to-date coverage of central topics such as radionuclide production, synthetic methodology, radiopharmaceutical development and regulations, and a wide range of practical applications. A valuable reference work for those new to the Radiopharmaceutical Sciences and experienced professionals alike, this volume explores the latest concepts and issues involving both targeted diagnostic and therapeutic radiopharmaceuticals. Contributions from a team of experts from across sub-disciplines provide readers with an immersive examination of radiochemistry, nuclear medicine, molecular imaging, and more. Features extensive new and revised content throughout Covers key areas of application for diagnosis and therapy in oncology, neurology, and cardiology Emphasizes the multidisciplinary nature of Radiopharmaceutical Sciences Discusses how drug companies are using modern radiopharmaceutical imaging techniques to support drug discovery Examines current and emerging applications of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT)
