الصفحة 4
الصفحة 4
Drugs used in murder and drugs facilitated sexual assaults
Since ancient times, the methods of committing crimes have varied and the methods of killing have varied. The killer has always sought to hide his crime. One of the methods of killing is poisoning the victim, but with the development of science also methods for detecting toxins inside the victim's body have developed. Also, in recent decades, drugs facilitating sexual assault have spread, which aim to make the victim unconscious and paralyze his resistance...
Drug Testing in Alternate Biological Specimens
Drug Testing in Alternate Biological Specimens provides researchers and forensic toxicologists with a convenient general text summarizing the state of knowledge today.
Drug safety evaluation : Methods and protocols
Focuses on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the Pig-a mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls.
Drug disposition and pharmacokinetics : Principles and applications for medicine, toxicology and biotechnology
Delivers an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics.
Drug Discovery and Evaluation
The 3rd edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal, and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described.
Drug Delivery Systems
Expands on the previous editions with a discussion of new and updated methods used to study drug delivery. Chapters cover topics such as drug delivery in cancer and intrathecal delivery of analgesics in humans. The increasing role of nanobiotechnology is reflected in eight of the sixteen chapters that include synthesis of gold nanoparticles; targeted siRNA delivery; and lipid nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Dermatotoxicology & respiratory toxicology = التسمم الجلدي والتنفسي
مصطلح " السم " غالبا يستخدم بالعامية لوصف المادة السامة - سواء كانت مادة آكالة (مخرشة)، أو مسرطنة، أو مطفرة، أو ماسخة، وإشارة إلى التلوث الضار وللتأكيد على مخاطر المواد الكيميائية. ويمكن تلخيص أساسيات علم السموم فيما يأتي: الجرعة /الاستجابة/ التعرض والاختلافات بالآثار الناتجة عن التعرض للخطر لدى الأشخاص. العديد منا يملك حس جيد بأساسيات السموم من خلال تجاربنا مع الكافيين و الكحول أو أي دواء أخر. وقد وجد أن آليات إصابة الجلد والرئتين تشكل سمية حادة أو مزمنة، حيث أن الاستعمال والجرعات المفرطة للمبيدات الحشرية أو الأدوية أو مواد أخرى تستهلك يوميا، يؤدي إلى تحويل هذين الجهازين (الجلدي والتنفسي) إلى بوابات للسمووقد وجد أيضا أن هامش العلاج ضيق جدا واحتمالية الدخول في النافذة السمية سهل جداز سنستعرض هنا أهم الآفات السمية الجلدية والرئوية من حيث آلية حدوثها وطرق علاجها.
Dangerous Pollutants (Xenobiotics) in Urban Water Cycle
The book focused on evaluation of impact of xenobiotics in the whole Urban Water Cycle are an interdisciplinary task which has a rising concern these days. Xenobiotics includes both inorganic elements like heavy metals, metalloids and man-made organic compounds such as pesticides, surfactants, solvents, fragrances, flavours, and pharmaceuticals as well as endocrine dis- pters.
Criminal Poisoning : Investigational Guide for Law Enforcement, Toxicologists, Forensic Scientists, and Attorneys
Investigational Guide for Law Enforcement, Toxicologists, Forensic Scientists, and Attorneys, leading forensic scientist John Trestrail offers a pioneering survey of all that is known about the use of poison as a weapon in murder. Topics range from the use of poisons in history and literature to convicting the poisoner in court, and include a review of the different types of poisons, techniques for crime scene investigation, and the critical essentials of the forensic autopsy. The author updates what is currently known about poisoners in general (psychological profile, types, and statistical analyses) and their victims (who gets poisoned, investigative considerations, and classic symptoms of poisoning).
Continental Scientific Drilling : A Decade of Progress, and Challenges for the Future
Scientific drilling is an indispensable tool of modern Earth science - search, as it provides the only means of obtaining direct information on processes operating at depth. Drilling allows for the determination of - situ properties of solid materials and fluids and permits testing of hypot- ses and models derived from surface observations. In addition, drill holes may be used as a natural laboratory for experiments and as observatories for long-term monitoring of on-going active processes. Earth drilling, therefore, plays a critical role in scientific research directed towards - proved understanding of the workings of our planet and has a key role in solving urgent socio-economic problems. As a rule, drilling projects are an integral component of major geosci- tific research programs, comprising comprehensive pre-site investigations, accompanying laboratory studies, the drilling phase itself, and consecutive measurements and tests in the drill hole. Such drilling programs are costly and thus only realizable to a limited extent. International cost sharing, the optimal utilization of all available resources, the incorporation of inter- tional leading experts, and the application of the existing know-how, as well as the selection of an optimal drilling location (“World Geological Site”), are thus essential elements of an international scientific drilling p- gram.
Contaminant Geochemistry : Interactions and Transport in the Subsurface Environment
This book combines earth science, subsurface hydrology and environmental geochemistry, providing a comprehensive background for specialists interested in the protection and sustainable management of the subsurface environment.The major focus of the book is on contaminant reactions in soil solutions, groundwater and porous media solid phases, accounting for their persistence and transformation in the subsurface, as they are transported from the land surface into groundwater.
Contact Dermatitis
Covers various aspects of the modern-day management of contact dermatitis. This title also covers irritant and allergic contact dermatitis with an emphasis being given to immunological mechanisms, molecular aspects of sensitizers, atypical clinical forms, reactions to medicaments, and occupational and environmental aspects.
Concepts in pharmaceutical biotechnology and drug development
Provides comprehensive coverage of the development of new pharmaceuticals and the enhancement of existing ones. It offers a comprehensive understanding of pharmaceutical biotechnology, including its underlying principles and practical applications from an industrial standpoint. While introducing the roles and applications of biotechnology in drug design and development, the book describes how developments in other fields, like genomics, proteomics, and high-throughput screening, have facilitated the discovery of novel therapeutic targets and drug development methods. It included concepts that are essential to biotechnology and apply to protein therapies. And provides a thorough overview of the ways in which biotechnology influences drug development, production, and regulation, and is a valuable resource for those seeking to enhance their understanding in this area.
Computer Aided Pharmaceutics and Drug Delivery : An Application Guide for Students and Researchers of Pharmaceutical Sciences
Examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems. This title provides in-depth knowledge of such useful software with illustrations from the latest researches. The book also fills in the gap between pharmaceutics and molecular modeling at micro, meso and maro scale by covering topics such as advancements in computer-aided Drug Design (CADD), drug-polymer interactions in drug delivery systems, molecular modeling of nanoparticles and pharmaceutics/bioinformatics.
Computational drug discovery and design
Provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput virtual screening, lead discovery and optimization, conformational sampling, prediction of pharmacokinetic properties using computer-based methodologies. Chapters also focus on the application of the latest artificial intelligence technologies for computer aided drug discovery.
Clinical toxicology : Principles and mechanisms ; 2nd ed.
Addresses the current principles and mechanisms of clinical toxicology. It examines the complex interactions associated with clinical toxicological events and chemical exposure and drug administration. The author places special emphasis on signs and symptoms of diseases and pathology caused by toxins and clinical drugs. He covers contemporary issues in clinical toxicology, such as biological and chemical toxins, changes in protocols for managing toxic ingestions, new antidotes, and changes in particular treatments. The chapters contain numerous drawings, figures, and tables to aid in comprehension.
Marine resource damage assessment : Liability and compensation for environmental damage
MARE-DASM research focused on: (i) the estimation and distribution of marine contaminants in order to assess their long term effects (ecotoxicology); (ii) the integration of these result into a Biological Effects SubModel and a mathematical model assessing the risks associated with accidental spillage of oil at sea and the damage this can cause (modelling); (iii) the assessment of the willingness to pay for ecological damage, based on the Contingent Valuation Method (economics); (iv) the development and evaluation of measures to be taken in order to guarantee a sustainable use of the Belgian part of the North Sea, taking into account the economic and social interests and values (social economics); (v) the potential to develop technical and legal procedures that allow ecological damage to the marine environment to be evaluated and compensated, taking into account constraints in national and international liability legislation (legal).
Marine bioactive molecules for biomedical and pharmacotherapeutic application
Explores cutting-edge research on the discovery and application of marine bioactive molecules for biomedical and pharmacotherapeutic purposes. The book begins by delving into the bioprospection of marine sponge microbiomes for bioactive metabolites using advanced metagenomics tools. It then explores metagenome mining approaches for the discovery of marine microbial natural products. The use of marine-derived fungi as a source of anticancer secondary metabolites is also discussed. The book then turns to the biomedical applications of marine-derived biomaterials, including marine biopolymers in tissue engineering and regenerative medicine. Marine-derived pharmaceuticals and polymeric nanostructures for cancer treatment are also examined.
Manifestations dermatologiques des maladies infectieuses, métaboliques et toxiques: Dermatologie et médecine ; Vol.2 = Dermatological manifestations of infectious, metabolic and toxic diseases : Dermatology and medicine ; Vol.2
Deals with the skin and mucous membrane manifestations observed during infectious, metabolic and toxic diseases. It is intended not only for dermatologists and internists, but also for healthcare professionals concerned with infectious, metabolic and toxic diseases.
Manifestations dermatologiques des connectivites vascularites et affections systémiques apparentées : Dermatologie et médecine = Dermatological manifestations of connectivitis, vasculitis and related systemic conditions: Dermatology and medicine
Deals with all the skin and mucous membrane manifestations observed during the various so-called systemic, common or rare diseases. Each chapter covers in an exhaustive and original way the clinical, anatomopathological and therapeutic knowledge essential to the practice of dermatology and internal medicine. The work is abundantly illustrated with color clinical iconography, carefully selected for its clinical representativeness. The didactic anatomopathological figures have been enriched with explanatory diagrams facilitating their reading by the practitioner unfamiliar with dermatological histology. Produced by a group of leading authors in their field, this book is intended for dermatologists, rheumatologists and internists as well as all professionals concerned with systemic diseases and internal medicine.
