الصفحة 41
الصفحة 41
An Introduction to Global Spectral Modeling
Numerical weather prediction is receiving increased attention as weather forecasters aim to improve the numerical models used to forecast the weather. This is a textbook on global spectral modeling, which is an important component for global weather forecasts at numerous operational centers. This book covers all areas of model development including numerical analysis, treatment of clouds, mountains, radiation, precipitation processes, and the surface layers over land and the ocean. The objectives of this book are to provide a systematic and sequential background for students, researchers, and operational weather forecasters in order to develop comprehensive weather forecast models. This is designed for a one semester introductory graduate level course on weather prediction methodologies. As a prerequisite it requires a basic background in meteorology, applied mathematics, and numerical analysis.
An Integrated Approach to Software Engineering
An Integrated Approach to Software Engineering introduces software engineering to advanced-level undergraduate and graduate students of computer science. It emphasizes a case-study approach whereby a project is developed through the course of the book, illustrating the different activities of software development. The sequence of chapters is essentially the same as the sequence of activities performed during a typical software project. All activities, including quality assurance and control activities, are described in each chapter as integral activities for that phase of development. Similarly, the author carefully introduces appropriate metrics for controlling and assessing the software process. Chapters in this revised edition, updated for today’s standards, include these new features: Software Process, Requirements Analysis and Specification, Software Architecture, Project Planning, Object Oriented Design, Coding,Testing,
Ambiguities in Decision-oriented Life Cycle Inventories: The Role of Mental Models and Values
Shows for the first time how mental models and values influence this attribution in the life cycle inventory step of LCA. One of the key findings is that the different management rules for a sustainable use of materials must be taken into account for the attribution of material and energy flows to a product. Otherwise, improvement options recommended by an LCA might turn out to even worsen the environmental situation if reassessed from a meta-perspective. As a consequence of this book, the claim of unambiguitiy (‘objectivity’) of the life cycle inventory must be abandoned. A group-model building process for LCA is developed that allows one to grasp the decision makers' mental models and values in the inventory analysis on a case- and situation-specific basis. Only by this, LCA results will become relevant in a decision-making process. Two case studies on the modelling of recycling and other end-of-life options of aluminium windows and beech wood railway sleepers in LCA complement the methodological part.
Alzheimer's disease : Peptide vaccine and immunotherapy
Peptide vaccines and immunotherapies against aggregating proteins involved in the pathogenesis and progression of Alzheimer's disease (AD) the ẞ-amyloid peptide (Aẞ) and tau are promising therapeutic avenues against AD. Two decades of effort has led to the controversial United States Food and Drug Administration (FDA) approval of the monoclonal antibody Aducamumab (Aduhelm), which has subsequentially sparked the revival and expedited review of promising monoclonal antibody immunotherapies that target Aẞ.
Alternative Splicing and Disease
Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.
Alkaliphiles : Genetic properties and applications of enzymes
The pioneering work of Dr. Koki Horikoshi on the discovery, research and applications of alkaliphilic bacteria are described here in their entirety. The isolation, distribution and taxonomy of alkaliphilic microorganisms as well as their cell structure and physiology are discussed for a basic understanding of these entities. The molecular biology and genome sequencing of some alkaliphilic bacterial strains are also presented. Part II of the volume focuses on enzymes of alkaliphiles and their applications. These include alkaline proteases, starch-degrading enzymes and numerous others. Some of these enzymes are currently in wide commercial use as laundry detergent additives and in wastewater treatment. Alkaliphiles are a relatively recent field of research that will no doubt provide avenues to a wide range of further discoveries and applications for a new generation of workers in bioscience and technology.
Algorithms in Bioinformatics ; Vol.4175 : 6th International Workshop, WABI 2006, Zurich, Switzerland, September 11-13, 2006, Proceedings
This book constitutes the refereed proceedings of the 6th International Workshop on Algorithms in Bioinformatics, WABI 2006, held in Zurich, Switzerland in September 2006 in the course of the ALGO 2006 conference meetings. The 36 revised full papers presented were carefully reviewed and selected from 100 submissions. All current issues of algorithms in bioinformatics are addressed, ranging from mathematical tools to experimental studies of approximation algorithms and reports on significant computational analyses. Numerous biological problems are dealt with, including genetic mapping, sequence alignment and sequence analysis, phylogeny, comparative genomics, and protein structure. For the first time also machine-learning approaches along with combinatorial optimization are covered.
Algorithms in Bioinformatics ; Vol. 3692 ; 5th international workshop, WABI 2005, Mallorca, Spain, October 3-6, 2005, Proceedings
this book present the proceedings of the 5th Workshop on Algorithmsin Bioinformatics (WABI 2005) which took place in Spain, 2005. The Workshop on Algorithms in Bioinformatics highlights research workspecifically developed to address algorithmic problems in biosequence analysis. The emphasis is therefore on statistical and probabilistic algorithms that addressimportant problems in the field of molecular and structural biology. the workshop aims to present recent research results, includingsignificant work in progress, and to identify and explore directions of futureresearch.Original research papers (including significant work in progress) or state-of-the-art surveys were solicited on all aspects of algorithms in bioinformatics,including, but not limited to: exact and approximate algorithms for genomics,genetics, sequence analysis, gene and signal recognition, alignment, molecularevolution, phylogenetics, structure determination or prediction, gene expressionand gene networks, proteomics, functional genomics, and drug design.
Algorithms in Bioinformatics ; 7th International Workshop, WABI 2007, Philadelphia, PA, USA, September 8-9, 2007, Proceedings
All current issues of algorithms in bioinformatics are addressed, ranging from mathematical tools to experimental studies of approximation algorithms and reports on significant computational analyses. Numerous biological problems are dealt with, including genetic mapping, sequence alignment and sequence analysis, phylogeny, comparative genomics, and protein structure. Furthermore the papers feature high-performance computing approaches to computationally hard learning and optimization problems in bioinformatics and cover methods, software and dataset repositories for development and testing of such algorithms and their underlying models.
Algorithms in Bioinformatics : Theory and Implementation
Explores a comprehensive and insightful treatment of the practical application of bioinformatic algorithms in a variety of fields. Delivers a fulsome treatment of some of the main algorithms used to explain biological functions and relationships. It introduces readers to the art of algorithms in a practical manner which is linked with biological theory and interpretation. The book covers many key areas of bioinformatics, including global and local sequence alignment, forced alignment, detection of motifs, Sequence logos, Markov chains or information entropy. Other novel approaches are also described, such as Self-Sequence alignment, Objective Digital Stains (ODSs) or Spectral Forecast and the Discrete Probability Detector (DPD) algorithm. Readers will also benefit from the inclusion of: A detailed presentation of new methods, such as Self-sequence alignment, Objective Digital Stains and Spectral Forecast ; A treatment of sequence alignment, including local sequence alignment, global sequence alignment and forced sequence alignment with full implementations ; Discussions of position-specific weight matrices, including the count, weight, relative frequencies, and log-likelihoods matrices ; A detailed presentation of the methods related to Markov Chains as well as a description of their implementation in Bioinformatics and adjacent fields ; An examination of information and entropy, including sequence logos and explanations related to their meaning ; A chapter on philosophical transactions that allows the reader a broader view of the prediction process ; Extensive worked examples with detailed case studies that point out the meaning of different results
Algorithms and Complexity ; 6th Italian Conference, CIAC 2006, Rome, Italy, May 29-31, 2006, Proceedings
Here are the refereed proceedings of the 6th Italian Conference on Algorithms and Computation, CIAC 2006. The 33 revised full papers presented together with 3 invited papers address such topics as sequential, parallel and distributed algorithms, data structures, approximation algorithms, randomized algorithms, on-line algorithms, graph algorithms, analysis of algorithms, algorithm engineering, algorithmic game theory, computational biology, computational complexity, communication networks, computational geometry, cryptography, discrete optimization, graph drawing, mathematical programming, and quantum algorithms.
Algorithms – ESA 2005 ; 13th Annual European Symposium, Palma de Mallorca, Spain, October 3-6, 2005, Proceedings
This volume contains the 75 contributed papers and the abstracts of the threeinvited lectures presented at the 13th Annual European Symposium on Algo-rithms (ESA 2005), held in Spain, 2005. respectively.Papers were solicited in all areas of algorithmic research, including but notlimited to algorithmic aspects of networks, approximation and on-line algo-rithms, computational biology, computational geometry, computational financeand algorithmic game theory, data structures, database and information re-trieval, external memory algorithms, graph algorithms, graph drawing, machinelearning, mobile computing, pattern matching and data compression, quantumcomputing, and randomized algorithms. The algorithms could be sequential,distributed, or parallel. Submissions were especially encouraged in the area ofmathematical programming and operations research, including combinatorialoptimization, integer programming, polyhedral combinatorics, and semidefiniteprogramming.Each extended abstract was submitted to one of the two tracks.
Algorithmic Aspects of Bioinformatics
Advances in bioinformatics and systems biology require improved computational methods for analyzing data, while progress in molecular biology is in turn influencing the development of computer science methods. This book introduces some key problems in bioinformatics, discusses the models used to formally describe these problems, and analyzes the algorithmic approaches used to solve them. After introducing the basics of molecular biology and algorithmics, Part I explains string algorithms and alignments; Part II details the field of physical mapping and DNA sequencing; and Part III examines the application of algorithmics to the analysis of biological data. Exciting application examples include predicting the spatial structure of proteins, and computing haplotypes from genotype data. This book describes topics in detail and presents formal models in a mathematically precise, yet intuitive manner, with many figures and chapter summaries, detailed derivations, and examples. It is well suited as an introduction into the field of bioinformatics, and will benefit students and lecturers in bioinformatics and algorithmics, while also offering practitioners an update on current research topics.
Algebraic Aspects of the Advanced Encryption Standard
The Belgian block cipher Rijndael was chosen in 2000 by the U.S. government’s National Institute of Standards and Technology (NIST) to be the successor to the Data Encryption Standard. Rijndael was subsequently standardized as the Advanced Encryption Standard (AES), which is potentially the world’s most important block cipher. In 2002, some new analytical techniques were suggested that may have a dramatic effect on the security of the AES. Existing analytical techniques for block ciphers depend heavily on a statistical approach, whereas these new techniques are algebraic in nature.
Alcohol problems in adolescents and young adults : Epidemiology. neurobiology. prevention. and treatment
Alcohol continues to be the substance of choice for today’s youth, leading to serious physical, psychological, and social consequences. Alcohol Problems in Adolescents and Young Adults ably addresses this growing trend. The latest entry in the Recent Developments in Alcoholism series, it comprehensively presents a wide-ranging clinical picture of teen drinking - epidemiology, neurobiology, behavioral phenomena, diagnostic and assessment issues, prevention and treatment data - in a developmental context. Fifty expert contributors display the scientific rigor, practical wisdom, and nuanced analysis that readers have come to expect from previous volumes.
Agricultural Research Management
Agricultural research is one of the most widespread forms of organized research in the world, in both developed and developing countries. Management of agricultural research involves many decisions that have scientific, social and political consequences. Every country has established agricultural research priorities based on many complex factors that must be considered when decisions are made on the choice of research problems to be investigated. Resources must be divided among projects that often compete for the limited funding available that supports the total research enterprise.
Agricultural Implications of the Fukushima Nuclear Accident (III)
Reports on studies undertaken at contaminated sites such as farmland, forests, and marine and freshwater environments, with a particular focus on livestock, wild plants and mushrooms, crops, and marine products in those environments. It also provides additional data collected in the subsequent years to show how the radioactivity levels in agricultural products and their growing environments have changed with time and the route by which radioactive materials entered agricultural products as well as their movement between different components (e.g., soil, water, and trees) within an environmental system (e.g., forests). The book covers various topics, including radioactivity testing of food products; decontamination trials for rice and livestock production; the state of contamination in, trees, mushrooms, and timber; the dynamics of radioactivity distribution in paddy fields and upland forests; damage incurred by the forestry and fishery industries; and the change in consumers’ attitudes. Chapter 19 introduces a real-time radioisotope imaging system, a pioneering technique to visualize the movement of cesium in soil and in plants.
Agency and causal explanation in economics
This book provides an exploration of the consequences of the ontological differences between natural and social objects (sometimes described as objects of nature and objects of thought) in the workings of causal and agency relationships.
Affine Density in Wavelet Analysis
Provides the first thorough and comprehensive treatment of irregular wavelet frames by introducing and employing a new notion of affine density as a highly effective tool for examining the geometry of sequences of time-scale indices.
Advancing Quality of Life in a Turbulent World
Environmental issues continued to loom large in the last decade of the twentieth century,especially environmental problems related to rising levels of CO emissions and 2 other greenhouse gases on the planet’s average temperatures and, subsequently, storm patterns. Floods and droughts, in combination with unseasonably high and low temperatures became the norm rather than the exception for large expanses of Africa,Asia and Oceania. Even large areas of Europe and NorthAmerica were s- jected to recurrent floods and droughts and experienced unseasonable extremes of hot and cold temperatures associated with man-made intrusions into the natural environment. And, still, a global plan of action to haltman-related patterns of def- estation, desertification, and over-fishing of the seas has yet to come into being. At the same time, the number of regional conflicts and civil wars increased and, with them, the lives of many women, children, old people and other n- combatants were lost in these conflicts.
