الصفحة 47
الصفحة 47
Cyclized Helical Peptides : Synthesis, Properties and Therapeutic Applications
Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity
Cyclin Dependent Kinase 5 (Cdk5)
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.
Cybersecurity for business : Organization-wide strategies to ensure cyber risk Is not just an IT Issue
Important and cost-effective innovations can substantially increase cyber risk and the loss of intellectual property, corporate reputation and consumer confidence. Over the past several years, organizations around the world have increasingly come to appreciate the need to address cybersecurity issues from a business perspective, not just from a technical or risk angle. Cybersecurity for Business builds on a set of principles developed with international leaders from technology, government and the boardroom to lay out a clear roadmap of how to meet goals without creating undue cyber risk.
Cutaneous Lymphomas : Unusual Cases 2
This book describes unusual cases of cutaneous lymphomas and is of special interest for clinicians and pathologists dealing with the vexing subject of cutaneous lymphoma. In addition to the case description, it gives the clinical, histological, and in most cases also the phenotypical features and the results of molecular techniques. A commentary puts the observations into the context of cutaneous lymphomas.
Cutaneous Lupus Erythematosus
Lupus erythematosus is a chronic inflammatory autoimmune disease characterized by a wide spectrum of manifestations with a variable evolution. There has been a long-standing need for a book with a unifying concept on the cutaneous manifestations of this disease. The book is based on multidisciplinary knowledge and is written by leading clinicians and scientists. It provides not only a comprehensive description of the vast variety of cutaneous abnormalities but also a synthesis of the relationship between cutaneous and systemic changes, including chapters on classification and clinical aspects, pathogenesis and pathologic features, and treatment and management of lupus erythematosus.
Customer success management : Helping business customers achieve their goals
Provides a clear understanding of CSM for practitioners based on comprehensibly prepared knowledge from practical and scientific resources. the book can be used as a practical guide to learn about CSM process and the roles, necessary capabilities, and expectations toward customer success managers. furthermore, it also shows how CSM differs from and, at the same time, relates to existing customer-related management concepts such as value-based selling, key account management and customer relationship management.
Current trends and future directions in prosthetic and implant dentistry in the digital era
Covers the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
Current Therapy in Endodontics
Recent advances in technology, materials, and equipment have changed the way endodontics is practiced today, thereby facilitating treatments with greater efficiency, precision, and success, ultimately leading to better outcomes. Current Therapy in Endodontics encompasses the recent discoveries and applications for this field in one clinically relevant volume. Evidence-based presentation of recent advances in the field of endodontics. Objective comparison of materials and instruments on the market Tables present key data and instruction for quick viewing and comprehension
Current techniques and materials in dentistry
Dental implants are one of the most interesting dental treatments. PEEK (polyetheretherketone) has recently been reported as a further innovation in polymer implant materials, although it has not yet met the requirements to be a biomechanical requirement. In the placement of mini-screws used in orthodontic treatments, micro-cracks caused by overtorquing in thick and hard bone, and the consequent heat production, can reduce the success rate. Computer-aided design/computer-aided manufacturing (CAD/CAM) techniques are becoming increasingly popular. Since complete dentures can be produced using an additive (3D printing) or subtractive (milling) process, CAD/CAM techniques for denture fabrication have many clinical and laboratory advantages.
Current medical diagnosis & treatment 2024
Emphasizes the practical features of clinical diagnosis and patient management in all fields of internal medicine and in specialties of interest to primary care practitioners and to subspecialists who provide general care.
Current concepts in dental implantology: from science to clinical research
Presents comprehensive information on all modern scientific and clinical methods used in today's dental implantology. Chapters address such topics as osseointegration and basic science in dental implantology, current trends and biomaterials of clinical relevance, advanced clinical techniques, peri-implantitis, and prosthodontic trends in dental implantology. This book provides a better understanding of the scientific approach to basic concepts in dental implantology and presents the results of many clinical studies.
Current Concepts in Autoimmunity and Chronic Inflammation
The ethiopathologies of autoimmune diseases are complex. A broad variety of cell types and gene products are involved. This book explores clinical and experimental evidence suggesting that the importance of an individual factor changes during the course of the disease.
Current Advances in Drug Delivery Through Fast Dissolving
Presents detailed information about FDDFs (Fast Dissolving/Disintegrating Dosage Forms) from their inception to recent developments. Readers will learn about the technical details of various FDDF manufacturing methods, formulation aspects, evaluation and methods to conduct clinical studies. The authors also give examples of marketed fast disintegrating/dissolving drug products in US, Europe, Japan, and India. This reference is ideal for pharmacology students at all levels seeking information about this specific form of drug delivery and formulation.
Cured II - LENT Cancer Survivorship Research and Education : Late Effects on Normal Tissues
Multimodal treatment lies at the heart of the improvement in cancer cure rates. However, the more aggressive the treatment delivery in terms of dose, time and volume for radiation and chemotherapy, the more adverse effects in normal tissues can be anticipated. Against this background, a major paradigm shift has taken place in that there is a new focus on cancer survivorship. Put another way, there has been a realization that prolongation of life must be accompanied by maintenance of the quality of life: the life worth saving must be worth living.
Curcumin : clinical uses, health effects and potential complications
Curcumin is a natural product with polyphenolic structure. It is used in therapeutic remedies alone or in combination with other natural substances. Many researchers are investigating it because of its biological activities such as: anti-inflammatory, anti-cancer, anti-protozoal, anti-viral, anti-bacterial and has been found to be effective for treatment of Alzheimer, depression, headaches, fibromyalgia, leprosy, fever, menstrual problems, water retention, worms and kidney problems etc. It is an active ingredient in dietary spice, turmeric. It has reactive functional groups: a diketone moiety and two phenolic groups. Despite its unique biological activities, it suffers from some shortcomings which include: gastrointestinal problems, poor bioavailability due to its poor absorption, short half-life, poor solubility in aqueous solutions, rapid systemic elimination and antithrombotic activity which can interfere with blood clotting. The first chapter of this book reviews the different delivery systems used for incorporation of curcumin and its derivatives, release kinetics and up to date in vivo results. Chapter two discusses curcumin nano and microencapsulation and its implications on clinical uses.
Cultural Competence in Health Care
It offers a wealth of this crucial knowledge with emphasis on day-to-day clinical work. Authors Tseng and Streltzer, well-known experts on transcultural medicine and therapy, start by differentiating between disease and illness and advise on a range of practical matters, from discussing culturally sensitive subjects to negotiating compromises between traditional healing and established medicine, so that readers will gain both useful working techniques and valuable empathy with clients.
Crown lengthening by diode laser
Crown lengthening is a surgical technique aimed at increasing the amount of supragingival tooth structure for restorative or aesthetic purposes. it involves the removal of hard and soft periodontal tissue to expose more tooth structure above the gum line , allowing for longer clinical crowns and maintaining the biologic width .Various methods such as scalpel ,electrosurgery and laser can be employed for crown lengthening , with lasers offering several advantages over traditional techniques , including precision , minimal bleeding ,sterilization ,reduced swelling and scarring , coagulation ,vaporization ,and ,minimal postoperative pain .
Critical point theory and its applications
The book include extrema, even valued functionals, weak and double linking, sign changing solutions, Morse inequalities, and cohomology groups. The applications described include Hamiltonian systems, Schrödinger equations and systems, jumping nonlinearities, elliptic equations and systems, superlinear problems and beam equations. Many minimax theorems are established without the use of the (PS) compactness condition.
Criminal justice in America : the encyclopedia of crime, law enforcement, courts, and corrections
Provides a comprehensive overview of issues and trends in crime, law enforcement, courts, and corrections that encompass the field of criminal justice studies in the United States.
Crimean-Congo Hemorrhagic Fever : A Global Perspective
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease associated with severe hemorrhagic manifestations. CCHF has been referred to as the "Asian Ebola." However, in fact, the disease is one of the most widely distributed tick-borne diseases in the world, occurring in Africa, Asia, Europe, and the Middle East. This volume covers major aspects of this important disease and the virus which causes it. Chapters are written by leading experts in their fields and detail historical, public health, epidemiological, and clinical aspects of CCHF and the genetics and molecular biology of the virus. Additional chapters focus on disease control, tick vectors and infection among animals, both natural and experimental.
