الصفحة 4
الصفحة 4
Molecular autoimmunity
The autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important challenge. Over the last few years, our understanding of the pathogenesis of autoimmune diseases has improved rapidly, leading to the emergence of elegant immunointervention strategies. Molecular Autoimmunity illustrates how cutting-edge research is continuing to advance our understanding of autoimmune disease mechanisms and identifies novel therapeutic targets that provide a hope for effective future treatments. This volume contains a selected number of exciting advances in unraveling autoimmune reactions, and the resulting new armory of experimental immunotherapies that may lead to new ways of controlling autoimmune reactions.
Modulation of host gene expression and innate immunity by viruses
This book is reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Infection of a naïve (non-immune) host with a virus elicits an immediate response which results in a cascade of changes in the host, including an interferon response (innate immunity). The outcome of this interaction is influenced by the genes of the virus as well as the genes of the host. Interestingly, different viruses do it in different ways. Not only is there a plethora of mechanisms used by the invading organisms, but the host has also evolved a great variety of redundant and robust countermeasures. This interplay of host and virus represents one of the most significant frontiers in biology today. A clearer understanding of the mechanisms involved will arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents. This book is sure to benefit students, scientists, and physicians working in the areas of virology, immunology, microbiology, and infectious diseases.
Modern parallel programming with C++ and assembly language : X86 SIMD development using AVX, AVX2, and AVX-512
Understand the essential details about x86 SIMD architectures and instruction sets including AVX, AVX2, and AVX-512. / Master x86 SIMD data types, arithmetic instructions, and data management operations using both integer and floating-point operands. / Code performance-enhancing functions and algorithms that fully exploit the SIMD capabilities of a modern x86 processor. Employ C++ intrinsic functions and x86-64 assembly language code to carry out arithmetic calculations using common programming constructs including arrays, matrices, and user-defined data structures. Harness the x86 SIMD instruction sets to significantly accelerate the performance of computationally intense algorithms in applications such as machine learning, image processing, computer graphics, statistics, and matrix arithmetic. / Apply leading-edge coding strategies and techniques to optimally exploit the x86 SIMD instruction sets for maximum possible performance.
Modern IoT onboarding platforms for advanced applications: a practitioner’s guide to KIS.ME
There is no doubt that digitalization solutions from Industry 4.0 and the Internet of Things (IoT) can be perceived as excellent candidate strategies capable of handling the above-stated issues concerning measurements and transparency. However, IoT tools themselves can provide appropriate data only, while their efficient integration and application are possible using a dedicated onboarding platform only. To settle this issue, the book undertakes the problem of modern IoT onboarding platforms for the advanced applications pertaining to manufacturing and logistics. In particular, instead of deliberating about a possible hypothetic platforms, an existing and efficient one is employed, which is called KIS.ME. KIS.ME (Keep It Simple. Manage Everything) is a complete IoT solution for a simple integration in manufacturing and logistics.
Modern industrial services : A cookbook for design, delivery, and management
This book is an outcome of several years of research, practice, and teaching experience of the authors on the challenges that underpin the successful switch to services for manufacturing firms. Ideal for a student as well as a practitioner, the book describes the industrial services ecosystem, the barriers and challenges, and a roadmap for building service excellence. Curated cases are used to describe the current approaches in practice to overcome the barriers. The book also provides several tools, each with a short introduction, that the authors have used successfully in projects to help overcome the servitization barriers. Many of these tools are from management, design thinking, or service design.
Modern front-end architecture : Optimize your front-end development with components, storybook, and mise en place philosophy
Learn how to build front-end applications that can help you ship applications faster with fewer defects. Many software projects fail because they are not planned well, or lack organization. Applying strategies from other industries can help you create better software. Explores the “mise en place” technique from cooking and reveals how you can apply it to the art of creating software. Describes to how to structure your code base for reuse, and how to communicate the code’s intent to other developers. You’ll develop your components in isolation and test these building blocks for quality at a granular level. Then compose these components as building blocks in increasingly complicated features. Finally, you’ll apply some strategies not directly related to code to ensure maximum quality and efficiency. You will : Structure an application as a series of components / Build a component library that others in an organization can leverage / Ensure quality and accessibility at a component level rather than a page or app level / Test code in a way that gives the maximum amount of confidence while providing an excellent developer experience / Automate repeatable tasks
Modern deep learning for tabular data : Novel approaches to common modeling problems
Synthesizes and presents novel deep learning approaches to a seemingly unlikely domain - tabular data. Whether for finance, business, security, medicine, or countless other domain, deep learning can help mine and model complex patterns in tabular data - an incredibly ubiquitous form of structured data. Part I of the book offers a rigorous overview of machine learning principles, algorithms, and implementation skills relevant to holistically modeling and manipulating tabular data. Part II studies five dominant deep learning model designs - Artificial Neural Networks, Convolutional Neural Networks, Recurrent Neural Networks, Attention and Transformers, and Tree-Rooted Networks - through both their 'default' usage and their application to tabular data. Part III compounds the power of the previously covered methods by surveying strategies and techniques to supercharge deep learning systems: autoencoders, deep data generation, meta-optimization, multi-model arrangement, and neural network interpretability.
Modern Control Systems ; 14th ed.
Written to be equally useful for all engineering disciplines, this text is organized around the concepts of control systems theory in the context of frequency and time domains. It provides coverage of both classical and modern methods of control engineering to give students a strong foundation in basic principles that they can utilize to explore advanced topics in later chapters. Emphasis is placed on real-world complex control systems and practical design applications as well as evolving design strategies like green engineering and human-centered design. Problem solving is strongly emphasized, with an abundance of problems of increasing complexity that help students learn to apply theory to computer-aided design and analysis concepts using MATLAB® and LabVIEW MathScript.
Modern Control Systems ; 13th ed.
Presents the structure of feedback control theory and to provide a sequence of exciting discoveries. The book demonstrates various real-world, global engineering problems while touching on evolving design strategies like green technology. Some of the themes at-hand include climate change, clean water, sustainability, waste management, emissions reduction, and minimizing energy. Throughout the text, students apply theory to the design and analysis of control systems.
Modern clinic design : strategies for an era of change
A comprehensive guide to optimizing patient experience through the design of the built environment. Written by a team of veteran healthcare interior designers, architects, and engineers, this book addresses the impacts of evolving legislation, changing technologies, and emerging nontraditional clinic models on clinic design, and illustrates effective design strategies for any type of clinic. Readers will find innovative ideas about lean design, design for flexibility Understand how recent industry developments impact facility design Learn how design strategies can help create a positive patient experience Examine emerging clinic models that are becoming increasingly prevalent Analyze the impact of technology on clinic design
Modern architecture and climate design before air conditioning
explores how leading architects of the twentieth century incorporated climate-mediating strategies into their designs, and shows how regional approaches to climate adaptability were essential to the development of modern architecture. Focusing on the period surrounding World War II'before fossil-fuel powered air-conditioning became widely available'Daniel Barber brings to light a vibrant and dynamic architectural discussion involving design, materials, and shading systems as means of interior climate control. He looks at projects by well-known architects such as Richard Neutra, Le Corbusier, Lúcio Costa, Mies van der Rohe, and Skidmore, Owings, and Merrill, and the work of climate-focused architects such as MMM Roberto, Olgyay and Olgyay, and Cliff May. Drawing on the editorial projects of James Marston Fitch, Elizabeth Gordon, and others, he demonstrates how images and diagrams produced by architects helped conceptualize climate knowledge, alongside the work of meteorologists, physicists, engineers, and social scientists. Barber describes how this novel type of environmental media catalyzed new ways of thinking about climate and architectural design.
Modelling Regional Scenarios for the Enlarged Europe : European Competitiveness and Global Strategies
The aim of this book is to tackle the question of what the European territory will look like over the next fifteen years by providing quali-quantitative territorial scenarios for the enlarged Europe, under different assumptions on future globalisation strategies of BRIC (Brazil, Russia, India and China) and East and West European countries. The approach is as neutral as possible vis-à-vis the results, leaving to a new forecasting model, the MASST model, built by the authors, to produce the tendencies and behavioural paths of regional GDP and population growth in each individual European region under alternative assumptions on the competitiveness strategies of different blocks of countries. The results are accompanied by strong policy messages intended to encourage long-term strategic thinking among a wide range of actors, scientists and policy makers in response to the risks and opportunities that the European territory will face.
Modelling in Mechanical Engineering and Mechatronics : Towards Autonomous Intelligent Software Models
Modelling in Mechanical Engineering and Mechatronics presents a model-centred approach focusing on distributed development and use of autonomous intelligent software models, particularly the efficiency of the models, and their interaction and integration into distributed autonomous intelligent systems. In order to systematise the available knowledge, a domain ontology is presented; a subset of which is used to create a modelling theory based on knowledge and experience in the areas of software engineering, mechanical engineering and mechatronics. This holistic view of modelling explains the purpose and the essence of modelling, as well as the benefits that are to be expected. It discusses the relations to other branches of engineering and science and as a result, it demonstrates strategies, methods and tools for unleashing the full power of modelling.
Modelling and Estimation Strategies for Fault Diagnosis of Non-Linear Systems : From Analytical to Soft Computing Approaches
This monograph presents a variety of techniques that can be used for designing robust fault diagnosis schemes for non-linear systems. The introductory part of the book is of a tutorial value and can be perceived as a good starting point for the new-comers to this field. Subsequently, advanced robust observer structures are presented. Parameter estimation based techniques are discussed as well. A particular attention is drawn to experimental design for fault diagnosis. The book also presents a number of robust soft computing approaches utilizing evolutionary algorithms and neural networks. All approaches described in this book are illustrated by practical applications.
Model Driven Engineering Languages and Systems ; Vol. 3713 : 8th International Conference, MoDELS 2005, Montego Bay, Jamaica, October 2-7, 2005, Proceedings
Constitutes the proceedings of the 8th International Conference on Model Driven Engineering Languages and Systems, MoDELS 2005, held in Montego Bay, Jamaica, in October 2005. This book includes 52 papers and 2 keynote abstracts. It covers such topics as process modelling, product families, state/behavioral modeling, design strategies and more.
Model Based Learning and Instruction in Science
This book describes new, model based teaching methods for science instruction. It presents research that describes these new methods in a very diverse group of settings: middle school biology, high school physics, and college chemistry classrooms. Mental models in these areas such as understanding the structure of the lungs or cells, molecular structures and reaction mechanisms in chemistry, or causes of current flow in electricity are notoriously difficult for many students to learn. Yet these lie at the core of conceptual understanding in these areas. The studies focus on a variety of teaching strategies such as discrepant questioning, analogies, animations, model competition, and hands on activities.
Mobilizing Adults for Positive Youth Development : Strategies for Closing the Gap between Beliefs and Behaviors
"In today's fast-paced, often-dehumanizing world, increasing positive adult involvement and influence is particularly vital. To further that goal, Mobilizing Adults for Positive Youth Development: Strategies for Closing the Gap between Beliefs and Behaviors brings together, in one concise volume, the advice and expertise of leading scholars dedicated to affecting positive youth development. Taken together, the chapters in this book provide a multifaceted, multidisciplinary blueprint for social change." "Mobilizing Adults for Positive Youth Development: Strategies for Closing the Gap between Beliefs and Behaviors is a must-have volume for both practitioners and researchers - in fact, for anyone interested and involved in working toward achieving positive youth development.
Mobilities of the Highly Skilled towards Switzerland : The Role of Intermediaries in Defining “Wanted Immigrants”
This book analyses the strategies of migration intermediaries from the public and private sectors in Switzerland to select, attract, and retain highly skilled migrants who represent value to them. It reveals how state and economic actors define “wanted immigrants” and provide them with privileged access to the Swiss territory and labour market. This book thus shifts the focus from an approach that takes the category of highly skilled migrant for granted to one that regards context as crucial for structuring migrants’ characteristics, trajectories, and experiences. Beyond consideration of professional qualifications, the ways decision-makers perceive candidates and shape their resource environments are crucial for constructing them as skilled or unskilled, wanted or unwanted, welcome or unwelcome.
Mining Complex Data ; ECML/PKDD 2007 Third International Workshop, MCD 2007, Warsaw, Poland, September 17-21, 2007, Revised Selected Papers
This book constitutes the refereed proceedings of the Third International Workshop on Mining Complex Data, MCD 2007, held in Warsaw, Poland, in September 2007, co-located with ECML and PKDD 2007.The 20 revised full papers presented were carefully reviewed and selected; they present original results on knowledge discovery from complex data. In contrast to the typical tabular data, complex data can consist of heterogenous data types, can come from different sources, or live in high dimensional spaces. All these specificities call for new data mining strategies.
Microinvasive Dentistry : Clinical Strategies and Tools
A comprehensive guide to techniques, technologies and tools used in microinvasive dentistry. Divided into four sections, the text begins with an overview of caries and its prevention. The following sections provide in depth discussion on diagnosis through various imaging devices, then different treatment options and technologies. The final section covers future developments including enamel regeneration and photobiomodulation.
