الصفحة 41
الصفحة 41
Dynamic Asset Allocation with Forwards and Futures
DYNAMIC ASSET ALLOCATION WITH FORWARD AND FUTURES is an advanced text on the theory of forward and futures markets which aims at providing readers with a comprehensive knowledge of how prices are established and evolve over time, what optimal strategies one can expect from the participants, what characterizes such markets, and what major theoretical and practical differences distinguish futures from forward contracts. The book proposes an approach of these markets from the perspective of dynamic asset allocation and asset pricing theory within an inter-temporal framework. The main ingredients that are used are the assumed absence of frictions and arbitrage opportunities in financial and real markets, the uniqueness of the economic general equilibrium, when such an equilibrium is required and the tools of continuous time finance, namely martingale theory and stochastic dynamic programming. The scope of DYNAMIC ASSET ALLOCATION WITH FORWARD AND FUTURES is essentially theoretical, with emphasis on economic meaning and financial interpretation. Regarding investment and/or hedging, focus is on optimal strategies rather than on actual practice. Simulations, however, are performed when important insights can be delivered as to the practical relevance of some theoretical results. Also, optimal strategies using futures are shown to differ markedly from those using forwards. The following issues are examined: pure hedging, investment and hedging in complete or incomplete markets, currency risk, optimal spreading, presence of stochastic dividend or convenience yields, pricing of non-redundant futures or forwards by means of general equilibrium analysis, and revisiting of existing Capital Asset Pricing Models.
Drying and wetting of building materials and components
Discusses important topics of heat and mass transfer in particulate materials Includes a set of new developments in the science of drying and wetting processes Fosters the encounter of a variety of scientific and engineering disciplines
Drug-Induced Oral Complications
Provides detailed information on the prevalence and manifestations of the most important oral complications associated with different drug treatments, focusing especially on recently developed therapies. Among the diverse adverse drug reactions covered are gingival overgrowth, ulcerations, lichenoid reactions, pigmentation, and bullous reactions. The potential direct toxic effects on bone of drugs that prevent bone mass loss, such as bisphosphonates and denosumab, are fully examined, as is the occurrence of spontaneous oral bleeding in patients receiving antithrombotic therapies. Further chapters focus on drug-induced taste disorders and salivary gland disturbances, including xerostomia, swelling, and hypersalivation. The enhanced risk of oral infections when using chemotherapy and biotherapy is addressed, and the closing chapter examines drug-related perioral and facial complications. This book is a collaborative work that brings together clinicians, surgeons, and specialists in drug safety surveillance.
Drug Targets in Kinetoplastid Parasites
The book contains 12 chapters contributed by eminent scientists working in this field. The articles deal mainly with two aspects: visual identification of targets and identification of therapeutic agents.Several targets like kDNA replication machinery, purine salvage pathway, purine and pyrimidine biosynthetic pathway, histone deacetylase, DNA topoisomerases, membrane transporter proteins, glycoproteins and glycolipids are discussed in this book. Since current treatments for kinetoplastid parasitic diseases are far from ideal, there is an urgent and genuine need to develop newer compounds as antiparasitic drug candidates. Therefore evelopment of some lead compounds against these parasites as well as drug resistance are also included in this book. Moreover the vast amount of information generated after publication of the "Trytrip" genome sequence now makes possible several new approaches for target identification and discovery of therapeutic agents. This book is an outcome of the contributions of many scientists working in this important area.
Drug Selectivity : An Evolving Concept in Medicinal Chemistry
Provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Drug interactions in infectious diseases : Mechanisms and models of drug interactions
Provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development
Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
Drinking in Victorian and Edwardian Britain : Beyond the Spectre of the Drunkard
Investigates the reasons why Victorians and Edwardians consumed alcohol in the ways that they did and explores the ideas about alcohol that circulated in the period. This book shows that they had many reasons for purchasing and consuming alcoholic substances and these were driven by broader social, cultural, medical and commercial factors. Although drunkenness may have been the most visible consequence of alcohol consumption, it was not the only type of drinking behaviour. Alcohol played an important social role in the everyday lives of Victorians and Edwardians where its consumption held many different meanings.
Domain Decomposition Methods - Algorithms and Theory
This book offers a comprehensive presentation of some of the most successful and popular domain decomposition preconditioners for finite and spectral element approximations of partial differential equations. It places strong emphasis on both algorithmic and mathematical aspects. It covers in detail important methods such as FETI and balancing Neumann-Neumann methods and algorithms for spectral element methods.
DNA Methylation : Basic Mechanisms
The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is not well understood. The stability, inheritability, and developmental flexibility of these patterns point to a major role that these patterns appear to play in determining structure and function of the genome.
DNA damage detection : Methods and protocols
Explores techniques in DNA damage analysis, important not only for understanding cellular health after exposure to genotoxic agents but also for assessing cellular ability of genome maintenance. The book explores traditional DNA damage measurement methods, as well as modern fluorescence-based analysis and high throughput automatic analysis methods. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
D-Modules, Perverse Sheaves, and Representation Theory
D-modules continues to be an active area of stimulating research in such mathematical areas as algebra, analysis, differential equations, and representation theory. Key to D-modules, Perverse Sheaves, and Representation Theory is the authors' essential algebraic-analytic approach to the theory, which connects D-modules to representation theory and other areas of mathematics. Significant concepts and topics that have emerged over the last few decades are presented, including a treatment of the theory of holonomic D-modules, perverse sheaves, the all-important Riemann-Hilbert correspondence, Hodge modules, and the solution to the Kazhdan-Lusztig conjecture using D-module theory.
Diversity and Inclusion in Global Higher Education : Lessons from Across Asia
This book offers pioneering insights and practical methods for promoting diversity and inclusion in higher education classrooms and curricula. It highlights the growing importance of international education programs in Asia and the value of understanding student diversity in a changing, evermore interconnected world
Disorders due to addiction and its therapy in Syria
Addiction is a broad and important concept that has a lot of bad consequences, the goal of our research is to talk at an overview of all its types in order to raise public health awareness, addiction is not limited to narcotic substances, but until there is a behavioral type that includes getting used to harmful habits, we as pharmacists will focus on drug dependence and its mechanism, which many patients suffer from its disorders...
Dislocation and Degradation of Proteins from the Endoplasmic Reticulum
The present volume of Current Topics in Microbiology and Immunology c- tains seven chapters that illuminate various aspects of a protein’s genesis and terminal fate in the endoplasmic reticulum (ER). Increased knowledge of the biosynthetic pathways of glycoproteins allowed the identi?cation of the ER as an important site where such quality control decisions were made.
Disease in Wild Animals : Investigation and Management
Wildlife diseases have become increasingly important recently due to their effect upon human health, veterinary medicine, wildlife, and conservation biology. Gary Wobeser's successful book from 1994 has been completely updated and enlarged in a new second edition. An in-depth overview of the available techniques for the investigation and management of disease in free-ranging animals is provided. The subjects are illustrated with examples drawn from around the world, with emphasis on the special requirements involved in working with wild animals. Techniques are assessed critically with regard to their efficacy and effectiveness.
Discrete-time Sliding Mode Control : A Multirate Output Feedback Approach
Sliding mode control is a simple and yet robust control technique, where the system states are made to confine to a selected subset. With the increasing use of computers and discrete-time samplers in controller implementation in the recent past, discrete-time systems and computer based control have become important topics. This monograph presents an output feedback sliding mode control philosophy which can be applied to almost all controllable and observable systems, while at the same time being simple enough as not to tax the computer too much. It is shown that the solution can be found in the synergy of the multirate output sampling concept and the concept of discrete-time sliding mode control.
Discrete, continuous, and hybrid Petri Nets
The book is a scientific monograph as well as a didactic tutorial which is easy to understand due to many exercises with solutions, detailed figures and several case studies. It demonstrates that Petri nets are a deep, practical and alive field important for researchers, engineers and graduate students in engineering and computer science.
Direct Democracy in Europe : Developments and Prospects
The initiative and referendum process offers extra channels of participation and can serve as an important supplementary institution in representative democratic systems. This first volume of the new series Direct Democracy in Modern Europe features sixteen systematic and broadly empirical approaches to the study of modern direct democracy within the context of European politics including - system contexts and effects of the initiative and referendum process - theoretical approaches and basic values in modern direct democracy - the quality and institutional design of direct democratic mechanisms - aspects of information and communication - institutional performance and economic effectiveness - transnational challenges and the development of direct democracy in Europe
Direct and indirect resin composite veneers
Re-establishing a patient’s lost dental asthetic appearance is one of the most important topics for contemporary dentistry.New treatment materials and methods have been coming on the scene, day by day, in order to achieve such an aim. Most dentists prefer more conservative and aesthetic approaches. Laminate veneers are restorations which are envisioned to correct existing abnormalities, esthetic deficiencies and discolorations. Laminate veneer restorations may be processed in two different ways: direct or indirect. Direct resin composite veneers are one of the most commonly used restorations in the treatment of poor esthetics in anterior teeth presenting unsatisfactory colour and shape, defective restorations, slight misalignment and fractures.
