الصفحة 5
الصفحة 5
Asymmetric Cell Division
Cell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.
Antioxidants effects in health : The bright and the dark side ; 1st ed.
Examines the role that antioxidants play in a variety of health and disease situations. The book discusses antioxidants’ historical evolution, their oxidative stress, and contains a detailed approach of 1) endogenous antioxidants, including endogenous sources, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; 2) synthetic antioxidants, including sources, chemistry, bioavailability, legal status, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; and 3) natural antioxidants, including sources, chemistry, bioavailability, mechanisms of action, possible prooxidant activity; beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies. Throughout the boo, the relationship of antioxidants with different beneficial and detrimental effects are examined, and the current controversies and future perspectives are addressed and explored. Antioxidants Effects in Health: The Bright and the Dark Side evaluates the current scientific evidence on antioxidant topics, focusing on endogenous antioxidants, naturally occurring antioxidants and synthetic antioxidants. It will be a helpful resource for pharmaceutical scientists, health professionals, those studying natural chemistry, phytochemistry, pharmacognosy, natural product synthesis, and experts in formulation of herbal and natural pharmaceuticals.
Analytical Ultracentrifugation of Polymers and Nanoparticles
Analytical ultracentrifugation (AUC) is a powerful method for the characterization of polymers, biopolymers, polyelectrolytes, nanoparticles, dispersions, and other colloidal systems. The method is able to determine the molar mass, the particle size, the particle density and interaction parameters like virial coefficients and association constants. Because AUC is also a fractionation method, the determination of the molar mass distribution, the particle size distribution, and the particle density distribution is possible. A special technique, the density gradient method, allows fractionating heterogeneous samples according to their chemical nature that means being able to detect chemical heterogeneity.
An introduction to pharmacovigilance ; 2nd ed.
Designed to aid the rapid understanding of the key principles of pharmacovigilance. Packed full of examples illustrating drug safety issues it not only covers the processes involved, but the regulatory aspects and ethical and societal considerations of pharmacovigilance. Covering the basics step-by-step, this book is perfect for beginners and is essential reading for those new to drug safety departments and pharmaceutical medicine students. The second edition is thoroughly revised and updated throughout and includes a new chapter on clinical aspects of pharmacovigilance.
An Introduction to Efficiency and Productivity Analysis
It is designed to be a "first port of call" for people wishing to study efficiency and productivity analysis. The book provides an accessible introduction to the four principal methods involved: econometric estimation of average response models; index numbers; data envelopment analysis (DEA); and stochastic firontier analysis (SFA). For each method, we provide a detailed introduction to the basic concepts, give some simple numerical examples, discuss some of the more important extensions to the basic methods, and provide references for further reading. In addition, we provide a number of detailed empirical applications using real-world data.
Advances in pharma business management and research ; Vol. 1
This book presents a unique collection of practical examples from the field of pharma business management and research. It covers a wide range of topics such as: 'Brexit and its Impact on pharmaceutical Law - Implications for Global Pharma Companies', 'Implementation of Measures and Sustainable Actions to Improve Employee's Engagement', 'Global Medical Clinical and Regulatory Affairs (GMCRA)', and 'A Quality Management System for R&D Project and Portfolio Management in a Pharmaceutical Company'.
Advances in Artificial Intelligence - IBERAMIA-SBIA 2006 ; 2nd International Joint Conference, 10th Ibero-American Conference on AI, 18th Brazilian AI Symposium, Ribeirao Preto, Brazil, October 23-27, 2006
This decision was a consequence of the successful event organized in 2000, when the First International Joint Conference IBERAMIA/ SBIA 2000 (7th Ibero- American Artifcial Intelligence Conference and 15th Brazilian Artifcial Intel- gence Symposium) occurred in Brazil. Moreover, in 2006 the artifcial intelligence community celebrated the golden anniversary of the 1956 Dartmouth Conference that marked the beginning of artifcial intelligence as a research feld. th SBIA 2006 was the 18 conference of the SBIA conference series, which is the leading Brazilian conference for the presentation of AI research and applications.
Advancements and Innovations in OMFS, ENT, and Facial Plastic Surgery
Covers updated practices and cutting-edge innovations pertinent to advanced Oral & Maxillofacial Surgeons, Otolaryngologists (Head and Neck Surgeons), and Facial Plastic Surgeons. Each chapter will review and update the reader on advancements in procedures and technologies in head and neck surgery.
Accessing and Sharing the Benefits of the Genomics Revolution
This edited volume explores the legal, economic and political context for the debate about intellectual property rights for traditional knowledge and genetic resources and critically analyses the theory and practice of access and benefits sharing efforts around the world. The book also investigates the current flashpoints—the David and Goliath battle between Monsanto and Percy Schmeiser over farmers’ rights; the dispute over coexistence of GM and organic production; and the ownership and control of human genetic materials stored in human gene banks around the world.
A Field Guide to Algebra
Focuses on the structure of fields and is intended for a second course in abstract algebra. Besides providing proofs of the transcendance of pi and e, the book includes material on differential Galois groups and a proof of Hilbert's irreducibility theorem. The reader will hear about equations, both polynomial and differential, and about the algebraic structure of their solutions. In explaining these concepts, the author also provides comments on their historical development and leads the reader along many interesting paths. In addition, there are theorems from analysis: as stated before, the transcendence of the numbers pi and e, the fact that the complex numbers form an algebraically closed field, and also Puiseux's theorem that shows how one can parametrize the roots of polynomial equations, the coefficients of which are allowed to vary. There are exercises at the end of each chapter, varying in degree from easy to difficult. To make the book more lively, the author has incorporated pictures from the history of mathematics, including scans of mathematical stamps and pictures of mathematicians.
A Course in Enumeration
Leads the reader in a leisurely way from the basic notions to a variety of topics, ranging from algebra to statistical physics. Its aim is to introduce the student to a fascinating field, and to be a source of information for the professional mathematician who wants to learn more about the subject.
