الصفحة 5
الصفحة 5
Novel Carrier Systems for Targeted and Controlled Drug Delivery
Presents novel carrier systems for the targeted and controlled drug delivery for the treatment of various diseases which are difficult to be treated with conventional drug delivery systems like cancer, autoimmune disorders, and emerging infectious diseases. It also reviews the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The book also explores the potential applications of the parenteral route of administration for the delivery of active pharmaceutical substances with a narrow therapeutic index and poor bioavailability. Further, the book presents common routes of administration for the systemic delivery of peptides and proteins. It also examines the applications of various implantable systems in drug delivery. The book also covers the important colloidal drug delivery systems, including liposomes and niosomes and solid lipid nanoparticles, and nanostructured lipid carriers.
Notch Signaling in Embryology and Cancer : Notch Signaling in Cancer
This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more.
Nonstandard Analysis
The book is an introduction with emphasis on those more advanced applications in analysis which are hardly accessible by other methods. Examples of such topics are a deeper analysis of certain functionals like Hahn-Banach limits or of finitely additive measures: From the viewpoint of classical analysis these are strange objects whose mere existence is even hard to prove. From the viewpoint of nonstandard analysis, these are rather 'explicit' objects.
Nonsmooth Variational Problems and their Inequalities : Comparison Principles and Applications
The main purpose of this book is to provide a systematic and unified exposition of comparison principles based on a suitably extended sub-supersolution method. This method is an effective and flexible technique to obtain existence and comparison results of solutions. Also, it can be employed for the investigation of various qualitative properties, such as location, multiplicity and extremality of solutions. In the treatment of the problems under consideration a wide range of methods and techniques from nonlinear and nonsmooth analysis is applied, a brief outline of which has been provided in a preliminary chapter in order to make the book self-contained.
Nonsmooth Mechanics and Analysis : Theoretical and Numerical Advances
Nonsmooth mechanics concerns mechanical situations with possible nondifferentiable relationships, eventually discontinuous, as unilateral contact, dry friction, collisions, plasticity, damage, and phase transition. The basis of the approach consists in dealing with such problems without resorting to any regularization process. Indeed, the nonsmoothness is due to simplified mechanical modeling; a more sophisticated model would require too large a number of variables, and sometimes the mechanical information is not available via experimental investigations. Therefore, the mathematical formulation becomes nonsmooth; regularizing would only be a trick of arithmetic without any physical justification. Nonsmooth analysis was developed, especially in Montpellier, to provide specific theoretical and numerical tools to deal with nonsmoothness. It is important not only in mechanics but also in physics, robotics, and economics.
Nonsmooth Analysis
The book treats various concepts of generalized derivatives and subdifferentials in normed spaces, their geometric counterparts (tangent and normal cones) and their application to optimization problems. It starts with the subdifferential of convex analysis, passes to corresponding concepts for locally Lipschitz continuous functions and finally presents subdifferentials for general lower semicontinuous functions. All basic tools are presented where they are needed; this concerns separation theorems, variational and extremal principles as well as relevant parts of multifunction theory. The presentation is rigorous, with detailed proofs. Each chapter ends with bibliographic notes and exercises.
Nonparametric Functional Data Analysis : Theory and Practice
Modern apparatuses allow us to collect samples of functional data, mainly curves but also images. On the other hand, nonparametric statistics produces useful tools for standard data exploration. This book links these two fields of modern statistics by explaining how functional data can be studied through parameter-free statistical ideas. This book starts from theoretical foundations including functional nonparametric modeling, description of the mathematical framework, construction of the statistical methods, and statements of their asymptotic behaviors. It proceeds to computational issues including R and S-PLUS routines. Several functional datasets in chemometrics, econometrics, and pattern recognition are used to emphasize the wide scope of nonparametric functional data analysis in applied sciences. The companion Web site includes R and S-PLUS routines, command lines for reproducing examples presented in the book, and the functional datasets. Rather than set application against theory, this book is really an interface of these two features of statistics. A special effort has been made in writing this book to accommodate several levels of reading.
Non-negative Matrices and Markov Chains
This book is a photographic reproduction of the book of the same title published in 1981, for which there has been continuing demand on account of its accessible technical level. Its appearance also helped generate considerable subsequent work on inhomogeneous products of matrices. This printing adds an additional bibliography on coefficients of ergodicity and a list of corrigenda.
Non-Native Language Teachers : Perceptions, Challenges and Contributions to the Profession
Now that non-natives are increasingly found teaching languages, and particularly English, both in ESL and EFL contexts, the identification of their specific contributions and their main strengths has become more relevant than ever.As a result, there has recently been a surge of interest in the role of non-native teachers but little empirical research has been published so far. This volume is particularly rich in providing different approaches to the study of non-native teachers: NNS teachers as seen by students, teachers, graduate supervisors, and by themselves. It also contributes little explored perspectives, like classroom discourse analysis, or a social-psychological framework to discuss conceptions of NNS teachers.
Non-metallic biomaterials for tooth repair and replacement
Focuses on the use of biomaterials for a range of applications in tooth repair and, in particular, dental restoration. Part one reviews the structure, modification and repair of dental tissues. The properties of enamel and dentin and their role in adhesive dental restoration are discussed, along with biomineralization and biomimicry of tooth enamel, and enamel matrix proteins (EMPs) for periodontal regeneration. Part two goes on to discuss the processing, bonding and wear properties of dental ceramics, glasses and sol-gel derived bioactive glass ceramics for tooth repair and replacement. Dental composites for tooth repair and replacement are then the focus of part three, including composite adhesive and antibacterial restorative materials for dental applications. T
Nonlinear Structural Engineering : With Unique Theories and Methods to Solve Effectively Complex Nonlinear Problems
This book is aiming to concentrate on the nonlinear static and dynamic analysis of structures and structural components that are widely used in everyday engineering applications. It approaches a nonlinear problem by mathematically converting it into an exact equivalent pseudolinear one, in contrast to commonly used approaches which are based on linear concepts. The new concepts, theories and methods introduced in this book, simplify a great deal the solution of the complex nonlinear problems, and also allow for the correct usage of the powerful existing linear methods of analysis.
Nonlinear Speech Modeling and Applications : Advanced Lectures and Revised Selected Papers
Presents the revised tutorial lectures given at the International Summer School on Nonlinear Speech Processing-Algorithms and Analysis held in Vietri sul Mare, Salerno, Italy in September 2004. The 14 revised tutorial lectures by leading international researchers are organized in topical sections on dealing with nonlinearities in speech signals, acoustic-to-articulatory modeling of speech phenomena, data driven and speech processing algorithms, and algorithms and models based on speech perception mechanisms. Besides the tutorial lectures, 15 revised reviewed papers are included presenting original research results on task oriented speech applications.
Nonlinear Optimization with Financial Applications
The book introduces the key ideas behind practical nonlinear optimization. Computational finance—an increasingly popular area of mathematics degree programmes—is combined here with the study of an important class of numerical techniques. The essentials of most currently popular algorithms are described and their performance is demonstrated on a range of optimization problems arising in financial mathematics. Theoretical convergence properties of methods are stated and formal proofs are provided in enough cases to be instructive rather than overwhelming. Practical behaviour of methods is illustrated by computational examples and discussions of efficiency, accuracy and computational costs. Supporting software for the examples and exercises is available
Non-Linear Optical Properties of Matte : From molecules to condensed phases
Non-Linear Optical Properties of Matter: From Molecules to Condensed Phases attempts to draw together both theory and application in this field. As such it will be of interest to both experimentalists and theoreticians alike. Divided into two parts, Part 1 is concerned with the theory and computing of non-linear optical (NLO) properties while Part 2 reviews the latest developments in experimentation.This book will be invaluable to researchers and students in academia and industry. It will be of particular interest to anyone involved in materials science, theoretical and computational chemistry, chemical physics, and molecular physics.
Nonlinear Optical Crystals : A Complete Survey
Nonlinear optical crystals are widely used in modern optical science and technology for frequency conversion of laser light, i.e. to generate laser radiation at any specific wavelength in visible, UV or IR spectral regions. This unrivalled reference book contains the most complete and up-to-date information on properties of nonlinear optical crystals. It includes: * Database of 63 common and novel nonlinear optical crystals * Periodically-poled and self-frequency-doubling materials * Full description of linear and nonlinear optical properties * Significant amount of crystallophysical, thermophysical, spectroscopic, electro-optic and magneto-optic information * 7 mini-reviews on novel applications, such as deep-UV light generation, terahertz-wave generation, ultrashort laser pulse compression, photonic band-gap crystals, x3 nonlinearity, etc. * More than 1500 different references with full titles It is a vital source of information for scientists and engineers dealing with modern applications of nonlinear optical crystals in quantum electronics, photonics, optoelectronics and laser physics.
Nonlinear Observers and Applications
The problem of state reconstruction in dynamical systems, known as observer problem, is undoubtedly crucial for controlling or just monitoring processes. For linear systems, the corresponding theory has been quite well established for several years now, and the purpose of the present book is to propose an overview on possible tools in that respect for nonlinear systems. Basic observability notions and observer structures are first recalled, together with ingredients for advanced designs on this basis. A special attention is then paid to the well-known high gain techniques with a summary of various corresponding recent results. A focus on the celebrated Extended Kalman filter is also given, in the perspectives of both nonlinear filtering and high gain observers, leading to so-called adaptive-gain observers. The more specific immersion approach for observer design is then emphasized, while optimization-based methods are also presented as an alternative to analytic observers.
Nonlinear Homogenization and its Applications to Composites, Polycrystals and Smart Materials ; Proceedings of the NATO Advanced Research Workshop, held in Warsaw, Poland, 23-26 June 2003
Although several books and conference proceedings have already appeared dealing with either the mathematical aspects or applications of homogenization theory, there seems to be no comprehensive volume dealing with both aspects. The present volume is meant to fill this gap, at least partially, and deals with recent developments in nonlinear homogenization emphasizing applications of current interest. It contains thirteen key lectures presented at the NATO Advanced Workshop on Nonlinear Homogenization and Its Applications to Composites, Polycrystals and Smart Materials. The list of thirty one contributed papers is also appended.
Nonlinear Fokker-Planck Equations : Fundamentals and Applications
Providing an introduction to the theory of nonlinear Fokker-Planck equations, this book discusses fundamental properties of transient and stationary solutions, emphasizing the stability analysis of stationary solutions by means of self-consistency equations, linear stability analysis, and Lyapunov's direct method. Also treated are Langevin equations and correlation functions. Nonlinear Fokker-Planck Equations addresses various phenomena such as phase transitions, multistability of systems, synchronization, anomalous diffusion, cut-off solutions, travelling-wave solutions and the emergence of power law solutions. A nonlinear Fokker-Planck perspective to quantum statistics, generalized thermodynamics, and linear nonequilibrium thermodynamics is given. Theoretical concepts are illustrated where possible by simple examples. The book also reviews several applications in the fields of condensed matter physics, the physics of porous media and liquid crystals, accelerator physics, neurophysics, social sciences, population dynamics, and computational physics.
Nonlinear finite element analysis of composite and reinforced concrete beams
Nonlinear Finite Element Analysis of Composite and Reinforced Concrete Beams presents advanced methods and techniques for the analysis of composite and FRP reinforced concrete beams. The title introduces detailed numerical modeling methods and the modeling of the structural behavior of composite beams, including critical interfacial bond-slip behavior. It covers a new family of composite beam elements developed by the authors. Other sections cover nonlinear finite element analysis procedures and the numerical modeling techniques used in commercial finite element software that will be of particular interest to engineers and researchers executing numerical simulations.
Non-Linear Electromechanics
This is the first book in which problems of electromechanics are considered from the perspective of analytical mechanics. The book includes fundamental results in the theory of non-linear electromechanical systems and will be useful both for researchers, engineers, scholars and graduate students of electromechanical faculties of technical universities. It includes not only theoretical results but also various examples from many industrial applications. A sizeable part of the book is devoted to the general theory of synchronous machines and electro-magnetic exciters of oscillations.
